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전립샘암 환자의 방사선 치료 중 전립샘 특이 항원의 변화 양상과 예후의 상관관계
공문규 ( Moon Kyoo Kong ),강진오 ( Jin Oh Kang ),최진현 ( Jin Hyun Choi ) 경희대학교 경희의료원 2010 慶熙醫學 Vol.26 No.1
Purpose: To evaluate the relationship between PSA change during curative radiotherapy and prognosis in prostate cancer. Methods: A total of 37 patients among 73 patients treated with curative radiotherapy from July 2002 to January 2008 in Kyung Hee university medical center were enrolled. According to pre-RT PSA values, patients were classified into two groups, group 1 (pre-RT PSA value≥12 ng/mL) and group 2 (pre-RT PSA value≥12 ng/mL). Group 1 was classified into two groups according to median PSAV(iRT) resulting group1 fast (PSAV(iRt)≤-1.35%/day) and group1 slow (PSAV(iRT)>-1.35%/day). Group 2 was classified into two groups according to the median PSAV(iRT) resulting group2 fast (PSAV(iRT)≤1 .05%/day) and group2 slow (PSA(iRt)>-1.05%/day). The stage, radiation dose, age, Gleason score and the rate of biochemical failure (BF) of these groups were analyzed. Results: Patient`s age, stage and radiation dose were not significantly different among groups. Among the group1 fast (n=10), 2 patients developed biochemical failure, while among group1 slow (n10), 6 patients developed (P=0.068). The median biochemical failure free survival of group1 fast and group1 slow was 24.9 and 10.7 months, respectively. Among the group2 fast (n=9) there was no biochemical failure, while among the group2 slow (n=8), 1 patient developed (P=0.331). Conclusion: Among the patients with high pre-RT PSA values, slower PSAV(iRt) showed a tendency of more biochemical failure, but there were no statistical significance. To identify more definitely the relationship between PSAV(iRT) and development of biochemical, further studies with larger sample are necessary.
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