[PART 5] 내 1년차의 기록❺ 김수미 코스웨이㈜ 대표_창업은 혼자 질주하는 게임 아냐

김수미,김미란 더스쿠프 2021 더스쿠프 Vol.- No.451

양측성 거대결절성 부신피질 과증식증 1예

김수미,최동섭,백세현,신동현,최윤상,박이병,나승운,김신곤 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.4

Cushing's syndrome associated with nodular adrenal glands will be divided into four main categories: adrenal adenoma, adrenal carcinoma, primary pigmented nodular adrenal dysplasia (PPNAD) and macronodular adrenal hyperplasia(MAH). The term macronodular adrenal hyperplasia is restricted to the presence of multiple nodules visible to the naked eye, ranging in size from 0.5 to 7.0 cm. We report a case of Cushings syndrome caused by bilateral macronodular adrenal hyperplasia (MAH). A 45-year-old man presented with Cushingoid features, hypertension and diabetes mellitus. Urine free cortisol was 449.9 mmol/day(27-276) and were not suppressed after administration of low-dose and high-dose dexamethasone. Plasma ACTH was very low(1.87 pmol/L(18)) and was not stimulated by administration of ovine CRH. In abdominal CT, both adrenal glands were markedly enlarged and nodular in appearance. Pituitary MRI showed no abnormal finding. Bilateral adrenalectomy was done. Histologic examination revealed multiple nodules and internodular hyperplasia. This case and other reports suggested that because of variable biochemical, radiologic and pathologic findings, macronodular adrenal hyperplasia represents a heterogeneous group of patients with varying degrees of adrenal autonomy (J Kor Soc Endocrinol 11:523~530, 1996)

자스민 오일에 의한 중년 여성의 타액 코티졸 조절

김수미,장경자,최태부,리순화,김형주 한국피부과학연구원 2009 대한피부미용학회지 Vol.7 No.1

This study focused on low level of cortisol and observed the effect of aromatherapy on middle aged women whose salivary cortisol level was below 10pg/ml. The first experimental group was the massage group with jasmine oil and the second experimental group was the inhalation group with jasmine oil using aroma lamp. The control group was the massage group with jojoba oil. The study objects were treated twice a week for 4 weeks. The stress were measured before the experiment and after the last experiment. The salivary cortisol level was measured before the experiment, after the second week of experiment and after the last experiment. As for the massage group with jasmine oil, the salivary cortisol level increased significantly and the stress was relieved significantly. As for the inhalation group with jasmine oil, the salivary cortisol level increased significantly from the second week, but in the fourth week it decreased. And the stress was relieved significantly. It was supposed that jasmonoid of jasmine oil which signaled responses of stresses in plants stimulated the secretion of cortisol in human body. As for the massage group with jojoba oil, there was no significant change. Conclusively, the massage treatment with jasmine oil was effective for controlling the salivary cortisol level and relieving stress in middle aged women because of the synegy effect between the ingredient, "jasmonoid" and the application method, "massage." 본 연구는 많은 중년 여성들에게 코티졸 저하 현상이 나타난다는 연구를 토대로, 타액 코티졸 농도가 10pg/ml 미만인 50대 중년 여성을 대상으로 아로마테라피를 수행하였다. 복부와 등에 자스민 오일로 마사지를 실시한 자스민 마사지군과 아로마 발향 램프로 자스민 오일을 흡입한 자스민 흡입군을 실험군으로, 호호바 오일로 복부와 등을 마사지 한 호호바 마사지군을 대조군으로 설계하였다. 실험은 일주일에 2회씩 총 4주 동안 진행되었다. 실험 전과 실험 2주 후, 4주 후에 타액 코티졸 농도를 측정하였고, 실험 전‧후에 스트레스를 측정하였다. 측정 결과, 자스민 마사지군은 타액 코티졸 농도 상승과 스트레스 완화에 효과가 있는 것으로 나타났다. 자스민 흡입군은 실험 2주 후에 타액 코티졸 농도가 상승하였지만 4주 후에는 감소하였고, 스트레스 완화에 효과가 있었다. 두 실험군의 타액 코티졸 농도가 상승한 것은 식물의 스트레스 반응에서 스트레스 대항 물질 분비에 신호 역할을 하는 jasmonoid란 자스민 오일 성분이 코티졸 분비를 촉진한 것으로 추정된다. 호호바 오일 마사지군은 효과가 없었다. 결론적으로, 자스민 마사지군이 jasmonoid라는 성분과 마사지라는 적용 방법이 상승 효과를 일으켜서 실험 기간 4주 동안 중년 여성의 타액 코티졸 농도의 지속적인 상승과 스트레스 완화에 효과가 있는 것으로 나타났다.

마약류 반납관리

김수미 韓國病院藥師會 2004 병원약사회지 Vol.21 No.4

10주간 줄없는줄넘기 운동이 비만 남자 중학생의 건강관련체력, 인슐린저항성 및 렙틴에 미치는 영향

김수미,박현정,이청무,최운영 한국웰니스학회 2012 한국웰니스학회지 Vol.7 No.2

The purpose of this study was to investigate effects of the ropeless-skipping exercise for prevention and improvement of obese middle school students and to provide the basic information of the effective exercise program for physical strength and growth improvement. Twenty-one obese middle school students were randomly assigned t three groups: EG1(Rope-skipping exercise group, n=7), EG2(Ropeless-skipping exercise group, n=7), CG(Control group, n=7) and the ropeless-skipping exercise have been operated for 10 weeks(45∼70% of HRR, 3days/week, 45mins/day). Paired t-test and ANCOVA were performed to analyze the difference among groups. Significance was set at a value of α<.05. The results were as follows. First, the rope-skipping exercise group and the ropeless-skipping group showed significant decrease in percent body fat (p<.05)and significant increases in left(p<.05) and right hand grip strength(p<.01), muscle endurance(p<.01), flexibility(p<.01) and cardiopulmonary endurance(p<.05) and significant differences have been shown in lean body mass(p<.01), left(p<.05) and right hand grip strength(p<.001), muscle endurance(p<.01), and cardio pulmonary endurance(p<.001) among three groups. Second, insulin resistance has decreased significantly in both the rope-skipping exercise group(p<.01) and the ropeless-skipping exercise group(p<.05) and leptin has decreased significantly in the ropeless-skipping exercise group(p<.05) and insulin resistance(p<.01) has significant difference between the rope-skipping exercise group and the control group. In the conclusion, the ropeless-skipping exercise is effective for obese middle school students by increasing lean body mass and decreasing of Insulin-resistance and leptin levels.

국가수준 대학입시 선다형 국사 문항이 교수·학습에 끼친 영향

김수미 역사교육학회 2015 역사교육논집 Vol.57 No.-

Influence of formats and contents of questions in national university entrance exam on the field of high school education can be evaluated to be absolute and works as an important factor deciding the direction of teaching-learning. Recent assessors and researchers maintain that assessment not only plays the role of measuring tool for (assessment of) examinees' abilities but also can have converse effect on learning contents and methods of learners and they have defined overall phenomenon of assessment having effect on teaching-learning as 'washback effect' (of assessment). Due to this washback effect of assessment on teaching-learning, questions in university entrance exam become the direction for Korean History education and standard of questions in the exams and actual questions in the exam become important factors which teachers should teach with their great influence in the field of teaching and teaching-learning activities. Thanks to washback effect of multiple-choice questions format in Korean History, it is apparent that teachers have prepared students for university entrance exams through respective school exams which fit the question format in university exam. In addition, thanks to washback effect of multiple-choice question contents in Korean History, repeated exam questions are perceived by teachers to be important contents to teach and by students to be contents to learn. Directions of Korean History class in high schools have been decided by the questions in university entrance exams each year and Korean History class has been conducted centering on the contents with high frequency of appearance in exams. Moreover, even the questions beyond the limit of curriculum become the contents to be learned once they are included in the university exam because questions once in the exams have the possibility to be applied again as questions from previous exams. Although assessment questions are important factors which decide the direction of teaching-learning in Korean History and improvement of assessment questions is effective and fast method to change teaching-learning, it is necessary to improve teaching-learning method at the same time to achieve the goal of Korean History education.

곤자쿠모노가타리슈(今昔物語集) 천축・진단부에 그려진 이방인 -무녀와 대칭되는 인물 설정의 의의-

김수미 중앙대학교 일본연구소 2022 日本 硏究 Vol.- No.57

In this paper, I would like to examine the composition of the figures of the shaman and the stranger in Konjaku-Monogatarishu.(Please mention the proper name of the specific work that you are examining over here.-memo from English editor) This will be done through a comparison with and a review of the source literature of the story of a stranger and its symmetrical relation to the figure of the shaman in Konjaku-Monogatarishu. In the case of Buddhist narratives, Vol.4-12, and Vol.7-16, the Stranger was a symbol of Buddhism and was represented by a symmetrical structure of a shaman (ritual religion)/stranger (Buddhism). In contrast, in secular folktales, Vol.10–33, the Stranger was a person who eradicated the ritual custom and was represented as a shaman who established a new royal law, creating a composition of the following opposition: the shaman (the ritual custom)/the stranger (the royal law). In this way, Konjaku-Monogatarishu provided an image of the stranger that was different from the source literature, establishing the stranger as an entity that breaks down ritual religions and customs and expands and builds the Buddhist and royal world. Further attention was paid to the final narrative, which depicts the construction of a royal law supported by a shamanistic woman, assuming that the shaman should be expelled. This contradiction in the text was the result of avoiding statement of the transformation of the national system by strangers, and it reveals one aspect of the multi-faceted world of Konjaku-Monogatarishu.

럭셔리 Jewelry Brand와 Jewelry Design의 Euro Trend 연구

김수미 한국일러스아트학회 2007 조형미디어학 Vol.10 No.3

The jewelry market, whose structure remains closed and where target consumers are limited, grows up into a special brand market in the age of rapid changes and development. During the period between the 1990s and 2000s, established luxury jewelry brands maintain them in collaboration with large-scale businesses, launching new general fashion brands. On the contrary, since then, such world-class luxury fashion brands begin new jewelry brands. Since 2000, this becomes a European trend in jewelry brand and design. The market structure of special luxury brands and jewelry design derives from the correlation between luxury fashion brand and band jewelry. This phenomenon is to be maintained. 폐쇄적 경향의 시장구조와 소비층이 제한적인 쥬얼리 시장은 최근 다른 어떤 제품분야보다도 급격한 변화와 발전시기를 맞아 특수한 브랜드 쥬얼리 시장으로 성장하고 있다. 이 같은 시기인 90년대 이후-2000년대에 전통적인 기존의 력셔리 쥬얼리 브랜드들은 대기업과 합류하여 그들의 기존브랜드를 유지하면서도 새로운 복합적 럭셔리 패션브랜드를 런칭하는 것과 같은 혁신적인 현상이 나타났다. 또한 그 후로 이 같은 세계적 규모의 럭셔리 패션브랜드가 이번에는 역으로 국제화적 거대규모매개를 통한 새로운 쥬얼리 라인을 개발 런칭하는 현상이 최근 2000년도 이후 럭셔리 쥬얼리 브랜드와 쥬얼리 디자인의 유로 트랜드(Euro Trend)인 것이며 이는 곧 럭셔리 브랜드와 브랜드 쥬얼리의 상호상환관계, 그리고 쥬얼리 시장과 럭셔리 패션브랜드의 상호상환관계성으로 빚어지는 특수한 럭셔리 jewelry brand와 jewelry Design의 시장구조를 생성시키고 있으며 이 같은 현상은 지속되어질 것이다.

웅진도독부의 요동 移置와 廢置

김수미 호남사학회 2012 역사학연구 Vol.45 No.-

In the 7th century, Gojong(高宗) of Tang Dynasty overthrew Baekje and Goguryeo, and then attempted to annex Silla as well. At that time,Tang Dynasty’s foreign policies for the East or expansion policy reached the summit, and Ungjin Dodokbu functioned as a base to execute the policies. Ungjin Dodokbu expelled from Baekje area by Silla in 672 moved to Geonan(建安) Fortress at Yodong in 676. In those days, Tang Dynasty could not check Silla because of wars against Ancient Tibet(吐蕃) and Dolgwol(突厥) in the North. Ungjin Dodokbu which had moved to Yodong was maintained to protect Yodong and check Silla while Tang Dynasty had a strength contest with the alien in the North in the late 7th century. Movement of the alien in the North and Silla’s continuous struggles resulted in Ungjin Dodokbu’s movement to Yodong. In February, 677, Buyeo Yung started for his new position as Dodok of Ungjin Dodokbu, and King Bojang as Dodok of Yodong Dodokbu. Andong Dohufu(安東都護府) moved to Sin seong(新城) at the same time. Buyeo Yung who served as Dodok of Ungjing Dodokbu was considered to be involved in the rebellion attempted by King Bojang, Ancient Tibet,Dolgwol, Malgal(靺鞨), and Silla from 679 to 681. Ungjin Dodokbu in Geonan Fortress was traditionally under the control of Goguryeo. Especially, because of Tang government’s indifference, Buyeo Yung had no choice but to rely on Goguryeo. In 681, the rebellion was revealed before its execution and King Bojang was sent into exile. Boyeo Yung was also exiled and died the next year when King Bojang also died. That is, Ungjin Dodokbu was involved in the rebellion attempted by King Bojang in 681,which resulted in its abolition. Likewise, the movement and abolition of Ungjin Dodokbu were closely related to Tang Dynasty’s foreign policies in the 7th century. In other words, the affairs of Ungjin Dodokbu was not limited in the Korean Peninsula, but it also was directly connected to international politics surrounding Tang Dynasty in the 7th century. 7세기 당 고종은 백제와 고구려를 멸망시키고, 신라마저도 병합시키려 하였다. 이 시기 당의 대외팽창정책은 절정에 이르렀고, 웅진도독부는 당의 대외정책을 수행하는 전진기지로 기능하였다. 672년 신라에 의해 백제 지역에서 축출된 웅진도독부는 676년 요동의 건안성으로 옮겨졌다. 이때 당은 북방의 토번・돌궐 등과의 전쟁으로 신라를 견제할 수 없는 형편이었다. 웅진도독부를 요동으로 옮긴 배경은 7세기 후반 북방 이민족들과 힘겨루기를 하는 당이 요동 지역을 방어하고, 신라를 견제하고자 하는 데서 찾을 수 있다. 결국북방 이민족들의 움직임과 신라의 끈질긴 항쟁은 웅진도독부를 요동으로 옮기는 결과를 불러왔던 것이다. 677년 2월 부여융은 웅진도독으로, 보장왕은 요동도독으로 부임하였고, 이와 동시에 安東都護府는 新城으로 옮겨졌다. 요동의 웅진도독부에 부임한 부여융은 679년에서 681년에 있었던 보장왕・토번・돌궐・말갈・신라 등이 대당 무력항쟁을 도모한 모반 사건에 함께 가담했던 것으로 여겨진다. 건안성의 웅진도독부는 전통적으로 고구려의 세력권 안에 있었다. 특히 당 조정의 무관심으로 부여융이 의지할 곳은 고구려 세력뿐이었다. 그리하여 681년 모반 사건이사전에 발각되어 보장왕이 유배되자, 부여융도 함께 유배되었다가 그 다음해보장왕과 함께 사망하였다. 즉 웅진도독부는 681년 보장왕 모반 사건에 연루되어 폐치되고 말았던 것이다. 이와 같이 웅진도독부의 이동과 폐치는 7세기당의 대외정책 및 국제 정세와 깊은 관련을 가지고 있었다.

A Review of Mechanisms of Implantation

김수미,김종수 한국발생생물학회 2017 발생과 생식 Vol.21 No.4

Implantation is a highly organized process that involves an interaction between a receptive uterus and a com-petent blastocyst. In humans, natural fecundity suggests that the chance of conception per cycle is relatively low (~30%) and two-third of lost pregnancies occur because of implantation failure. Defective implantation leads to adverse pregnancy out-comes including infertility, spontaneous miscarriage, intrauterine fetal growth restriction and preeclampsia. With use of advanced scientific technologies, gene expression analysis and genetically-engineered animal models have revealed critical cellular networks and molecular pathways. But, because of ethical restrictions and the lack of a mechanistic experiment, comprehen-sive steps in human implantation have still not been completely understood. This review primarily focuses on the recent ad-vances in mechanisms of implantation. Because infertility is an emerging issue these days, gaining an understanding the mo-lecular and hormonal signaling pathway will improve the outcome of natural pregnancy and assisted reproductive technology.