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권규택,육현균,이수정,Yi Hyung Chung,Han Su Jang,유종상,조경훈,공현석,신대근 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.4
The objective of this study was to evaluate the effect of yellow mealworm (Tenebrio molitor L.) exuviae (ME) given as a prebiotic in 20% of the diet fed to BALB/c mice. Analysis of the ME revealed that it was mostly composed of crude protein (52.94%), crude fiber (10.70%), and moisture (10.54%). When ME was fed to mice for 8 weeks, the number of intestinal lactic acid bacteria increased, reaching similar numbers (4.50 ± 0.80 CFU/ mL) to those (4.70 ± 0.80 CFU/mL) of the control group not fed ME. Microbiome analysis showed that 8 weeks feeding of ME promoted the growth of Bifidobacteriaceae and Lactobacillaceae compared to the POS group, indicating the positive effects of feeding 20% ME on the intestinal microbiota of mice. These results suggest that ME can be considered as a dietary prebiotics to improve human gut microbial population, but further application study to human is necessary.
Kaempferol이 인간의 전립선암세포인 DU145의 이동과 침윤에 미치는 영향
권규택,강상욱,강영희,윤정한 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.4
Kaempferol is a natural flavonol found in strawberries, teas, apples, and onions. Previous studies have reported that kaempferol has anti-proliferative activities and induces apoptosis in many cancer cell lines. In this study, we investigated the anti-metastatic effects of kaempferol in DU145 human prostate cancer cells and elucidates the relevant mechanisms. DU145 cells were cultured in the presence of 0∼60 μmol/l kaempferol. Kaempferol dose-dependently inhibited the migration, invasion, and adhesion of DU145 cells. Kaempferol decreased the secretion of urokinase-type plasminogen activator (uPA), matrix metalloproteinase (MMP)-9, and vascular endothelial growth factor (VEGF) in concentration-dependent manners. Furthermore, kaempferol inhibited the phosphorylation of signal transducer and activator of transcription (STAT)3. These results indicate that the inhibition of STAT3 signaling may be a mechanism by which kaempferol regulates the expression of proteins involved in regulating the migration and invasion of DU145 cells. (Cancer Prev Res 15, 299-305, 2010)