식물기반 치료용 항체생산

김영관,소양강,박다영,김현순,전재흥,추영국,고기성,Kim, Young-Kwan,So, Yang-Kang,Park, Da-Young,Kim, Hyun-Soon,Jeon, Jae-Heung,Choo, Young-Kug,Ko, Ki-Sung 한국식물생명공학회 2010 식물생명공학회지 Vol.37 No.3

Antibodies are powerful and versatile tools to play a critical role in the diagnosis and treatment of many diseases. Their application has been enhanced significantly with the advanced recombinant DNA and heterologonous expression technologies, allowing to produce immunotherapeutic proteins with improved biofunctional properties. However, with currently available technologies, mammalian cell-based therapeutic antibody production, as an alternative for production in humans and animals, is often not plentiful for passive immunotherapeutics in treatment of many diseases. Recently, plant expression systems for therapeutic antibodies have become well-established. Thus, plants have been considered to provide an attractive alternative production system for therapeutic antibodies, as plants have several advantages such as the lack of human pathogens, and low cost of upstream production and flexible scale-up of highly valuable recombinant glycoproteins. Recent advances in modification of posttranslational processing for human-like glycosylation in transgenic plants will make it possible that plant can become a suitable protein expression system over the animal cellbased current production system. This review will discuss recent advances in plant expression technology and issues for their application to therapeutic antibody production.

시간영역 광 간섭 단층촬영 시스템의 소형 엔도스코프 제작 및 영상구현

김영관,이성헌,김용평,Kim, Young-Kwan,Lee, Sung-Hun,Kim, Yong-Pyung 한국광학회 2010 한국광학회지 Vol.21 No.5

We fabricated and characterized a compact endoscopic catheter for optical coherence tomography. The optical delay line (ODL), composed of a cylindrical piezoelectric transducer (PZT) and an optical fiber, was operated with a 1 kHz sinusoidal driving wave in the time-domain. When the ODL was driven with a sinusoidal wave function, the axial scanning speed was 6 m/s and the axial acquisition rate was 2000 line/s at a depth of about 3 mm. Endoscopic OCT images of a human finger and earhole were successfully obtained with an image rate of ten frames per second.

조종 숙련도 변화에 따른 심리적 리스크 이미지의 변화에 대한 평가

김영관,임현교,Kim, Yeong-Gwan,Im, Hyeon-Gyo 대한인간공학회 2003 대한인간공학회지 Vol.22 No.1

The resonance behaviour needs be understood to identify the mechanisms responsible for the dynamic characteristics of human body, to allow for the non-linearity when predicting the influence of seating dynamics. and to predict the adverse effects caused by various magnitudes of vibration. However, there are currently no known studies on the effect of vibration magnitude on the transmissibility to thoracic or lumbar spine of the seated person. despite low back pain(LBP) being the most common ailment associated with whole-body vibration. The objective of this paper is to develop a proper mathematical human model for LBP and musculoskeletal injury of the crew in a maritime vehicle. In this study, 7 degree-of-freedom including 2 non-rigid mass representing wobbling visceral and intestine mass, is proposed. Also. when compared with previously published experimental results, the model response was found to be well-matching. When exposed to various of vertical vibration, the human model shows appreciable non-linearity in its biodynamic responses. The relationships of resonance for LBP and musculoskeletal injury during whole-body vibration are also explained.

유기 EL 디스플레이의 현황과 전망

김영관,Kim, Yeong-Gwan 한국정보디스플레이학회 2001 한국정보디스플레이학회지 Vol.2 No.2

Two possible ways of lowering the production cost of crystalline silicon wafers for solar cells

김영관,Jung Min Kim 한양대학교 세라믹연구소 2004 Journal of Ceramic Processing Research Vol.5 No.3

Making a thinner wafer is a simple way of reducing the production costs of silicon solar cells. However, supporting this thin wafer in some way is necessary to protect the solar cell from breakage. A cheap substrate needs to be developed and attached to the thin silicon solar cell with aluminum paste. Silicon solar cells of 150 µm thickness with a sintered substrate on the back side show a 5.4% conversion efficiency as a solar cell. Compared to commercial silicon cells, a lower short circuit current (Jsc) is obtained. This might be due to the poor conduction in the back layer of aluminum which is absorbed into the supporting substrate during the annealing for bonding. Another way of lowering wafer costs is to apply the extrinsic gettering method to the silicon wafers made from cheap silicon raw materials which possibly contain metal impurities. Damage induced during the slicing process of the silicon wafers with wire saws is found to generate dislocations after the oxidation process which may contribute to the gettering. Therefore, without any additional process, cheaper raw materials are expected to be used for the cost reduction of the silicon wafers.

급성췌장염후에 발생한 췌장-대장루 1예

김영관,동석호,김효종,김병호,이정일,장영운,장린 ( Young Kwan Kim,Seok Ho Dong,Hyo Jong Kim,Byung Ho Kim,Jung Il Lee,Young Woon Chang,Rin Chang ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.5

Pancreatic fistula is used to encompass communication between the pancreatic duct and the skin (external fistula), between the pancreatic duct and hollow viscera, and between the pancreatic duct and peritoneal or pleural cavities (internal fistula). The majority of pancreatic fistulas are external fistula. The common causes of pancreatic fistula were trauma and pancreatic surgery. Pancreatic fistula due to pancreatitis was rare. Pancretico-colonic fistula accompanying pancreatitis did not occur during the eary, acute phase of pancreatitis, but rather as a consequence of pancreatic abscess and/or pesudocyst. The major site of fistula was in the transverse colon, the splenic flexure, and the descending colon in order. We experience a case of pancreatico-colonic fistula after acute alcoholic pancreatitis associated with a protracted course of disease and pancreatic abscess. We report this case with the review of the literature.

광간섭 단층촬영(OCT)용 PZT 광경로 지연기에서의 편광모드 분산 및 열요동 보상

김영관,박성진,김용평,Kim, Young-Kwan,Park, Sung-Jin,Kim, Yong-Pyung 한국광학회 2005 한국광학회지 Vol.16 No.6

광간섭 단층촬영(OCT)용으로 원통형 압전소자(PZT)와 단일모드 광섬유를 이용한 광경로 지연기를 제작하여 그 특성을 분석하였다. 광경로 지연기에서 발생하는 편광모드 분산은 편광조절기로 조절하였고, 열요동을 2중 광경로 지연기를 구성하여 최소화하였다. 이중 광경로 지연기는 단일 광경로 지연기에 비해 2배의 측정 깊이와 속도를 구현하여 $18.6\pm0.5{\mu}m$의 해상도. 측정 깊이 1.68 mm, 측정 녹도 360.4 mm/s를 각각 얻었다.

위성산업 활성화를 위한 정책방향

김영관,Kim, Yeong-Gwan 한국위성정보통신학회 1999 위성통신과 우주산업 Vol.7 No.2

INTELSAT 구조개편 현황과 전망

김영관,Kim, Yeong-Gwan 한국위성정보통신학회 1998 위성통신과 우주산업 Vol.6 No.1

밀폐공간내 복사에 의한 고체연료 점화의 실험적 연구

김영관,백승욱,Kim, Yeong-Gwan,Baek, Seung-Uk 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.11

An experimental study has been conducted to explore the behaviors of the radiative ignition of polymethylmetacrylate(PMMA) in a confined enclosure such as the ignition delay time, PMMA surface temperature, the ignition location and the ignition process. In addition, the effects of hot wall orientation on the ignition delay and PMMA surface temperature were studied. When the hot wall is located at the bottom, ignition delay time is the shortest. Ignition surface temperature becomes the lowest for the hot top wall case. These are due to buoyancy effect. Since the radiative heat flux of hot wall is rather lower than laser source, the ignition is considered to be controlled by the mixing process. Therefore, the ignition location, where appropriate mixture of fuel and oxygen exists, occurs near the hot wall. The flame propagates along the hot wall where there exists sufficient oxygen.