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권진선,김다연,서효원,정성현,김재호,김문석 한국조직공학과 재생의학회 2014 조직공학과 재생의학 Vol.11 No.3
We explored the utility of poly(vinylalcohol) (PVA) film as a pharmaceutical transdermal carrier of eryth-romycin (EM) for the treatment of acne. EM-loaded PVA films were manufactured using PVA solution containingdifferent amounts of EM in the presence or absence of various additives. Among the additives tested (glycerin, PEG,Tween80, CCT oil, and carboxymethylcellulose [CMC]), glycerin and PEG were suitable for the preparation of EM-loaded PVA films. Several additives controlled the characteristic endothermic peaks of PVA and EM. Permeation ofEM into the skin was measured using the prepared PVA films loaded with different EM concentrations and additives. EM from the EM-loaded PVA films showed sustained release behavior, and altering the amount of EM loaded andthe additive allowed us to control the amount of EM released from these films. In conclusion, the PV films describedhere can serve as pharmaceutical transdermal carriers for sustained EM release.
권진선,김경해,김다연,이빛나,이봉,김재호,민병현,김문석 한국조직공학과 재생의학회 2012 조직공학과 재생의학 Vol.9 No.1
In this study, we chose valproic acid (VA) for inducing neural differentiation in rat muscle-derived stem cells (rMDSCs). After pre-induction with basic fibroblast growth factor (bFGF) and subsequent treatment with VA,VA-related cytotoxicity to rMDSCs was relatively low. In addition, VA-treated rMDSCs exhibited a neural-like morphology after 1, 4, and 7 days. The immunocytochemical results of VA-treated rMDSCs showed abundant cells stained positive for neuron-specific enolase (NSE) and neuron filament (NF) as neural markers, oligodendrocyte transcription factor 2 (Olig-2) as an oligodendrocyte marker, and glial fibrillary acidic protein (GFAP) as an astrocyte marker. Our results suggest that rMDSCs can be differentiated into a neural-like phenotype by using VA.