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It is necessary to implant a separate device through the skin to measure the flow rate that can indicate the operation status of a ventricular assist device. This has some limitations: high risk of infection and the need to install equipment that can communicate with the implanted device. So this study aims to make in-vivo assessment of blood flow rate estimation using pre-development cardiac output estimation system. The blood flow rate measured in-vivo by an ultrasonic blood flow meter and that based on the inner pressure variation were proved to be similar to each other. Therefore, it is expected that the blood flow rate estimation technique in this study will be able to estimate the flow rate without separate measurement equipment after the implantation of a ventricular assist device.
In pulsatile artificial heart, the abrupt change in blood pressure and flow cause the blood cell damage. So, to mitigate the abrupt blood pressure and flow change, it is vary important that the actuator should be controlled to reduce blood flow output change as well as the design of an actuator. We controlled the moving position of the actuator and it is enable to have various locus and different from the previous moving velocity control scheme. In in-vitro experiments, we compared the effect on the blood pressure and flow according to each position locus.
Drug Drug controller is maintain the injected drug rate in body, and it is device for the controls of drug injection accordinng to the condition of patient. More conventional drug controllers were developed, but the most devices were limited to control of drug rate because of control in person patient`s. In the study, Drug controller is developed by thermopneumatic using PDMS. In order to verify the injection rate of drug controller is measured in the pressure change according to the injection rate by in-vitro, and the accuracy is compared with the conventional drug controller.