경영효율성 분석을 위한 메타-프론티어법 이용에 관한 실증적 연구

강진원(Jin-Won Kang),한욱상(Uk-Sang Han) 한국무역연구원 2018 무역연구 Vol.14 No.3

This study evaluates efficiency from the viewpoint of the short-term and long-term of general construction companies. In general, people think that the higher the rating, the higher the efficiency. The data envelopment analysis (DEA) was used to analyze the significance of these hypotheses, and the meta-frontier was used to evaluate the hypotheses. Data envelopment analysis (DEA) is non-parametric analysis method which is commonly used in efficiency analysis. DEA is a methodology for identifying the relative efficiency of DMUs. It is introduced by Charnes, Cooper and Rhodes (CCR). As a result of the analysis, the overall construction industry showed very high operating efficiency, and most of the inefficiency of the technical efficiency is the result of low scale efficiency. Only 2 out of 2,595 firms with an increase in size (IRS) in economies of scale were found to have 47, and the rest were downsized. The same results were obtained when applied to individual groups. The lower the rating, the lower the efficiency, which is also the cause of economies of scale. And there is no difference in efficiency between regions.

큰 특발성 비신단락이 있는 문맥압항진증 환자에서의 비정맥 혈류방향과 혼수와의 관계

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),김원호(Won Ho Kim),이문형(Moon Hyoung Lee),천선희(Seon Hee Cheon),한광협(Kwang Hypb Han),박인서(In Seo Park) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2

N/A In patients with portal hypertension, the splenorenal shunt is one of the most common portosys- temic collaterals. Spontaneous hepatic encephalopathy frequently occurs in these patients, due to neurotoxic substances that bypass the liver and act on the central nervous system directly. Therefore it is important to assess portal hemodynamics in portal hypertensive patient with porto-systemic shunt. We examined the portal blood flow by the Doppler flowmetry system in 9 patients with liver cirrhosis and 3 patients with hepatocellular carcinoma associated with liver cirrhosis who had large spontaneous splenorenal shunts. Of the 12 subjects, 7 patients had a history of spontaneous hepatic encephalopathy and 5 patients did not. One of the 5 patients with a history of spontaneous hepatic encephalopathy and 4 of the 5 patients without such a history had mild esophageal varices. We could assess the direction of splenic venous flow in 6 patients with a history of spontaneous hepatic encephalopathy and they all showed reversed flow. Only one patient among the 5 patients without such a history showed reversed splenic venous flow. The portal vein diameter was signifi- cant)y smaller in patients with a history of spontaneous hepatic encephalopathy (0.88+0.27 cm) than in patients without this history (1.32+0.08 cm)(p<0.01j. We conc1uded that the direction of splenic venous flow and the diameter of the portal vein in portal hypertensive patients with a large splenorenal shunt may be important factors in the development of spontaneous hepatic encephalopathy.

소화성 궤양에 대한 Famotidine 의 치료효과

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),문영명(Young Myung Moon),정재복(Jae Bock Chung),이상인(Sang In Lee),전재윤(Chae Yoon Chon),김상애(Sang Ae Kim),함기백(Ki Back ham),한광혀(Swang Hyub Han) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1

N/A For the evaluation of clinical efficacy of famotidine, a new, potent, long-acting histamine H2-receptor antagonist, in patients with gastric and duodenal ulcer, 42patients with endoscopically-proved active gastric ulcer (19 patients) and duodenal ulcer (23 patients) were admitted to this trial. Thirty two patients were treated with famotidine 20 mg b.i.d. and 10 with cimetidine 200 mg q.i.d. up to 8 weeks. The observed results were as follows: 1) The complete healing rates of gastric ulcer by endoscopic examination at 4,6 and 8 weeks were 50.0%, 68.8% and 93.8% in famotidine group, and 33.3%, 66.7% and 100.0% in cimetidine group, respectively. 2) The complete healing rates of duodenal ulcer by endoscopic examination at 4, 6 and 8 weeks were 62.5%, 81.3% and 100.0% in famotidine group, and 57.1%, 71.4% and 85.7% in cimetidine group, respectively. 3) Abnormal laboratory finding after treatment was found only in one case in famotidine group, but 3 cases in cimetidine group. 4) There was no significant difference in symptomatic improvement between two groups and mild side effects were complained of in 5 of 32 famotidine group (15.6%) and 4 of 10 cimetidine group (40. 0%). In conclusion, data from the present ivestigation suggest that Famotidine is effective in the treatment of gastric and duodenal ulcer, and is well tolerated on a short-term basis. Further and more extensive studies are necessary to confirm these findings.

pm 위암의 (胃癌) 임상적(臨床的) 고찰

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),문영명(Young Myung Moon),이상인(Sang In Lee),김지영(Ji Young Kim),한광협(Kwang Hyub Han),전재윤(Chae Yoon Chon) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1

N/A Hitherto stomach cancer is divided into early and advanced cancers. Pm gastric cancer occupies an intermediate position between early cancer and advanced cancer, not only from infiltrating depth and prognosis but also from diagnostics, macroscopic features and pathological histology. we observed the characteristics of pm gastric canccr in 77 cases among 731 gastrectomized cases for cancer which had been experienced for 10 years from July 1969 to July 1979 at Severance Hospital. The following results vere obtained. The incidence of pm cancer was 10.5 per cent in 731 cases of gastric cancer submitted for resection. 2. The peak of incidence was in the age group 50-59, and the average age was 53. 6 years and the male outnumbered the female with a ratio of 2.4: l.3. Pm cancer was most often seen on the A area(76.6%), then on the M area(16.9%) and the C area(6.5%) vertically, and on the lesser curvature side especially in the pyloric antrum transversely. 4, Incidence of pm cancer seen from the histological classification: the most frequent type was differentiated adenocarcinoma. 5. Incidence of pm cancer according to macroscopic classificatoin: the type of the Borrmann variety was higher percentage(75%) than the type simulating early gastric cancer(8%) In the former, Borrmann III type was most often seen with a rate of 44 per cent, followed in the order of frequency by- Borrmann II type, Borrmann I type, and Borrmann Ⅳ type. 6. Lymph node metastasis of pm cancer was negative in 48 per cent and positive in 52 percent.

간의 국소적 지방 침윤 1예

강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),정재복(Jae Bock Chung),한광협(Kwang Hyub Han),김원호(Won Ho Kim),박찬일(Chan Il Park),유형식(Hyung Sik Yoo),김중영(Joong Young Kim),한은경(Eun Kyung Han) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2

N/A Focal fatty infiltration of the liver, a poorly characterized entity, was discovered incidentally at postmortem examination in the past, After both ultrasound and computed tomography (CT) have been extensively used over the past few years for imaging the hepatic parenchyma, it was possible to demonstrate focal fatty infiltration of the liver. Focal fatty infiltration of the liver may simulate mass lesions, so it is important to distinguish from space occupying lesions of the liver. Recently we encountered a case of focal fatty infiltration of the liver, which mimicked a liver tumor. It was detected by ultrasound and we performed abdominal CT, RBC liver scan, angiography and ultrasound guided needle biopsy. The diagnosis of focal fatty infiltration of the liver was established histologically.

신종·재출현 전염병 관리를 위한 새로운 백신 기술

강진한(Jin-Han Kang) 한국역학회 2006 Epidemiology and Health Vol.28 No.1

  Although the development of vaccines has been one of the most important contributions of immunology to medicine and public health, and despite vaccination having been proven as the most effective and cheapest medical practice to prevent infectious diseases, infectious diseases still remain the main cause of human deaths and new infectious diseases continue to emerge. Furthermore, we face an unprecedented succession of new pathogens able to jump species barriers and infect humans, even as we continue to be frustrated in our efforts to control devastating diseases such as HIV, malaria and tuberculosis. Hence the need to develop new vaccines and improve existing vaccines. Other challenges for scientists include rapid identification and response to emerging diseases and successful intervention in re-emerging infectious diseases.   Remarkable progress in molecular biology and biotechnology is making possible the development and improvement of new and old vaccines. Recombinant DNA technology, genetic attenuation of viral and bacterial pathogens and their use as vectors for heterologous proteins, naked DNA vaccines and peptide vaccines represent the most popular approaches hitherto adopted.   Reverse genetics and reverse vaccinology are now used to investigate new vaccines. Genome-based reverse vaccinology is very useful and a major tool in vaccine development. The rapid identification of the genome sequence to new pathogens enables the speedy development of diagnostic tools as well as recombinant expression of targets for vaccine.   Strengthening research and development in vaccines, including international cooperation, may be the most effective next step to control and prevent infectious diseases worldwide.

건강한 소아에서의 47계대 Oka주 수두약독화 생백신의 면역원성 및 안전성에 관한 연구

강진한,김종현,서병규,Kang, Jin Han,Kim, Jong Hyun,Suh, Byung Kyu 대한소아감염학회 1997 Pediatric Infection and Vaccine Vol.4 No.2

목 적 : 국내 건강한 소아에서의 47계대 배양된 Oka주 수두 약독화 생백신의 단기간내 체액성 면역원성과 안전성 평가를 위해 본 연구를 시행하였다. 대상 및 방법 : 1997년 4월부터 1997년 8월까지 5개월간 가톨릭대학부속 성모자애병원 육아상담실을 방문한 소아와, 서울, 인천, 수원 지역에 있는 4곳의 보육원에 수용되고 있는 원아들 중 과거력상 수두에 이환되지 않았고, 수두백신 접종력이 없으며 중한 기저질환이나 약제 및 백신에 알레르기가 없는 12개월에서 15세 사이 연령의 건강한 소아를 대상으로 하였다. 백신의 접종은 1,400 PFU 용량의 47 계대 Oka주 수두백신을 상완 삼각근에 1회 피하 주사하였다. 단기간(접종후 6주)의 체액성 면역원성을 평가하기 위해 모든 피접종아에서 접종전, 접종 6주 후에 채혈하여 FAMA 법과 효소 면역법으로 수두 대상포진 바이러스의 세포막 항체와 IgG를 측정 비교하였다. 그리고 안전성 평가를 위해 접종 30분내 즉각반응, 접종 3일내 국소 및 전신반응, 접종 6주후까지의 백신에 의한 전신성 부작용 발생을 관찰하였다. 결과 : 1) 총 99명의 소아에서 접종과 검사가 완료되었다{육아상담실; 33명, 보육원 66명). 이들 중 49명은 접종전 대상포진 바이러스 항체 검사상 음성이었고 50명은 양성으로 판명되었다. 이 두군의 연령 및 성별분포는 유사하였다. 2) FAMA 법으로 시행한 검사상 접종전 음성군에서 97.9%의 양전율을 보였고, 음성군 및 양성군 모두에서 의의있는 GMT 상승을 보였다. 3) 효소 면역법으로 시행한 결과에서는 접종전 음성군에서는 100%의 항체 양전율을 보였고, 그리고 양성군에서도 항체가는 접종후 유의하게 상승하였다. 4) 경한 주사부위의 발적, 동통, 부종, 경결 등의 국소반응과 보챔, 식욕부진 등의 전신반응이 있었으나 3일내에 소실되었고, 이후 6주간 백신에 의한 부작용은 전례에서 관찰되지 않았다. 결 론 : 이상의 결과로 볼 때에 47계대 배양된 Oka주 수두백신은 단기간내에 높은 체액성 면역원성이 유발되고 안전성이 있음을 알 수 있었다. 그러나 이 백신의 광범위한 사용을 위해서는 지속적으로 장기간의 체액성 및 세포 매개성 면역원성 검증과 야외임상 대조설험 등이 요구되어 진다. Purpose: We performed this study to find out short period humoral immunogenicity and safety of 47 passaged Oka strain live attenuated varicella vaccine(1,400PFU) in 12 months to 15 years aged healthy children. Methods: Ninety nine healthy chidren, who have no histories of varicella vaccination, recent chicken pox illness and contact, allergy to other vaccines and underlying severe diseases, were involved in this study from April 1997 to August 1997. 5ml blood were collected before vaccination and after vaccination from all vaccinees to measure varicella membrane antibody by FAMA, and varicella IgG antibody by EIA. And immediate reactions within 30 minutes after vaccination, local and systemic reactions within 3 days after vaccination and vaccine induced systemic illness during 6 weeks postvaccination period were observed in all vaccinees to identify side effects of study vaccine. Results: 1) 49 seronegative and 50 seropositive vaccinees were identified in both prevaccination serologic tests. 2) Serologic responses after vaccination measured by the FAMA in seronegative group showed that the mean GMT level revealed 64.0, and seroconversion rate was 97.9%. And serologic responses after vaccination measured by the FAMA in seropositive group showed that the mean GMT level(242.2) was markedly elevated comparing with the mean GMT level(9.2) of pre vaccination. 3) The results of EIA in seronegative group revealed that postvaccination mean GMT was 435.2(prevaccination GMT; 78.7), and 100% seroconversion rate. Also, the results of EIA in seropositve group showed that the mean GMT level(769.9) of postvaccination was almostly two fold hihger than the mean GMT level(419.7) of prevaccination. 4) Observed local reactions like injection sites redness, pain, hardness and itching sense were mild and disappeared within 3 days, also shorterm systemic reactions like irritability, lethargy, poor appetites and rash were not remarkable. And there were no remarkable side effects due to vaccine during study period in all vaccinees. Conclusion: We confirmed that 47 paasaged Oka strain live attenuated varicella vaccine has high shorterm humoral immunogenicity and safety. However, we need more detail and longterm humoral and cell mediated immunogenicity studies of this vaccine including clinical field trials.

06 식품의약품안전처 SESSION : 잔류농약의 일일섭취허용량 자료 연구

강진석 ( Jin Seok Kang ),김영희 ( Young Hee Kim ),곽경아 ( Kyung A Kwak ),한범석 ( Beom Seok Han ) 한국환경농학회 2014 한국환경농학회 학술대회집 Vol.2014 No.-

현재 식품 중 잔류농약 위해평가 체계에 대한 비교 연구는 거의 전무한 상태이며, 농약의 안전성 자료는 각 나라마다 상이할 수가 있으므로, CODEX, 유럽, 미국, 일본 등 국가별 자료를 비교.분석하여 국내 잔류농약의 위해평가 체계를 확립할 필요가 있다. 본 연구에서는 조사대상 농약 100 종에 대한 식품 중 잔류농약에 대한 코덱스, 일본, 유럽, 미국, 한국 등의 위해성 국제평가기관에서 발표한 안전성 자료를 분석한 후 프로파일을 작성하고, 국외 주요 독성 자료 Data base를 구축하여 식품 중 잔류농약 기준.규격 제.개정의 근거 자료로 활용하고, 안전관리 지원의 과학적 근거를 제공하고자 하였다. 식품을 통해 소량의 농약을 섭취하더라도 인체에서의 대사 반응에 의해 제거될 수 있으며, 일생동안 섭취를 해도 건강에는 영향이 없음을 국제적으로 과학적 근거로 제시하는 것이 ADI(Acceptance Daily Intake, 일일섭취허용량)이다. ADI는 국제기구나 각 국가의 농약관리기관에서 독성전문가들이 농약의 독성자료를 검토하여 위해성평가 전문가회의를 통해서 설정하게 된다. 각국의 안전성 자료를 분석한 결과 설정된 ADI는 주요국가 기관 등의 독성의 endpoint, SF, NOAEL 선정 등 설정지침에 따라 일반증상, 체중변화, 사료섭취량변화, 혈액학적 변화, 조직병리학적변화 등의 독성영향이 있었으며, 설정된 ADI의 근거 endpoint는 각국의 주요 기관의 안전성 자료에서 조직병리학적 판독에 근거한 병리학적 소견이 가장 많았고, 다음으로 생리학적 변화(혈액, 뇨 등)의 사례가 많은 것으로 나타났다. 또한 각국의 주요기관 농약의 안전성 자료에서 ADI값은 kasugamycin 등이 기관별로 상이한 것으로 조사되었다. 하지만 대부분의 경우는 ADI 값이 국가별로 동일하거나 유사하였으며, 주요국가 기관별 ADI 값의 차이는 안전계수의 차이와 실행한 독성시험의 종류가 다른 것으로 조사되었고, 각국 전문가의 독성자료에 대한 견해차이가 있으므로, 추후 농약의 안전성 자료에 대한 자세한 분석이 필요할 것으로 판단되었다.

에크린 한선낭종 2예

강진수(Jin Soo Kang),김태흥(Tae Heung Kim),박기범(Ki Beom Park),김규한(Kyu Han Kim) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.2

We report two cases of eccrine hidrocystoma, one in a 13-yeair-old-female and the other a 56-year-old male. In the first case, rnultiple pale blue, translucent, discrete yellow papules of one years duration were noted on the nose tip of the nose. The second case presented with a tiny asympt,omatic papule superimposed on a slightly erythematous 2cm-sized, round patch on the forehead for 2 months. In both cases, the histopathology demonstrated a cystic space filed with eosinophilic amorphous material. The cyst wall was lined by two layers of cuboidal pithelial cells with eosinophilic cytoplasm. PAS staining showed PAS-positive materials in he cytoplasm of cyst wall epithelium, lumen, and eccrine gland cells. Topical application of 10% atropine sulfate and surgical excision were performed in the each cases with improvernent. (Kor J Dermatol 1992;30(2): 244-248)

간장 및 담도 : 생검으로 확진된 지방간의 임상적 고찰

강진경(Jin Kyung Kang),최흥재(Heung Jae Choi),전재윤(Chae Yoon Chon),박찬일(Chan Il Park),윤정한(Jung Han Yoon),임대순(Dae Soon Yim) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1

N/A Fatty liver is caused by derangement of fat metabolism and can be reversed by removal of contributing factors. The contributing factors of fatty liver include overweight, chronic alcoholism, diabetes mellitus, malnutrition, and drug abuse such as tetracycline. In this study, age and sex distribution, contributing factors, clinical features, liver function tests, correlation of grade of fatty liver to body weight, liver function test and viral markers were reviewed. Clinical diagnosis, peritoneoscopic diagnosis, and pathologic findings were compared in 54 cases with fatty liver proven by peritoneoscopic liver biopsy who were admitted to Yonsei University Severance Hospital from January 1981 to June 1985. The following results were obtained. 1) The mean age of 54 cases was 39. 9 years and the male to female ratio was 2.9 to 1 2) Contributing factors of fatty liver were overweight in 27 cases(50.0%), chronic alcoh- olism in 23 cases(42.5%), diabetes mellitus in 8 cases(14.9%), and malnutrition in 1 case (1 .9%). Overweight was the only contributing factor in 13 cases(24.o%), chronic alcoholism only in 12 cases(22.2%) There were more than one contributing factors in 16 cases(29.7%) and no definite contributing factors in 12 cases(22.2%). 3) Easy fatigability was the most frequent symptom which was found in 28 cases(52.7%) and hepatomegaly was the most common physical finding which was found in 26 cases (48.6%). 4) The r-GTP level was increased in 43 cases(80%), SGOT in 35 cases(65.5%), SGPT in 40 cases(74.5%), and triglyceride in 37 cases(68.9%). 5) The r-GTP and SGOT level were more elevated with statistical significance in chronic alcoholic group than in overweight group. G) There were no correlations of grade of fatty liver to body weight and liver function tests. 7) Eleven cases(22.5%) of 49 cases were HBsAg positive which was significantly higher than that of normal population in Korea. 8) A clinical diagnosis prior to peritoneoscopy was chronic hepatitis in 34 cases(62.8%), alcoholic liver disease in 9 cases(16.7%), fatty liver in 5 cases(9.2%), and HBsAg carrier in 4 cases(7.5%) A peritoneoscopic diagnosis was fatty liver in 3l cases(57.4%), chronic hepatitis in 10 cases(18.5%), acute unresolved hepatitis in 5 cases(9.3%), and normal liver in 8 cases(14.8%). In summary, the clinical diagnosis of fatty liver was made only in 5 cases(9.2%), and peritoneoscopic diagnosis of fatty liver in 31 cases(57.4%). The majority of the rest was chronic hepatitis. Therefore, it is mandatory to perform liver biopsy to distinguish fatty liver from chronic hepatitis.