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권준철,권오환,정래웅,김나윤,송선아,최일섭,이준옥,Takahiko Horiuchi 한국통합생물학회 2021 Animal cells and systems Vol.25 No.3
LBAL was developed as an adalimumab (Humira®) biosimilar using Chinese hamster ovary cell lines. Comparable quality, safety, and efficacy between a biosimilar and its reference product should be ensured for regulatory approval. Here, we present the results of a comprehensive physicochemical and biological characterization between LBAL and Humira®. As physicochemical attributes, primary and higher-order structure, N-glycan profile, and disulfide linkage were investigated. Biological attributes were evaluated by target/receptor binding analysis and in vitro/ex vivo cell-based assays, which are linked to mechanisms of action. As a result, LBAL had the identical amino acid sequence, similar post-translational modifications and N-/C-terminal variants, and comparable primary, secondary, and tertiary structures and disulfide linkage profile. However, some differences in N-glycan profiles were observed. Biological activities, including tumor necrosis factor (TNF) binding, TNF-neutralization, apoptosis, Fc receptor binding, and complementdependent cytotoxicity, were largely consistent. Despite a slightly lower antibody-dependent cellular cytotoxicity activity in LBAL, this difference was not significant under physiological conditions. As indicated, this extensive analytical characterization and functional comparison assessment showed that LBAL was similar to Humira®, with minor differences of no clinical relevance. Taken together, our comparative assessment of physicochemical and biological attributes demonstrated that LBAL is structurally and functionally very similar to Humira®, supporting the biosimilarity of clinical efficacy and safety.
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권준철,정용규,고정하 한국정보통신설비학회 2016 한국정보통신설비학회 학술대회 Vol.2016 No.09
Evaluation and rating for Smart City is going on in the world. The evaluation indicators known to the world are SSC-KPI and ITU-T indicators. But it is need special way for the attainment of the required indicators. European smart city ranking evaluation index is evaluated by reference to the city of Humanities and Social Assessment Report unrelated to IT such as nation from the city's target rating. However, quantitative evaluation in an objective according to the European Smart City ranking and ITU-T SSC-KPI indicators of is believed unlikely. In this paper, we promoted the idea in a useful way that it can ensure the sustainability of the city to take advantage of the information gathered by the information gathering and various routes of the city each part of utilizing IT and the National Informatization local information, ubiquitous city. It would come to pursue such a policy.
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권준철 에스케이텔레콤 (주) 2012 Telecommunications Review Vol.22 No.3
스마트 단말의 기술 발전에 힘입어 다양한 형태의 개인 맞춤형 서비스가 활성화 되고 있다. 그러나 다양한 형태의개인정보 수집으로 인한 정보화 역기능 문제가 제기되고 있어 개인의 다양한 상황정보를 기반으로 하는 개인 맞춤형서비스의 부정적 측면이 우려가 높아지고 있다. 본 논문은 지금까지 공급자 중심의 콘텐츠 제공방식에서 공간정보 및개인정보를 개인 스마트 단말에서 직접 관리하는 공간 맞춤형 개인 서비스를 제안한다. 그리고 이러한 방식의 맞춤형서비스를 위한 스마트 단말의 기본적인 구성이 무엇인가를 도출하여 제시한다.
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