자궁경부 질 세포검사에서 관찰되는 자궁내막세포의 의의

강미선,윤혜경,Kang, Mi-Seon,Yoon, Hye-Kyoung 대한세포병리학회 2002 대한세포병리학회지 Vol.13 No.1

The significance of endometrial cells on cervicovaginal smears is underestimated. The aim of this study is to evaluate the detection rate of endometrial cells on cervicovaginal smears. The materials consisted of two groups. Group I was 701 cervicovaginal smears from patients with no gynecological problems. Group II was 208 cervicovaginal smears from patients with abnormal uterine bleeding followed by endometrial curettage; 31 cases of endometrial adenocarclnoma(CA), 19 cases of endometrial hyperplasia(HP), 83 cases of dysfunctional uterine bleeding(DUB), and 75 cases of normal endometrium. Cervicovaginal smears were reviewed according to the criteria of The Bethesda System. Endometrial cells were identified in 15 of 701 cases(2.1%) in group I and 64 of 208 cases(30.8%) in group II. Among group II, detection rate of endometrial cells was the highest in CA (51.6%) compared to HP(26.3%), DUB(41.0%), and normal endometrium(12.0%) (p<0.05). Cytologic atypia of endometrial cells was not found In group I, but was more frequently identified in CA(87.5%) than in HP(10.5%) or DUB(14.7%) (p<0.05). Exfollatlon of endometrial cells might be related to abnormal endometrial lesion, and reporting of endometrial cells in the cervicovaginal smear may increase a chance to detect endometrial lesions especially in patients with abnormal uterine bleeding.

유방 병변 256례의 세침흡인 세포학적 진단 및 조직학적 진단과의 비교연구

강미선,정수진,윤혜경,Kang, Mi-Seon,Jung, Soo-Jin,Yoon, Hye-Kyoung 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2

Fine needle aspiration cytology of breast lesion is well known as a simple, economic and effective diagnostic modality. For the evaluation of cytohistologic correlation, 256 cases of cytologic smears and subsequent histologic sections during 2-year period from Jan. 1995 to Dec. 1996 were reviewed. 1. Fifteen cases(5.9%) were proven as insufficient for evaluation, and 13 of them were fibrocystic change histologically. One case of carcinoma exhibiting sufficient amount of aspirates with no malignant cells on smear was regarded as inadequate. 2. Cytohistologic correlation of 240 cases revealed sensitivity 87.0%, specificity 100.0%, positive predictive value 100.0%, negative predictive value 97.0%, false positive rate 0.0% and false negative rate 13.0%. Total diagnostic accuracy is 95.7%. 3. Total 6 cases of negative were due to small amount of aspirates containing scantiness of malignant cells in two and underestimation in four. 4. Diagnostic concordance rates of fibrocystic change and fibroadenoma were 95.5% and 80.0%, respectively. Diagnostic discrepancies were noted in 7 cases of fibrocystic change and 6 cases of fibroadenoma, however, cytologic discrimination of two entities was not easy in seven of them. 5. In a case of phyllodes tumor and a case of duct ectasia, the discrepancy was due to targeting error. Other three cases(lymphoma, adenomyoepithelioma and granulomatous mastitis) were misinterpreted because of poor acquaintance with those entities. Diagnostic accuracy of fine needle aspiration cytology of breast lesions are relatively high. However, good technique on aspiration and adequate interpretation are necessary to reduce the false negative rate and the discrepancy between cytologic and histologic diagnoses.

김치에서 분리한 유산균 Lactobacillus plantarum의 이화학적 특성 및 ${\beta}-galactosidase$ 활성

강미선,이영환,Kang, Mi-Seon,Rhee, Young-Hwan 한국응용생명화학회 1996 Applied Biological Chemistry (Appl Biol Chem) Vol.39 No.1

김치에서 분리한 유산균 중에서 Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli(ATCC33694) 그리고 Bacillus substilis(ATCC 6633) 등 5종의 미생물에 대한 항균성이 우수한 3주(No. 49, No. 61, No. 75)를 최종 선발하여 동정한 결과 Lactobacillus plantarum으로 동정 되었다. 이들 3 균주를 starter로 사용하여 요구르트 등 여러 발효식품에 응용할 수 있는지 검토하기 위하여, 이들 균주로 요구르트를 제조한 후 요구르트의 ${\beta}-galactosidase$ 활성도를 균주 첨가 후 24시간 부터 72시간 동안 경시적으로 조사하였다. 그 결과 48시간 후에 효소활성은 최고에 도달하였으며 그 후 시간이 경과함에 따라 감소하였다. 또한 2시간 동안 경시적으로 요구르트 고유의 pH값보다 낮은 산성조건에서 ${\beta}-galactosidase$ 활성도와 생존율을 측정한 결과 pH 3.5에서 2시간 후에는 3균주 모두 50% 정도 활성이 감소하였으나 pH 2.5와 pH 1.5에서 ${\beta}-galactosidase$ 활성은 거의 없었다. 유산균의 생존율은 pH 3.5에서 2시간 후 거의 변화가 없었고, pH 2.5에서는 각각 $0.12%{\sim}0.75%$ 그리고 pH 1.5에서는 생존율이 거의 없었다. 한편, 제조 요구르트의 이화학적 성질을 조사한 결과 요구르트 고유의 pH 값은 4.08 부터 4.30사이이었으며, 적정산도는 $1.05{\sim}l.25%$ 점도는 $1,818{\sim}2,124\;cps$, 생균수는 $7.3{\times}10^8{\sim}3.0{\times}10^9\;cfu/m{\ell}$였다. 유산균이 살아있는 상태로 장내에 도달할 수 있는지의 여부를 간접적으로 나타내는 완충능을 측정하기 위하여 1.0N HCl로 요구르트 $100\;m{\ell}$를 고유의 pH값에서 2단위 낮은 pH값까지 적정한 결과 소모된 HCl량은 $11.98{\sim}13.02\;m{\ell}$이었고 1.0 N NaOH로 4단위 높은 pH값까지 적정하는데 소모된 NaOH량은 $10.82{\sim}12.86\;m{\ell}$로 시판 요구르트 보다 높은 완충능을 보여 주었다. Three strains of inhibitory lactic acid bacteria (No. 49, No. 61, No. 75) against Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escheirchia coli(ATCC33694) and Bacillus subtilis(ATCC6633) were isolated from kimchi, and then, identified to be Lactobacillus plantarum after examinations of their biological and physiological characteristics. To investigate a possible application of these three lactobacilli in milk fermentation industry, we made yogurts and then evaluated their ${\beta}-galactosidase$ activities at various; incubation time(from 24 hrs to 72 hrs). The result of experiment was that ${\beta}-galactosidase$ activities were reached maximum at 48 hrs and that reduced gradually with the lapse of time. And the ${\beta}-galactosidase$ activity of lactobacilli, and their viable cell counts at $37^{\circ}C$ for 2 hrs under various pH conditions were investigated. ${\beta}-galactosidase$ activities of 3 strains were reduced 50% at pH 3.5, but there were no remaining activities at pH 2.5, and pH 1.5, respectively. The frequency of the survival cell of lactobacilli in yogurt were $0.12{\sim}0.75%$ at pH 2.5, $$6.3{\times}10^{-5}{\sim}2.7{\times}10^{-3}% at pH 1.5, respectively, but there was no significant difference at pH 3.5. The values of original pH, titratable acidity as lactic acid, viscosity, and viable cells of yogurts were $4.08{\sim}4.30,\;1.05{\sim}1.25%,\;1,818{\sim}2,124\;cps\;and\;7.3{\times}10^8{\sim}3.0{\times}10^9\;cfu/m{\ell}$, respectively. To estimate buffer capacity of yogurt, the volume of 1.0 N HCl to 2 unit below original pH of yogurt($100\;m{\ell}$) was $11.98{\sim}13.02\;m{\ell}$ and the volume of 1.0N NaOH to 4 unit above original pH of yogurt($100\;m{\ell}$) was $10.82{\sim}12.86\;m{\ell}.

어린잎채소의 생산·가공 공정 중 미생물 오염도 분석 및 총균수 예측모델 개발

강미선,김현정,Kang, Mi Seon,Kim, Hyun Jung 한국급식외식위생학회 2021 급식외식위생학회지 Vol.2 No.2

This study was performed to assess the microbiological quality and safety of microgreen sampled from harvesting farms and food processing plant in Korea. The samples were analyzed for total viable counts, coliforms, Enterobacteriaceae, Escherichia coli, Salmonella spp., Listeria monocytogenes, Vibrio parahaemolyticus, Bacillus cereus, and Staphylococcus aureus. Total viable counts were highly contaminated in samples collected from farms (7.7~8.2 log CFU/g) and the final products (5.8~7.8 log CFU/g), respectively. B. cereus was detected less than 100 CFU/g, which was satisfied with Korean standards (<1,000 CFU/g) of fresh-cut produce. A predictive model was developed for the changes of total viable counts in microgreens during storage at 5~35℃. The predictive models were developed using the Baranyi model for the primary model and the square root model for the secondary model. The results obtained in this study can be useful to develop the safety management options along the food chain, including fresh-cut produce storage and distribution.

변형광고의 유형별 주목효과

강미선(Mi-Seon Kang),정만수(Man-Soo Chung),박현수(Hyun-Soo Park) 한국언론학회 2004 한국언론학보 Vol.48 No.4

MANET 환경에서 노드의 이동성을 인지하는 하이브리드 라우팅 방안

강미선(Mi-Seon Kang),금동원(Dong-Won Kum),조유제(You-Ze Cho) 한국정보과학회 2013 정보과학회논문지 : 정보통신 Vol.40 No.2

이동 애드혹 네트워크(MANET: Mobile Ad hoc Network)는 별도의 인프라 없이 다수의 노드들이 무선통신을 이용하여 데이터를 전달하는 차세대 무선 네트워킹 기술이다. 일반적으로 망 토폴로지의 변화가 작은 환경에는 proactive 라우팅 방식이 적합하고, 노드의 이동에 따른 망 토폴로지의 변화가 큰 환경에는 reactive 라우팅 방식이 적합하다. 그러나 이동 애드혹 네트워크의 많은 응용분야에서 이동 노드들은 항상 움직이는 게 아니라, 이동 후 일정한 지역 내에 오랫동안 머물렀다가 다시 이동하는 패턴을 보인다. 따라서 본 논문에서는 노드의 이동성을 고려하는 reactive와 proactive 방식을 혼합한 새로운 hybrid 라우팅 방안(MAHR: Mobility-Aware Hybrid Routing)을 제안한다. 제안 방안은 기본적으로 reactive 라우팅 방식을 사용하며 이웃 노드 수의 변화율을 기반으로 core node를 선정한다. 선정된 core node는 자신의 라우팅 테이블을 proactive 하게 유지한다. 제안 방안의 성능 분석은 random way point와 Levy walk 이동성 모델을 기반으로 ns-2 시뮬레이션을 통해 기존 방안에 비해 패킷 전달률과 라우팅 오버헤드에서 우수함을 보였다. Mobile Ad-hoc Networks (MANETs) are self-configuring networks of mobile nodes connected by wireless links that form an arbitrary topology. In general, proactive routing is more suitable for a stationary network, while reactive routing is better for a mobile network with a high mobility. In many applications, a node in a MANET is mobile, yet it can also fluctuate between being mobile and being stationary. In this paper, we propose a Mobility Aware Hybrid Routing (MAHR) approach for MANETs, which varies its routing between reactive and proactive approaches to adapt to node mobility. This scheme selects core nodes using a changing ratio of the number of neighbor nodes by considering node mobility. This paper evaluates the performance of the proposed scheme using the random way point model and Levy walk model by the ns-2 simulation. Simulation results show that the proposed routing protocol outperformed existing routing protocols in terms of packet delivery ratio and relative routing overhead.

노드 이동성 모델에 따른 AODV와 OLSR 라우팅 프로토콜의 성능 분석

강미선(Mi-Seon Kang),금동원(Dong-Won Kum),조유제(You-Ze Cho) 한국통신학회 2011 韓國通信學會論文誌 Vol.36 No.7

가족개념의 대안에 기반한 주거정책의 거시적 방향 제안

강미선(Kang Mi-Seon),장미현(Jang Mi-Hyun) 대한건축학회 2009 대한건축학회논문집 Vol.25 No.8

The ideology based on a nuclear family in industrial society has been organized in social systems. It has brought the separation between work and family life, and between public and private spheres, and been reflected in residential areas and urban spaces. Families has changed remarkably for the last 30 years. In the face of the care deficit, the modern model of a nuclear family with a male provider is of no use anymore. It should be made an alternative to the concept of a family; the recognition of family diversity, the incorporation of work, family life, and a community, and the socialization of care work. But current residential policies and the development plans of residential areas are incongruent and insufficient to overcome a care crisis. Based on the alternative, this study proposes the orientation of residential policies as the physical foundation for the public care responsibility and the incorporation of work, family life with a community as a unit. It includes a discussion on the relation between residents and local communities as well as between a resident and housing. These features are as follows: 1) the supply of a diversity of housing for the various needs of families, 2) the connection with human resources of a community, a industry, a country, and so on, 3) the supply of the public service system connected with medical treatment, public welfare, health, education, employment, urban planning, and etc., and 4) the operation by the participate of residents and residents groups based on a local community and the support of a country.

노드 이동성 모델에 따른 AODV 라우팅 프로토콜 성능 분석

강미선(Mi-Seon Kang),금동원(Dong-Won Kum),박진수(Jin-Su Park),조유제(You-Ze Cho) 한국통신학회 2010 한국통신학회 학술대회논문집 Vol.2010 No.11

기사체광고의 실태와 개선방안

강미선(Kang Mi Seon) 한국광고홍보학회 2003 한국광고홍보학보 Vol.5 No.1