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      • KCI등재

        SSResUnet 모델을 이용한 위성 영상 토지피복분류

        강주형,김민성,김성진,곽수영 한국전기전자학회 2023 전기전자학회논문지 Vol.27 No.4

        본 논문에서는 사용자의 개입없이 고해상도 위성 영상을 활용하여 정밀한 토지피복분류를 위해 U-Net 네트워크 모델에 SPADE구조를 결합한 SSResUNet 모델을 제안한다. 제안하는 네트워크는 위성 영상의 공간적 특성을 보존하여 복잡도가 높은 환경에서도강인한 분류모델이라는 장점이 있다. 다목적실용위성 3A 영상을 통해 학습한 결과 기존 U-Net, U-Net++ 대비 뛰어난 결과를 보였으며 평균 IoU 76.10, Dice 86.22의 성능을 도출하였다. Traditional methods for voltage estimation may face limitations in accuracy and robustness, prompting the need

      • KCI등재

        소아 기능성 요실금의 진단과 치료

        강주형 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.11

        Functional urinary incontinence, the absence of any neurologic or structural abnormality as a cause of urinary incontinence in children, is one of the most common clinical problems encountered in pediatric and urologic departments, and it can be socially and emotionally distressing for the affected children. The prevalence rates of functional urinary incontinence in school-aged children are not very high and differ between boys and girls. The underlying mechanisms of functional urinary incontinence are heterogenous and can be associated with the following dysfunctions of both the storage and voiding patterns of the bladder: overactive bladder, dysfunctional voiding, lazy bladder syndrome, HinmanAllen syndrome, giggle incontinence, and vaginal voiding. Treatment methods for urinary incontinence in children should be chosen according to these clinical conditions. Treatment modalities generally consist of the treatment of comorbid conditions such as urinary infection and constipation, behavior therapy to modify learned voiding patterns, and pharmacotherapy primarily with anticholinergics and α-adrenergic blockers. This review discusses the optimal treatment modalities, including treatment of the underlying voiding disorders, and diagnostic approaches related to functional urinary incontinence in children.

      • KCI등재

        토양으로부터 genomic DNA의 효과적인 분리

        강주형,김보혜,이선이,김영진,이준원,박영민,안순철,Kang Ju-Hyung,Kim Bo-Hye,Lee Sun-Yi,Kim Yeong-Jin,Lee Ju-Won,Park Young Min,Ahn Soon-Cheol 한국생명과학회 2005 생명과학회지 Vol.15 No.6

        Although valuable microbes have been isolated from the soil for the various productions of useful components, the microbes which can be cultivated in the laboratory are only $0.1-1\%$ of all microbes. To solve this problem, the study has recently been tried for making the valuable components from the environment by directly separating unculturable micrbial DNA in the soil. But it is known that humic acid originated from the soil interrupts various restriction enzymes and molecular biological process. Thus, in order to prevent these problems, this study modified the method separated soil DNA with phenol, CTAB and PEG. In order to compare the degree of purity for each DNA and the molecular biological application process, $A_{260}/A_{280}$ ratio, restriction enzymes, and PCR were performed. In case of DNA by the modified method, total yield of DNA was lower but $A_{260}/A_{280}$ ratio was higher than the previously reported methods. It was confirmed that the degree of purity is improved by the modified method. But it was not cut off by all kinds of tested restriction enzymes because of the operation of a very small amount of interrupting substances. When PCR was operated with each diluted DNA in different concentrations and GAPDH primer, the DNA by the modified method could be processed for PCR in the concentration of 100 times higher than by the previously reported separation method. Therefore, this experiment can find out the possibility of utilization for the unknown substances by effectively removing the harmful materials including humic acid and help establishing metagenomic DNA library from the soil DNA having the high degree of purity.

      • KCI등재

        사마귀양 낭종 1예

        강주형,박정환,김정수,노영석 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.2

        Vcrrucous cyst is a rare form of epidermal cyst showing verrucous changes of their stratified squamous epithelial lining, characterized by papillomatosis, acanthosis, and hypergranulosis with large, irregular keratohyaline granules. In addition, vacuolated keratinocytes, parakeratosis, and squamous cddies are often present. Herein, we describe a 45-year-old woman with a verrucous cyst, which occurred on left axilla three months ago, showing the above-mentioned characteristic histologic features. Both the immunohistochemical stain and polymcrase chain reaction for the common antigen for human papillomavirus and DNA chip study for human papillomavirus were negative. (Korean J Dermatol 2004;42(2):232~235)

      • KCI등재

        레닌 억제제가 실험적 사구체 콩팥염에 미치는 효과 - 예비 보고

        강주형,허재경,이영숙,한지영,하일수 대한소아청소년과학회 2009 Clinical and Experimental Pediatrics (CEP) Vol.52 No.8

        Purpose : We performed this study in order to investigate the effect of direct renin inhibition on an experimental animal model with nephrotoxic serum nephritis and tried to give useful information for clinical research and renin inhibitor treatment. Methods : Thirty BALB/c 6-week-old male mice were divided into 4 groups: control group (CO, n=5), control-treatment group with aliskiren (CT, n=5), disease group (DO, n=10), and disease treatment group with aliskiren (DT, n=10). Nephritis was induced by an intravenous injection of 0.25 mg/g weight of rabbit anti-GBM immunoglobulin G. Model 2002 Alzet mini-osmotic pumps (Durect Corp.) for aliskiren infusion were implanted into CT and DT. Each group strain was sacrificed serially one at a time on day 14. We estimated the protein-creatinine ratio in 12-hour-collected urine (UP/Cr) and measured the mesangial matrix score in the PAS-stained kidney of each strain. Results : One strain at CT and DT died on day 6 and 7, respectively. Each group strain was sacrificed serially at a time on day 10 because DO were seriously ill. The UP/Cr of each group is as follows: CO, 31.24±6.54 mg/mg, CT, 23.38±13.60 mg/ mg, DO, 112.72±10.97 mg/mg, DT 114.07±32.30 mg/mg. There was no significant difference between DO and DT. The mesangial matrix score of each group was CO, 0.23±0.10; CT, 0.13±0.03; DO, 1.90±0.48; and DT, 1.28±0.41, respectively, and there was a significant difference between DO and DT in the extent of mesangial matrix expansion (P=0.008). Conclusion : We found that renin inhibition was able to suppress the mesangial matrix expansion in experimental mice with acute nephritis, although there were no significant differences in UP/Cr. 목 적 : 급성 사구체 콩팥염 실험동물을 이용하여 레닌 억제제를 일정기간 투여한 후 정상군과의 비교를 통해 그 효과를 평가함으로써 임상연구 및 치료를 위해 유용한 지식을 제공하고자 이 연구를 시행하였다. 방 법 : 총 30마리의 재태연령 6주, 수컷 BALB/c 생쥐를 정상군(n=5), 정상치료군(n=5), 질병군(n=10), 질병치료군(n=10) 네 집단으로 분류하고 질병은 항사구체 기저막 항체를 주입하여 유발하였다. 질병유발과 동시에 레닌억제제를 osmotic mini pumps를 통해 피하로 투여하였고 질병유발 14일째 쥐를 도살하여 각 군별로 소변의 단백/크레아티닌 비와 각 개체의 사구체의 메산지움의 확장 정도를 점수화하여 비교하였다. 결 과 : 질병 유발 6일째 질병군에서 한 마리, 7일째 질병치료군중 한 마리가 사망하였다. 10일째 질병군 개체들에서 급성 병색이 나타나 각 군별로 질병 유발 10일째 소변의 단백/크레아티닌 비를 산출하였고 도살 후 떼어 낸 콩팥 조직에서 사구체의 메산지움의 확장 정도를 평가하였다. 소변의 단백/크레아티닌 비가 같은 군에 속한 다른 개체들과의 값보다 현저한 차이를 보인 질병군 한 개체를 제외한 후 측정한 결과 정상군은 31.24±6.54 mg/mg, 정상치료군은 23.38±13.60 mg/mg, 질병군은 112.72±10.97 mg/mg, 질병치료군은 114.07±32.30 mg/mg으로 질병군에서 의미 있는 소변 단백/크레아티닌 비의 상승을 확인할 수 있었고(P<0.05) 서로 다른 군들 사이에서는 차이를 나타내지 않았다. 메산지움의 확장 정도는 정상군은 0.23±0.10, 정상치료군은 0.13±0.03, 질병군은 1.90±0.48, 질병치료군은 1.28±0.41로 정상군과 질병군 사이에 유의한 차이가 있는 것으로 나타났고(P< 0.05), 질병군과 질병치료군 사이에서도 P=0.008로 유의한 차이를 나타내었다. 결 론 : 급성 사구체 콩팥염 실험동물을 이용한 레닌 억제의 효과를 알아 본 이번 실험에서 소변의 단백/크레아티닌 비에서 차이는 뚜렷하지 않았지만 메산지움의 확장 정도를 평가한 병리학적 소견에 있어서는 의미 있는 차이를 확인 할 수 있었다.

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