원발성 및 전이성 구강편평세포암종 세포주에서 p21 및 p73 mRNA발현에 관한 연구

강정훈,김경욱,이재훈,Kang, Jeong-Hoon,Kim, Kyung-Wook,Lee, Jae-Hoon 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.6

There were many controversies in the cause and progress of tumorigenesis. Recently, studies on the mutation of genes related to the tumor have extensively been performed due to development of molecular biology. Structural and morphological changes of chromosomes, which are related to the abnormal activation of oncogenes or inactivation of tumor suppression genes, transform the normal cells into the tumor cells. p53 and Rb are well known tumor suppressor genes, while oncogenes include c-myc, bcl-2 and ras, etc. When exposed to cell damaging agents, p53 inhibits cell growth by inducing transcription of p21. Especially p73, which is homo-logy of p53, frequently deleted in melanoma, neuroblastoma, colon cancer, and breast cancer, when over produced, p73 activates the transcription of p21, bax-1 and inhibits cell growth by inducing apoptosis. For study on mRNA expression of p21 and p73, normal oral keratinocytes, and cell lines of primary and metastatic oral squamous cell carcinoma were cultured and then electrophoresis and RT-PCR(reverse transcription-polymerase chain reaction) were performed. 1. The mRNA of p21 and p73 in normal oral keratinocyte expressed lower than that of primary squamous cell carcinoma. 2. The mRNA of p21 in metastatic oral squamous carcinoma cell lines was expressed as various patterns compared with that of normal oral keratinocyte. 3. In the metastatic oral squamous cell lines, the mRNA of HN8 expressed higher than that of HN12 or HN19. 4. The mRNA of p73 in primary oral squamous cell lines expressed 4-5 times higher than that of normal keratinocyte. 5. In metastatic oral squamous cell lines, there was no significant expression of p73 mRNA compared with that of normal oral keratinocyte. From the results obtained in this study, mRNA expression of p73 in primary oral squamous cell lines was remarkable, while mRNA expression of p21 and p73 in metastatic oral squamous cell lines were statistically insignificant.

커넥티드 차량 빅데이터 고속처리 SW 기술

강정훈(Kang Jeong Hoon),최효섭(Choi Hyo Seop),고재진(Ko Jae Jin),채철승 한국통신학회 2019 한국통신학회 학술대회논문집 Vol.2019 No.1

장-일치 개념에 의한 신 고차 불구속 모드 합성법

강정훈(Jeong Hoon Kang),김윤영(Yoon Young Kim) 한국소음진동공학회 1999 한국소음진동공학회 학술대회논문집 Vol.1999 No.6

천연기념물 백로와 왜가리 번식지의 실태 및 관리방안

강정훈(Jeong-Hoon Kang),이상기(Sang-Gi Lee),최병진(Byung-Jin Choi),오흥식(Hong-Shik Oh),김남춘(Nam-Choon Kim) 한국조류학회II 2009 한국조류학회지 Vol.16 No.1

본 연구는 천연기념물로 지정된 백로와 왜가리 집단번식지 훼손에 따른 천연기념물 번식지의 보호와 관리방안을 마련하기 위하여 2008년 5월부터 9월까지 무안 용월리, 양양 포매리, 통영 도선리, 횡성 압곡리, 여주 신접리, 진천 노원리 지정지역에서 번식지의 실태, 개체수, 대체가능한 서식지를 조사 분석하였다. 천연기념물로 지정된 번식지역의 훼손은 백로류의 지속적인 분변으로 인해 고사목이 증가하고, 번식지 주변 지역의 환경변화 요인이나 번식지 지정 후 관리미흡 등이 주요 요인인 것으로 나타났다. 백로와 왜가리 번식지역을 2002년과 2008년 개체수를 비교한 결과, 전남 무안을 제외한 백로와 왜가리의 개체수가 감소한 것으로 나타났고, 경남 통영 번식지는 현재 백로와 왜가리가 도래하지 않는 것으로 나타났다. 번식지내 백로류 분변으로 인한 고사목의 증가는 영소목의 감소로 나타났다. 백로와 왜가리 번식지의 장기적인 관리방안에 있어 번식지가 훼손될 시 대체가능서식지를 분석하기 위해 번식지 주변 10㎞이내의 현번식지와 환경이 유사한 지역을 GIS분석을 통하여 고도, 경도, 식생, 번식지와 도로와의 거리를 분석하였다. 분석결과, 각 번식지별 대체가능한 서식지가 약 3개소 있는 것으로 나타났다. This study analyzed current status, number of organisms, and alternative sites in the designated areas Yongwol-ri in Muan, Pomae-ri in Yangyang, Doseon-ri in Tongyeong, Abgok-ri in Hoengseong, Sinjeob-ri in Yeoju, and Nowon-ri in Jincheon, from May to September in 2008 in order to develop plans to protect and manage the habitats of natural monuments to cope with the damage of the habitats of heron and egret which are designated as natural monuments. The damage of the habitats of species designated as natural monuments was mainly caused by the accumulation of the excretion of herons continuously killing trees, changes in the environment around the habitat, and the negligence in management after the habitat designation. The number of birds counted in 2002 and 2008 were compared by their habitats and the number of herons and egrets decreased in overall habitats excluding Muan in Jeollanam-do and the habitat in Tongyeong in Gyeongsangnam-do is currently unvisited by herons and egrets. The increase of trees killed by the excretion of herons within the habitat led to the decrease of nest trees. Concerning the long term management plan of heron and egret habitats, the altitude, longitude, plantation, and the distance between the habitat and road of the areas within 10㎞ radius of current habitats that have the environment similar to current habitats were studied through GIS analysis in order to examine alternative habitats that can replace current habitats for serious damages. The analysis showed approximately 3 possible alternative habitats in each habitat.

공공시설물을 이용한 환경그래픽표현에 대한 연구

강정훈(Kang Jeong Hoon),안병진(Ann Byoung Jin),이명희(Lee Myung Hee) 한국디자인학회 2006 한국디자인학회 학술발표대회 논문집 Vol.- No.-

산업용 집진기의 전력 사용량 모니터링 시스템 연구

강정훈(Jeong-hoon Kang),고원식(Won-sik Ko),임호정(Ho-jung Lim),유준재(June-jae You) 한국통신학회 2015 한국통신학회 학술대회논문집 Vol.2015 No.06

태백산맥을 경계로 한 박새(Parus major) 소리의 지리적 변이

강정훈(Jeong-Hoon Kang),함규황(Hahm Kyu-Hwang) 한국조류학회II 1999 한국조류학회지 Vol.6 No.2

‘義理’의 윤리문화와 ‘義務’의 윤리문화 비교

강정훈(Kang, Jeong-Hoon) 한국공공사회학회 2015 공공사회연구 Vol.5 No.2

우리사회의 윤리문화를 이해하고 전망하는데 있어 ‘의리’와 ‘의무’는 중요한 가치개념에 속한다. 그래서인지 동아시아 전통의 의리학에 대한 접근이나 서구 윤리학의 의무론 범주를 다룬 독립적 연구들은 다수 발견할 수 있다. 그럼에도 이 둘의 연관성을 다룬 비교연구는 찾아보기 힘들다. 따라서 이 둘을 비교대상으로 삼는 연구는 나름의 의미를 가진다고 짐작한다. 일단 여기에서는 우리의 일상 언어습관에서 그 차이와 기원을 짐작하는 일로부터 단초를 시작한다. 한편 제자백가에서 다채롭게 나타나는 의리에 대해서는 유가를 대표로 삼고 서구전통의 의무에 대해서는 칸트의 이해를 주요한 대상으로 삼아 그 비교를 펼치는 일이 주요한 내용이 된다. 이런 과정을 통해서 의리와 의무의 동일성과 차이성이 얼마간 명료하게 드러나는 일을 기대할 수 있다. 나아가 이들을 중시하는 윤리문화의 모습들이 어떤 특성을 갖는지에 대해서도 살필 수 있다. This paper aims to study on compare the ethical culture of fidelity(義理) and duty(義務) as important values in Korea. It is not easy to find out the approach to consider and compare the two values, even though they have had the independent and different tradition of study in the East and the West. To compare those values and ethical cultures, I will explore any difference and its origin in the ordinary ways of languages. The term of fidelity is represented in the Confucian tradition and in Kantian view the conception of duty is related to the western tradition. By comparing the two values articulated in our ordinary life, it is expected the difference as well as the similarity between them. This enables us to establish a prospective to the ethical culture that has paid attention to fidelity and duty.

장-일치 개념을 적용한 신 고차 구속 모드 합성법

강정훈(Jeong Hoon Kang) 한국소음진동공학회 2000 한국소음진동공학회 학술대회논문집 Vol.2000 No.1

조선조(朝鮮朝)의 도덕적 일탈사례(逸脫事例)에 대한 윤리문화적 이해

강정훈 ( Jeong Hoon Kang ) 한국윤리학회 2010 倫理硏究 Vol.78 No.1

This essay aims to explore the aspect of ethical culture based on ethical situations in the Chosen Dynasty that has a monarchial system from Confucianism. The most fundamental root in Confucian societies is in the ethics of family. In Confucianism, the conception of family is beyond that of natural establishment and extended into concrete virtues in the society, which consists of the three bonds and five relationship(三綱五倫). This feature can also be recognized in the contexts of the pictures of Confucian conducts in the Hangsildo(『行實圖』). In particular, in the Chosen Dynasty the three bonds -between king and retainers, between father and son, and between husband and wife- is superior to the five relationships, which shows the attempt to make spread Confucian ethics under the political thoughts. However, there are ethical deviances in the Chosen Dynasty, even though it tries to cultivate its members in the idea of moral politics. This essay would pay an attention to two categories: one is that a son hit his father, another that a husband killed his wife. Those kinds of cases are against the main principle of the three bonds, centered on the relation between father and son, and five relationships rooted in that between husband and wife. In this sense, to investigate the cases of the two categories may give us a clue to find out the characteristic of ethical culture in the Chosen Dynasty. Those ethical deviances as well as the orders of Confucian ethics should be contextualized in terms of ethical culture as the results of certain ways of life in a group or society based on its morality. This means that to grasp ethical lives in the Chosen Dynasty is not to examine the cases by legal aspects but to reveal their ethical meanings. Concerning the types of ethical culture, the subject tends to be encouraged to live in the type of ethical culture of community, while the classes of elites can be in the bureaucrats by ethical culture of civil society. In a clique of the bureaucracy, however, the type of ethical culture of community is more powerful in the Chosen Dynasty, because which has priority is different by certain situations, especially whether two areas of public and private interests are divided, overlapped, or obscure.