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        • KCI등재

          정선 갓의 영양성분 및 세포기반 항산화 활성 분석

          권희연,이옥환,최선일,조봉연,최승현,심완섭,한웅호,장길웅,최예은,여진희,조주현 한국식품영양학회 2019 韓國食品營養學會誌 Vol.32 No.5

          The purpose of this study was to demonstrate the quality characteristics of Brassica juncea cultivated in Jeongseon (BJJ), South Korea. We analyzed the nutritional components and antioxidant activity of BJJ. As a result of the free sugar analysis, the contents of glucose and fructose in BJJ were 0.29±0.02 g/100 g and 0.10±0.00 g/100 g, respectively. The major fatty acids were palmitic acid, octadecenoic acid and stearic acid. The palmitic acid was the highest at 31.22% of all fatty acids. The major minerals were identified as Ca, P, K, Mg and Na. The contents of vitamin B1, vitamin B2, vitamin B6, vitamin C and vitamin E in BJJ were 0.02±0.00 mg/100 g, 0.087±0.01 mg/100 g, 0.02±0.00 mg/100 g, 0.56±0.06 mg/100 g and 0.20±0.03 mg α-TE/100 g, respectively. As a result of the free amino acid analysis, total amino acid contents in BJJ were 2,801.21±115.38 mg/100 g. L-proline content was the highest (744.30±119.06 mg/100 g) in BJJ. BJJ extract inhibits reactive oxygen species production in 3T3-L1 adipocytes. Also, BJJ extract exhibits a protective effect on oxidative stress in H2O2-induced human dermal fibroblast. These results indicate that BJJ comprises various valuable nutrients which can be used as functional food ingredients.

        • KCI등재

          좁은잎천선과 및 조릿대 혼합 추출물의 항산화 성분과 항산화 활성

          권희연,최선일,한웅호,문효,장길웅,최예은,강준철,조주현,이옥환,Kwon,,Hee-Yeon,Choi,,Sun-Il,Han,,Xionggao,Men,,Xiao,Jang,,Gill-Woong,Choi,,Ye-Eun,Kang,,Jun-Chul,Cho,,Ju-Hyun,Lee,,Ok-Hwan 한국식품과학회 2020 한국식품과학회지 Vol.52 No.4

          The purpose of this study was to evaluate the antioxidant components and activities of HR02/04(8:2)-W, a mixture of S. quelpaertensis Nakai and F. erecta var. sieboldii. We investigated the p-coumaric acid, total flavonoid, and total phenol contents. To evaluate the antioxidant efficacy, we measured the 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline6-sulfonic acid) diammonium salt (ABTS) radical scavenging activity, FRAP activity, reducing power, and ORAC value. We observed the protective effect of hydrogen peroxide against cell damage in human dermal fibroblasts. As a result of the experiment, the p-coumaric acid, total flavonoid, and total phenol contents were 75.62±1.56 mg/100 g, 21.57±0.84 mg rutin equivalent (RE)/g, and 21.25±1.31 mg gallic acid equivalent (GAE)/g, respectively. In the experiments on antioxidant activity, HR02/04(8:2)-W was found to have significantly increased antioxidant activity. In the human dermal fibroblasts, the HR02/04(8:2)-W treated groups could effectively protect cells against oxidative damage. In this study, we confirmed that HR02/04(8:2)-W is a material with effective physiological antioxidant activity. 본 연구에서는 HR02/04(8:2)-W에 대한 항산화 성분 및 생리활성을 평가하기 위하여, p-coumaric acid 함량, 총 플라보노이드 및 총 페놀 함량, DPPH, ABTS 라디칼 소거능, FRAP 활성, reducing power, ORAC value를 측정하였다. 또한, 피부 섬유아세포에서 hydrogen peroxide에 의하여 산화적 스트레스가 유도된 세포 모델에서의 HR02/04(8:2)-W의 산화 손상 보호효과를 측정하기 위하여 XTT assay 및 H2-DCFDA assay를 진행하였다. HPLC를 이용한 p-coumaric acid 함량 분석 결과, HR02/04(8:2)-W 내의 p-coumaric acid는 75.62±1.56 mg/100 g 함유되어 있는 것으로 나타났으며, 총 플라보노이드 함량 및 총 페놀 함량은 각각 21.57±0.84 mg RE/g, 21.25±1.31 mg GAE/g으로 측정되었다. DPPH 및 ABTS 라디칼 소거활성 시험에서 HR02/04(8:2)-W의 농도 유의적으로 소거활성이 증가하는 것을 확인하였으며, FRAP 활성 및 reducing power 측정에서도 우수한 항산화 활성을 보였다. ORAC assay 결과 control 보다 5배 이상 높은 수치를 보이며 효과적으로 라디칼 저해 활성을 보였다. 항산화 실험에서의 뛰어난 항산화 활성은 HR02/04(8:2)-W에 함유된 페놀류들에 의한 것으로 판단된다. 피부 섬유아세포를 이용한 실험에서, HR02/04(8:2)-W을 300 ㎍/mL의 농도까지 세포의 생존력에 영향을 미치지 않는 것으로 나타났으며, hydrogen peroxide 처리에 의하여 56%까지 감소되었던 세포 생존율을 최대 78%까지 증가시키며 효과적으로 세포를 보호했음을 확인하였다. H<sub>2</sub>-DCFDA 염색을 통하여 세포 내의 ROS의 양을 측정하였을 때, hydrogen peroxide처리에 의하여 control군 대비 137%까지 증가하였던 ROS를 최대 89% 까지 감소시킴으로써 세포 내 활성산소를 효과적으로 억제하였다. 이상의 결과를 종합하여 볼 때, HR02/04(8:2)-W이 뛰어난 항산화 생리활성 기능을 가지고, 세포 내 활성산소를 효과적으로 제거할 수 있는 소재임이 확인되었으며, 천연물 유래 기능성 식품원료로서의 활용 가능성이 매우 넓을 것으로 판단된다.

        • KCI등재

          Medial Crease Formation in Unfavorable Subbrow Excision: Medial Crease in Subbrow Excision

          권희연,정의철 대한미용성형외과학회 2015 Archives of Aesthetic Plastic Surgery Vol.21 No.3

          Background Various surgical techniques have been developed to address senile upper eyelids. Upper blepharoplasty has limited efficacy in natural periorbital rejuvenation for severe lateral hooding of the upper eyelids, as well as often producing a ‘surprised look'. Subbrow excision is a popular method in East Asia for the correction of eyelid drooping, especially on the lateral side as periorbital rejuvenation. However, medial upper eyelid skin redundancy often tends to be undercorrected. Here, we present a few cases of revisional blepharoplasty, especially for medial crease formation, to improve aesthetic results. Methods Five patients, for a total of 10 eyelids, who underwent revisional blepharoplasty from January 2011 to January 2015 after a previous subbrow excision, were included. Patients were dissatisfied with uncorrected excessive skin on the medial part of the upper eyelid after a previous subbrow excision; thus, they underwent revisional blepharoplasty for medial crease formation. Results During the follow-up period, patients were aesthetically satisfied with the postoperative results. No patients suffered from any complications during the follow-up period. Conclusions After a previous unfavorable subbrow excision, medial crease formation, via a very minimally invasive technique, could be a favorable option to improve patient satisfaction without postoperative complication or discomfort.

        • KCI등재
        • KCI등재

          표준화된 고려엉겅퀴 추출물의 아질산염 소거능 및 항염증효과

          권희연(Hee-Yeon Kwon), 최선일(Sun-Il Choi), 조봉연(Bong-Yeon Cho), 최승현(Seung-Hyun Choi), 심완섭(Wan-Sup Sim), 한웅호(Han Xionggao), 장길웅(Gill-Woong Jang), 이옥환(Ok-Hwan Lee) 한국식품저장유통학회 2019 한국식품저장유통학회지 Vol.26 No.3

          본 연구에서는 고려엉겅퀴를 건강기능식품 소재로 활용시 기초자료를 제공하고자 고려엉겅퀴의 항염증 효과를 규명하고자 수행되었다. 고려엉겅퀴 추출물을 이용하여 아질산염 소거능, XTT 세포독성평가, NO 생성 저해능 평가, RT-PCR을 진행하였다. 고려엉겅퀴 추출물의 아질산염 소거능 측정 실험 결과, 양성대조군으로 사용된 BHA 처리 실험군과 마찬가지로 농도 유의적으로 아질산염 소거능이 증가하는 것을 확인하였다. XTT 세포독성 평가 실험 결과, 고려엉겅퀴 추출물 50, 100, 200 μg/mL의 농도에서 독성이 없음을 확인하고 이어지는 항염증 효과를 측정하는 실험에 사용하였다. NO 생성 저해능 평가 실험 결과, 양성대조군으로 사용된 indomethacin과 마찬가지로 고려엉겅퀴 추출물 50, 100, 200 μg/mL에서 농도 유의적으로 염증반응 매개물질인 NO의 생성량이 감소되는 것을 확인할 수 있었다. 또한 RT-PCR 실험 결과, COX-2와 iNOS은 양성대조군으로 사용된 indomethacin 처리 실험군과 마찬가지로 고려엉겅퀴 처리군에서 생성량이 감소된 것을 확인 할 수 있었고, IL-6와 TNF-α의 경우에서도 양성대조군으로 사용된 AICAR 처리 실험군과 같이 고려엉겅퀴 처리군에서 생성이 억제된 것을 확인 할 수 있었다. 이러한 연구결과로 볼 때 고려엉겅퀴 추출물이 대식세포에 의해 생성되는 염증반응의 매개물질인 NO의 생성을 억제하고, 염증반응 관련 cytokine들의 생성도 억제함에 따라 염증반응을 완화시키는데 도움을 줄 것으로 판단된다. 따라서 고려엉겅퀴가 천연 항염증활성과 아질산염 소거능을 갖는 제품 개발에 있어서 유용한 식물자원 원료로써 사용될 수 있을 것으로 사료된다. The purpose of this study was to determine nitrite scavenging activity and the anti-inflammatory effect of Cirsium setidens (C. setidens), which is perennial herb belonging to the Compositae family that is found mainly in Gangwon province, Korea. We studied nitrite scavenging ability, cell viability, nitric oxide production, and inflammatory-related gene expression in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Our results indicated that C. setidens extract increased the nitrite scavenging ability in a dose-dependent manner. In order to determine the cytotoxicity and the concentration range of C. setidens extract suitable for treating RAW 264.7 cells, the XTT assay was performed. C. setidens extract did not have any cytotoxic effect at contractions of 50, 100 and 200 μg/mL and the absorbance values were 103.30±9.61, 99,98±12.99 and 101.15±11.49%, respectively. Also, C. setidens extract decreased the nitric oxide production of RAW 264.7 cells in a dose-pendent manner. In order to determine whether C. setidens extract inhibits inflammation-related factors, such as COX-2, iNOS, IL-6 and TNF-α. In RAW 264.7 cells treated with C. setidens extract, COX-2, iNOS, IL-6 and TNF-α levels were decreased to 55, 84, 83 and 77%, respectively. Based on these results, C. setidens was revealed to have anti-inflammatory effect to be potentially material in functional food.

        • KCI등재

          청경채 및 경수채 어린잎 추출물의 항산화활성

          권희연(Hee-Yeon Kwon), 이수미(Su-Mi Lee), 최선일(Sun-Il Choi), 조봉연(Bong-Yeon Cho), 최승현(Seung-Hyun Choi), 심완섭(Wan-Sup Sim), 한웅호(Han Xionggao), 장길웅(Gill-Woong Jang), 이옥환(Ok-Hwan Lee), 박덕환(Duck-Hwan Park) 한국식품저장유통학회 2019 한국식품저장유통학회지 Vol.26 No.3

          본 연구에서는 청경채, 경수채 어린잎을 건강기능식품 소재로 활용 시 기초자료를 제공하고자 청경채와 경수채 어린잎의 항산화 활성 및 성분을 규명하고자 수행되었다. 청경채와 경수채 어린잎 추출물을 이용하여 DPPH 라디칼 소거활성, ABTS 라디칼 소거활성, FRAP 활성, 총 페놀 함량, 총 클로로필 함량, 총 카로티노이드 함량 측정과 ORAC 지수 측정을 하였다. DPPH 라디칼 소거활성, ABTS 라디칼 소거활성, FRAP 활성 측정 결과 청경채와 경수채 어린잎 추출물 모두 농도 의존적으로 활성이 증가하는 것을 확인 할 수 있었다. 총 페놀 함량 측정 결과, 청경채와 경수채 어린잎 추출물에서 각각 14.66±0.11, 15.92±0.29 mg GAE/g으로 측정되었다. 총 클로로필 함량 측정 결과, 청경채 어린잎 추출물의 총 클로로필 함량은 9.26±0.09 μg/mL, 경수채 어린잎 추출물의 총 클로로필 함량은 6.48±0.11 μg/mL이었다. 총 카로티노이드 함량 측정 결과 청경채와 경수채 어린잎 추출물에서 각각 1.62±0.01 μg/mL, 1.09±0.02 μg/mL로 청경채 추출물의 카로티노이드 함량이 높은 것으로 확인되었다. ORAC 지수를 측정한 결과 청경채와 경수채 어린잎 추출물 각각 928.4±17.7, 987.2±20.3 μM TE/g의 값을 나타내었다. 본 연구의 실험 결과를 바탕으로 청경채와 경수채 어린잎의 항산화 기능성을 확인하고 생리활성에 도움을 줄 수 있는 성분들의 함량을 측정함으로써 체내에서 산화적 손상에 대한 방어기전을 향상시키는 기능성 식품의 소재로의 이용가능성을 확인하였다. The purpose of this study was to investigate antioxidant activities of B. campestris var. chinensis and B. juncea L. Czern var. Laciniata Makino baby leaf extract. We studied DPPH radical scavenging activity, ABTS radical scavenging activity, ferric ion reducing antioxidant power (FRAP), total phenol contents, the total chlorophylls contents, total carotenoid contents and oxygen radical absorbance capacity (ORAC). Our results showed that antioxidant activities(DPPH radical scavenging activity, ABTS radical scavenging activity, FRAP) of the B. campestris var. chinensis baby leaf extract were significantly increased in a dose-dependent manner. Also, these baby leaf extracts had the highest total chlorophyll and carotenoid contents (9.26±0.09 μg/mL and 1.62±0.01 μg/mL). However, B. juncea L. Czern var. Laciniata Makino baby leaf extract showed higher in total phenol content (15.92±0.29 mg GAE/g) and ORAC value (987.18 μM TE/g) than those (14.66±0.11 mg GAE/g and 928.39 μM TE/g) of B. campestris var. chinensis baby leaf extract. Our study provide a basic data for the development of functional foods using two kinds of sprouts by analyzing the antioxidant and physiological activities of these extracts. These results suggest that functional foods can be developed using two kinds of baby leaf.

        • KCI등재

          이중결함가설에 따른 읽기장애 하위유형의 특성과 읽기 하위기술 간 차이

          권희연 ( Hoe Yeon Kweon ), 전병운 ( Byung Un Jeon ) 한국특수아동학회 2012 특수아동교육연구 Vol.14 No.2

          본 연구는 읽기장애아동의 음운인식과 명명속도를 일반아동들의 수행수준을 기준으로 각 하위유형으로 분류하고, 읽기 하위기술인 단어재인, 읽기 유창성, 읽기 이해에서 보이는 특성을 알아보기 위하여 실시되었다. 연구대상자는 읽기장애아동 30명이었으며, 동수의 일반아동을 표집하여 읽기장애 하위유형을 분류하는 기준으로 삼았다. 연구결과, 네 개의 하위유형이 존재하였으며, ``이중결함형``은 모든 학년에서 골고루 나타났으며, 결과적으로 가장 많은 숫자를 보여 이중결함가설의 타당성을 보여주는 것으로 볼 수 있다. 읽기장애 하위유형은 일반아동과의 읽기 하위기술에서도 모두 유의미한 차이를 나타냈으며, ``명명속도 결합형``의 읽기 수행이 ``음운인식 결함형``에 비해 저조하게 나타나 한국어 사용 읽기장애아동에 대한 지속적인 연구가 필요함을 시사하였으며, ``이중결함형``은 가장 심각한 읽기문제를 나타내었다. 마지막으로 이러한 연구결과에 따른 논의와 후속연구의 방향성을 제시하였다. The purpose of this study was to investigate the characteristics and difference between subgroups of children with reading disabilities according to the double-deficit hypothesis. Subgroups of children with reading disabilities were divided with phonological awareness, naming speed. And the 3 subgroups of reading abilities, decoding skills of words (nonsense word reading, regular words, irregular words), reading fluency, reading comprehension were measured, Data were collected from 30 first-third grade children with reading disabilities in elementary school, While 30 children with general reader was utilized as norms for Z score of children with reading disabilities, The classification according to double-deficit hypothesis (neither deficit, phonological awareness-deficit only, naming speed-deficit only, double-deficit) were performed to determine whether double-deficit hypothesis are applied to the children spoken a hangul. The results of this study were as following: When the double-deficit hypothesis was used as a framework to identify four mutually exclusive subgroups of readers based on patterns of processing deficits (PA only, NS only, Double-Deficit, Neither), it represented that the double-deficit subgroup had the lowest performance in all aspects of reading (decoding skills of words, reading fluency, reading comprehension, and the neither subgroup had the highest performance in all aspects of reading. We expected that the NS only subgroup would outperform the PA only subgroup in all aspects excluding reading fluency, but the opposite performance represented for this study. So the PA only subgroup showed the more performance in all aspects of reading than the PA only subgroup. These results strengthen the double deficit hypothesis for assessing and designing intervention with reading disabled children in a transparent orthography Through this study did not include many participants, and the instrument of measurement didn`t have enough validity, the implications of these results for assessing and designing intervention with reading disabled children were that the naming speed is critical, helpful for those children spoken hangul than English speaker. Thus, the instrument of measurement proved validity will be needed for following study to identify good predictors of reading skills.

        • KCI등재

          고구려 고분벽화의 摸寫圖 제작 연구

          권희연(Kwon, Hee-Yeon) 백산학회 2008 白山學報 Vol.- No.81

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          In this study, we chose good technical examples of replicas of Goguryeo mural paintings excavated in the tombs, which are considered as cultural heritage of mankind, and conducted research on the examples by technique. Except for replicas which were made by Japanese researchers during the Japanese colonial rule, we conducted research on the replicas of Goguryeo murals containing the same images, colors, and textures of originals by making replicas with different techniques. The first technique is a Japanese method which was used to make a record while Japanese researchers were excavating Goguryeo tomb murals. The second one is a method using mortar and paints which is similar to western Fresco. The third one is called Secco which is painting on a dried plastered wall. The fourth one is restoring damaged parts focusing on subjects rather than backgrounds to study and utilize characters. The last one is making a replica by making dots to copy an original specifically. The second and third method need to make plastered walls to make replicas and the first, fourth, and last one is making replicas on the paper. Comparing the replicas, which were made based on different techniques, to photos of original Goguryeo tomb murals, we found some limitations of every replicating technique to some degree to restore exactly the same formative factors such as forms and colors. First of all, there is a physical limitation that we cannot see original wall paintings firsthand. Second, as we followed the old method of making replicas, it was impossible to describe specifically. On the contrary, to restore original wall paintings, it is needed to use other special methods of replicating. Therefore, a method of making a replica is highly determined by a purpose of the replica, such as to record a course of excavating a tomb mural, to study a method of making a replica, to restore damaged cultural heritage, to use as an educational material on cultural properties, and to make cultural properties into modernized contents. This study can provide a clue to methods of making Goguryeo mural paintings and compare characteristics, significance, and utilization of other methods of replicating Goguryeo mural paintings that are made by other researchers. This study on various methods of making replicas can provide an opportunity not only to restore cultural heritage but also to retrace the origin of Korean paintings, to propose necessity to maintain and develop traditional painting methods, and to find the right direction for Korean modern paintings.

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