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기관지천식 환아에서 EPA / DCHA 의 투여가 임상경과 및 기도반응에 미치는 영향
고영율(Young Yull Koh) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1993 소아알레르기 및 호흡기학회지 Vol.3 No.1
N/A I have studied the effect of dietary fish oil supplementation (1.8gm/day of eicosapentaenoic acid and 1.2gm/day of docosahexaenoic acid) for 12 weeks on the clinical course, and the methacholine and allergen induced airway responses in 12 asthmatic children. Diurnal peak expiratory flow, symptom scores, and bronchodilator use were measured for clinical course assessment, and methacholine and allergen bronchial provocation tests were performed before and after dietary supplementation of EPA/DCHA. There was no significant change in any of clinical measurements. However, the magnitude of methacholine induced bronchoconstriction and allergen induced early or late asthmatic responses were significantly attenuated following EPA/DCHA. Although the above results indicated that fish oil supplementation has little effect on the clinical severity of asthma, they may have some therapeutic implication insofar as EPA/DCHA attenuate the airways response to various stimuli.