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고재훈,문송미 대한의학회 2018 Journal of Korean medical science Vol.33 No.39
To evaluate methicillin-resistance (MR) rates among community-associated (CA) Staphylococcus aureus infections in the Korean military, we screened electronic medical records of 223 patients with S. aureus infection in a military referral hospital from 2012 to 2017. During the study period, MR rates did not change annually, and were not different between officers and conscripted personnel. Among conscripted personnel, MR rates in CA S. aureus infections did not increase with longer duration of military service, both in trend analysis and multivariate analysis. In conclusion, MR rates among CA S. aureus infections did not increase during military service in Korea.
고재훈,김시호,강철인,조선영,이남용,정두련,백경란,송재훈 대한의학회 2019 Journal of Korean medical science Vol.34 No.2
We implemented a carbapenem-saving strategy in hemato-oncology patients from 2013, using an empirical combination of piperacillin-tazobactam and amikacin for high-risk hemato-oncology patients with febrile neutropenia, who remain hemodynamically unstable > 72 hours despite initial cefepime treatment. All-cause mortality was not different between the two periods (6.54 and 6.57 deaths per 1,000 person-day, P = 0.926). Group 2 carbapenem use significantly decreased after strategy implementation (78.43 vs. 67.43 monthly days of therapy, P = 0.018), while carbapenem-resistant gram-negative bacilli did not show meaningful changes during the study period. Our carbapenem-saving strategy could effectively suppress carbapenem use without an increase of overall mortality.
고재훈,정두련,박소연,백진양,김소현,강철인,백경란,이남용,송재훈 대한의학회 2013 Journal of Korean medical science Vol.28 No.7
Although pandemic community-associated (CA-) methicillin-resistant Staphylococcus aureus (MRSA) ST30 clone has successfully spread into many Asian countries, there has been no case in Korea. We report the first imported case of infection caused by this clone in a Korean traveler returning from the Philippines. A previously healthy 30-yr-old Korean woman developed a buttock carbuncle while traveling in the Philippines. After coming back to Korea, oral cephalosporin was given by a primary physician without any improvement. Abscess was drained and MRSA strain isolated from her carbuncle was molecularly characterized and it was confirmed as ST30-MRSA-IV. She was successfully treated with vancomycin and surgery. Frequent international travel and migration have increased the risk of international spread of CA-MRSA clones. The efforts to understand the changing epidemiology of CA-MRSA should be continued, and we should raise suspicion of CA-MRSA infection in travelers with skin infections returning from CA-MRSAendemic countries.
Cyanuric Chloride 잔기를 갖는 ${\beta}-Cyclodextrin$ 유도체의 합성과 섬유 방향가공에의 응용
고재훈,박윤철,김진우,김영호,Ko, Jae-Hoon,Park, Yoon-Cheol,Kim, Jin-Woo,Kim, Young-Ho 한국섬유공학회 2007 한국섬유공학회지 Vol.44 No.4
[ ${\beta}$ ]-Cyclodextrin derivative containing cyanuric chloride moiety (${\beta}CD-CC$) was synthesized by a reaction of ${\beta}-cyclodextrin\;({\beta}CD-CC)$ with cyanuric chloride in alkaline condition. FT-IR and UV spectra along with the results of elemental analysis indicated that cyanuric chloride was bound to ${\beta}CD$. Remaining monochlorotriazine group in ${\beta}CD-CC$ was expected to be used as a reactive site for cellulosic fibers. The ${\beta}CD-CC$ could be used as a host material for inclusion complex of various guest molecules. As an example, vanillin, a flavoring agent in foods and others, was included in the ${\beta}CD-CC$ to make a perfume inclusion complex. UV analysis showed that the vanillin-included complex of ${\beta}CD-CC$ released vanillin more slowly than vanillin itself, which reveals that it can be used as a feasible fragrant finishing agent for textiles.
S-511 : HIV 감염 환자에서 피부의 좁쌀 결핵으로 발현한 IRIS 1 예
고재훈,신범수,이성수,임경숙,이우주,유정래,강철인 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Tuberculosis is one of the most common opportunistic diseases in human immunodeficiency virus (HIV)-infected patients in Korea and extra-pulmonary infections are frequently observed in those patients. Cutaneous miliary tuberculosis is a rare form of tuberculosis presented by a papulopustular eruption and hematogenous dissemination of Mycobacterium tuberculosis to multiple organs, which was previously reported among progressed HIV-infected patients. We report the first case of cutaneous miliary tuberculosis which developed as a manifestation of immune reconstitution inflammatory syndrome (IRIS) after initiating antiretroviral therapy (ART).
가교도가 다른 열민감성 Poly(N-isopropylacrylamide) 수화겔의 팽윤 및 수축 거동
고재훈,김영호,Ko, Jae-Hoon,Kim, Young-Ho 한국섬유공학회 2007 한국섬유공학회지 Vol.44 No.3
Poly(N-isopropylacrylamide)(PNIPAAm) hydrogels were synthesized via radical polymerization of N-iso-propylacrylamide in aqueous medium using ammonium persulfate and N,N'-methylenebisacrylamide (MBA) as an initiator and a crosslinking agent, respectively. PNIPAAm hydrogels exhibited a critical gel transition temperature (CGTT) at $32{\sim}34^{\circ}C$. Swelling and deswelling behaviors of the hydrogels with different crosslinking densities were analyzed by measuring swelling ratio below and above CGTT. The swelling ratio of the hydrogel below CGTT decreased with increasing MBA concentration, while that above CGTT increased. As MBA concentration increased, the micropore size decreased, however, the number of micropore increased slightly in the freeze-dried hydrogels swollen in water at $25^{\circ}C$ (below CGTT) before drying. The micropore became smaller and denser in the des deswollen state. The swelling ratio of the hydrogels decreased slightly with the repeated swelling and deswelling treatment.
A Novel Design of UPS with Useful Customer Load Management Function
고재훈,최태성,류제창,이홍원,이정훈,채홍문,전승규,김재언 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.2
Traditional Uninterruptible Power Supplies (UPS) only provide stable power to critical loads in emergency situations, while Energy Storage Systems (ESS) perform functions such as generator output stabilization, frequency control, peak shaving, and load leveling. As the global ESS market expands, various ESS supply policies are being implemented in a number of countries. Accordingly, research and development of a hybrid UPS-ESS system combining the advantages of UPS and ESS are underway in order to ensure critical load stability in case of emergency. For such a situation, we propose the development of a system with a customer load management function by simply adding a converter and battery pack to a widely used conventional UPS. The proposed system in this paper is more economical than a hybrid UPS-ESS system or an ESS. In addition, the proposed system performs peak-clipping and load-shifting according to time-based rates, and has a longer power outage time in case of emergency without needing to communicate with the existing UPS.