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신민경 ( Min Kyung Shin ),홍경국 ( Kyung Kook Hong ),유박린 ( Bark Lin Lew ),김낙인 ( Nack In Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12
Microscopic polyangiitis (MPA) is a systemic vasculitis that is histologically characterized by small vessel involvement. Although MPA is primarily associated with necrotizing and crescentric glomerulonephritis and pulmonary capillaritis, MPA often has cutaneous features. We report a case of microscopic polyangiitis with acral necrosis as the skin manifestation. A 56-year-old man presented with acral dry gangrene on tip of finger and toe and reticulated erythema on leg. He had suffered from proteinuria, hemoptysis, and arthralgia. Histopathologically, small vessel vasculitis without granuloma was seen. A high serum level of pANCA was detected by ELISA. This is a relatively rare disease, which has a poor prognosis in the absence of aggressive therapy, and is infrequently reported in dermatologic journals in Korea. (Korean J Dermatol 2007;45(12):1298∼1302)
목향(木香)이 고지방 식이에 의한 비만으로 유발된 인슐린 저항성 mouse의 염증 및 인슐린 저항성에 미치는 영향
오재선,마영훈,최승범,김종호,김경국,전상윤,Oh, Jae-Seon,Ma, Young-Hun,Choi, Seung-Bum,Kim, Jong-Ho,Kim, Kyung-Kook,Jeon, Sang-Yun 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4
Objectives: Obesity is an important cause of insulin resistance that leads to obese type 2 diabetes. Recently it has been found that obesity is associated with adipose tissue accumulation which causes systemic inflammation. In this study, we investigated effects of Inula helenium on the inflammation in high fat diet-induced insulin resistance mouse. Methods: Insulin resistance was induced in C57BL/6 male mice (19~21 g) on a 60% fat diet. Mice were divided into 3 groups (n=6) of normal, control and Inula helenium. After 12 weeks, body weight, FBS, oral glucose tolerance test (OGTT), serum level of insulin, epididymal fat pad, liver weight and the gene expression of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6, interleukin (IL)-10 and cluster of differentiation (CD) 68 were measured. Also, adipose tissue macrophage was analyzed by fluorescence activated cell sorting. Results: Inula helenium significantly reduces oral glucose tolerance levels, insulin serum level and adipose tissue macrophage. Also Inula helenium increased IL-10 gene expression and decreased CD68 gene expression. Conclusions: These results show that Inula helenium has anti-insulin resistance and anti-inflammatory effects on a high fat diet-induced insulin resistance mouse model.