Fluconazole 제제의 생체이용률 비교시험

권지윤,윤성도,조동현,길영식,김수경,Kwon, Gee-Youn,Yoon, Sung-Do,Cho, Dong-Hyun,Gil, Young-Sig,Kim, Soo-Kyung 대한임상약리학회 2003 Translational and Clinical Pharmacology Vol.11 No.2

Background: This study was conducted to evaluate the bioavailability of Fluconazole formulation in healthy Korean volunteers. Furthermore, the bioequivalence of $Flukan^{\circledR}$ capsule, a fluconazole preparation from Korea United Pharm, Inc., was determined. Methods: The study employed a randomized, two-way crossover Latin square design with a two-week washout period. The test product was $Flukan^{\circledR}$ capsule (Korea United Pharm Inc., South Korea) and the reference was $Diflucan^{\circledR}$ capsule (Pfizer Inc.). The two products were administered in 150 mg single oral doses into 26 healthy Korean volunteers. Serial blood samples were collected for a period of 120 hours. Plasma fluconazole concentrations of the two brands were measured by HPLC using UV detector, and the pharmacokinetic parameters including $AUC_t,\;C_{max},\;T_{max}$, and half-life were determined from plasma concentrations of both formulations. Results: Both formulations were well tolerated in 26 volunteers. Mean $AUC_t,\;C_{max}$ of $Flukan^{\circledR}$ capsule were 1.068 $(90%\;confidence\;interval:\;1.0057{\leq\delta\leq}1.1349)$ and 1.017 $(90%\;confidence\;interval:\;0.9633{\leq\delta\leq}1.0749)$ compared to those of $Diflucan^{\circledR}$ capsule. Mean half-life of $Flukan^{\circledR}$ capsule was $30.41{\pm}5.44$ and that of $Diflucan^{\circledR}$ capsule was $30.74{\pm}5.86$ hr. The powers $(1-{\beta})$ for $AUC_t\;and\;C_{max}$ were above 90%. The pharmacokinetic parameters $(AUC_t,\;C_{max},\;T_{ max})$ were analyzed statistically with K-BE test 2002 (KFDA). Conclusion : No significant differences between two formulations were observed in terms of $AUC_t\;and\;C_{max}$, the main pharmacokinetic parameters used for bioequivalence evaluation. The results satisfied the bioequivalence criteria of KFDA guidelines, and $Flukan^{\circledR}$ capsule was determined to be bioequivalent to $Diflucan^{\circledR}$ capsule.

리튬 이차전지 음극용 Cu₃Si의 고온에서의 전기화학적 특성

권지윤,류지헌,김준호,채오병,오승모,Kwon, Ji-Y.,Ryu, Ji-Heon,Kim, Jun-Ho,Chae, Oh-B.,Oh, Seung-M. 한국전기화학회 2010 한국전기화학회지 Vol.13 No.2

DC magnetron 스퍼터링을 이용해 구리(Cu) 호일 위에 실리콘(Si)을 증착한 후 $800^{\circ}C$에서 열처리하여 $Cu_3Si$를 얻고, 이의 리튬 이차전지용 음극으로서 특성을 조사하였다. $Cu_3Si$는 Si 성분을 포함하고 있으나 상온에서 리튬과 반응하지 않았다. 선형 주사 열-전류(linear sweep thermammetry, LSTA) 실험과 고온 충방전 실험을 통하여, 상온에서 비활성인 $Cu_3Si$가 $85^{\circ}C$ 이상에서는 활성화되어 Si 성분이 전환(conversion)반응에 의해 리튬과 반응함을 확인하였다. $Cu_3Si$에서 분리된 Si는 $120^{\circ}C$에서 Li-Si 합금 중에서 리튬의 함량이 가장 많은 $Li_{21}Si_5$ 상까지 리튬과 반응함을 유사 평형 조건(quasi-equilibrium)의 실험으로부터 알 수 있었다. 그러나 정전류 조건($100\;mA\;{g_{Si}}^{-1}$)에서는 리튬 합금반응이 $Li_{21}Si_5$까지 진행되지 못하였다. 또한 $120^{\circ}C$에서 전환반응에 의해 생성된 Li-Si 합금과 금속 상태의 Cu는 충전과정에서 다시 $Cu_3Si$로 돌아감, 즉 $Cu_3Si$와 리튬은 가역적으로 반응함을 확인하였다. $120^{\circ}C$에서 $Cu_3Si$ 전극은 비정질 실리콘 전극보다 더 우수한 사이클 특성을 보여 주었다. 이는 비활성인 구리가 실리콘의 부피변화를 완충하여 집전체에서 탈리되는 현상을 완화하고 결과적으로 전극이 퇴화하는 것을 억제하기 때문인 것으로 설명할 수 있다. 실제로 비정질 실리콘 전극은 충방전 후에 실리콘 층의 균열과 탈리가 관찰되었으나, $Cu_3Si$ 전극에서는 이러한 현상이 관찰되지 않았다. A $Cu_3Si$ film electrode is obtained by Si deposition on a Cu foil using DC magnetron sputtering, which is followed by annealing at $800^{\circ}C$ for 10 h. The Si component in $Cu_3Si$ is inactive for lithiation at ambient temperature. The linear sweep thermammetry (LSTA) and galvano-static charge/discharge cycling, however, consistently illustrate that $Cu_3Si$ becomes active for the conversion-type lithiation reaction at elevated temperatures (> $85^{\circ}C$). The $Cu_3Si$ electrode that is short-circuited with Li metal for one week is converted to a mixture of $Li_{21}Si_5$ and metallic Cu, implying that the Li-Si alloy phase generated at 0.0 V (vs. Li/$Li^+$) at the quasi-equilibrium condition is the most Li-rich $Li_{21}Si_5$. However, the lithiation is not extended to this phase in the constant-current charging (transient or dynamic condition). Upon de-lithiation, the metallic Cu and Si react to be restored back to $Cu_3Si$. The $Cu_3Si$ electrode shows a better cycle performance than an amorphous Si electrode at $120^{\circ}C$, which can be ascribed to the favorable roles provided by the Cu component in $Cu_3Si$. The inactive element (Cu) plays as a buffer against the volume change of Si component, which can minimize the electrode failure by suppressing the detachment of Si from the Cu substrate.

한국 내 할랄 식품을 둘러싼 갈등 구조에 대한 선교적 이해

권지윤(Jee Yun Kwon) 횃불트리니티신학대학원대학교 한국이슬람연구소 2016 Muslim - Christian Encounter Vol.9 No.2

The meaning of Halal in Islam is an object or action which is permissible to use or engage in their religious and daily lives in accordance with Islamic law. Haram has an opposite meaning and accordingly it is often described as a forbidden action which is unlawful and against Islamic Scriptures. The principles deriving from Halal and Haram are important for Muslims and they are obliged to abide by those principles in their daily lives because they are based on the Scriptures in Quran. These principles are applied to the dietary life of Muslims as the meaning of food in their life represents not only the cultural peculiarities of the Islam but also the unique identity in their social relationship. For this reason, Islamic food (Halal food) can be expressed as the cultural and social identity of Muslims. Most of Muslims accept that the concept of Islam represents their distinctive religious, cultural, political and social life. Having Halal food, therefore, is quite understandable as a standard of life from a perspective of Islamic world. It permeates their everyday lives. Along with unexpected increase of Muslim’s population since the 1990s in South Korea, Muslim’s population reached more than 200 thousand including traditional Korean Muslims who were born and grew in South Korea. These Muslims in South Korea have tended to keep Islamic principles including Halal food although South Korea is not an Islamic country. Because of this tendency, these Muslims have experienced the conflicts between their Islamic principle and Korean standard of living based on its culture in respect of dietary life. These conflicts can be divided into two classifications i.e., internal and external conflicts. An internal conflict is resulted from Muslim’s adaption process to Korean culture because Muslims likely feel difficult to adapt to Korean food and its culture. An External conflict is resulted from the circumstances where Muslims and non Muslims encounter each other in Korean context given that non-Muslims likely do not understand Halal food. With the rapid growth of Korean Muslim’s population despite it being minority group, South Korean central and local governments announced a policy, particularly, regarding Islamic food. It has resulted in significant cultural complexity regarding Islam in South Korea. In fact, there have been external conflicts and social controversies after the policy announcement in January 2016. In response, the central and local governments decided to withdraw its policy related to Islamic food taking into account growing tensions resulted from external conflicts and social controversies thereby. Nevertheless, Koreans will continue to face these conflicts and social controversies given that Korean Muslim’s population continues to rise. In this context, we need to pay close attention to these conflicts from a perspective of Christian mission. In terms of Christian mission, we need to become a witness of gospel. As a witness of gospel, we can help them. In other words, we can assist Muslims to overcome their internal conflicts by inviting them to our life and sharing our food culture. In this way, the conflicts can be reduced, and as a result Muslims and non-Muslims can be more harmonized in terms of Christian mission without adversarial confrontations with respect to Halal food. All of this is possible through Christian mission when we become a witness of gospel.

한국 이슬람여성에 대한 이해

권지윤(Jee Yun Kwon) 횃불트리니티신학대학원대학교 한국이슬람연구소 2012 Muslim - Christian Encounter Vol.5 No.1

지속가능한 도시재생사업을 위한 마을관리협동조합 운영

권지윤(Ji-Yoon Kwon),정남수(Nam-Su Jung),기동욱(Dong-Wook Ki),유형진(Hyeong-Jin Yu) 한국지역사회생활과학회 2021 한국지역사회생활과학회 학술대회 자료집 Vol.2021 No.11

중간지원조직 활동가 직무역량모델 개발과 실증연구

권지윤 ( Kwon Ji Yoon ),김두순 ( Kim Doo Soon ) 한국인력개발학회 2020 HRD연구 Vol.22 No.3

본 연구는 중간지원조직 활동가의 효율적인 운영을 위해 델파이 조사를 통한 직무역량모델을 구축하고 실증연구로 직무역량의 적합성 여부를 타진하는 데 그 목적이 있다. 문헌고찰 및 전문가 검토를 통해 43개 역량을 도출하였고 이를 통해 작성된 설문지를 활용하여 전문가 11인을 대상으로 2차에 걸친 델파이 조사를 실시하였다. 분석결과 중간지원조직 활동가의 직무역량에는 최종적으로 6개 역량군, 23개 역량, 23개 정의가 도출되었으며, 이를 토대로 직무역량모델을 개발하였다. 중간지원조직 활동가의 직무역량을 파악하기 위해 직무역량을 측정지표로 실증연구를 실시하였다. 분석결과 ‘교육기획 및 운영 역량군’, ‘사업 기획 역량군’, ‘마을운영조직 관리 및 지원 역량군’, ‘마을개발사업운영 및 지원 역량군’, ‘마을 현안·갈등 관리 및 지원 역량군’, ‘지역협력체계구축 역량군’의 순서로 역량에 대한 평가가 나타났다. 본 연구는 중간지원조직 활동가의 직무역량모델을 제시하고 세분화된 역량을 규명했다는 측면에서 큰 의의가 있다. This study aim is to develop a job capacity model through Delphi survey for the efficient operation of intermediate organization activists and to examine whether they are suitable as empirical research. The ability extracted through previous studies was prepared by questionnaire for Delphi survey, and the Delphi survey was conducted two times for 11 experts. Finally, 6 competency groups, 23 sub-competencies, and 23 definitions were derived from the job capacity of the intermediate organization activists. Based on this, a job capacity model was developed and an empirical analysis was conducted using it as a measurement index. In order to identify job capacity of the intermediate organization activists, empirical research was conducted as a measurement index of job capacity. The results of this study are as follows: ‘business planning capacity group’, ‘community management and support capability group’, ‘community development project operation and support capability group’, ‘community issues, conflict management and support capacity group’, ‘capacity group for establishment of regional cooperation system’. This study has great significance in that it presented the job capacity model of the intermediate organization activists and identified the subdivided capacity. Academic, practical, and policy implications and limitations of this study were presented.

농촌마을 유형별 주민역량교육에 관한 연구 - 색깔있는 마을 만들기를 중심으로 -

권지윤(Ji-Yoon Kwon),김은수(Eun-Soo Kim),배성의(Sung-Eui Bae) 한국농촌지도학회 2015 농촌지도와 개발 Vol.22 No.1

The rural development business policy of our country is seeking to change the existing top-down development method to the bottom-up development one. As residents’ participation in village development is being focused, residents’ competence has come to be considered important. Thus, this study classified the village type by investigating resources of the target villages in Chungcheongnam-do through a rural forum, and examined education needs targeting the residents of the villages through a survey. The preferred the types, of education according to the types of farm villages were examined. It is needed to raise the efficiency of enhancing village development competence by regarding execution of the priority of competence enhancing education as a practical strategy. This also can be used as the baseline data for rural catchment typing research.

한국 내 예멘 난민이슈에 대한 이해

권지윤(Jee Yun Kwon) 횃불트리니티신학대학원대학교 한국이슬람연구소 2018 Muslim - Christian Encounter Vol.11 No.2

아르바이트 알씨카

권지윤(Jiyoon Kwon),강민성(Minseong Kang),강혜준(Hyejun Kang),권성철(Seongcheol Kwon),박철형(Cheolhyeong Park),최혜정(Hyejeong Choi),홍동권(Hong Dong-Kweon) 한국정보과학회 2018 한국정보과학회 학술발표논문집 Vol.2018 No.12

소아 특발성 후두엽 뇌전증: 임상적 특징 및 예후인자

권지윤(Ji Yoon Kwon),김건하(Gun-Ha Kim),은소희(SoHee Eun),은백린(Baik-Lin Eun),변정혜(Jung Hye Byeon) 대한소아신경학회 2017 대한소아신경학회지 Vol.25 No.3

Purpose: Among syndromes of idiopathic occipital lobe epilepsy there are Panayioto poulos syndrome (PS) and idiopathic childhood occipital epilepsy of Gastaut (ICOE-G). However, the classification of epilepsy syndrome is difficult to diagnose at the first seizure because of varying characteristics. We analyzed the different clinical charac teristics and prognostic factors of idiopathic occipital lobe epilepsy. Methods: Forty-three patients who had at least two unprovoked seizures, no abnor malities on magnetic resonance imaging, no known etiology of seizure, and mainly occipital spikes on electroencephalography were retrospectively enrolled at the Korea University Medical Center. A good prognosis was defined as being seizure-free and taking two or less drugs for 1 year. Results: Among all patients, the proportion of PS was 44.2%, ICOE-G was 7.0% and unclassified group was 48.8%. The age at seizure onset was 4.5±2.6 years (mean±SD) in the PS group, and 8.3±2.1 years in the ICOE-G group. The follow-up duration was 10.8±6.0 years. The percentage that the initial diagnosis had not been changed was 66.7% in the PS group and 100% in the ICOE-G group. Among other related symp toms only emesis (P<0.001) and visual symptoms (P=0.007) had varying characteri stics between the PS and ICOE-G groups. Patients with PS had a better prognosis than those with ICOE-G or unclassified group (odds ratio [OR]=58.8). Patients with 1 more autonomic symptoms had a worse prognosis (OR=3.8). Conclusion: This study showed that only symptoms of emesis and visual symptoms can differentiate between PS and ICOE-G. More autonomic symptoms were associated with worse prognosis in childhood occipital lobe epilepsy.