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항염증제로서 2-아릴-5-벤즈옥사졸프로피온산 유도체의 합성
최홍대,곽용실,금덕현,손병화 동의대학교 기초과학연구소 1995 基礎科學硏究論文集 Vol.5 No.1
A facile synthesis of 2-aryl-5-benzoxazolepropionic acid derivatives(10a-d), which are potent antiinflammatory agent, is reported. Methyl α-(p-hydroxyphenyl)propionate(5) was prepared from Froedel-Crafts reaction of isopropoxy benzene with methyl α-chloro-α(methylthio) acetate(1), followed by desulfurization, methylation and clevage of ether bond. Compounds(10a-d) were made from(5) by sequence of nitration, reduction, formation of benzoxazole ring, and hydrolysis in good yields, respectively.
항염증제로서 2-아릴-5-벤즈옥사졸프로피온산 유도체의 합성
최홍대(Hong Dae Choi),곽용실(Yong Sil Kowak),금덕현(Dek Hyun Geum),손병화(Byeng Wha Son) 대한약학회 1994 약학회지 Vol.38 No.5
A facile synthesis of 2-aryl-5-benzoxazolepropionic acid derivatives(10a-d), which are potent antiinflammatory agent, is reported. Methyl alpha-(p-hydroxyphenyl)propionate(5) was prepared from Friedel-Crafts reaction of isopropoxy benzene with methyl alpha-chloro-alpha-(methylthio) acetate(1), followed by desulfurization, methylation and clevage of ether bond. Compounds(10a-d) were made from(5) by a sequence of nitration, reduction, formation of benzoxazole ring, and hydrolysis in good yields, respectively.