Drug-Release Performance of Acrylic Hydrogel Membranes Synthesized Using a Novel Cross-linker

Dong-Yoon Kang(강동윤),Gi-Wan Kwon(권기완),Kyung-Hye Jung(정경혜),Sung-Ho An(안성호),Inn-Kyu Kang(강인규) 한국고분자학회 2016 폴리머 Vol.40 No.4

하이드로젤 콘택트렌즈는 약물 충전과 방출을 조절할 수 있는 형태이기에 안과 약물 전달 점안액의 대체재로 도입되었다. 이 논문에서는 polypropylene 몰드 안에서 새로운 가교제인 ethylaluminium diacrylate(EADA)와 methyl methacrylate(MMA), 2-hydroxyethyl methacrylate(HEMA), N-vinyl pyrrolidone(NVP)의 공중합을 통해 아크릴 하이드로젤 막을 제조하였다. 그리고 하이드로젤 막의 팽윤 거동과 기계적 물성을 조사하였다. 약물 방출 성능은 친수성약물 timolol maleate와 사이크로덱스트린으로 포접한 소수성 약물인 α-tocopherol로 평가하였다. 또한 비교를 위하여 기존의 가교제인 ethylene glycol dimethacrylate(EGDMA)를 사용한 하이드로젤을 제조하였다. 실험결과 EADA 가교제로 제조한 하이드로젤 막의 인장강도(0.168 MPa)는 EGDMA로 제조한 하이드로젤 막의 인장강도(0.136 MPa) 보다 훨씬 향상되었다. 0.1mol% EADA로 가교시켜 만든 하이드로젤 막은 30시간 후 66%의 α-tocopherol 약물방출을 나타낸 반면 0.1 mol% EGDMA로 가교시켜 만든 하이드로젤 막은 동일한 시간 동안에 42%의 약물방출을 나타내었다. 한편, 2일간의 섬유아세포 배양실험에서 EADA를 함유하는 하이드로젤 막은 EGDMA를 함유하는 하이드로젤 막보다 훨씬 우수한 생리활성을 나타내었다. Hydrogel soft contact lenses have been introduced as alternatives to eye drops for ophthalmic drug delivery, because of their controllable drug loading and release behavior. In this study, acrylic hydrogel membranes were prepared by copolymerization of the novel cross-linker, ethylaluminium diacrylate (EADA), with methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (HEMA), and N-vinylpyrrolidone (NVP) in a polypropylene mold. The swelling behavior and mechanical properties of hydrogels containing the newly designed cross-linker were then investigated. Drug release performance was evaluated using a hydrophilic drug, timolol maleate, and a cyclodextrin inclusion complex of the hydrophobic drug, α-tocopherol. For comparison, hydrogels were also prepared using a conventional cross-linker, ethylene glycol dimethacrylate (EGDMA). As the results, tensile strength of the hydrogel membranes using EADA (0.168 MPa) was significantly improved compared to that of the hydrogels made with EGDMA (0.136 MPa). The hydrogel membrane cross-linked with 0.1 mol% EADA showed 66% α-tocopherol release after 30 h while the hydrogel membrane crosslinked with 0.1 mol% EGDMA showed 42% α-tocopherol release. After 2 days of incubation, human fibroblasts on the hydrogel membrane containing EADA showed significantly greater viability than those on EGDMA-containing hydrogel.

經穴歌賦 중 分寸歌에 대한 연구

Kang Dong-yoon(姜棟允),Jo Hak-jun(趙學俊) 대한한의학원전학회 2009 대한한의학원전학회지 Vol.22 No.3

After having comparison, the Bunchon-ga in nine books -『Chimguchwiyeong(鍼灸聚英)』, 『Nengmunjeonsudong-injihyeol(凌門傳授銅人指穴)』, 『Chimgumundae(針灸問對)』, 『Gyeongrakgo(經絡考)』, 『Gyeongrakhoepyeon(經絡匯編)』, 『Geumchimbijeon(金針秘傳)』, 『Jagusimbeop-yogyeol(刺灸心法要訣)』, 『Chimgubongwon(鍼灸逢源)』 『Chimgusinseo(鍼灸神書)』, and invested the difference based on 『Chimguhak(鍼灸學)』, 『WHO standard acupuncture point location 』 I got some conclusion like below. Two kinds of Bunchon-ga are similar in 『Chimguchwiyeong』, 『Nengmunjeonsudong-injihyeol』, and also in 『Gyeongrakgo(經絡考)』, 『Gyeongrakhoepyeon(經絡匯編)』, and 『Geumchimbijeon(金針秘傳)』 Bunchon-ga of twelve meridian is different from their order - Stomach meridian(胃經), Bladder meridian(膀胱經), Kidney meridian(腎經), Triple Energizer meridian(三焦經), and Gallbladder meridian(膽經). In nine kinds of Bunchon-ga, missing acupuncture points(漏落穴) are generally located on the first line of Bladder meridian(膀胱經) - from Daejeo(大杼) to Baekhwansu(白環兪), and Pungsi(風市), Haegye(解谿), Yangsi(羊矢), Geummaek(急脈) are not appeared in them, Hyeopdang(脇堂), Michung(眉衝), Yanghyeol(陽穴) are recorded. There are some parts adapted different way of proportional bone chon - from Yanggok(陽谿) to Gokji(曲池) in Large Intestine meridian[大腸經], from Sanggu(商丘) to Umreungcheon(陰陵泉) in Spleen meridian[脾經], and from Oegwan(外關) to Sadok(四瀆) in Triple Energizer meridian[三焦經]. The acupuncture points explained by structure, there are many different finger chons between some books. Bunchon on breast and abdomen, is generally explained by vertical, horizontal finger chon based on Governor vessel[任脈], vertical explanations of each book have little difference opinions, but horizontal have many. Especially, the locations of Eunmum(殷門), Bukeuk(浮郄) and Wiyang(委陽) are extremely different from 『Chimguhak(鍼灸學)』, and 『WHO standard acupuncture point locations』.

가상·증강 현실을 이용한 원전 작업에서의 활용 방안

강동윤(Dong-Yoon Kang),김성현(Sung-Hyun Kim),김희철(Hee-Cheol Kim) 한국정보통신학회 2022 한국정보통신학회 종합학술대회 논문집 Vol.26 No.1

e-Nego 시스템 구축에 따른 전자선화증권 활성화에 관한 일고찰

강동윤(Dong-Yoon Kang),함영진(Young-Jin Ham),박종돈(Chong-Don Park) 중앙대학교 한국전자무역연구소 2011 전자무역연구 Vol.9 No.3

본 논문은 국내 e-Nego 시스템의 상용화를 위해서는 전자선화증권의 활성화 역시 필수적으로 구현되어야 한다는 전제하에 기존의 전자선화증권 운영방식의 비교를 통해 활성화의 장애요인을 알아봄으로써 전자선화증권의 활성화 방안을 도출하는데 그 목적이 있다. 전자선화증권이 활성화되기 위해서는 첫째로 유통성의 확보가 최우선적으로 해결되어야 할 것이며, 둘째는 국내ㆍ외 인프라 확충이 필요하다는 것이다. 셋째는 전자선화증권에 대한 홍보활동 강화 및 전자선화증권 서비스 요금의 현실화가 필요하다. 본 논문은 주로 문헌연구에 치중함으로써 실증적인 분석이 미흡하여 구체적이고 심층적인 연구를 수행하지 못한 한계를 가지고 있다. 향후 e-Nego 시스템의 상용화와 관련한 전자선화증권에 대한 실증분석을 할 필요가 있다. This study aims to derive the way to reinvigorate electronic bill of lading by discussing the problems in reinvigoration by discussing the problems in existing system of electronic bill of lading under the assumption that commercialization of e-Nego system is mandatory for reinvigoration of electronic bill of lading. For the reinvigoration of electronic bill of lading, the first step will be the securement of negotiability, then the second will be the securement of domestic and foreign infrastructure. Third, there should be a greater effort for promotion of electronic bill of landing and setting up realistic service fee. However, this study still has a limitation in that it has insufficiency in empirical study and more detailed research in electronic bill of lading. In further researches, there is a necessity for more detailed empirical study on commercialization of e-Nego system.

전자의무기록을 이용한 DRESS (drug reaction with eosinophilia and systemic symptoms) 증후군 탐색

강동윤 ( Dong Yoon Kang ),장동연 ( Dong Yeon Jang ),손경희 ( Kyung Hee Sohn ),강성윤 ( Sung Yoon Kang ),김주영 ( Ju Young Kim ),조상헌 ( Sang-heon Cho ),강혜련 ( Hye-ryun Kang ) 대한천식알레르기학회(구 대한알레르기학회) 2018 Allergy Asthma & Respiratory Disease Vol.6 No.3

Purpose: Since drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is very rare and difficult to diagnose, its exact epidemiology is still unknown. If screening tools based on laboratory results or electronic medical records are available, the occurrence of DRESS syndrome can be monitored in real time. Methods: To screen cases with DRESS syndrome, all the results of both eosinophil and alanine transaminase (ALT) level from July 2014 to June 2015 were analyzed by 36 searching conditions for the signal detection of 7 definite DRESS cases among 199,924 patients during the study period. Those searching conditions were diverse combinations of different cutoff levels of eosinophil and ALT with or without nursing records presenting skin symptoms. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value were calculated for individual searching conditions. Results: As cutoff levels of eosinophil and ALT for screening DRESS increased from 3% to 5% and 40 U/L to 300 U/L, respectively, the sensitivity decreased from 100% to 42.9% and the PPV increased from 0.06% to 13.0%. A combination of eosinophil >10% and ALT >300 U/L which had the highest PPV among 36 search conditions could detect DRESS syndrome by sensitivity 42.9% and PPV 13.0%. When nursing records for skin symptoms were added, PPV was augmented to 21.4%. Conclusion: A combination of eosinophil and ALT levels is a useful search condition for the screening of DRESS syndrome. Nursing records can provide an additional increment in PPV. (Allergy Asthma Respir Dis 2018;6:149-154)

에페리손에 의한 즉시형 과민반응 증례 보고

강동윤 ( Dong Yoon Kang ),이진 ( Jin Lee ),손경희 ( Kyoung-hee Sohn ),강성윤 ( Sung Yoon Kang ),조윤숙 ( Yoon Sook Cho ),강혜련 ( Hye-ryun Kang ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.4

Eperisone is a widely used muscle relaxant and believed to be relatively free of adverse drug reactions. However, a rare case of fatal anaphylaxis has been reported in the literature. Poor awareness due to its rarity and combined administration with other drugs are the major hurdles in diagnosing eperisone-induced anaphylaxis. We experienced 3 cases of immediate hypersensitivity reaction occurring after eperisone administration. Case 1, a 63-year-old female, was admitted via the Emergency Department with urticaria, generalized erythroderma, sore throat, chest discomfort, and dyspnea within 1 hour after administration of common cold remedy. Case 2, a 58-year-old male, visited our allergy clinic to detect culprit drugs. He experienced itching, urticaria, hypotension for several hours after administration of the pills for back pain in the last 3 years. Case 3, a 58-year-old male developed urticaria and dyspnea after administration of medication for a headache. He also experienced urticaria and facial edema after administration of the common cold remedy. Among the medications, eperisone hydrochloride was proven as the culprit drug and others were excluded through oral provocation tests. We advised them to avoid eperisone and issued drug safety card. Clinicians should be aware that eperisone hydrochloride is a potential culprit agent of fatal anaphylaxis. (Allergy Asthma Respir Dis 2017;5:228-231)

Consideration on How to Vitalize Export through the Sixth Industrialization of the Special Zone for Excellent Native Land Resources

Dong-yoon Kang(강동윤),Cha-young Yun(윤차영) 한국국제상학회 2018 國際商學 Vol.33 No.4

Ⅰ. 서론 Ⅱ. 지역특구의 개요 및 선행연구 검토 Ⅲ. 우수 향토자원 지역특구의 특성 분석 Ⅳ. 우수 향토자원특구의 수출활성화 방안 Ⅴ. 결론 참고문헌 본 연구는 우수 향토자원 지역특구의 특성을 6차산업화와 연계하여 분석함으로써 수출활성화 방안을 제시하는데 있다. 우수 향토자원 지역특구는 대부분 사업주체가 지방자치단체장이며 2차 산업을 중심으로 1ㆍ3차 산업을 견인하는 가공중심형의 지역특구라는 특성을 보인다. 즉, 내수시장 중심의 지역적 한계를 벋어나지 못하고 있는 상황이다. 그러므로 유통 및 수출산업이 중심이 되는 6차산업화 구조로의 변화가 필요한 것이다. 우수 향토자원 지역특구의 수출활성화를 위해서는 지방자치단체, 지역민간기업 및 지역연구기관의 협업이 필수적이다. 따라서 다음과 같은 협업방향을 제안한다. 첫째, 지방자치단체와 민간기업의 합작회사를 통한 내수시장 유통활성화 및 수출판로 개척이 필요하다. 둘째, 해외시장 개척을 위해 지역 내 생산자를 통합하는 규모의 경제 실현이 필요하다. 셋째, 지역특구 상품의 글로벌 마케팅방안이 모색되어야 한다. 넷째, 지역연구기관의 상품개발을 위한 전문인력 양성이 필요하다.

시계열 DB를 이용한 생체신호 데이터 수집 및 모니터링 시스템

강동윤(Dong-Yoon Kang),주문일(Moon-Il Joo),Ali Hussain,김희철(Hee-Cheol Kim) 한국정보통신학회 2021 한국정보통신학회 종합학술대회 논문집 Vol.25 No.2

최근 건강에 대한 관심이 증가하며 다양한 생체정보를 수집할 수 있는 웨어러블 시장이 확대되고 있다. 또한 이러한 생체신호를 통한 원격의료와 헬스케어 서비스가 보편화될 것으로 예상된다. 본 논문에서는 IoT 장비를 통해 수집한 생체신호를 데이터베이스에 저장 및 웹을 통해 실시간 모니터링이 가능한 서비스를 소개한다. 생체 데이터의 수집 및 저장과 실시간 모니터링을 시스템을 구현함으로 다양한 건강관리 진단에 활용될 수 있다. Recently, as interest in health increases, the wearable market that can collect various biometric information is expanding. In addition, telemedicine and healthcare services through these bio-signals are expected to become common. In this paper, we introduce a service that can store bio-signals collected through IoT equipment in a database and monitor them in real time through the web. By implementing a system for collecting and storing biometric data and real-time monitoring, it can be utilized for various health management diagnosis.

논문(論文) : 경맥(經脈)과 락맥(絡脈)의 순행(循行) 양식(樣式)과 영(營),위기(衛氣)의 운행(運行) 특징(特徵)의 상관성(相關性)에 대한 고찰(考察)

강동윤 ( Dong Yoon Kang ),조학준 ( Hak Jun Jo ) 대한한의학원전학회 ( 구 대한원전의사학회 ) 2006 대한한의학원전학회지 Vol.19 No.2

1차 및 2차 항결핵제에 의한 DRESS (drug reaction with eosinophilia and systemic symptom) 증후군 1예와 문헌 고찰

황영훈 ( Young-hoon Hwang ),장동연 ( Dong Yeon Jang ),강성윤 ( Sung Yoon Kang ),손경희 ( Kyung-hee Sohn ),강동윤 ( Dong Yoon Kang ),이창훈 ( Chang Hoon Lee ),강혜련 ( Hye-ryun Kang ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.2

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially fatal drug-induced systemic hypersensitivity response characterized by erythematous eruption, fever, leukocytosis with eosinophilia, and internal organ involvement. Antitubercular agents are potential causative agents for DRESS syndrome but difficult to verify as a culprit drug, since antitubercular agents are coadministered as a combination regimen. A 42-year-old female with endobronchial tuberculosis was diagnosed with DRESS syndrome after 4-week treatment of isoniazid, rifampicin, ethambutol, and pyrazinamide with prednisolone 50 mg. All the antitubercular agents were stopped and replaced with levofloxacin, cycloserine, p-aminosalicylic acid, and kanamycin. However, severe exacerbation of DRESS syndrome compelled the patient to discontinue the administration of the second-line antitubercular agents. Two months later, the patient underwent a patch test for all the antitubercular agents which had been used, and the results showed positivity to isoniazid and cycloserine. We report a rare case of DRESS syndrome that reacted to cycloserine as well as isoniazid. Development of coreactivity to other drugs should be differentiated with a flare-up reaction in the management of DRESS syndrome. (Allergy Asthma Respir Dis 2017:5:111-116)