산양의 실험적 납중독에 관한 임상병리학적 관찰 II. 조직내 무기질함량 분석 및 병리해부학적 관찰

권오덕,이현범,Kwon, Oh-deog,Lee, Hyun-beom 대한수의학회 1993 大韓獸醫學會誌 Vol.33 No.3

Present experiments were undertaken in order to clarify the clinico-pathological characteristics of lead poisoning in goats. Twenty goats were divided into three experimental groups(A, B and C) and a control(D). The three experimental groups received diets contaminated artificially with 10(A group), 200(B group) and $1,000(C group){\mu}g/g$ of lead for 70 days, respectively. The control group received normal diets. Hair samples collected one or two weeks interval were examed for the lead content. On day 70. all the animals were necropsied and various organs were examined pathoanatomically. In addition, various organs were analyzed for lead, zine, copper, iron and calcium content by atomic absorption spectrophotometry. From these experiments following results were obtained ; The lead content of hair was significantly increased from the $42^{nd}$, $21^{st}$ or $14^{th}$ day in all the three groups, which showed significant correlation with lead content of liver and spleen. The lead content of various organs including kidney, liver, spleen, ileum, bone and abomasum were significantly increased in accordance with the lead contamination. The increase was most prominent in abomasal wall. The zinc and copper content of liver, brain, ileum, skin, kidney, lung or muscle were increased in B and C groups whereas the iron and calcium content showed no significant change. Pathoanatomically, degeneration or necrosis of proximal convoluted tubules of kidney, peripheral necrosis of liver, fundic gland necrosis of abomasum and cerebral edema were observed in B and C groups.

환경적 지속성 측면의 도시계획요소가 거주만족도에 미치는 영향연구

권성실(Kwon, Seong-Sil),오덕성(Oh, Deog-Seong) 한국도시설계학회 2004 도시설계 : 한국도시설계학회지 Vol.5 No.3

전북지방에저 생산된 가축사료내 카드뮴 함량에 관한 조사연구

권오덕,Kwon Oh-Deog 한국임상수의학회 1992 한국임상수의학회지 Vol.9 No.1

Present study was undertaken in order to evaluate the cadmium contents of various feedstuffs produced in Chonbuk area. Fifty-five samples were collected from 5 regions. All of the samples were dry-ashed and analyzed for cadmium content using atomic absorption spectrophotometer. The results obtained were summarized as followed : 1. The cadmium content in $\mu\textrm{g}$/g of agriculture by-products were measured with the following mean values and ranges : soybean pod 3.15${\pm}$0.51(2.40∼3.81), rice bran 2.87${\pm}$0.23(2.50∼3.09), rice straw 1.66${\pm}$0.85(1.08∼3.14), rice hull 0.86${\pm}$0.45(0.41∼1.35). 2. The cadmium content in $\mu\textrm{g}$/g of pasture plants were measured with the following mean values and ranges : kudzu 5.65${\pm}$1.00(4.87∼7.29), sagebrush 4.86${\pm}$1.24(2.89∼6.24), clove, 4.28${\pm}$0.75(2.99∼4.86), lespedeza 3.99${\pm}$1.21(2.38∼4.94), Korean lawn grass 2.24${\pm}$1.04(1.33∼3.44), reed 1.99${\pm}$0.95(0.88∼2.91), cornstalk 1.61${\pm}$0.99(0.38∼3.12). 3. The regional mean values for all kinds of samples were Okgu-gun 3.19${\pm}$2.09$\mu\textrm{g}$/g, Mooju-gun 3.15${\pm}$1.73$\mu\textrm{g}$/g, Wanju-gun 3.05${\pm}$1.76$\mu\textrm{g}$/g, Namwon-gun 2.85${\pm}$1.70$\mu\textrm{g}$/g, Jeongup-gun 2.85${\pm}$1.25$\mu\textrm{g}$/g.

전북지방에서 생산된 가축사료내 납 함량에 관한 조사연구

권오덕,Kwon Oh-Deog 한국임상수의학회 1992 한국임상수의학회지 Vol.9 No.1

Present study was undertaken in order to evaluate the lead contents of various feedstuffs produced in Chonbuk area. Fifty-five samples were collected from 5 regions. All of the samples were dry-ashed and analyzed for lead content using atomic absorption spectrophotometer. The results obtained were summarized as followed : 1. The lead content in $\mu\textrm{g}$/g of agriculture by-products were measured with the following mean values and ranges : soybean pod 7.01${\pm}$2.49(4.71∼10.66), rice bran 4.56${\pm}$0.90(3.17∼5.65), rice straw 3.89${\pm}$2.01(1.29∼6.33), rice hull 1.92${\pm}$1.77(0∼3.63). 2. The lead content in $\mu\textrm{g}$/g of pasture plants were measured with the following mean values and ranges : kudzu 20.29${\pm}$4.75(14.84∼25.34), clover 13.92${\pm}$2.68(10.17∼16.44), lespedeza 10.91${\pm}$9.00 (3.35∼23.54), sagebrush 10.75${\pm}$3.28(5.14∼13.18), Korean lawn grass 5.05${\pm}$2.29(2.57∼7.79), cornstalk 3.91${\pm}$2.55(0.50∼7.22), reed 2.92${\pm}$1.88(0.50∼5.73). 3. Seventeen samples (30.9%) out of 55 samples showed lead content of more than 10$\mu\textrm{g}$/g which are said to be the upper limit value for all animals. 4. The regional mean v짓ues for 리1 kinds of samples were Wanju-gun 10.02${\pm}$8.55$\mu\textrm{g}$/g, Mooju-gun 8.16${\pm}$4.91$\mu\textrm{g}$/g, Namwon-gun 7.09${\pm}$4.59$\mu\textrm{g}$/g, Okgu-gun 7.06${\pm}$7.11$\mu\textrm{g}$/g, Jeongup-gun 6.35${\pm}$6.50$\mu\textrm{g}$/g.

산양(山羊)에 있어서 Potassium 및 Urea가 Magnesium의 대사(代謝)에 미치는 영향(影響)

권오덕,이현범,Kwon, Oh-deog,Lee, Hyun-beom 대한수의학회 1985 大韓獸醫學會誌 Vol.25 No.1

In the present studies, the effects of dietary high-potassium and high-urea on the metabolism of magnesium, calcium and potassium were checked as an aid to clarify the pathogenesis of hypomagnesaemia(so-called grass tetany) in ruminant. A total of 5 Korean native female goats kept in metabolic cage were received high-potassium(Mg: 0.25%, Ca: 0.94%, K: 5.41%), high-urea(Mg: 0.25%, Ca: 0.94%, K: 0.72%) or control(Mg: 0.25%, Ca: 0.94, K: 0.72%) ration for 15 or 21 days. Daily intakes, fecal and urinary excretions and serum concentrations of magnesium, calcium and potassium were measured with an atomic absorption spectrophotometer. The results obtained were summarized as follows: In high-potassium group, absorption, urinary excretion and serum concentration of magnesium were significantly (p<0.01, p<0.01 and p<0.05 respectively) decreased compared with the control group. On the other hand, the body retention was significantly (p<0.01) increased. However, no clinical symptom of hypomagnesaemic tetany was observable throughout the experimental period. No significant effects on the metabolism and seurm content of calcium were detected in the high-potassium group. In the high-potassium group, significant increase in absorption (p<0.01), urinary excretion (p<0.05) and body retention (p<0.01) of potassium were recognized. However, no significant difference in the concentration of serum was observable between the two groups. In high-urea group, no significant difference in the metabolism of magnesium and potassium or in the serum content were recognized compared with the control group. In high-urea group, tthe absorption, urinary excretion, body retention and serum content of calcium were decreased compared with the control group.

랫드에 있어서 키토산이 납중독의 대사에 미치는 영향

권오덕(Oh-Deog Kwon),정규용(Kyu-Yong Jung) 한국독성학회 2003 Toxicological Research Vol.19 No.4

This study was carried out to investigate the effect of chitosan on lead metabolism in SD rats. Ten male rats were divided into a experimental group and a control group. Each experimental and control rats were administered by water contaminated with 100 mg/l of lead for 4 weeks, respectively. Experimental group received diets supplemented artificially with 5% of chitosan for 4 weeks. Body weight change, food and water consumption, fecal and urinary excretion, and fecal and urinary lead excretion were measured. There were no significant differences in body weight gain, food<br/> and water consumption, and fecal and urinary excretion between the two groups. However, fecal lead excretion of rats fed the diet containing 5% of chitosan were higher than the control group. Whereas urinary lead excretion of rats fed the diet containing 5% of chitosan were lower than the control group. The results suggested that the oral administration of chitosan prevents the gastrointestinal lead absorption in rats.

컴팩트 도시의 지속가능한 도시모형으로서의 가능성 연구

권성실(Kwon, Seong-Sil),오덕성(Oh, Deog-Seong) 한국도시설계학회 2004 도시설계 : 한국도시설계학회지 Vol.5 No.4

수송 스트레스 및 영양결핍에 기인한 일본원숭이의 집단 폐사

권오덕 ( Oh Deog Kwon ),정규식 ( Kyu Shik Jeong ),이근우 ( Keun Woo Lee ),이창민 ( Chang Min Lee ),임채웅 ( Chae Woong Lim ),도재철 ( Jae Cheul Do ) 한국가축위생학회 2003 韓國家畜衛生學會誌 Vol.26 No.2

There was a mass outbreak of death caused by transport stress and malnutrition in Japanese macaques imported from Japan at a farm stock in Korea, which were diagnosed on the ground of history taking, clinical finding, hematological examination and necropsy. Twenty eight Japanese macaques imported from Japan died suddenly from the 4th day after arrival in a farm. These animals were confined very small cages individually and lose the appetite for 10 days from shipping. Main clinical findings observed from alive Japanese macaques consisted of hypothermia and dehydration. On hematological observation for typical 4 cases showed increased erythrocytes and packed cell volume. On serum biochemical examination for 3 cases showed hypoglycemia, whereas blood urea nitrogen, aspartate aminotransferase and alanine aminotransferase were increased. On necropsy for 3 cases, hemorrhage and congestion were observed on the lung and the walls of stomach and intestine were thinned. Histologically, hemorrhagic pneumonia and enteritis with loss of villi were seen. The death of these animal was caused by poor management during transport, which was resulted in transport stress and malnutrition.

Epidemiological Investigation of Diseases in Korean Native Suckling Calves

권오덕,최경성,이승옥,정환,이주묵,Kwon, Oh-Deog,Choi, Kyoung-Seong,Lee, Seung-Ok,Jang, Hwan,Lee, Joo-Mook The Korean Society of Veterinary Clinics 2000 한국임상수의학회지 Vol.17 No.1

This study was carried out to investigate the epidemiological prevalence of diseases from birth to weaning in 268 Koeran native calves which was delivered from three stock farm in Chonbuk area. We examined body weight gain, incidence rate of diseases and mortality rate in relation to age, season, environmental temperature and rearing management conditions for one year. The results of this experiment were as follows: Birth weight and body weight gain of Korean native calves born of primiparae were lower than those of multiparae. Body weight gain of diseased calves was lower than normal calves. Of 268 delivered calves, 242 calves(90.3%) were affected with gastronistestinal and/or respiratory diseases. The prevalence of the diseases were gastronitestinal disease(54.1%), gastronitestinal and respiratory disease(21.6%), and respiratory disease(14.5%). Of 242 diseased calves, 33 calves(13.6%) were occurred gastronitestinal disease and respiratory disease at different time respectively. Of 268 delivered calves, 126 calves were died(47%). The prevalence of the death were gastronitestinal disease(31.4%), gastronitestinal and respiratory disease(14.5%), and respiratory disease(1.1%). 81% of the diseases and 76.2% of the death were occurred in winter and a change of season(December to May). 59.1% of the diseases and 52.4% of the death were occurred at atmospheric temperatures below 1$0^{\circ}C$. 91.7% of the diseased calves and 96.8% of the dead calves were born of primiparae. 77.2% of the gastronitestinal disease were occurred within 2 weeks old, and the incidence was decreased with increasing age. Whereas the incidence of respiratory disease was incidence with ageing, and 69.2% of the respiratory disease were occurred between 2 weeks and 5 weeks old. And 62% of the gastronitestinal and respiratory disease wre occurred between 1 week and 3 weeks old. 65.1% of the dead calves were died within 2 weeks old. The morbidity and population mortality rate in each farm stock were 56.5%-104.9%, and 14.5%-64.2%, respectively.

Rat에 있어서 실험적 납중독이 체조직내 납 및 무기질함량에 미치는 영향

권오덕,이주묵,이승옥,박진호,이현범,장종식,채준석,Kwon, Oh-deog,Lee, Joo-mook,Lee, Seung-ok,Park, Jin-ho,Lee, Hyun-beom,Jang, Jong-sik,Chae, Joon-seok 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.3

This experiment was carried out to clarify the effect of lead poisoning on the lead and essential trace elements homeostasis of tissues in rats. Fifty female Wistar rats, 7 weeks old, were divided into four experimental groups(B, C, D, and E) and a control(A). The four experimental groups received diets contaminated artificially with 10 (B group), 100 (C group), 1,000 (D group) and 5,000 (E group) ${\mu}g/g$ of lead as lead acetate, respectively. The control group received normal diet. Rats were necropsied on the 4th or 8th week of experimental periods and heart, liver, spleen, kidney, muscle, lung and hair were taken. The tissues were analysed for lead, copper, zinc, iron and calcium content by atomic absorption spectrophotometry. From these experiments following results ware obtained ; In C group, lead content of the heart, liver, kidney and hair were significantly increased both on the 4th and 8th week of experiment. In D and E group, lead content of all tissues including heart, liver, spleen, kidney, muscle, hair and lung were significantly increased in accordance with the lead contamination both on the 4th and 8th week of experiment. In C group, copper content of tissues were significantly increased in the heart, liver, kidney and lung on the 4th week and all tissues on the 8th week of experimental periods. In D and E group, copper content of the liver were significantly increased both on the 4th and 8th week of experiment. But the copper content of tissues were gradually decreased compared with C group in accordance with the lead contamination. Especially the content in spleen, heart or kidney were significantly decreased compared with the control group. The zinc content of kidney, heart, or spleen were decreased in D and E groups whereas the iron and calcium content showed no significant change.