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김가연(Ga Yeon Kim), 이승제(Seung Je Lee), 전미지(Mi Ji Jeon), 김보민(Bo Min Kim), 김근태(Geun Tae Kim), 강상문(Sang Moon Kang), 이기영(Kee Young Lee), 신은진(Eun Jin Shin), 김상용(Sang Yong Kim), 김영민(Young Min Kim) 한국생물공학회 2018 KSBB Journal Vol.33 No.1
The purpose of this study was to investigate the skin-whitening effects of Niacinamide-dipeptide Convergence (Niacin-peptide). To evaluate skin-whitening effects of Niacin-peptide, we performed tyrosinase inhibition assay and L-DOPA oxidation inhibition assay. These results demonstrated that Niacin-peptide decreased melanin production through tyrosinase inhibition. Also, we measured expression level of melanogenesis-related mRNA and proteins by reverse transcription-polymerase chain reaction (PCR) and western blotting. Results of PCR and Western blotting were showed that Niacin-peptide reduced expression of microphthalmia- associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), tyrosinase related protein-2 (TRP- 2) and tyrosinase. Thus, we identified the skin-whitening effect of Niacin-peptide and this finding demonstrated that Niacinamide-dipeptide Convergence may have potential as cosmetic ingredient.
Ye Seul Park(박예슬), Gun He Nam(남건희), Kyung Jo Jo(조경조), Hye Won Kawk(곽혜원), Je-Geun Yoo(유제근), Jin Dong Jang(장진동), Sang Moon Kang(강상문), Sang Yong Kim(김상용), Young Min Kim(김영민) 한국생물공학회 2019 KSBB Journal Vol.34 No.3
Collagen is decomposed by MMP-1, an enzyme induced by transcription factor activator protein 1 (AP-1) and matrix metalloproteinase-9 (MMP-9). Action of MMPs in inflammatory response promotes inflammatory cell movement and secretion, resulting in wrinkles on the skin. After using Bacillus sp. fermentation system and water, Artemisia vulgaris was fermented to prepare different solvent fractions using water, dichloromethane, hex ane, n-butanol, and ethyl acetate. These fractions were used to assess their effects on cell survival, wound healing, MMP-1/MMP-9 and procollagen type I C-peptide (PICP) expression, and skin turnover. MTT assay showed that cell viability of each treated group was 103% to 121%, indicating that A. vulgaris fractions were not toxic compared to control (cell viability: 100%). Wound healing assay revealed that wound healing ability in each treated group was 51% to 61%. This was lower than wound healing area in the control. Using RT-PCR, inhibition of MMP-1/MMP-9 gene expression was examined. As a result, each group treated with fraction showed reduced expression of both MMP-1 and MMP-9 compared to tumor necrosis factor-α (TNF-α) treatment group. Effects on collagen biosynthesis were analyzed using a PICP ELISA Kit. The group in which Artemisia vulgaris was treated increased collagen synthesis from 141 to 262ng/mL compared to the control group. Three-dimensional cell culture revealed that each fraction could increase skin wall formation. These results suggest that each fractions has anti-aging and anti-wrinkle effects on the skin, indicating its suitability as a functional material.