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김원규,민상웅 한국우주과학회 2003 Journal of Astronomy and Space Sciences Vol.22 No.3
인공우주물체의 추적 및 관측을 위해 LX-200 12인치 망원경시스템을 도입하여 시스템의 구동부(모터, 모터드라이버, 모션컨트롤러)를 응답특성이 빠르고 능동제어가 가능한 것으로 개선하였다. 또한, PC를 이용하여 대상물의 실시간 궤적정보를 계산하여 모터 드라이버 내의 PID 제어기에 신호를 제공하였고, 명령신호 제어주기도 20ms까지 줄였다. 그 결과, 가대의 구동속도는 $18^{circ}/sec$로 향상되고 상용시스템보다 응답속도가 빠르며 대상물의 이미지 관측시 flipping 현상을 최소화하는 시스템을 개발하였다. Recently, we have reconstructed LX-200 12inch telescope system for tracking and observing man-made space object. Motor, motor driver and motion controller were up-graded for getting faster respond characteristic and active control available. Also, command signal was offered to the PID controller into motor driver as computed real orbiting information of objects using PC, and it's control period of command signal was reduced to the 20ms. As the result, slew speed of the mount system was in proved up to $18^{\circ}/sec$ and respond speed of the system was faster than that of commercial system. Also, flipping state of image observed could be minimized by the up-graded system.
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김원규 고신대학교(의대) 고신대학교 의과대학 학술지 1993 고신대학교 의과대학 학술지 Vol.9 No.2
-Abstract- The dermoid cyst is the most common ovarian germ cell neoplasm and comprises approximately 10% of all ovarian tumors. Primary malignant degeneration of a benign cystic teratoma of the ovary is not frequent, but does occur. This sequence can be assumed when the unquestionably malignant lesion occurs in a definitely localized area of a dermoid that is otherwise entirely bening. The incidence of primary malignant degeneration of a benign cystic teratoma of the ovary is variously reported to be from 0.8% to 8%. This great divergence can be partially explained by the inclusion of small series of cases, for more extensive ones, report the incidence to be from 0.8% to 3.8%. Any types of malignant degeneration or a combination of malignancies can arising in benign cystic teratomas of the ovary. Among those rare tumors with malignant change in a benign dermoid, 80-88% are squamous, 6-7% are adenocarcinoma, and 7-8% are sarcomas of various types and the remainder include thyroid carcinomas, carcinoids and melanomas and choriocarcinomas and mixed malignancies (ex : adenosquamous and epidermo-sarcoma). We experienced a case of adenosquamous cell carcinoma arising in benign cystic teratoma of lt. ovary in 56 years old woman, so we report this case with a brief review of literatures.
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김원규 고신대학교 의학부 1993 高神大學校 醫學部 論文集 Vol.9 No.2
The dermoid cyst is the most common ovarian germ cell neoplasm and comprises approximately 10 % of all ovarian tumors. Primary malignant degeneration of a benign cystic teratoma of the ovary is not frequent, but does occur. This sequence can be assumed when the unquestionably malignant lesion occurs in a definitely localized area of a dermoid that is otherwise entirely benign. The incidence of primary malignant degeneration of a benign cystic teratoma of the ovary is variously reported to be from 0.8 % to 8 % . This great divergence can be partially explained by the inclusion of small series of cases, for more extensive ones. report the incidence to be from 0.8% to 3.8%. Any types of malignant degeneration or a combination of malignancies can arising in benign cystic teratomas of the ovary. Among those rare tumors with malignant change in a benign dermoid, 80-88 % are squamous. 6- 7 % are adenocarcinoma, and 7 - 8 % are sarcomas of various types, and the remainder include thyroid carcinomas, carcinoids and melanomas, and choriocarcinomas, and mixed malignancies (ex : adenosquamous and epidermo-sarcoma) We experienced a case of adenosquarmous cell carcinoma arising in benign cystic teratoma of It ovary in 56 years old woman, so we report this case with a brief review of literatures.
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김원규 고신대학교의과대학 2006 고신대학교 의과대학 학술지 Vol.21 No.2
Background and Purpose : The prognostic factors for predicting the clinical progress in ovarian cancer have not been clear up to date. Among the several prognostic factors for ovarian cancer suggested recently, Cyclooxygenase-2(COX-2) has drawn the most attention. This study tested an hypothesis that expression of COX-2 is the indication of carcinogenesis. COX is an enzyme responsible for the production of prostaglandins from arachidonic acid. COX-2 is induced by cytokines, growth factors, and tumor promotors and it is an early response gene in inflammation, and there is a growing evidence that COX-2 expression is important in carcinogenesis. It is thought that COX-2 may regulate cell proliferation, mitosis, cell adhesion, apoptosis, immune surveillance and angiogenesis during carcinogenesis. This study was conducted to examine the relation of COX-2 to epithelial ovarian cancer and to examine its effect on the survival rate, thus proving its usefulness as prognostic factor. Methods : Thirty-one patients with epithelial ovarian cancer who went under surgery at Kosin University Hospital from 1995 (January) to 2001 (December) participated in this study. Using the immunohistochemistry method on the tissue samples, COX-2 levels in the patients were compared with 12 other patients with benign ovarian tumor. Univariate analysis was tested with Chi-square and survival rate was tested using the Kaplan-Meier and Log-rank methods. And for the indicators that revealed a significant difference, cox-proportional hazard model was additionally used for the multivariate analysis. Results : Five year survival rate for the 31 patients of epithelial ovarian cancer was 58.4%. Both histologic type (p<0.05) and the FIGO stage (p<0.05) were found to have a statistically significant relationship with the survival rate. Regarding epithelial ovarian tumor, there was a significantly higher level of COX-2 (p<0.05) in the patients with cancer compared to those with benign tumor. Age as the prognostic factor was positively correlated with COX-2. The positive group of COX-2 showed significantly lower survival rate than negative group (respectively, p<0.05). In the multivariate analysis only FIGO stage showed statistically significant relationship. Conclusion : In this study COX-2 couldn't be an independent prognostic factor for ovarian cancer due to multivariate analysis, but we can suggest that COX-2 might play a role in ovarian carcinogenesis.
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