Treadmill 최대 운동시 Impedance 심장기록법의 개선에 의한 마라톤 선수의 심박출량과 산소소비량과의 관계

강두희,황수관,연동수,유선희,김덕원,Kang, Doo-Hee,Hwang, Soo-Kwan,Yeon, Dong-Soo,Yuh, Seon-Hee,Kim, Deok-Won 대한생리학회 1990 대한생리학회지 Vol.24 No.2

Maximal cardiac output and oxygen uptake $(VO_{2max})$ were measured during treadmill exercise for seven top-class marathoners and nine non-athletes using impedance cardiograph developed by one of the authors (DW Kim). Results of this study are summarized as belows. 1) New shoes with sponge and silicon rubber attached to the soles were developed to reduce motion artifact during treadmill exercise. Ensemble everaging techneque with the developed shoes was also used to improve the measurement of stroke volume using impedance cardiography. 2) Maximal cardiac output of the athletes, 14.98 L/min, was significantly higher than that of the non-athletes, 13.46 L/min. As maximal heart rate of the marathoners is lower than that of non-athletes, stroke volume of the former is significantly larger than that of the latter. 3) $VO_{2max}$ of the marathoners, 59.38 ml/kg/min, was higher than that of the non-athletes, 40.22 ml/kg/min. At the anaerobic threshold. $VO_{2max}$ of the former was 62.3% of $VO_{2max}$ and this was significantly higher than that of the non-athletes, 57.2%, This results indicates that the marathoners have higher aerobic capacity than the non-athletes. 4) The marathoners showed larger $VO_2$ than the non-athletes at the same cardiac output, indicating that a-v $O_2$ of the former is higher than that of the latter. 5) Maximal systolic pressure of the marathoners was higher than that of the non-athletes, and so was maximal rate-pressure products. These results indicate that heart oxygen consumption rate $(hVO_2)$ of the marathoner is higher than that of the non-athletes is mainly due to higher stroke volume. And higher oxygen consumption of the marathoners is due to higher stroke volume. And higher oxygen consumption of the marathoners is due to their larger a-v $O_2$. The marathoners show both higher threshold and $VO_{2max}$. Especially, measurement of cardiac output during treadmill exercise by improved impedance cardiography is expected to contribute in study of cardiac function of athletes.

심장기능에서 Ca^(++)의 역할 : Role of Ca^(++) in cardiac function

강두희 연세대학교 의과대학 1987 연세의대논문집 Vol.20 No.1

심근에 작용하는 수종 약물이 쥐의 심근의 'Regenerative $Ca^{++}$ Release'에 미치는 영향

강두희,이중우,Kang, Doo-Hee,Lee, Joong-Woo 대한생리학회 1977 대한생리학회지 Vol.11 No.2

The present experiment was conducted to see whether or not several cardioactive agents influence the 'regenerative $Ca^{++}$ release' in the mechanically disrupted cardiac cells. The mechanically disrupted cardiac cells were prepared by the method of Kerrick and Best from the ventricle of rat. The tension development of the disrupted cardiac cells was measured with a mechanoelectric transducer (RCA 5734). The results were summarized as follows 1) 2 mM caffeine enhanced the regenerative $Ca^{++}$ release, whereas 2 mM Procaine inhibited the $Ca^{++}$ release as reported by other investigators. 2) Epinephrine at concentrations of $10^{-7},\;10^{-6}\;and\;10^{-5}M$ increased the regenerative $Ca^{++}$ release significantly but showed a poor dose response on the $Ca^{++}$ release. 3) Propranolol showed no effect on the regenerative $Ca^{++}$ release when studied alone. Furthermore, it showed no antagonistic effect on an increased regenerative $Ca^{++}$ release induced by epinephrine. 4) Other cardioactive agents such as acetylcholine, ouabain, isoproterenol and c-AMP at concentrations of $10^{-6}M$ showed no effect on the regenerative $Ca^{++}$ release. From the above results, it may be concluded that the cardioactive actions of these agents are not related directly to the process of regenerative $Ca^{++}$ release.

한국 해녀에서 잠수복 착용이 작업시간 및 열대사에 미치는 영향

강두희,강복순,이중우,김희중,Kang, Doo-Hee,Kang, Bok-Soon,Lee, Joong-Woo,Kim, Hee-Joong 대한생리학회 1976 대한생리학회지 Vol.10 No.1

Rectal temperature, skin temperature and oxygen consumption were measured in five women divers during diving under two conditions a) wearing a cotton bathing suit and b) wearing a diving suit and the following results were obtained. 1. The duration of the diving period was 30 min with the cotton bathing suit whereas it was above 120 min with the diving suit. 2. The average rectal temperature fell to $34.5^{\circ}C$ after 30 min of diving with the cotton bathing suit. On the other hand, with the diving suit, immediately after submersion, the rectal temperature rose about $3^{\circ}C$ and remained at about $39^{\circ}C$ throughout the diving period of 120 min. 3. Average mean skin temperature during diving was $11^{\circ}C$ and $21^{\circ}C$ with cotton bathing suit and with the diving suit, respectively. The mean body temperature fell to $25^{\circ}C$ with the cotton bathing suit while it reached $32^{\circ}C$ with the diving suit at the end of each diving period. 4. Oxygen consumption during diving was three fold of the pre-dive level with the cotton bathing suit but it was two fold with the diving suit. 5. Total extra heat loss was 323 kcal during 120 min of diving with the diving suit. On the contrary, with the cotton bathing suit, it was 528 kcal for 30 min, These results may suggest that the prolongation of the diving period with the diving suit is primarily due to maintenance of core temperature at more or less physiological level as a result of reduction in conductive heat loss from the body surface to the water and the Preferential distribution of blood in the core area.

담낭내 담즙의 농축 및 산성화기전에 관한 연구

강두희 ( Doo Hee Kang ) 대한내과학회 1963 대한내과학회지 Vol.6 No.10

심근에 작용하는 수종 약물이 쥐의 심근의 Regenerative Ca⁺⁺ Release 에 미치는 영향

강두희(Kang, Doo-Hee),이중우(Lee, Joong-Woo) 대한생리학회 1977 대한생리학회지 Vol.11 No.2

The present experiment was conducted to see whether or not several cardioactive agents influence the regenerative Ca⁺⁺ release in the mechanically disrupted cardiac cells. The mechanically disrupted cardiac cells were prepared by the method of Kerrick and Best from the ventricle of rat. The tension development of the disrupted cardiac cells was measured with a mechanoelectric transducer (RCA 5734). The results were summarized as follows 1) 2 mM caffeine enhanced the regenerative Ca⁺⁺ release, whereas 2 mM Procaine inhibited the Ca⁺⁺ release as reported by other investigators. 2) Epinephrine at concentrations of 10^-7, 10^-6 and 10^-5M increased the regenerative Ca⁺⁺ release significantly but showed a poor dose response on the Ca⁺⁺ release. 3) Propranolol showed no effect on the regenerative Ca⁺⁺ release when studied alone. Furthermore, it showed no antagonistic effect on an increased regenerative Ca⁺⁺ release induced by epinephrine. 4) Other cardioactive agents such as acetylcholine, ouabain, isoproterenol and c-AMP at concentrations of 10^-6M showed no effect on the regenerative Ca⁺⁺ release. From the above results, it may be concluded that the cardioactive actions of these agents are not related directly to the process of regenerative Ca⁺⁺ release.

근육 생리

연동수,강두희 대한스포츠의학회 1989 대한스포츠의학회지 Vol.7 No.2

동면에 관한 연구 - 혈중 Insulin 농도의 변화 -

강복순,강두희,Kang, Bok-Soon,Kang, Doo-Hee 대한생리학회 1972 대한생리학회지 Vol.6 No.1

Physiological changes in hibernating animals (Manchurian Chipmunk and Hamster) were studied during various phases of the hibernation. The results obtained are summarized as follows. 1. Rectal temperature was declined markedly during hibernation, whereas it remained constant even in exposure of the animals to 0 C environment if the animals were not prepared for hibernation. As body temperature was lowered, heart rate was also markedly reduced as well as respiration and blood pressure. 2. The electrical activity recorded from cortical structure was characterized by replacement of fast wave activity by slow wave activity as body temperature was lowered and became flat at body temperature below 20C. 3. Blood glucose level showed no clear seasonal variations. However, the glycogen contents of the liver were markedly greater during the cold seasons than during the warm seasons. 4. Blood levels of insulin showed no clear seasonal variations.

Myosin ATPase의 조직화학적 염색에 영향을 미치는 인자들

김현만,강두희 연세대학교 의과대학 1982 연세의대논문집 Vol.15 No.1

겨울철 개구리 (Rana temporaria)의 $Na^{+}$이온 대사

이중우,강두희,Lee, Joong-Woo,Kang, Doo-Hee 대한생리학회 1973 대한생리학회지 Vol.7 No.1

$Na^{+}$ balance was studied in Rana temporaria, which hibenates in fresh water in the winter time. $Na^{+}$ uptake rate, skin $Na^{+}$ loss rate, urinary $Na^{+}$ loss rate and $Na^{+}-K^{+}$ adenosine triphosphatase(ATPase) were measured at two different temperatures $1{\sim}2^{\circ}C\;and\;20{\sim}24^{\circ}C$ respectively. The results obtained were as follows: 1. $Na^{+}$ uptake rates in the frog in an artificial Pond water (APW) were found to be $8.28{\pm}0.73\;and\;2.19{\pm}0.37\;{\mu}Eq/g/day\;at\;20{\sim}24^{\circ}C\;and\;1.0{\sim}2.5^{\circ}$ respectively. 2. $Na^{+}$ loss rate through the frog skin to APW were found to be $4.26{\pm}0.72\;and\;0.93{\pm}0.21\;{\mu}Eq/g/day$ at the same temperatures. 3. Mean rates of urinary $Na^{+}$ loss at $20{\sim}24^{\circ}C\;and\;3{\sim}4^{\circ}C$ were found to be $3.02{\pm}0.73\;and\;0.78{\pm}0.13\;{\mu}Eq/g/day$ respectively. 4. The activities of $Na^{+}-K^{+}$ activated ATPase of frog skin fragments were found to be $258{\pm}39.4\;and\;49.6{\pm}7.1\;{\mu}M\;Pi/g$ protein/hr at $24^{\circ}C\;and\;2^{\circ}C$ respectively. From the above results, it may be concluded that frogs can take up enough $Na^{+}$ through the skin from APW exceeding skin loss Plus urinary loss at $1{\sim}2^{\circ}C$. It is suggested that $Na^{+}$ transport across frog skin is closely related with $Na^+-K^+$ ATPase since $Q_{10}\;of\;Na^{+}$ uptake is much similar to that of the activities of $Na^{+}-K^{+}$ ATPase.