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Xenopus Oocytes에서 발현된 세로토닌 3형 수용체에 대한 근이완제의 구조적 차이에 따른 억제 효과
민경태,남용택,오경미,Yang, Jay 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.37 No.2
Background : The serotonin type 3 receptors are diffusely distributed in both the central and the peripheral nervous system. Physiological and pathophysiological processes thought to be mediated by this receptor include nausea and vomiting, peripheral nociception and central antinociception, conditioned aversion response to drugs, anxiety, and cognition. Because of the structural similarity between the nicotinic acetylcholine receptor and the 5HT3 receptor, we investigated the effects of clinically used neuromuscular blockers on the 5HT3 receptor function related with PONV. Methods : A cDNA clone encoding the full length murine 5HT3a receptor was subcloned into an oocyte expression vector and 50 ng of cRNA transcribed in vitro injected per oocyte. After 24 72 h incubation, oocytes were placed into a recording chamber continuously perfused with frog Ringer's solution and electrophysiological recordings were obtained by the two electrode voltage clamp technique. Serotonin with or without the various drugs were bath applied by a computer controlled solenoid valve. Peak currents induced by the drug applications were measured and dose responses were obtained. Results : The 5HT3 receptor expression in Xenopus oocyte was identified by the pharmacologic tools. Serotonin induced rapid inward currents, and thus was showed dose-dependent: KD = 2.5 μM, Hill coefficiency = 2.09. Inhibition by the neuromuscular blockers showed dose-dependence and their inhibitory potency on 5HT3 receptor (IC50) was in order of d-tubocurarine (0.046 μM) > vecuronium (16.32 μM) > gallamine (1,169 μM). Conclusions : There was a different inhibitory effect of nicotinic cholinergic antagonists, clinically used neuromuscular blockers, on the 5HT3 receptor and a judicious selection of them might contribute to reducing the incidence of PONV clinically. (Korean J Anesthesiol 1999; 37: 295∼302)
요통한자(腰痛患者)에 대(對)한 경천골공(經薦骨孔) 경막외(硬膜外) 스테로이드 주입요법(注入療法) -병례보고(病例報告)-
민경태,윤덕미,오흥근,Min, Kyeong-Tae,Yoon, Duck-Mi,Oh, Hung-Kun 대한통증학회 1989 The Korean Journal of Pain Vol.2 No.1
Steroid and local anesthetics were injected into the epidural space through the posterior sacral foramen or lumbar approach in 4 patients for the purposes of relieving severe low back pain and radiculopathy. These patients were referred from other sections dealing with low back pain and radiculopathy, because one could not tolerate the surgical stress due to a heart problem, another two did not want the operation and the last had post-laminectomy status. All patients were satisfied with the results subjectively.