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육형동,강민용,황의창,박재영,정창욱,송채린,서성일,변석수,곽철,홍성후,정진수,이학민 대한비뇨의학회 2020 Investigative and Clinical Urology Vol.61 No.5
Purpose: The clinical impact of the platelet-to-lymphocyte ratio (PLR) on the prognosis of patients with metastatic renal cell carcinoma (mRCC) remains controversial. We investigated the associations between elevation of the PLR and disease prognosis in patients with synchronous mRCC. Materials and Methods: The data of 1,505 patients with synchronous mRCC were retrospectively analyzed. The entire cohort was stratified into two subgroups according to PLR. Kaplan–Meier and Cox proportional analyses were performed to investigate the possible associations between the PLR and disease prognosis. Results: There were 921 patients with a high PLR and 584 patients with a low PLR by use of the cutoff of 146. The patients with a high PLR had worse clinical characteristics in terms of advanced clinical stage (p<0.001) and rate of lymph node invasion (p=0.036). The Kaplan–Meier analysis showed that patients with a high PLR had significantly shorter overall survival (OS) (p<0.001) and cancer-specific survival (CSS) (p<0.001). The multivariate Cox analysis revealed that the PLR was an independent predictor for shorter OS (hazard ratio [HR], 1.345; 95% confidence interval [CI], 1.183–1.530; p<0.001) and CSS (HR, 1.318; 95% CI, 1.156–1.502; p<0.001). In the subgroup analyses, the PLR showed a significant association with survival outcomes in the subgroup with clear cell type (all p<0.05) but not in the subgroup with the non–clear cell type. Conclusions: The PLR was an independent prognostic factor for survival outcomes in patients with mRCC. However, the association was statistically significant only in patients with clear cell type mRCC.
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2021 대한비뇨기종양학회 신암연구회 Consensus Statement: 전이성 신세포암의 종양감축 신적출술
이찬호,강민용,곽철,김성한,김정권,박재영,서성일,서일영,서준교,송완,Song Cheryn,육형동,이상철,이형호,정진수,정창욱,조정기,최창일,추설호,한준현,Hwang Eu Chang,김미소,김찬(Chan Kim),최석환,홍성후 대한비뇨기종양학회 2022 대한비뇨기종양학회지 Vol.20 No.3
Purpose: The Korean Renal Cancer Study Group (KRoCS) provides consensus recommendations on the role of cytoreductive nephrectomy (CRN) in patients with metastatic renal cell carcinoma (mRCC).Materials and Methods: A group of mRCC experts from the Korean Urological Oncology Society convened at the 2021 KRoCS meeting on CRN for mRCC.Results: The consensus document was developed to address 4 questions related that were judged to be the most relevant to patient care: (1) Is there a role for CRN in patients planning targeted therapy? (2) Is there a role for CRN in patients planning immuno-oncology agents? (3) When is the optimal time of CRN in patients planning systemic treatment? (4) What is the ideal patient selection for CRN? The panelists have come up with following consensus. For mRCC patients, CRN should be considered only in those with IMDC (International Metastatic Renal Cell Carcinoma Database Consortium) favorable and intermediate risk disease, regardless of the systemic treatment plans. Timing of CRN should consider the risk group as well as the number of risk factors, but is generally recommended for after assessing the degree of response to initial systemic treatment. Patients with good performance status, limited metastatic burden on top of resectable primary tumor are candidates recommended for CRN with or without metastasectomy with priority.Conclusions: In conclusion, there is still a role for CRN in the multimodality treatment of mRCC. Careful patient selection is of paramount importance. As the treatment landscape of mRCC continues to change, the role of CRN in the current immuno-oncology era will require more exploration.
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최중원,송채린,서준교,강민용,최창일,육형동,이찬호,김정권,조정기,함원식,황의창,정창욱,고영휘,박재영,서성일,박병관,정진수,곽철,홍성후 대한비뇨기종양학회 2023 대한비뇨기종양학회지 Vol.21 No.1
Purpose: Increased abdominal imaging brought about an explosive increase in the incidental detection of small renal masses (SRMs). In the absence of optimal guidelines for health screening, as well as subsequent diagnostic and therapeutic action plans, incidentally detected SRMs may likewise increasingly become a dilemma, especially in an aging society. In the current study, we aimed to describe the current practice patterns for incidentally detected SRMs among urologic oncologists and to identify key indicators in action plans for active surveillance. Materials and Methods: A survey containing 18 questions on SRM management patterns was designed. In June 2022, an online survey was sent to all 711 active members of the Korean Urological Oncology Society via email. After response collection, a consensus meeting of the Korean Renal Cancer Study Group, which 19 specialists attended, was held to analyze the results. Results: In total, 176 responses from participants practicing in an academic setting were obtained (24.8%, 176 of 711). Regarding the age of patients with SRMs, 42.6% (n=72) responded that they would recommend diagnostic evaluation and definitive treatment for anyone under 80 years of age as long as the patient was healthy. The most commonly used target indicators for surveillance termination were a tumor growth rate above a certain velocity (57.9%, n=102) and size increase above a certain diameter (36.9%, n=65). Renal mass biopsy was recommended in very select cases (<10% of all patients) by most respondents (53.4%, n=94), followed by “not using it at all” in 25.6% (n=45). Conclusions: We described the current practice patterns for incidentally detected SRMs among urologic oncologists and identified key indicators in action plans for active surveillance. This survey provided robust information, empowering physicians with a detailed knowledge of practice patterns and valuable insights on SRMs.
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전강민(Jeon, Gangmin),이행우(Lee, Heangwoo),서장후(Seo, Janghoo),김용성(Kim, Yongseong) 한국생태환경건축학회 2016 한국생태환경건축학회 논문집 Vol.16 No.5
Purpose: As the energy consumed by buildings increases, there is a growing need for studies and technology development to address this issue. One of the solutions to excessive energy use by buildings is the light-shelf, which is a natural lighting system enabling efficient reduction in light energy, and research in this area has been intensive. However, most of the studies about the light-shelf are limited to the light environment, and thus the application of their findings to an actual environment in the form of a design may be problematic. Therefore, the purpose of the present study is to provide fundamental data for light-shelf design by carrying out a light-shelf performance evaluation on the basis of the light environment and the heating and cooling environment. Method: In the present study, a testbed was established to conduct a light-shelf performance evaluation by measuring the electric power consumption of lighting and heating and cooling devices depending on the existence of a light-shelf and its angle. Result: The findings of the present study are as follows: 1) With respect to the uniformity of the indoor light environment amenity, the optimum angle of a light-shelf was found to be 30° for the summer solstice and the winter solstice. 2) With respect to the reduction of electric power consumption by indoor lighting devices, the optimum light-shelf angle at the summer solstice is 30°, at which time electric power consumption may be reduced by 10.2% in comparison with when no light-shelf is applied. However, at the winter solstice, a light-shelf may increase the energy consumption for lighting in comparison with when no light-shelf is applied, and this should be taken into account in the design of a light-shelf. 3) In terms of reducing the electric power consumption of heating and cooling devices, the optimum angle of a light-shelf was found to be 30° for the summer solstice, while a light-shelf is inappropriate for the winter solstice since a light-shelf creates shade and thus increases the heating energy consumption. 4) To summarize the findings above, the optimum angle of a light-shelf is 30° for the summer solstice, but the installation of a light-shelf may in some circumstances increase the energy consumed by lighting devices as well as by heating and cooling devices. Therefore, more studies and technology development may need to be performed to solve the problem of increased energy consumption at the winter solstice.
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