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림프종양 구진증과 연속선상으로 발생한 CD30 양성 원발성 피부 이형성 대세포 림프종
고재완 ( Jae Wan Go ),김신한 ( Shin Han Kim ),이상엽 ( Sang Yeop Yi ),조한경 ( Han Kyoung Cho ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.12
Lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (ALCL) are grouped under the category of cutaneous T-cell lymphomas as CD30+ lymphoproliferative disorders. Though LyP is clinically characterized by chronic recurrent papulonodular cutaneous lesions, it shows malignant features on the histologic findings. LyP is associated with lymphomas, including primary cutaneous ALCL, mycosis fungoides and other lymphoproliferative disorders. A few cases of LyP related to ALCL have been reported in Korea. We report here on an interesting case of primary cutaneous ALCL that developed in succession after LyP in a 38-year-old female. (Korean J Dermatol 2010;48(12):1081∼1085)
고양시 소재 명지병원 피부과 환자의 통계적 고찰(2004~2008)
고재완 ( Jae Wan Go ),조한경 ( Han Kyoung Cho ),강원형 ( Won Hyoung Kang ),노병인 ( Byung In Ro ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.8
Background: There have been many reports that have focused on the incidence of skin diseases in big cities or provinces. However, there have been no reports concerning the data of a new town such as Goyang City. Objective and Methods: To study the prevalence of common dermatoses in the new town and to compare this with the previous reports, we reviewed the records of 15,064 outpatients who visited the Department of Dermatology at Myongji Hospital from 2004 to 2008, and we statistically analyzed the findings. Results: The study results are summarized as follows: Of the 15,064 outpatients, the total number of male patients was 6,779 (45.0%), and the number of female patients was 8,285 (55.0%). The most frequent age group was the fourth decade followed by the first decade, third decade and fifth decade, and these 4 age groups comprised 63.7% of the total outpatients. The 15 most common dermatoses were found to be viral warts, dermatophytosis, atopic dermatitis, seborrheic dermatitis, pruritus, urticaria, irritant contact dermatitis, herpes zoster, alopecia, allergic contact dermatitis, acne, other eczema, melanocytic nevus, molluscum contagiosum and postinflammatory hyperpigmentation. For the occurrence of dermatoses as disease groups, 1) viral diseases, 2) diseases resulting from fungi and yeasts, 3) atopic dermatitis, eczema and noninfectious immunodeficiency disorders, 4) contact dermatitis and drug eruptions, 5) pruritus and neurocutaneous dermatosis, 6) seborrheic dermatitis, psoriasis, recalcitrant palmoplantar eruptions, pustular dermatitisand erythroderma, 7) erythema and urticaria, 8) Melanocytic nevi and neoplasm, 9) disturbances of pigmentation, and 10) diseases of skin appendages constituted 82.2% of the total. Conclusion: The distinct characteristic of skin diseases of the new town Goyang City showed a high incidence of viral warts and viral skin diseases, as compared to the previous reports. (Korean J Dermatol 2009;47(8):896~903)
Diclofenac 주사 후 발생한 Nicolau 증후군
고재완 ( Jae Wan Go ),김신한 ( Shin Han Kim ),노병인 ( Byung In Ro ),오화은 ( Hwa Eun Oh ),조한경 ( Han Kyoung Cho ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.9
Nicolau syndrome or embolia cutis medicamentosa is a rare complication of a still largely unidentified pathogenesis at the site of intramuscular injections of various drugs. It is characterized by development of an acute, severe pain around the injection site followed by a localized erythema, a reticular rash, a hemorrhagic patch and varying degrees of tissue damage. The disease outcomes vary from atrophic ulcers and pigmentation to lower limb paralysis and limb amputation. We describe a 34-year-old woman with the diagnosis of this syndrome after she received an intramuscular diclofenac-beta-dimethyl-aminoethanol injection to the lateral aspect of the right upper buttock. The patient was treated by surgical debridement with concomitant primary closure. (Korean J Dermatol 2010;48(9):786~789)
한국인 가와사키병 환자의 피부병변의 특징에 관한 연구(2006~2010)
고재완 ( Jae Wan Go ),은영민 ( Young Min Eun ),김신한 ( Shin Han Kim ),이상윤 ( Sang Yoon Lee ),정진영 ( Jin Young Jung ),조한경 ( Han Kyoung Cho ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.9
Background: Kawasaki disease (KD) is an acute inflammation of middle-sized arteries such as the coronary artery. KD is an important disease due to its high mortality rate, which approaches 1~2% without appropriate treatment. Since the various mucocutaneous lesions of KD are related to the dermatologic field, dermatologists should take an interest in this disorder and understand the lesions. Objective: To evaluate the characteristics of cutaneous lesions in Korean patients with KD. Methods: A total of 919 patients with KD were assessed at the department of pediatric cardiology and dermatology, Myongji hospital between January 2006 and December 2010. Results: Of the 919 patients, 566 (61.6%) were diagnosed with typical KD and 353 (38.4%) with atypical KD. KD was most frequent in the 4 year-old group (22.7%), and the ratio of male to female was 1.5:1. Among the mucocutaneous manifestations, erythema of the oropharyngeal mucosa (75.7%) occurred most frequently, followed by polymorphous trunk rash (41.7%), and changes of palms and soles (25.6%). A total of 606 patients (65.9%) with KD had associated diseases as follows: pneumonia (211 patients; 34.8%), pharyngotonsilitis (168 patients; 27.7%), gastroenteritis (132 patients; 21.8%), asthma (15 patients, 2.5%), atopic dermatitis (11 patients, 1.8%). Conclusion: Our study shows that change in the lips or oral cavity is the most common mucocutaneous manifestation in both classic and atypical KD. Also, morbiliform rash is the most common pattern of polymorphous rashes. Interestingly, erythema multiforme-like lesions occupied accounted for a considerable portion of KD cases compared to previous studies. (Korean J Dermatol 2011;49(9):795~800)
고재완 ( Jae Wan Go ),김신한 ( Shin Han Kim ),조한경 ( Han Kyoung Cho ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.9
Common warts are small, benign tumors, and they are usually self limiting hyperkeratotic skin lesions that are infected by human papillomavirus (HPV). Although warts can occur at any age, they are most often seen in children and young adults. It is most commonly found on the acral skin of the hands and fingers, but the lesions may occur anywhere on the skin surface. There are some cases with uncommon forms for the shape and distribution, but there have been no reported cases of common warts occurring on the finger web in a mirror image form in Korea. Herein, we report on an interesting case of common warts that occurred on the right 4th finger web in a mirror image form in a 3-year-old Korean boy. (Korean J Dermatol 2010;48(9):807~809)
고재완 ( Jae Wan Go ),김신한 ( Shin Han Kim ),이상윤 ( Sang Yoon Lee ),노병인 ( Byung In Ro ),조한경 ( Han Kyoung Cho ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.2
Angiosarcoma is a rare, aggressive vascular neoplasm of the endothelial cell origin. It is usually seen in male, elderly patients and generally has a poor prognosis due to its high potential for metastasis. They arise at various sites such as skin, soft tissue, heart and great vessels. However, the tumors have a predilection for skin and superficial soft tissue. Most angiosarcomas of the skin arise in the three clinical variant; primary angiosarcoma of the face and scalp in the elderly patients; following lymphedema, and post radiation or trauma. Although, this tumor tend to recur locally and metastasize to the viscera, especially in the lung, but cutaneous metastasis of angiosarcomas from the internal organ are uncommon. Herein, we report a patient with cutaneous metastasis from primary cardiac angiosarcoma in the right atrium. (Korean J Dermatol 2012;50(2):130~133)
Methoxy Polyethylene Glycol-Epoetin Beta에 의해 유발된 백혈구파쇄성 혈관염
이상윤 ( Sang Yoon Lee ),고재완 ( Jae Wan Go ),김신한 ( Shin Han Kim ),손현옥 ( Hyun Ok Son ),조한경 ( Han Kyoung Cho ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.1
Methoxy polyethylene glycol-epoetin beta (Mircera(R), Roche), a third-generation erythropoiesis-stimulating agent (ESA) is known as a continuous erythropoietin receptor activator (CERA). In patients with anemia associated with chronic kidney disease (CKD), it is administered intravenously or subcutaneously. Treatment-related adverse events induced by methoxy polyethylene glycol-epoetin beta occurred in 6%. Hypertension, diarrhea and nasopharyngitis were the most commonly reported adverse events. Cutaneous adverse reactions are rarely experienced with methoxy polyethylene glycol-epoetin beta including maculopapular eruption, facial erythema, and tinea pedis. To the best of our knowledge, no cases of leukocytoclastic vasculitis associated with methoxy polyethylene glycol-epoetin beta have ever been published in medical literature. Herein, we report on a case of leukocytoclastic vasulitis induced by methoxy polyethylene glycol-epoetin beta in a patient with anemia associated with chronic kidney disease. (Korean J Dermatol 2013;51(1):49∼52)
원형탈모증 환자의 발병 연령별 임상 양상과 장기간의 추적을 통한 예후 연구
조선영 ( Sun Young Jo ),고재완 ( Jae Wan Go ),허은필 ( Eun Phil Heo ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.6
Background: Alopecia areata is an autoimmune disease that presents as non-scarring hair loss and can affect all age groups. The clinical course of alopecia areata is unpredictable. Objective: This study aimed to analyze the characteristics, treatment response, and relapse rate of alopecia areata in patients of different ages with long-term follow-up. Methods: The medical records of 121 patients diagnosed with alopecia areata were retrospectively reviewed, and their prognosis was assessed on the basis of various indices. Results: A total of 121 patients, including 24 cases of childhood-onset, 83 adult-onset, and 14 late-onset alopecia areata, were analyzed. In the first episode, 72.7%, 14.7%, and 9.9% of patients had mild, moderate, and severe alopecia areata, respectively. A significant and complete response was observed in 66.7%, 89.2%, and 100% of childhood-onset, adult-onset, and late-onset patients, respectively. The duration of the initial episode showed a negative correlation with age. The overall frequency of relapse was 47.1%, whichc significantly declined with time, with a majority (63.3%) of relapses occurring in the first year. Younger age at initial presentation and thyroid diseases were strongly associated with poor prognosis. Conclusion: Younger patients showed a tendency of poor prognosis regardless of the prognostic factors. A longer follow-up period might be required for the younger onset patients. (Korean J Dermatol 2020;58(6):397∼405)
정신지체를 동반한 다수의 위성병변을 가진 거대선천멜라닌세포모반
손현옥 ( Hyun Ok Son ),고재완 ( Jae Wan Go ),이상윤 ( Sang Yoon Lee ),김신한 ( Shin Han Kim ),조한경 ( Han Kyoung Cho ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.3
Giant congenital melanocytic nevi (GCMN) are defined as melanocytic nevi that are greater than 20 cm in largest dimension at birth. GCMN is a relatively rare condition, affecting approximately 1 in 20,000 newborns. Patients with GCMN on the posterior axis and in the presence of many satellite nevi are associated with neurocutaneous melanosis. A 37-year-old female with mental retardation had dark brown nevi with hair on her back (paraspinal) and on her lower extremities. In addition, she has multiple satellite lesions distributed over her trunk and extremities. Herein, we present a case that demonstrates a relationship between CNS abnormality and multiple satellite nevus in GCMN patients with a review of the relevant literature. (Korean J Dermatol 2013;51(3):185∼188)