제56차 춘계학술대회 : 일반연제 3 ; 종양 2 : 색소성 상피양 세포 모반 1예

강주형,노영석 대한피부과학회 2004 초록집 Vol.42 No.10

지능형 감시시스템을 위한 배회, 도주, 침입자 검출

강주형,곽수영 한국정보과학회 2012 한국정보과학회 학술발표논문집 Vol.39 No.1C

[행복일기] 동물병원 24시

강주형 샘터사 2011 월간 샘터 Vol.496 No.-

Bioavailability of xanthorrhizol following oral administration of a supercritical extract of Java turmeric

강주형,원지현,황재관,강원구 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.10

Although xanthorrhizol, a sesquiterpenoid oil obtained from the rhizome of Curcuma xanthorrhiza Roxb., known as Java turmeric, has many pharmacological effects, its pharmacokinetics remain unclear. Therefore, we investigated the pharmacokinetics of xanthorrhizol in mice and rats. Xanthorrhizol was administered intravenously and orally to mice, while xanthorrhizol and a Java turmeric supercritical extract were administered orally to rats. The terminal half-life (t1/2), clearance, and absolute bioavailability (BA) of xanthorrhizol in mice were almost 8 h, 6.5 L/h/kg, and 10.2%, respectively. In comparison, the clearance of xanthorrhizol was 3-fold higher in rats than mice. The absolute BAs of xanthorrhizol in rats were 12.9% and 13.4% after oral administration of xanthorrhizol and a supercritical extract, respectively. Our results regarding the pharmacokinetics of xanthorrhizol could guide the conversion of intravenous and oral doses, and help identify the optimal maintenance doses of xanthorrhizol and the extract for desirable pharmacodynamic effects.

[행복일기] 엄마, 아빠 그리고 ‘우리 아기’

강주형 샘터사 2011 월간 샘터 Vol.495 No.-

EEG Feature Engineering for Machine Learning-Based CPAP Titration Optimization in Obstructive Sleep Apnea

강주형,김여진,양지선,정승원,황성은,오유란,이향운 한국인터넷방송통신학회 2023 International journal of advanced smart convergenc Vol.12 No.3

Obstructive sleep apnea (OSA) is one of the most prevalent sleep disorders that can lead to serious consequences, including hypertension and/or cardiovascular diseases, if not treated promptly. Continuous positive airway pressure (CPAP) is widely recognized as the most effective treatment for OSA, which needs the proper titration of airway pressure to achieve the most effective treatment results. However, the process of CPAP titration can be time-consuming and cumbersome. There is a growing importance in predicting personalized CPAP pressure before CPAP treatment. The primary objective of this study was to optimize the CPAP titration process for obstructive sleep apnea patients through EEG feature engineering with machine learning techniques. We aimed to identify and utilize the most critical EEG features to forecast key OSA predictive indicators, ultimately facilitating more precise and personalized CPAP treatment strategies. Here, we analyzed 126 OSA patients' PSG datasets before and after the CPAP treatment. We extracted 29 EEG features to predict the features that have high importance on the OSA prediction index which are AHI and SpO2 by applying the Shapley Additive exPlanation (SHAP) method. Through extracted EEG features, we confirmed the six EEG features that had high importance in predicting AHI and SpO2 using XGBoost, Support Vector Machine regression, and Random Forest Regression. By utilizing the predictive capabilities of EEG derived features for AHI and SpO2, we can better understand and evaluate the condition of patients undergoing CPAP treatment. The ability to predict these key indicators accurately provides more immediate insight into the patient’s sleep quality and potential disturbances. This not only ensures the efficiency of the diagnostic process but also provides more tailored and effective treatment approach. Consequently, the integration of EEG analysis into the sleep study protocol has the potential to revolutionize sleep diagnostics, offering a time-saving, and ultimately more effective evaluation for patients with sleep-related disorders.

Improvement of Self-healable Automotive Clearcoat Using Sunlight Irradiation

강주형,손다해,정지은,김진철,박영일 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.2

SSResUnet 모델을 이용한 위성 영상 토지피복분류

강주형,김민성,김성진,곽수영 한국전기전자학회 2023 전기전자학회논문지 Vol.27 No.4

본 논문에서는 사용자의 개입없이 고해상도 위성 영상을 활용하여 정밀한 토지피복분류를 위해 U-Net 네트워크 모델에 SPADE구조를 결합한 SSResUNet 모델을 제안한다. 제안하는 네트워크는 위성 영상의 공간적 특성을 보존하여 복잡도가 높은 환경에서도강인한 분류모델이라는 장점이 있다. 다목적실용위성 3A 영상을 통해 학습한 결과 기존 U-Net, U-Net++ 대비 뛰어난 결과를 보였으며 평균 IoU 76.10, Dice 86.22의 성능을 도출하였다. Traditional methods for voltage estimation may face limitations in accuracy and robustness, prompting the need

Polyurethane-based Automotive Clearcoat with Self-healing Performance under Sunlight Radiation

강주형,정지은,김진철,손다해 한국공업화학회 2024 한국공업화학회 연구논문 초록집 Vol.2024 No.0

레닌 억제제가 실험적 사구체 콩팥염에 미치는 효과 - 예비 보고

강주형,허재경,이영숙,한지영,하일수 대한소아청소년과학회 2009 Clinical and Experimental Pediatrics (CEP) Vol.52 No.8

Purpose : We performed this study in order to investigate the effect of direct renin inhibition on an experimental animal model with nephrotoxic serum nephritis and tried to give useful information for clinical research and renin inhibitor treatment. Methods : Thirty BALB/c 6-week-old male mice were divided into 4 groups: control group (CO, n=5), control-treatment group with aliskiren (CT, n=5), disease group (DO, n=10), and disease treatment group with aliskiren (DT, n=10). Nephritis was induced by an intravenous injection of 0.25 mg/g weight of rabbit anti-GBM immunoglobulin G. Model 2002 Alzet mini-osmotic pumps (Durect Corp.) for aliskiren infusion were implanted into CT and DT. Each group strain was sacrificed serially one at a time on day 14. We estimated the protein-creatinine ratio in 12-hour-collected urine (UP/Cr) and measured the mesangial matrix score in the PAS-stained kidney of each strain. Results : One strain at CT and DT died on day 6 and 7, respectively. Each group strain was sacrificed serially at a time on day 10 because DO were seriously ill. The UP/Cr of each group is as follows: CO, 31.24±6.54 mg/mg, CT, 23.38±13.60 mg/ mg, DO, 112.72±10.97 mg/mg, DT 114.07±32.30 mg/mg. There was no significant difference between DO and DT. The mesangial matrix score of each group was CO, 0.23±0.10; CT, 0.13±0.03; DO, 1.90±0.48; and DT, 1.28±0.41, respectively, and there was a significant difference between DO and DT in the extent of mesangial matrix expansion (P=0.008). Conclusion : We found that renin inhibition was able to suppress the mesangial matrix expansion in experimental mice with acute nephritis, although there were no significant differences in UP/Cr. 목 적 : 급성 사구체 콩팥염 실험동물을 이용하여 레닌 억제제를 일정기간 투여한 후 정상군과의 비교를 통해 그 효과를 평가함으로써 임상연구 및 치료를 위해 유용한 지식을 제공하고자 이 연구를 시행하였다. 방 법 : 총 30마리의 재태연령 6주, 수컷 BALB/c 생쥐를 정상군(n=5), 정상치료군(n=5), 질병군(n=10), 질병치료군(n=10) 네 집단으로 분류하고 질병은 항사구체 기저막 항체를 주입하여 유발하였다. 질병유발과 동시에 레닌억제제를 osmotic mini pumps를 통해 피하로 투여하였고 질병유발 14일째 쥐를 도살하여 각 군별로 소변의 단백/크레아티닌 비와 각 개체의 사구체의 메산지움의 확장 정도를 점수화하여 비교하였다. 결 과 : 질병 유발 6일째 질병군에서 한 마리, 7일째 질병치료군중 한 마리가 사망하였다. 10일째 질병군 개체들에서 급성 병색이 나타나 각 군별로 질병 유발 10일째 소변의 단백/크레아티닌 비를 산출하였고 도살 후 떼어 낸 콩팥 조직에서 사구체의 메산지움의 확장 정도를 평가하였다. 소변의 단백/크레아티닌 비가 같은 군에 속한 다른 개체들과의 값보다 현저한 차이를 보인 질병군 한 개체를 제외한 후 측정한 결과 정상군은 31.24±6.54 mg/mg, 정상치료군은 23.38±13.60 mg/mg, 질병군은 112.72±10.97 mg/mg, 질병치료군은 114.07±32.30 mg/mg으로 질병군에서 의미 있는 소변 단백/크레아티닌 비의 상승을 확인할 수 있었고(P<0.05) 서로 다른 군들 사이에서는 차이를 나타내지 않았다. 메산지움의 확장 정도는 정상군은 0.23±0.10, 정상치료군은 0.13±0.03, 질병군은 1.90±0.48, 질병치료군은 1.28±0.41로 정상군과 질병군 사이에 유의한 차이가 있는 것으로 나타났고(P< 0.05), 질병군과 질병치료군 사이에서도 P=0.008로 유의한 차이를 나타내었다. 결 론 : 급성 사구체 콩팥염 실험동물을 이용한 레닌 억제의 효과를 알아 본 이번 실험에서 소변의 단백/크레아티닌 비에서 차이는 뚜렷하지 않았지만 메산지움의 확장 정도를 평가한 병리학적 소견에 있어서는 의미 있는 차이를 확인 할 수 있었다.