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김경중,고명관,심호찬,김창래,정여진,김태오 대한소화기학회 2019 대한소화기학회지 Vol.73 No.6
Intussusception is a common in pediatric age group. But it is rare in adults. And intussusception caused by tumor account for 1% of bowel obstructions in adult. Intussusception is an extremely rare cause of abdominal pain in pregnancy. In particular, cases of Intussusception due to colorectal cancer during pregnancy have never been reported in Korea. Our patient is a 34 years old woman who presented at 14 weeks of her second pregnancy. She presented with right lower abdominal discomfort and intermittent palpable mass which was usually spontaneously resolved. In the MRI study, pathologic asymmetric wall thickening was still noted and ileocolic intussusception was noted, and in colonoscopy, there was ulcerofungating mass around ileocecal valve which may be a leading point of intussusception. Biopsy was done. Pathologic finding was poorly differentiated adenocarcinoma. Under the patient agreement, we performed dilatation and curettage and laparoscopic right hemicolectomy and lymph node dissection. Now she is receiving a FOLFOX chemotherapy.
광안정제로 멜라닌이 첨가된 Montelukast 각인 전분 기반 바이오 소재의약물 방출 특성
김경중,김지윤,심왕근,윤순도 한국고분자학회 2024 폴리머 Vol.48 No.1
In this study, montelukast (MTL) imprinted starch-based biomaterials using mungbean starch (MS), polyvinyl alcohol (PVA), melanin (MEL) as a light stabilizer, and plasticizers were synthesized by the casting method and heat curing process. MTL release properties were evaluated at different temperatures and pH 5.5. Biomaterials were characterized using FE-SEM and FTIR. In addition, physical properties such as mechanical and water resistance properties for biomaterials were investigated. Results of MTL release properties in the buffer solution indicated that MTL was released about 36.74% within 120 min. In addition, MTL release from MEL-added biomaterials was increased about 1.30-1.43 times by thelight stabilizer. In case of MTL release using the artificial skin, MTL was released continuously for 12 h, and the MTL releasefrom MEL-added biomaterials was increased by about 1.54 times. MTL release in buffer solution followed the pseudo-Fickian diffusion mechanism, whereas the MTL release in artificial skin followed the non-Fickian diffusion mechanism.
김경중,박창우,김은태,박민용 한국지능시스템학회 2005 한국지능시스템학회논문지 Vol.15 No.3
This paper presents online identification algorithm for TSK fuzzy model. The proposed algorithm identify structure of premise part by using distance, and obtain the parameters of the piecewise linear function consisting consequent part by using recursive least square. Only input space was considered in Most researches on structure identification, but input and output space is considered in the proposed algorithm. By doing so, outliers are excluded in clustering effectively. The existing other algorithm has disadvantage that it is sensitive to noise by using data itself as cluster centers. The proposed algorithm is non-sensitive to noise not by using data itself as cluster centers. Model can be obtained through one pass and it is not needed to memorize many data in the proposed algorithm. 본 논문에서는 TSK 퍼지 모델을 위한 온라인 식별 알고리즘을 제안한다. 제안된 알고리즘은 거리를 이용하여 TSK 퍼지 모델에 대한 전건부의 구조를 식별하고, 재귀적 최소자승법으로 후건부를 구성하는 부분 선형 함수들의 매개 변수를 구한다. 대부분의 다른 연구들에서는 전건부의 구조를 구하기 위해서 클러스터링을 수행할 때 입력 공간에서만 고려하였으나. 제안된 알고리즘에서는 입력 공간 및 출력 공간 모두에서 고려하여, 아웃라이어를 효과적으로 배제할 수 있다. 기존의 대부분의 다른 알고리즘에서 샘플 데이터자체를 클러스터의 중심으로 사용하여 잡음에 민감한 단점이 있었으나, 제안된 알고리즘에서는 데이터 자체를 클러스터의 중심으로 사용하지 않아 잡음에 대해 민감하지 않다. 제안된 알고리즘은 많은 데이터의 저장을 필요로 하지 않고, 한 번 통과함으로써 모델을 구할 수 있다.