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윤정숙 ( Jong Suk Yoon ),곽희준 ( Hee Jun Kwak ),김윤형 ( Yoon Hyoung Kim ),신영종 ( Young Jong Shin ),유기정 ( Ki Jeong Yoo ),유명종 ( Myeong Jong Yu ) 대한원격탐사학회 2013 大韓遠隔探査學會誌 Vol.29 No.1
레이더 전파고도계는 레이더 신호를 지표면으로 송신하여 반사되어 돌아오는 신호로 항공기에서 지표면까지의 거리를 측정하는 센서이다. 이러한 레이더 전파고도계의 특성 분석을 위하여 비행 시험을 통해 레이더 전파고도계와 LiDAR를 동시에 획득하여 LiDAR DSM을 레이더 전파고도계 분석을 위한 참조자료로 사용하였다. LiDAR로 획득한 지표면의 점 자료들은 격자로 보간하여 DSM을 제작하였다. 비행 시험은 2012년 6월에 수행하였으며, 레이더 전파고도계 자료에 대하여 레이더 방정식에서 거리(range) 및 RCS와 관련된 반사되는 지표면의 면적에 따른 특성 측면에서 해석하였다. 결과적으로 빔폭이 넓은 항공기용 레이더 전파고도계는 가까운 거리에 있는 최근점의 영향보다는 RCS와 관련이 있는 지표면의 면적이나 반사도에 더 많은 영향을 받고 있다는 것을 알 수 있다. The Radar altimeter transmits radio signals to the surface, receives the backscattered signals and measures the distance between the airplane and the nadir surface. The measurements of radar altimeter are affected by various factors on the surface below the aircraft. This study performed flight campaigns in June 2012 and acquired raw data from radar altimeter, LiDAR and other sensors. Based on the LiDAR DSM (Digital Surface Model) as a reference data, the characteristics of radar altimeter were analyzed in the respect of range and surface area affecting on the receiving power of the radar altimeter. Consequently, the radar altimeter was strongly affected by the surface area within beam width and reflectivity related to RCS (Radar Cross Section) rather than range.
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β-Asarone이 Lipopolysaccharide에 의한 생쥐 해마의 염증성 사이토카인 발현과 학습 및 기억 장애에 미치는 영향
최문숙 ( Moon Sook Choi ),곽희준 ( Hee Jun Kwak ),권기중 ( Ki Jung Kweon ),황지모 ( Ji Mo Hwang ),신정원 ( Jung Won Shin ),손낙원 ( Nak Won Sohn ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.6
Objectives : β-Asarone (BAS) is an active ingredient in Acori Rhizoma. This study investigated anti-neuroinflammatory and memory ameliorating effects of BAS in systemic lipopolysaccharide (LPS)-treated C57BL/6 mice. Methods : BAS was administered orally at doses of 7.5, 15, and 30 mg/kg for 3 days prior to LPS (3 mg/kg, intraperitoneal) injection. Pro-inflammatory cytokine mRNA, including tumor necrosis factor-α (TNF-ㅍ), interleukin (IL)-1β and IL-6, was measured in hippocampus tissue using real-time polymerase chain reaction at 4 h after the LPS injection. An ameliorating effect of 30 mg/kg BAS on learning and memory impairment in the LPS-treated mice was verified using the Morris water maze test. Results : BAS significantly attenuated up-regulation of TNF-α, IL-1β, and IL-6 mRNA in hippocampus tissue of the LPS-treated mice. In acquisition training test, BAS improved learning performance of the LPS-treated mice with a significant decrease of escape latency to the platform. In memory retention test, BAS also ameliorated memory impairment of the LPS-treated mice with a significant increase of swimming time in zones neighboring to the platform, number of target heading, and memory score. Conclusion : The results suggest that inhibition of pro-inflammatory cytokines and neuroinflammation in the hippocampus by BAS could be one of the mechanisms for BAS-mediated ameliorating effect on learning and memory impairment in LPS-treated mice.
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원지(遠志)가 뇌혈류 저하에 의한 흰쥐 뇌조직의 산화적 손상과 해마신경세포 자연사에 미치는 영향
구용모 ( Yong-mo Koo ),곽희준 ( Hee-jun Kwak ),권만재 ( Man-jae Kwon ),송민철 ( Mincheol Song ),이지승 ( Ji-seung Lee ),신정원 ( Jung-won Shin ),손낙원 ( Nak-won Sohn ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.1
Objectives : Polygalae Radix (POL) has an ameliorating effect on learning and memory impairment caused by cerebral hypoperfusion. In regard to POL``s action mechanism, this study was carried out to investigate the effects of POL on oxidative damage and neuronal apoptosis induced by cerebral hypoperfusion in rats.Methods : The cerebral hypoperfusion was induced by permanent bilateral common carotid artery occlusion(pBCAO) in Sprague-Dawley rats. POL was administered orally once a day (130 mg/kg of water-extract) for 28days starting at 4 weeks after the pBCAO. Superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in the brain tissue were measured using ELISA method. Expressions of 4-hydroxynonenal (4HNE) and 8-hydroxy-2``- deoxyguanosine (8-OHdG) were observed using immunohistochemistry. In addition, neuronal apoptosis was evaluated with Cresyl violet staining, TUNEL labeling, and immunohistochemistry against Bax and caspase-3.Results : POL treatment significantly increased SOD activities and significantly reduced MDA levels in the cerebral cortex. The up-regulations of 4HNE and 8-OHdG expression caused by pBCAO in the CA1 of hippocampus were significantly attenuated by POL treatment. POL treatment also restored the reduction of CA1 thickness and CA1 neurons caused by pBCAO and significantly attenuated the apoptotic markers including TUNEL-positive cells, Bax, and caspase-3 expression in the CA1 of hippocampus. Conclusions : The results show that POL attenuated the oxidative damage in brain tissue and neuronal apoptosis in the hippocampus caused by the cerebral hypoperfusion. It suggests that POL can be a beneficial medicinal herb to treat the brain diseases related to cerebral hypoperfusion.
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간섭계 레이더 고도계를 활용한 지형참조항법의 성능 분석
정승환(Seung-Hwan Jeong),윤주홍(Ju-Hong Yoon),박민규(Min-Gyu Park),김대영(Dae-Young Kim),성창기(Chang-Ki Sung),김현석(Hyun-Suk Kim),김윤형(Yoon-Hyung Kim),곽희준(Hee-Jun Kwak),선웅(Woong Sun),윤국진(Kuk-Jin Yoon) 한국항공우주학회 2012 韓國航空宇宙學會誌 Vol.40 No.4
본 논문에서는 간섭계 레이더 고도계를 활용한 지형참조항법의 성능을 분석하고자 한다. 간섭계 레이더 고도계는 항체의 주변 지형의 고도 중 가장 높은 값을 측정값으로 취함으로써 항법의 정확성을 향상시키고 있다. 이에 본 연구에서는 간섭계 레이더 고도계의 적용에 따른 새로운 측정 모델을 제시하고 이에 따른 지형참조항법 시스템을 구축하려 한다. 또한 필터에 따른 지형참조항법의 성능 분석을 위하여 확장형 칼만 필터, 무향 칼만 필터, 파티클 필터를 적용하며 여러 환경의 변화에 따른 지형참조항법의 성능을 도출고자 한다. The paper experimentally verifies the performance of Terrain-Aided Navigation (TAN) using an interferometric radio altimeter, which is recently used due to its accuracy. First, we propose a TAN system that utilizes an interferometric radio altimeter as a measurement system. Second, we implement extended Kalman filter, unscented Kalman filter, and particle filter to evaluate the performance of TAN according to the selection of filters and the difference of environments.
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