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- 저자 : 권경술 ( Kyung-Sool Kwon ) (검색결과 220 건)
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유경성 지방섬유종의 임상 및 병리조직학적 관찰 - 표재성 피부지방종성 모반과의 비교 관찰 -
권경술,서경형,장호선,정태안,오창근 ( Kyung Sool Kwon,Kyung Hyung Seo,Ho Sun Jang,Tae Ahn Chung,Chang Keun Oh ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5
Background:Nevus lipomatosus cutaneous superficialis(NLCS) was originally classified into two clinical types:a multiple form and a solitary one. Mehregan et al proposed the term pedunculated lipofibroma for the solitary form of NLCS in view of its distinctive clinicopathological features. Objective:Pedunculated lipofibroma is a relatively rare benign connective tissue proliferation abnormality characterized by ectopic adipose tissue in the dermis. The purpose of this study was to investigate the differences in clinicopathological findings between pedunculated lipofibroma and NLCSs. Methods:we performed the comparative clinicopathological studies of pedunculated lipofibromas and NLCSs among 9,940 patients who had skin biopsies for hisitopathological diagnosis during a recent 20 yeat period. In addition, we reviewed the NLCS cases previously reported in Korea. Results:We found 12 cases(0.12%) of pedunculated lipofibromas which showed a female preponderance. The lesions usually appeared as large, solitary, slow-growing, pedunculated to dome-shaped, skin-colored nodules or masses showng predilection for the buttock and upper thigh. However, 33.3% of lesions were present on non-pelvic girdle areas such as the back, upper arm, scalp, axilla and anterior chest. Most of the patients had a solitary lesion except for two patients who had two lesions. Histopathologically, all of the lesions were characterized by the presence of a central fatty core of mature adipose tissue infiltration admixing with dense stromal collagen. Several appendageal structures, perivascular and periappendageal deposition of mucin, and perivascular infiltration of mast cells were present in all of the lesions. Otherwise obvious acanthosis or papillomatosis were not present in the epidermis. We found 4 cases(0.04%) of NLCSs and reviewed 9 reported cases of NLCSs, which did not show the sexual differences in incidence. The lisions usually appeared as skin-colored confluent nodules which formed the zosteriform or cerebriform plaques. The majority of lesions(92.3%) were present on the pelvic girdle area except for one case with shoulder lesions. Histopathologically, all of the lesions showed the mature adipose tissues, epidermal hyperkeratoses, acanthoses, follicular pluggings and well-developed pilo-sebaceous units. Conclusion:Because of the distinctive clinicopathological differences between the solitary and multiple forms of NLCS, we agree with Mehregan’s proposal of nominating this solitary lesion as pedunculated lipofibroma.(Korean J Dermatol 1997;35(5):854∼862)
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표재성 및 심재성 진균증의 진단에 있어서 Fungi - FluorR solution 염색의 유용성에 관한 연구
권경술,임채성,장호선,정태안,오창근 ( Kyung Sool Kwon,Chae Sung Yim,Ho Sun Jang,Tae Ahn Chung,Chang Keun Oh ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5
Background: Mycoses of deep tissues requir e prompt recognition and early institution of treatment. Sometimes, it is quite difficult to find fungal elements in tissue section with special stains and to culture on Sabouraud media. Previously it has been shown that Fungi-Fluor solution (calcofluor white) bind t fungi present in frozen and paraffin tissue sections. Fungi present in such specimens stained with Fungi-Fluor solution have a distinct green-blue fluorescence when examined by fluorescent microscopy. Objective : The purpose of this study is to evaluate the diagnostic value of the Fungi-Fluor solution for detecting fungal element in the tissue. Methods : Fungi-Fluor staining was done with a paraffin-embedded tissue section of several superficial and cutaneous deep mycoses. Then we viewed this through a fluorescent microscope with excitation of 250-400 nm and compared these staining results to PAS staining. Results: The results of this study are summarized as follows : 1. In the several superficial mycoses such as tinea corporis & tinea capitis, Fungi-Fluor staining method revealed more fungal elements with high sensitivity compared to PAS stain. 2. In the several cutaneous deep mycoses such as sporotrichosis, Fungi-Fluor staining method revealed more fungal elements than PAS stain, and revealed some fungal elements which were not detected by PAS stain. Conclusion : The Fungi- fluor staining solution is a rapid, inexpensive, highly sensitive method to detect fungal element in the tissue. (Korean J Dermatol 1997;35(5): 870-876)
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각화 극세포종과 편평 세포암에서 TGF - βs 발현에 관한 면역조직화학적 연구
권경술,이현태,장호선,정태안,오창근 ( Kyung Sool Kwon,Hyun Tae Lee,Ho Sun Jang,Tae Ahn Chung,Chang Keun Oh ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5
Background: Because of the clinical and histological similarities of keratoacanthoma(KA) and squamous cell carcinoma(SCC), it is often difficult to differentiate. Transforming growth factor-bs (TGF-bs) are the multifunctional peptides that regulate the cellular growth and differentiation. It has been known that the isoforms of TGF-b(TGF-b1, TGF-b2, TGF-b3) are differently expressed in human cancers such as basal cell carcinoma, pancreatic cancer, thyroid cancer, etc. Objective : The purpose of this study was to examine the expression patterns of TGF-b isoforms on KA and SCC using the immunohistochemical staining method with anti-TGF-bs antibodies and to evaluate the usefulness of this method in distinguishing each other. Methods : We performed immunoperoxidase staining(LSAB technique) using polyclonal anti-TGF-b1, b2, and b3 antibodies from the formalin-fixed, paraffin-embedded biopsy specimens obtained from 11 patients with KA, 11 pntients with SCC, and 10 healthy volunteers. Results : In the normal skins, TGF-b1, b2 and b3 were almost negative or only weakly positive in the epidermis, whereas TGF-b3 was moderately to strongly positive in the suprabasal layer. In KAs, the expression patterns of TGF-b1, b2, and b3 were similar to those of the normal skins. In SCCs, however, the expression of TGF-b1 was increased and TGF-b3 was decreased compared with the normal skins. Conclusion : In these results, the immunohistochemical staining using the anti-TGF-bs antibodies, especially anti-TGF-b1 and b3, can be used for the differentiation of KA and SCC. Also, it can be suggested that the charige of expressions of TGF-b isoforms in the epidermis may play an important role in the carcinogenesis of SCC. (Korean J Dermatol 1997;35(5): 863-869)
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정상인과 지루 피부염 환자에서 두부 전풍의 발생 빈도에 관한 관찰
권경술 ( Kyung Sool Kwon ),차형기 ( Hyoung Gi Cha ),장호선 ( Ho Sun Jang ),정태안 ( Tae Ahn Chung ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1
Background: Pityrosporum yeast is a normal resident flora of the skin. Its hyphal form can be found on the lesions of pityriasis versicolor. Our previous studies showed that pathogenic pityrosporal hyphae coulc be found on a clinically normal scalp. We called it pityriasis versicolor of the scalp. This species may be involved in the pathogenesis of seborrheic dermatitis. Objective : We investigated the incidence of pityrosporal hyphae on the scalp of patients with seborrheic dermatitis and normal persons, and compared the results between the two groups. Methods : 202 patients with seborrheic dermatitis, 350 normal persons were studied. Scalp scrapings were stained with 20% Parker ink-KOH(P-KOH) solution. The number of pityrosporal hyphae per high power field(x 400) were counted according to a grading method(1, to 3+). Results : The incidence of pityriasis versicolor of the scalp was 28.7% in patients with seborrheic dermatitis, and 21.7% in normal persons. However the incidence of pityriasis versicolor of the scalp in seborrheic dermatitis in the age group of the second and sixth decades was two fold higher, 43.3%, 40.9%, respectively than in the normal control groups, from 9.5% to 25.0%. In the case of sex distribution, the incidence of pityriasis versicolor of the scalp in female patients of seborrheic dermatitis was two fold higher, 34.8%, than in the normal control, 18.8%. According to seasonal variation, the incidence was higher in spring(21.7%) and summer(34.3%) in the control group, and higher in spring, fall and summer, 31.2, 31.4 and 39.2%, respectively, in people with seborrheic dermatitis. Conclusion : The results of this study showed that the incidence of pityriasis versicolor of the scalp in patients with seborrheic dermatitis and normal person is similar, There were, however some differences between them according to age, sex and season. (Kor J Dermatol 1996;34(1): 10-16)
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권경술(Kyung Sool Kwon),한을희(Eul Hee Han),정태안(Tae Ahn Chung),신항계(Hang Kye Shin),김천기(Cheon Gi Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1
A 51-year-old female developed a distinctive perioral rash, conisting of discrete or confluent erythematous papules for one and a half years. Histopathologic examiriation revealed upper dermal granulomas admixed with lymphoytes. Pieces of hair shaft were staincd peri-dish by AFB in the center of granuloma, which might play a role in the formation of the granuloma She also had used corticosteroid ointment intermittently duririg this time. There were no associated systemic abnormalities. The lesions resolved after two month treatment with oral corticosteroid and tetrac cline. (Kor J Dermatol 1994; 32(1): 182-185)
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건선 환자에서 혈청 지질 및 지질단백 검사 소견에 대한 연구
권경술 ( Kyung Sool Kwon ),서경형 ( Kyung Hyung Seo ),장호선 ( Ho Sun Jang ),정태안 ( Tae Ahn Chung ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1
Background: Previous studies have demonstrated that patients with psoriasis may have an increased risk of contacting a variety of noncutaneous diseases, including arterial and venous occlusive diseases. Changes in plasma lipid and lipoprotein composition in patients with psoriasis may be the reason for the increased risk of atherosclerosis in these patients. Objective : This study was carried out to investigate the differences of serurn lipid, lipoprotein and apolipoprotein levels between the psoriasis patients and control groups and to suggest which are related with atherogenic risk in the psoriasis. Methods : Serum lipid, lipoprotein and apolipoprotein levels were measured in 100 patient with psoriasis and in 30 healthy people. Results : In the serum lipids study total cholesterol, TG, LDL-C and VLDL-C levels were lower and HDL-C level was higher in the psoriasis group than in the control group. Statistical significant differences were noticed in total cholesterol levels between the female psoriasis patients and the female control groups. In the serum lipoproteins study apolipoprotein B and lipoprotein (a) levels were higher and apolipoprotein A I level was lower in the psoriasis group than in the control group, and statistical significant differences of apolipoprotein B and lipoprotein (a) levels were noticed in the atherogenic risk group and severe psoriasis group compared with the control group. Conclusion : These findings suggest that the atherogenic risk in psoriasis is related with the high level of apolipoproteins especially apolipoprotein B, and is not related with serum lipid. (Kor J Dermatol 1996;34(1): 102-108)
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권경술(Kyung Sool Kwon),한을희(Eul Hee Han),정태안(Tae Ahn Chung),최석주(Suk Joo Choi),이준호(Joon Ho Lee) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1
A 28-year-old female devei,oped five rice-sized erythematous telaniectatic solid papules of her left side of cheek and numerous light brownish flat papules of her face two years before visiting our department of dermatology. Biopsy results of the erythematous papule vere dermal infiltration by well-differentiated, however, somewhat atypical and varying sized plasma cells involving epidermis, and the flat papule was that of verwca plana. Bone marrow aspirate was essentially normal. Primary cutaneous plasmacytoma is a rare disease. A significant proportion of patients with this ent on to develop systemic disease with a poor prognosis. Our patient was not treatead, bit only excised partially for biopsy. All skin lesions involuted two years later spontaneously and rema ns well until now six years later without recurring. (Kor J Dermatol 1994; 32(1): 144-148)
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