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곽남주 ( Nam Ju Kwak ),박남규 ( Nam Gu Park ),김혜영 ( He Young Kim ),최기원,엄재호 ( Je Ho Eom ),김동운 ( He Young Kim ),조명찬 ( Meong Chan Choi ),윤제진 ( Se Jin Yun ),김승택 ( Sung Taek Kim ),이상도 ( Sang Do Lee ) 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.4
Objectives: In chronic obstructive pulmonary disease, nocturnal hypoxemia is associated with pulmonary hypertension, arrhythmia and increased mortality during sleep. So a noninvasive, inexpensive method of predicting significant sleep-associated nocturnal hypoxemia would be desirable for patients being investigated and treated for chronic obstructive pulmonary disease. This study was performed to identify the incidence and accurate predictive indicators for nocturnal hypoxemia in these patients. Methods: We measured nocturnal SaO₂ during sleep and overnight change of urinary uric acid/creatinine ratio and performed daytime arterial blood gas analysis and pulmonary function test in twenty-eight patients with chronic obstructive pulmonary disease. Results: 1) Nocturnal hypoxemia occurred in 12 of 28 COPD patients (43%), 9 of 13 blue-bloaters (70%) and 3 of 15 pink-puffers (20%). The incidence of nocturnal hypoxemia was higher in blue-bloaters than pink-puffers (p$lt;0.05). 2) Daytime PaO₂ was lower and PaCO₂ was higher in hypoxemia group than those of normoxemia group (p$lt;0.05). 3) There was significant correlation between daytime PaO₂ and nocturnal lowest SaO₂ in hypoxemia group (r=0.72, p$lt;0.05). 4) There were no correlations between daytime PaO₂ and nocturnal mean SaO₂ and between daytime PaCO₂ and lowest or mean nocturnal SaO₂ in hypoxemia group. 5) Overnight change of urinary uric acid/creatinine ratio was not significantly different between hypoxemic and normoxemic group. 6) There was no significant difference in pulmonary function test values between hypoxemic and normoxemic group. Conclusion: These data indicate that daytime PaO₂ is an useful indicator to predict nocturnal hypoxemia in chronic obstructive pulmonary disease but overnight change of urinary uric acid excretion is not.
Objectives: In the third trimester hypertensive pregnancies, we would like to evaluate effects of white coat hypertension, severity of hypertension and diurnal variation of blood pressure on the fetal outcome by using 24-hour ambulatory blood pressure monitoring. Methods: Hypertensives(n=50) and normotensives (n=14) in the third trimester of the pregnancy underwent 24-hour ambulatory blood pressure monitoring. We excluded hypertensives(n=5) who became pre-eclampsia patients. Hypertensives(n=45) were classified as white coat hypertensives(n=14, mean ambulatory blood pressure $lt;139/87mmHg) and sustained hyprtensives(n=31). Sustained hypertensives(n=31) were divided as moderate to severe hypertensives(n=5, systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100mmHg) and mild hypertensives(n=26). Sustained hypertensives were also divided into two groups which had diurnal variation of blood pressure or not. To exclude effects of hypertension severity, effects of diurnal variation wane evaluated in hypertensives with similar mean arterial blood pressure. Gestational age, body weight, body weight for gestational age were used as parameters of the fetal outcome. Results : 1) The prevalence of white coat hypertension was 28%(14/50). 2) There were no significant differences in the fetal outcome between normotensives(n=14) and white coat hypertensives(n=14). 3) Body weight of fetus and body weight for gestational age in moderate to severe hypertensives(n=5) were less than those of mild hypertensives(n=26), but gestational age was not significantly different between two groups. 4) Body weight of fetus and body weight for gestational age in sustained hypertensives without diurnal variation(n=10) were less than those with diurnal variation(n=8), but gestational age was not significantly different between two groups. 5) All hypertensives who became pre-eclampsia (n=5) were severe hypertensives and had no diurnal variation of blood pressure. Conclusion: White coat hypertension in the third trimester was quite often and did not affect on the fetal outcome. The more severe hypertension and/or absence of diurnal variation of blood sure caused poor fetal outcome. Patients who became pre-eclampsia were severe hypertensives and had no diurnal variation of blood pressure. Ambulatory blood pressure monitoring may have several roles in the antenatal management of hypertenison.
Background: A new tumor marker, TAG-72 has been identified using monoclonal antibody B72.3. It is found in a wide variety of carcinomas but rarely expressed in normal adult tissue and benign lesions. Methods: The presence of TAG-72 in serum samples from patients with gastric carcinoma and benign gastrointestina1 disease was evaluated using the CA72-4 assay. Results: Elevated levels of serum TAG-72 antigen were found in 2S(39.1%) of 64 gastric carcinona patients and none of 32 benign gastrointestinal disease patients. The serum concentrations of TAG-72 were compared to those of CEA. The positive rate of CEA in gastric carcinoma and benign gastrointestinal disease patients was 37.5% and 9.4%, respectively. These resu]ts indicate a preferential expression of TAG-72 compared to CEA in gastric carcinoma patients versus in patients with a benign disorder. Combination assay using CA72-4 and CEA RIAs unchanged positive rate(50%, p$gt;0.05). Patients with the tnore advanced stage of gastric carcinoma revealed the higher positive rate of serum CA72-4 and the ]evels were increased in all patients with recurrent gastric carcinoma. Conclusions: These results suggest that the measurement of serum CA72-4 in patients with gastric carcinoma serve a complementary role to differentiate the disease from benign gastric lesions and may be useful to predict the disease recurrence in postoperative patients.