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구용의,강민철,이선화,김순한,김재이,김은정,김연희,유병옥,김주원,최계선,이향미,지영애,홍무기 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
꿀벌의 무저병을 치료하기 위하여 테트라싸이클린 계열의 항생물질(TCs)이 널리 사용되고 있으며,이러한 사용은 벌꿀중 Cs의 잔류문제를 일으킬 수 있다. 따라서 벌꿀중 잔류하는 TCs의 분석법이 팔요하며, 본 연구에서는 벌꿀클의 옥시테트라싸이클린(OTC), 테트라싸이클린fC), 클로르테트라싸이 클린(CTC), 독시싸이클린(DC)끌 분석하기 위해 두가지 HPLC방법을 사용하였다. 아카시아꿀, 잡화꿀,토종꿀, 방꿀등 4가지 종류의 댈꿀에 대한 회수율 및 검출한계를 측정하였다. 형광검출기를 이웅한 분석법에서는 0.Sppm의 수준에온 회수율은 OTC는 91.4~98.2%, TC는 84.B~94.4%, CTC는 뚬.I~105.9%, DC는 뽀.5~져.5%이었으며, 검출한계는 OTC와 TC는 0.01ppf CTC차 OC는 0.05ppm이었다. 자외선검출기를 이용한 분석법에퍼는 0.Sfpm의 수준에서 회수율은 OTC는 78.3~97.0%, TC는 76.8~86.8%, CTC는 89.6~99.5%, Df는 91.I~93.8%이었으며, 검출한계는 OTC와 TC는 0,01ppm, CTC와 DC는 0.02ppm이었다. 두 ITPLC법으로 국내산 벌꿀 140건과 외국산 벌꿀 29건을 조사한 결과 OTC,TC, CTC, BC 모두 검출되지 않았다. ln order to prevent foul brood of honey-bees, tetracycline antibiotics(TCs) are widely used in honey-bee culture. Such usage may resu)t in residues of TCs in honey.Therefore, the establishment of a method for residue analysis of TCs in honey is required.Two HPLC methods for oxytetracycline(OTC), tetracycline(TC), chlortetracycline(CTC) anddoxycycline(DC) in honey have been established. The recoverles of OTC, TC, CTC and BCfrom 4 kinds of honelr(acacia honey, mixed flower honey, native honey, chestnut honey) spikedat a level of 0.Sppm by HPLC with fluorescence detection are 91.4 ~98.2%, 84.B~94.4%, 85.1 ~105.9%, 86.5 ~94.5% refpectively. The limits of detection in honey b.# HPLC with fluorescencedetection are 0.01ppm for OTC and TC, and 0.05ppm for CTC and DC respectively. And therecoveries of OTC, TC, CTC and DC from 4 kinds of honey spiked at a level of 0,Sppm byHPLC with UV detection are 78.3 ~97.0%, 76,8 ~86.8%, 89.6 ~99.5%, 91,1 ~93,8% respectively.The Ihuts of detection in honey by HPLC with UV detection are 0.01ppm for OTC and TC,and 0.02ppm for CTC and DC respectively The residual TCs(OTC, TC, CTC, DC) were notde7ected in the 169 samples of honey(domestic honey 140, imported honey 29) by two HPLCmethods.
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구용의,Gu, Yong-Eui 한국식품연구원 2008 한맛한얼 Vol.1 No.3
최근 전분당업계에서 전분당의 원료로 그동안 수입하던 일반 옥수수 대신 유전자 재조합 옥수수를 수입하면서 유전자 재조합 식품에 대한 논란이 다시 가열되고 있다. 1996년 유전자 재조합 콩이 처음 상업적으로 재배된 지 10년이 지났지만 유전자 재조합 식품에 대한 논란은 아직도 계속되고 있다. 이런 상황에서 우리나라에서는 유전자 재조합 식품을 어떻게 관리하는지 살펴본다면 유전자재조합 식품을 이해하는데 많은 도움이 될 것이다.
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A Study on the Characteristics of PSA Device using RTA Process and Trench Technology
구용서,강상원,안철,Koo, Yong-Seo,Kang, Sang-Won,An, Chul The Institute of Electronics and Information Engin 1991 전자공학회논문지-A Vol.28 No.9
This paper presents the 1.5\ulcorner PSA bipolar device which establishes the performance improvement such as the reduction of emitter resistance and substrate junction capacitance. To achieve the above electrical characteristics, RTA process and trench isolation technology were adapted. The emitter resistance and substrate capacitance of npn transistor having 1.5$[\times}6{\mu}m^{2}$emitter area was measured with 63$\Omega$and 28fF, respectively. The minimum propagation delay time shows 121ps at 0.7mW from the measurement of 31 stage ring oscillator.
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구용서,유성욱,정기영,조경희 대한수면연구학회 2014 Journal of sleep medicine Vol.11 No.2
Objectives: This study was performed in order to delineate whether the onset of symptom onset follows circadian rhythm and to identify potential clinical characteristics with similar circadian distribution as that of symptom onset time in stroke patients. Methods: We retrospectively analyzed the data of subjects who were registered in a prospectively collected stroke registry in Korea University Medical Center Anam Hospital from September 2007 to December 2013. A Cosinor analysis was used to examine the circadian variation of the symptom onset of stroke as well as various clinical parameters. Results: A total of 2,047 patients with stroke were analyzed in our study. The Cosinor analysis showed significant circadian rhythm of stroke occurrence existed according to the symptom onset time of stroke (p<0.001) and the peak time for stroke occurrence was 12:22 (95% confidence interval 11:29–17:41). Cosinor analyses of other variables also showed significant circadian variation of age, fasting glucose, high-density lipoprotein (HDL), and lowdensity lipoprotein. The circadian distribution of low HDL was similar to that of stroke occurrence. Conclusions: The prevalence of stroke occurrence and low level of HDL peaked during the morning. J Korean Sleep Res Soc 2014;11(2):6
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