http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
인삼분의 비율별 첨가급식이 백서의 성장 및 수종 장기중 지질함량에 미치는 영향
황우익,김성미,Hwang, Woo-Ik,Kim, Sung-Mee 생화학분자생물학회 1978 한국생화학회지 Vol.11 No.4
인삼분의 비율별 첨가급식에 의한 동물의 성장 및 체성분 변동에 미치는 영향을 관찰하고자 이유직후의 체중이 94내지 100g 범위의 웅성 백서 50마리를 대상으로 하여 5종의 식이군으로 나누어 30일간 사육하연서 관찰 하였다. 식이는 대조식이와 대조식이에 인상분을 2%, 4%, 6% 및 8%씩 첨가하여 5종을 만들었고 동물은 각 해당 식이별로 5군으로 나누어 30일간 사육하면서 체중증가량, 식이 및 단백질 섭취량, 식이효율과 단백질 효율등을 측정하고 그 후 희생하여 각장기중 성분을 측정하였다. 이 결과 인삼의 첨가급식 효과는 기본식이(대조식이) 중 단백질 함량과 질에 따라 차이가 있음을 알 수 있었다. 즉 기본식이 중 단백질 함량이 낮을 경우 인삼급식효과가 양호하였고 높을수록 그첨가급식 효과는 뚜렷하지 않으며 오히려 식이효율 및 단백질 효율이 저하되었다. 한편 인삼첨가급식에 의하여 간장과 심장중 지질함량 및 total cholesteral 함량은 저하됨을 알 수 있었다. This Study was devised to ovserve the effects on the lipid metabolism and gained body weight of Albino rats by feeding of diet supplemented with 2% to 8% Ginseng root powder. The Albino rats (50 heads), weighing 94 to 104g, were divided into five diet groups, which were 1) stock diet as control, 2) 2% Ginseng diet (stock diet contained 2% Ginseng powder), 3) 4% Ginseng diet, 4) 6% Ginseng diet and 5) 8% Ginseng diet. The each group was maintained with corresponding diet for 30 days and then sacrificed. The growth rate of rats, the consumption and efficiency ratios of food and protein were determined during the feeding term, and after sacrifice of the animals, the contents of lipid and cholesterol in some organs and serum were analyzed. The results obtained are summarized as follows, 1. The growth rate was highest in the control group and decreased to order of increasing content of Ginseng powder in diet. 2. The consumptions and the efficiency ratios of food and protein were significantly decreased diet groups containing more 6% Ginseng powder than the control group. 3. Lipid contents in liver and heart were decreased by feeding of diet supplemented with 2% to 8% Ginseng powder compared to the control group. 4. The total cholesterol contents in the liver and heart were decreased by feeding of diet supplemented with 2% to 8% Ginseng powder as well as changing of the lipid contents. As the results of above, the lipid metabolism in the rat was influenced by feeding of the diet supplemented with Ginseng powder.
마늘로부터 항암성 성분의 추출 및 그의 항암성활성 특성에 관한 연구
황우익,Hwang, Woo-Ik 생화학분자생물학회 1980 한국생화학회지 Vol.13 No.4
본 연구는 마늘 추출액이 in vitro와 in vivo에서 암세포의 중식에 미치는 영향을 관찰하여 마늘로부터 항암제 개발에 기초자료를 제공 하고자 계획하였다. 암세포는 흰생쥐의 백혈병성 임파모세포(L5178 Y cells)와 복수육종 세포(sarcoma 180 cells)를 대상으로 각각 in vitro와 in vivo에서 배양하면서 실험에 사용하였고 마늘 추출액은 실온과 $90^{\circ}C$내지 $100^{\circ}C$에서 추출한 수용성 추출물과 이들 각액에서 산(acid)에 불용성품의 제거액 및 산에 불용성분의 각 용액을 사용하여 각액의 항암성활성을 측정한 바 다음과 같은 결과를 얻었다. 1. 마늘의 실온 추출액의 활성 (L5178Y cells의 증식억제 효과)은 농도에 비례하지 않고 어느농도 이상에서야 강하였다. 2. 마늘의 가열 추출액의 활성은 농도에 비례하여 점차 증가되었다. 3. 마늘의 실온 추출액 중 산에 불용성분에는 활성이 없었으나 가열 추출액 중의 것에는 활성이 상당히 남아 있었다. 4. Sarcoma 180 세포를 접종시킨 동물에 마늘 추출액을 투여(특히 복강내 주사시)할 때 생존기간의 연장효과가 있었다. 이상의 결과로 보아 마늘의 수용성 성분중에 L5178Y cells 또는 sarcoma 180 cells등의 암세포의 증식 억제 효과가 있음을 알 수 있었다. The number of patient with tumor is rapidly getting increase year by year, but antitumor agent has not been much developed. Therefore the studies on the development of anticancer drug is one of the most important task in the medical science field. In this study I have attemped to obtain basic data for the development of anticancer drugs from the garlic. The cancer cells used were leukemic cells (L5178Y) and sarcoma 180 cells cultured in vitro and in vivo, respectively. The garlic extracts were prepared by extraction in water at room temperature and $90^{\circ}C$ to $100^{\circ}C$, and two filtrates were prepared by removing of acid insoluble part from above both extracts. The experimental results obtained are summarized as follows; 1. The garlic extract obtained at room temperature inhibited the growth rate of leukemic cells (L5178Y) in vitro. However the effect was not proportional to the concentration of the extract added, and the inhibitory effect appeared strongly at above range of a given concentration. 2. The garlic extract at $90^{\circ}C$ to $100^{\circ}C$ also inhibited the cell growth (5178Y) in vitro and the inhibitory effect was parallel to the concentration of extract added. 3. Acid insoluble part in garlic extract prepared at room temperature was shown no inhibitory effect, but that in boilled ($90^{\circ}C$ to $100^{\circ}C$) garlic extract indicated considerable inhibitory activity. 4. Survival time of Swiss mice inoculated the sarcoma 180 cells was extended by treatment with garlic extract. (specially in injection group) compared with the control group. From the above results it was found that water extracts of garlic. were shown the inhibitory effects on the growth of some cancer cells.
小魚粉中 Alcohol Extract 가 白鼠 臟器內 數種 酵素活性에 미치는 影響
黃祐翊,田鍾權,金南一,李萬祚 中央醫學社 1971 中央醫學 Vol.20 No.3
1)epartnient'of Nutrition and Biochemistry, Woo Sok University Medical College, Seoul, Korea This experiment was designed to observe some influence on the enzyme activities in some organs of rats by -feeding. rice diet adding alcohol extracts from fish flour. Sixty six-male Albino rats were used as the experimental animals and the subjects were divided into eleven diet groups and each group was fed on the corresponding diet for forty days. The activities of alkaline phosphatase, glutamic oxaloacetic transaminase (G. O: T) and glutamic pyruvic transaminase (G. P. T) were determined in their serum and- liver. The obtained results are summarized as follows, 1. The alkaline phosphatase activity in the. liver was. decreased by the feeding of the rice diet with the alcohol extracts compared with-the rice diet group, and the activity in the group feeding rice diet with the residure(the portion after removing alcohol extracts from fish flour) was more increased than whole fish flour feeding group. 2. The G.O.T. activities in the serum and liver were more increased by the feeding of the rice diet with the alcohol extract than the rice diet. 3. In the G.P.T. activity in the liver of the group feeding rice diet with alcohol extracts from fish flour was increased, whereas the group feeding 10%casein die with alcohol extracts was decreased.