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β-carotene과 Protein-bound polysaccharide(PS-K)가 악골 이식암에 미치는 영향에 관한 실험적 연구
어영선,조한국 慶熙大學校 齒科大學 1993 慶熙齒大論文集 Vol.15 No.1
The purpose of this study was to evaluate the inhibitory effect of 03-carotene and PS-K on the oral transplanted tumor by the transplantation of Sarcoma 180 ascite tumor cells in the bone of incisor tooth germ region of the right mandible. Three week-aged 56 male mice(ICR), weighing 20gm, were devided to 4 experimental groups and 2 control groups. Experimental group 1(12 mice) was transplanted 0.05ml Sarcoma 180 ascite tumor cells per a mouse with 25 Gauge syringe. Group 2(12 mice) was supplied orally 3 times per week with 1-2m1(3-carotene that was dissolved in soybeam milk after transplantation of Sarcoma 180. Group 3 (12 mice) was administered orally 3 times per week with 2m1 PS-K solution that was dissolved in soybeam milk at a dosage of lgm/200ntl after transplantation. Group 4(12 mice) administered 0-carotene and PS-K with the same method. Control group 5(6 mice) was administered 0-carotene and PS-K only and group 6(2 mice) was untreated control. Five mice of each experimental group and 1 mouse of group 5 were sacrificed at 4, 6, 8, 10, 12, 14 days after experimentation. Then the mandible was removed, fixed in 10°N-Formalin and decalcified in 5% nitric acid. And embedded in paraffin; sectioned to 4― 6?m thickness, and stained with Hematoxylin and Eosin, Masson's trichrome and Van Gieson by the usual method; The results were as follows 1. Sarcoma 180 transplanted group revealed inflammatory reaction, degeneration and necrosis of transplanted region, located at 4 days, active malignancy of tumor cells at 6 days, infiltration into the alveolar bone and the periodontal membrane at 8 days, infiltrative proliferation into the periapical portion, adjacent muscular tissue, salivary gland and deep jaw bone at 10, 12 days. 2. The growth of the transplanted tumor cells was inhibited slightly in 0-carotene administered group, morelyinhibited in PS-K administered group and markedly inhibited in 0-carotene and PS-K combined group. 3. There are marked infiltration of lymphocytes due to exudative inflammatory reaction in the adjacent tissue to the transplanted tumor cells. 4. Control group were administered 0-carotene and PS-K only, revealed congestion of blood vessels at 4 days, edematous and hemorrhagic features at 8, 10 days.
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어영선 漢陽大學校 工學技術硏究所 1999 工學技術論文集 Vol.8 No.1
전자 패키지의 고주파 효과를 고려한 파워 및 그라운드 평판에 대한 새로운 마이크로웨이브 회로 시뮬레이션 모델을 제시한다. 패키지의 평판에 대한 등가 회로는 그리드 형태로 모델하였고 각각의 셀에 대한 파라미터의 추출은 Fasthenry를 이용하였다. 제시된 평판 모델의 검중을 위해 측정한 S-파라미터 결과[2]와 full-wave 시뮬레이션을 통한 S-파라미터 결과를 모두 5-파라미터 영역에서 상호 비교한다. 마이크로웨이브 회로 시뮬레이션 모델을 이용하여 고주파 영역에서 문제가 될 수 있는 패키지의 불완전한 그라운드 및 파워 효과 등을 보다 정확히 예측할 수 있는 것을 보인다. A new microwave circuit simulation model of the power and ground plane of a package is presented. The equivalent circuit is modeled with grid cells. The circuit parameters of each cell were extracted by using Fasthenry. To verify the developed circuit model, its s-parameters are compared with the measured s-parameters[2] and the full-wave simulation-based s-parameters. Consequently, it is shown that our microwave circuit simulation model of the package can accurately predict imperfect ground/power effects under the high frequency operation of the electronic package.
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A Novel Transmission Line Characterization Based on Measurement Data Reconfirmation
어영선,Eo, Yungseon The Korean Institute of Electromagnetic Engineerin 2016 전자파기술 Vol.27 No.3
In the high-frequency characterizations of planar circuit components, measurement data may not be physical. It is mainly due to resonance effects concerned with discontinuities which are inevitable for a planar component characterization. In this paper, a novel accurate transmission line characterization method is presented that excludes the resonance effects based on measurement data reconfirmation. For the physically obvious data acquisition near the resonance frequencies of a transmission line, the additional lines with different line lengths are fabricated on the same substrate. The test transmission lines are characterized by using vector network analyzer (VNA) in 100 MHz to 26.5 GHz. It is shown that an accurate transmission line characterization can be achieved with the proposed measurement data reconfirmation technique.
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어영선 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1
A coupling noise due to a silicon substrate is presented. The coupling parameters between the transmission lines are extracted, taking the silicon substrate effects into account. Since the electromagnetic fields in the silicon-based IC interconnects are propagated with slow wave mode, effective dielectric constant and different ground planes with the multi-layer dielectric structures were employed for inductance and capacitance matrix determination. Then accurate signal transient simulations were performed with HSPICE by using the parameters. It was shown that the simulation results have excellent agreements with high-speed time domain measurements, i.e., TDR/TDT measurements.
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Signal Integrity for Submicron-Technology-Based High Speed and High Density VLSI Circuits
어영선 대한전자공학회 1995 CAD 및 VLSI 설계연구회지 Vol.4 No.1
High speed signal transients related with signal integrity such as signal degradation, crosstalk, dispersion, and simultaneous switching noises (reference potential fluctuation) of high density and high speed VLSI circuit interconnects are presented. The effect of signal loss, dispersion, crosstalk, and simultaneous switching of VLSI interconnects have been investigated using frequency variant transmission line parameters. To characterize the accurate signal variation on lossy interconnects, mathematical analysis of multiconductor system were employed. Introducing the limitations and deficiencies of simulation and Computer Aided Design (CAD) tools, existing interconnect models are compared. Particularly, it is demonstrated with the worst; case crosstalk model that the deep-submicron-based VLSI system may be catastrophic due only to crosstalk. Unlike the conventional circuit designs, high speed and high density circuit designs without guaranteeing the signal integrity in the early design stage result in intermittently disastrous circuit failures. With this work, the signal integrity problems which are pretty important for high performance VLSI circuit design can be predicted in the early phase of circuit design.
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