악골 골수염의 처치

국민석 대한치과의사협회 2008 대한치과의사협회지 Vol.46 No.12

Porous polyethylene을 이용한 관골증대술의 임상연구

국민석,안진석,김영준,박홍주,오희균,Kook, Min-Suk,An, Jin-Suk,Kim, Young-Joon,Park, Hong-Ju,Oh, Hee-Kyun 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.3

The malar mound defines the contour of the lateral face between the inferior orbital rim and the mandible, and hypoplasia or asymmetry of this region is readily noticeable. A flat, hypoplastic malar eminence can make the face blunt and wearisome, which contributes to a premature aged appearance. Patients with congenital or traumatic flattening of the malar eminence can obtain esthetic improvement with implants. Indications for placement of malar implants to improve the appearance of subtle flattening or to enhance the esthetic harmony of a patient's face have been suggested in several studies. Many augmentation materials, such as silicone, proplast, polyamide, and porous polyethylene implants have been used. Many methods of localization have been described, the key to proper placement of the implants lies in a through understanding of the esthetics of the malar mound. From August 2001 to June 2007, 12 patients with malar depression who visited the Department of Oral and Maxillofacial Surgery, Chonnam National University Hospital were treated by augmentation malarplasty with Porous polyethylene. The location and amount of augmentation are determined by preoperative interview, physical examinations, facial models and radiographic findings. 12 patients were satisfied with the results of augmentation malarplasty and severe complications were not occurred.

가토대퇴정맥에서 미세혈관문합시 Argatroban의 국소세척 및 전신투여가 혈전형성에 미치는 영향

국민석(Min-Suk Kook),박홍주(Hong-Ju Park),오희균(Hee-Kyun Oh) 대한구강악안면외과학회 2005 대한구강악안면외과학회지 Vol.31 No.4

Purpose: For the reconstruction of maxillofacial defect created by trauma, infection, or tumor etc, the role of microvascular anastomosis or vessel graft has been increased. Many methods has been tried to increase the success rate of microvascular anastomosis. Various anticoagulants and thrombolytic agents have been used to reduce the failure rate of microvascular anastomosis and avoid re-operation. Many drugs, however, have been used in the limited cases because most of these drugs may cause complications, such as allergy, fever or systemic bleeding. This study was performed to evaluate the influence of the Argatroban on patency and thrombosis in microvascular anastomosis when it is used for local irrigation or general administration. Materials & methods: Eight mature rabbits, weighing 2kg, were used. After exposing both femoral veins, the artificial thrombotic model was made by crushing injury using a smooth needle holder, and the transverse incision were made on femoral vein. The animals were divided into 4 groups according to Argatroban administration methods; control group (n=4), topical irrigation of lumen with saline solution; experimental group 1 (n=4), topical irrigation of lumen with Argatroban saline solution; experimental group 2 (n=4), topical irrigation of lumen with heparin followed by intravenous injection of Argatroban; experimental group 3 (n=4), topical irrigation of lumen with Argatroban followed by IV of Argatroban. Microvascular anastomosis was done with 10-0 Ethilon. The patency was evaluated by empty-and-refill test 30 minutes and 3 days after microanastomosis. The thrombus formation was examined 3 days after microanastomosis by surgical microscope. The histologic findings were also examined. Results: 1. Thirty minutes after microvascular anastomosis, the patency of all experimental groups was better than that of control group, but there was no significant difference among groups. 2. Three days after microvascular anastomosis, the patency of all experimental groups was more improved than that of control group (p<0.05). There was no significant difference among experimental groups. 3. Three days after microvascular anastomosis, the amount of thrombus in all experimental groups was less than that of control group (p<0.05). There was no significant difference among experimental groups. 4. Histologically, a lot of luminal thrombus was observed around sutured area in control group. Few luminal thrombus was observed in all experimental groups. The necrotic changes were observed on the sutured vein wall in all specimens. Conclusion: These results indicate that topical irrigation and/or intravenous administration of Argatroban is effective in improving patency and preventing thrombus formation after microvascular anastomosis.

상악동저 거상술 후 Osstem Implant (US II / SS II)의 다기관 후향적 임상연구

국민석(Min-Suk Kook),박홍주(Hong-Ju Park),김수관(Su-Gwan Kim),김영균(Young-Kyun Kim),조용석(Yong-Seok Cho),최갑림(Gab-Lim Choi),오영학(Young-Hak Oh),오희균(Hee-Kyun Oh) 대한구강악안면외과학회 2008 대한구강악안면외과학회지 Vol.34 No.3

Purpose: The purpose of this study was to evaluate the Osstem􀋓 implants (US II/SS II implants) through the retrospective study for the clinical success rate during the installation of the Osstem􀋓 implants (US II/SS II implants) by using of the procedures of maxillary sinus floor elevation. Materials and methods: The current study was researched in the 6 medical institutions: Chonnam National University, Chosun University, Pusan DaeDong Hospital, Bundang Seoul National University Hospital, Ap-Seon Clinic, and All Clinic. Based on the total number of 116 patients whose treatment was the installation of the US II/SS II implants with the procedures of the maxillary sinus floor elevation, they were conferred on the dental records of the patients under the joint consultation of the 6 medical institutions. On the dental recording charts, there were included in as the following; the name of the institutions, gender, age, with or without smoking or drinking, with or without the generalized diseases, the height of the alveolar bone on the operational sites, elapsed edentulous state period, the state of the opposed or adjacent teeth, the methods of the maxillary sinus floor elevation, secondary time period for surgery, the lengths, types, and diameters of implants, with or without bone transplantation or the types of bone, postoperative current bone height, current adjacent soft tissue state of the implants, with or without the success of the installations of the implants. We have done our survey with the clinical and radiolographical examinations and dental questionaries. The success and survival rate of the implants was evaluated. Results 1. Total number of the patients with the installation of the US II implants were 62. The 252 numbers of US II implants were installed on the 89 maxillary sinuses. The patient s mean age was 54.1 years old and there were 36 men and 27 women. 2. Total number of patients with the installation of SS II implant were 57. The 165 numbers of SS II implants were planted on the 80 maxillary sinuses. Their mean age was 48.7 years old and there were 37 men and 20 women. 3. The follow-up period was 30.7 months(21-49 mon) on average. The vertical bone loss of installed implants after the procedures of the maxillary sinus elevation was 1.1 mm on average in SS II and 1.3 mm on average in US II. There existed no statistical significance on each group. The mean enlarged bone height after the maxillary sinus floor elevation was 8.2 mm. 4. For the procedures of the maxillary sinus elevation, the Lateral approach technique occupied 87.1%, which was the most used one. In addition, the most frequently used transplanted bone was autogenous bone only which was 72.7% during the maxillary sinus floor elevation. 5. The complication of maxillary sinus floor elevation were perforation of sinus membrane, disesthesia on doner site, exposure of cover screw and exposure of maxillar bone. 6. The survival rate of US II and SS II after maxillary sinus floor elevation was 99.2% and 95.8%, respectively. And the success rate of US II and SS II after maxillary sinus floor elevation was 97.6% and 89.7%, respectively. Conclusion : On the evaluation of the analysis of our study, both US II and SS II implants showed the excellent clinical results by use of the procedures of maxillary sinus floor elevation.

비글견 경골에서 임플란트 식립 시 혈소판 농축 혈장이 골형성에 미치는 영향

국민석(Min-Suk Kook),정승곤(Seunggon Jung),심경미(Kyung-Mi Shim),강성수(Seong-Soo Kang),박홍주(Hong-Ju Park),유선열(Sun-Youl Ryu),오희균(Hee-Kyun Oh) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.2

Introduction: The purpose of this study is to evaluate the effect of platelet rich plasma in bone formation and osseointegration of implant installed in the bone marrow space. Materials and Methods: Five beagle dogs were used as experimental animals. Two implants were installed on each tibia in the dogs. Implants of the control group were installed with no additional graft. Those of the experimental group 1 were installed with autogenous bone graft from the ilium autogenous bone. Platelet rich plasma (PRP) alone was used in experimental group 2 and the mixture of PRP and autogenous bone was used in experimental group 3. The animals were sacrificed at 8 weeks after implantation. The parts of tibia containing implant were harvested and radiographs were taken for radiographic examination. The specimens were prepared for histological examination and histomorphometric analysis of implant-bone contact ratios. Results: 1. All implants showed sufficient osseointegration in the cortical bone radiographically and histologically, but osseointergration in the marrow space was not satisfactory. 2. Histomorphometrically, the implant-bone contact ratios in the bone marrow was sequentially high in the experimental group 3 (autogenous bone+ PRP group), group 1 (autogenous bone group), group 2 (PRP group), and control group (non-additive). 3. It was verified that there was statistical significance between two experimental groups (group 1 and 3) and the other groups (group 2 and control group). (P<0.005) 4. However, there was no statistical significance between group 3 and group 1, also group 2 and control group respectively. Conclusion: These results suggest that platelet rich plasma is effective to osseointegration in the implant installation but there is no statistical significance.

환자를 위한 선수술 교정 접근 방법

국민석(Minsuk Kook) 대한치과의사협회 2017 대한치과의사협회지 Vol.55 No.4

The traditional orthognathic surgery treatment consists of three steps: preoperative orthodontic treatment, orthognathic surgery, and postoperative orthodontic treatment, and the average treatment period is usually two years. Also, patients with Class III malocclusion should spend more time getting their facial features worse during the decompensation process. However, most of the patients who want orthognathic surgery visit the chief complaints of appearance improvement, and resolve this address as soon as possible. The concept of °ÆSurgery - First "does not cause a facial imbalance caused by decompensation for the pre – operative correction period, and the patient can obtain an improved facial profile immediately after the operation. In addition, the correction period is shortened by Regional Acceleratory Phenomenon (RAP) after surgery. However, it is not applicable to all patients. Patients with severe crowding, severe curve of spee or reverse curve of spee, severe transverse discrepancy of the maxilla and mandibular arch, and severe incisal angles are less likely to apply the technique. Although it is not yet possible to apply this technique to all patients, it has many advantages over the conventional method. Especially, the patients" preference is increasing due to the rapid appearance improvement and the shortening of the total treatment period.

MC3T3 preosteoblast cell line의 5-(and-6)-carboxy-2’,7’-dichlorofluorescein diacetate, succinimidyl ester mixed에 의한 fluorescent labelling

국민석(Min-Suk Kook) 대한구강악안면외과학회 2005 대한구강악안면외과학회지 Vol.31 No.6

Background. 5-(and-6)-carboxy-2’,7’-dichlorofluorescein diacetate, succinimidyl ester mixed (CFSE) is the fluorescent labelling agent of living cells and used to trace the cells in vivo after transplatnation of various cells. The CFSE labelled cells can maintain fluorescence for up to 7 days after labelling. The MC3T3-E1 cell line (MC3T3) has been used for many studies about osteoblast, which is well known as a mouse preosteoblast. So the CFSE would be used to trace the transplanted MC3T3. However there are few reports about CFSE labelling of MC3T3. This study is aimed to know about adequate concenturation and incubation time of CFSE to MC3T3. Materials and methods. The MC3T3 was incubated in a humidified atmosphere of 95% air with 5% CO2 at 37℃ using α-minimal essential medium(α-MEM) containing10% FBS and gentamycin. Ten mM CFSE solution in dimethylsulphoxide (DMSO: 1%) was diluted with phosphate buffered saline (PBS) and final concentration of culture medium was, respectively, 5, 10, 15, 20, 25 and 30 μM. Then the MC3T3 was incubated with CFSE in a humidified atmosphere of 95% air with 5% CO2 at 37℃ for 5, 10, 15, 20, 25, 30, 35, 40 and 45 minutes in each concentration. The fluorescence of CFSE labelled cells was analysed with a inverted fluorescence microscope. The duration of cell labelling was also studied. Trypan blue dye exclusion test was done for cell viability. Results. For concentration between 5 and 10 μM, CFSE did not significantly label the MC3T3 in vitro. The destruction of MC3T3 was observed at the concentration of 20 μM. In the concentration of 15 μM, the best labelling was obtained at an incubation period between 15 and 30 minutes. The MC3T3 labelled with an incubation period of 15 minutes at 15 μM was still fluorescent 7 days after CFSE labelling. The mean cell viability was 95.93%. Conclusion. These results suggests an incubation period of 15 minutes at 15 μM of CFSE provides best labelling of MC3T3 in vitro.

하악 구치부에서 발생한 편평치성종양

송성용,오희균,임원봉,김지선,김상우,전상미,국민석,박민영,Hui Zheng,최홍란,김옥준 대한구강악안면병리학회 2013 대한구강악안면병리학회지 Vol.37 No.4

Squamous odontogenic tumor (SOT) is a rare benign neoplasm first described by Pullon et al. in 1975. Clinically and histologically, it is confused with ameloblastoma, carcinoma and local periodontoal disease. We report a case of SOT occuring in a 16-year-old female in the right mandibular angle location associated with an impacted molar

유두상 림프종성 낭선종에서 발생한 편평상피세포암

이희돈,송성용,임원봉,김지선,김상우,전상미,Hui Zheng,임순임,박지일,국민석,최홍란,김옥준 대한구강악안면병리학회 2013 대한구강악안면병리학회지 Vol.37 No.4

A Warthin’s tumor of major salivary glands, in particular of parotid glands, is a common benign tumor that may occur synchronously or metachronously in the same or contralateral gland. Moreover, epithelial malignance associated with a Warthin’s tumor is extremely rare, and exists in three forms; epidermoid carcinoma, adenocarcinoma, and undifferentiated carcinoma. The reports, related with a case of squamous cell carcinoma arising in a Warthin’s tumor at the parotid gland were reported only additional 3 cases from 1999 to 2010; 30 cases reported up to 1999.[2,4,7] This case report was a extremely rare case where both a primary squamous cell carcinoma and a Warthin's tumor were coexisting in the same

이부에 발생한 지방육아종의 외과적 적출

이상아,임원봉,김지선,김상우,전상미,Hui Zheng,박홍주,국민석,오희균,최홍란,김옥준 대한구강악안면병리학회 2013 대한구강악안면병리학회지 Vol.37 No.5

We present a case of lipogranuloma of the chin in a 17-year-old man. The lesion was revealed as lipogranuloma in radiological and histopathological findings and did not recur after being surgically removed. Lipogranuloma is a granulomatous inflammation with marked sclerosing response to the fatty tissue caused by foreign material injection. Despite lipogranuloma was reported as a complication arising from injection of oil-based substances into soft tissues for the purpose of cosmetic therapy, patient in this case had no history of foreign material injection. We expect that patient had a history of traumatic injury on his right chin that he doesn’t remember. Definitive treatment of lipogranuloma is surgical excision and usually involves secondary reconstruction. Regarding the physical and psychological complications of this practice, prevention is required the most but once occurred accurate history taking and biopsy is important to diagnosis