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신윤호(Shin Yun-ho),권정일(Kwon Jeong-il),정정훈(Jung-hoon) 대한조선학회 2012 대한조선학회 학술대회자료집 Vol.2012 No.5
Analysis and review of survivability is one of the most important aspects when ships are designed. Because aiming points of threat towards the ship in the battle field could not be estimated exactly, probabilistic and statistic approach is frequently introduced to evaluate and enhance the ship survivability. Some commercial survivability analysis programs are used to perform the analysis for enhancement of susceptibility, vulnerability and recoverability but, they are usually classified and impossible to be exported to other countries because of their national security. In this paper, the methodology to evaluate the vulnerability of the warship in aspects of structure, redundancy and its mission capability at the concept design stage is proposed by using our developing program. In addition, the analysis results using the developed codes are shown.
김선영 ( Seon Young Kim ),권중구 ( Joong Goo Kwon ),김명환 ( Myung Hwan Kim ),오재영 ( Jae Young Oh ),박진홍 ( Jin Hong Park ),박경찬 ( Kyung Chan Park ),류정일 ( Jung Il Ryoo ),류헌모 ( Hun Mo Ryoo ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.5
Protein-losing enteropathy (PLE) is a syndrome characterized by excessive gastrointestinal protein loss, resulting in hypoproteinemia and edema. A variety of benign and malignant conditions can be associated with PLE and acute leukemia is a very rare cause of PLE. We report a case of PLE associated with acute lymphoblastic leukemia. A 27-year-old man was admitted due to watery diarrhea, epigastric pain and bilateral leg edema. Laboratory findings showed hypoproteinemia and polycythemia. The diagnosis of PLE and acute lymphoblastic leukemia were confirmed on the measurement of fecal α1-antitrypsin clearance and bone marrow examination. After systemic chemotherapy and autologous stem cell transplantation, his clinical symptoms and abnormal laboratory findings were gradually improved. (Korean J Gastroenterol 2012;60:320-324)
L-Carnitine, pyridoxine hydrochloride, DL-α-tocopheryl acetate를 이용한 분유모델시스템의 마이얄반응생성물 저감화 조건 최적화
정혜림(Hye-Lim Jung),남미현(Mi-Hyun Nam),홍충의(Chung-Oui Hong),표민철(Min-Cheol Pyo),오준구(Jun-Gu Oh),김용기(Young Ki Kim),최유영(You Young Choi),권정일(Jung Il Kwon),이광원(Kwang-Won Lee) 한국식품과학회 2015 한국식품과학회지 Vol.47 No.1
본 연구는 분유모델시스템에 L-carnitine, pyridoxine hydrochloride, DL-α-tocopheryl acetate를 첨가하여 Maillard 반응에 의해 생성된 MRPs를 저감화 시키기 위한 최적조건을 찾기 위해 RSM의 CCD를 이용하였다. L-Carnitine (X₁), pyridoxine hydrochloride (X₂), DL-α-tocopheryl acetate (X₃)의 농도를 독립변수로 하고 형광도와 HMF 함량을 종속변수로 각각 설정하였다. 종속변수 회귀식의 결정계수(R<SUP>2</SUP>)는 각각 0.942, 0.861로 반응표면분석 모델에 적합하였다. 형광도와 HMF 함량은 L-carnitine과 pyridoxine hydrochloride의 농도가 낮을 때 DL-α-tocopheryl acetate의 농도가 감소할수록 그 값이 급격히 감소하였다. L-Carnitine의 농도가 높을 때 pyridoxine hydrochloride의 농도가 20 μM 이하로 감소할수록 형광도가 감소하였고 HMF 함량은 L-carnitine의 농도에 관계없이 pyridoxine hydrochloride의 농도가 20 μM 이하로 감소할수록 감소하는 경향을 나타냈다. 본 실험에서 분유모델시스템에서 생성된 MRPs를 저감화 할 수 있는 최적조건으로 L-carnitine, pyridoxine hydrochloride, DL-α-tocopheryl acetate의 농도는 각각 2.26, 15.77, 20.63 μM이었다. 이때 형광도는 77.4%였고 HMF 함량은 248.7 ppb로 각각 유단백질-유당 마이얄 반응생성물(LC, lactose+sodium caseinate)대비 MRPs를 22.6, 23.1% 감소시킬 수 있다고 예측할 수 있었다. 또한, RSM을 통해 찾은 최적 조건의 실험값으로 형광도는 79.3%였고 HMF 함량은 247.6 ppb로 각각 LC대비 MRPs를 20.7, 17.8% 감소 시켰다. 따라서, L-carnitine, pyridoxine hydrochloride, DL-α-tocopheryl acetate의 최적화된 혼합을 통하여 분유제조 시 MRPs 생성을 저감화 시킬 수 있을 것으로 생각된다. The Maillard reaction is a non-enzymatic reaction between amino and carbonyl groups. During milk processing, lactose reacts with milk protein through this reaction. Infant formulas (IFs) are milk-based products processed with heattreatments, including spray-drying and sterilization. Because IFs contain higher Maillard reaction products (MRPs) than breast milk, formula-fed infants are subject to higher MRP exposure than breast milk-fed ones. In this study, we investigated the optimization of conditions for minimal MRP formation with the addition of L-carnitine (L-car), pyridoxine hydrochloride (PH), and DL-α-tocopheryl acetate (α-T) in an IF model system. MRP formation was monitored by response surface methodology using fluorescence intensity (FI) and 5-hydroxymethylfurfural (HMF) content. The optimal condition for minimizing the formation of MRPs was with 2.3 μM L-car, 15.8 μM PH, and 20.6 μM α-T. Under this condition, the predicted values were 77.4% FI and 248.7 ppb HMF.
신윤호(Shin, Yun-ho),권정일(Kwon, Jeong-il),정정훈(Chung, Jung-hoon) 한국해양환경·에너지학회 2012 한국해양환경공학회 학술대회논문집 Vol.2012 No.5
Analysis and review of survivability is one of the most important aspects when ships are designed. Because aiming points of threat towards the ship in the battle field could not be estimated exactly, probabilistic and statistic approach is frequently introduced to evaluate and enhance the ship survivability. Some commercial survivability analysis programs are used to perform the analysis for enhancement of susceptibility, vulnerability and recoverability but, they are usually classified and impossible to be exported to other countries because of their national security. In this paper, the methodology to evaluate the vulnerability of the warship in aspects of structure, redundancy and its mission capability at the concept design stage is proposed by using our developing program. In addition, the analysis results 니sing the developed codes are shown.