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강현민,이광호,임청산,권기록 대한약침학회 2014 Journal of pharmacopuncture Vol.17 No.2
Objectives: This study was performed to analyze a 13-week repeated dose toxicity test of Sweet Bee Venom (SBV) extracted from bee venom and administered in Sprague-Dawley (SD) rats. Methods: Male and female 5-week-old SD rats were treated once daily with SBV (high-dosage group: 0.28 mg/kg; medium-dosage group: 0.14 mg/kg; or low-dosage group: 0.07 mg/kg) for 13 weeks. Normal saline was administered to the control group in a similar manner (0.2 mL/kg). We conducted clinical observations, body weight measurements, ophthalmic examinations, urinalyses, hematology and biochemistry tests, and histological observations using hematoxylin and eosin (H&E) staining to identify any abnormalities caused by the SBV treatment. Results: During this study, no mortality was observed in any of the experimental groups. Hyperemia and a movement disorder were observed around the area of in all groups that received SBV treatment, with a higher occurrence in rats treated with a higher dosage. Male rats receiving in the high-dosage group showed a significant decrease in weight during the treatment period. Compared to the control group, no significant changes in the ophthalmic parameters, the urine analyses, the complete blood cell count (CBC), and the biochemistry in the groups treated with SBV. Compared to the control group, some changes in organ weights were observed in the medium-and the high-dosage groups, but the low-dosage group showed no significant changes. Histological examination of thigh muscle indicated cell infiltration, inflammation, degeneration, and necrosis of muscle fiber, as well as fibrosis, in both the medium- and the high-dosage groups. Fatty liver change was observed in the periportal area of rats receiving medium and high dosages of SBV. No other organ abnormalities were observed. Conclusion: Our findings suggest that the NOAEL (No Observed Adverse Effect Level) of SBV is approximately 0.07 mg/kg in male and female SD rats.
소목(Caesalpinia sappan L.의 心材) 열수추출물의 항influenza virus 활성 성분에 대한 HPLC 분석
강현민 龍仁大學校 自然科學硏究所 1999 自然科學硏究所論文誌 Vol.4 No.1
Influenza virus is one of the most common infectious virus of mankind. Though chemotherapeutic reagents and antibiotics against influenza virus have been developed in many countries, none of those reagents is satisfactory to mankind in regard of their toxicity and side effects. In order to investigate anti-influenza viral activity of Korean traditional drugs, boiling water extract of the heartwood of Caesalpinia Sappan L was fractionized by solvent extraction method. Each fraction were then screened against influenza virus by disc diffusion method. Among the fractions, diethyl ether fraction exhibited anti-influenza viral activity. The diethyl ether fraction was then analyzed by HPLC(C-18 reverse phase).
소목(Caesalpinia sappan L.의 心材) 메탄올 추출물의 항influenza virus 활성성분 연구
강현민 龍仁大學校 1999 용인대학교 논문집 Vol.17 No.-
Influenza virus is one of the most common infectious virus of mankind. Though chemotherapeutic reagents and antibiotics against influenza virus have been developed in many countries, none of those reagents is satisfactory to mankind in regard of their toxicity and side effects. To investigate anti-influenza viral compounds amongst Korean traditional medicine, methanol extract of the heartwood of Caesalpinia Sampan L was fractionized by solvent extraction method. Each fraction were then screened against influenza virus by disc diffusion method. Among the fractions, diethyl ether fraction exhibited anti-influenza viral activity. The diethyl ether fraction of the methanol extract was then analyzed by HPLC (C-18 reverse phase) and its chromatogram was compared with the diethyl ether fraction of the water extract.
기록물 생산기관명 접근점 제어 온톨로지 기술에 관한 연구
강현민,Kang, Hyen Min 한국정보관리학회 2018 정보관리학회지 Vol.35 No.3
기록물 생산기관에 부여된 행정표준기관코드(Standard Administration Code) 식별기호체계를 이용하여 동일 정체성과 동일 신원을 지닌 기록물 최종 생산기관명을 유일한 우선어 형식(preferred form)으로 정의하였다. 또한 동일 정체성과 동일 신원을 지닌 생산기관명에 대해 다양한 형식의 언어와 문자로 알려진 이형형식의 접근점 중에 대표 이름형식 접근점을 선정하고 온톨로지로 기술하였다. 이로써 과거부터 현재에 이르기까지 동일 정체성과 동일 신원의 생산기관이 생산한 모든 기록물에 대해 식별 접근할 수 있도록 하였다. 또한 '출처주의 원칙'과 '원질서 존중의 원칙'이라는 기본적인 기록물 관리 원칙을 온톨로지 환경에서도 준수함으로써, 기록물에 대한 관리방식 개선과 이용자들에게 기록물 접근의 편의성 및 확장된 검색결과를 제공할 수 있도록 하였다. This study defined the name of records producing institution as the unique preferred form of access point which has same identification and same entity by using Standard Administration Code, and also described the name of records producing institution which has various name form as formal-name form of access point, which has same identification and same entity. This study make us be able to identify and access to all of the records that institution, has same identification and same entity, has produced. And the mechanic, I designed by ontology would make reinforce 'the principle of provenance' and 'respect for orignal order' and make user satisfy in useability of archives and expanded retrieval results.
국내 프로야구단 상대적 효율성 평가를 통한 발전방안 연구
강현민,장재열,이현섭 한국체육정책학회 2017 한국체육정책학회지 Vol.15 No.1
The purpose of this study was to evaluate the relative managerial efficiency of 10 Korean professional baseball teams in the 2015 season through Data Envelopment Analysis. Each team’s salary including players and coaching staffs for the input variable and the number of wins during the regular season and the size of home game attendance for the output variable were used respectively. And the data were analyzed using Frontier Analyst 4.0 and EnPAS 1.0 program. The results of this study were as follows. First, KT, Doosan, Nexen were measured as the efficiency frontier with the score of 100% based on CCR model. Second, according to BCC model, KIA, KT, NC, Samsung, Nexen and Doosan were recorded 100% efficiency score. Third KIA, NC, Lotte, SK, Samsung, Hanhwa and LG showed scale inefficiency, LG was inefficient under the condition of increasing returns to scale and the rest were inefficient under the condition of decreasing returns to scale. Regarding the results, some practical schemes are made to balance between team’s salary expenditure and performance. Moreover, effective marketing inducements for attracting spectators have to developed consistently to boost the managerial efficiency.