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저분자량 수용성 키토산을 이용한 microspheres 의 제조와 방출 거동
나재운,장미경,김원석,최창용,공병기,권중근 한국공업화학회 2001 응용화학 Vol.5 No.2
In this study, the drug release behaviors of low molecular water soluble chitosan(LMWSC) microspheres was investigated. The LMWSC microspheres having good spherical geometry and a smooth surface were prepared by crosslinking agent, glutaraldehyde, chitosan aqueous in liquid paraffin oil contained emulsifier, span80. This LMWSC microspheres were prepared by loading drug, Norfloxacin(NFx). In vitro, the release experiment was carried out in phosphate buffered saline (PBS, 0.1M, pH 7.4) at 37±0.5℃. The release kinetic of NFx was governed not only amounts of cross-linking agent but also drug contents and particle size parameter. Resultantly, the higher amounts of cross-linking agent, the higher drug contents and the larger particle size resulted in slower the drug release.
저분자량 수용성 키토산을 이용하여 제조된 Microspheres 의 생분해성
나재운,장미경,김원석,최창용,공병기,권중근 한국공업화학회 2001 응용화학 Vol.5 No.2
This study introduced the novel colon targeting drug delivery system as preparing the microspheres loaded drug using low molecular water soluble chitosan(LMWSC). This LMWSC microspheres are a suitable device for pharmaceutical application because of theirs biodegradable, biocompatibility, and mucoadhesive characteristics. The LMWSC was prepared by acid decomposition with high molecular insoluble chitosan. And then the WSC microspheres were prepared by crosslinking agent, glutaradehyde, chitosan aqueous in liquid paraffin oil contained emulsifier, span80. The morphology of the LMWSG microspheres which were prepared according to amounts of cross-linking agent was observed by a scanning electron microscopy(SEM). This LMWSC microspheres were prepared by loading drug, Norfloxacin(NFx). In vitro, the biodegradable experiment was carried out in phosphate buffered saline(PBS, 0.1M, pH 7.4) at 37±0.5℃. It was observed that the biodegradability was influenced by amounts of cross-linking agent.