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여성 주요우울증 환자에서의 통각예민도와 혈장 β-endorphin양 면역 반응치
김명정,노재영 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.1
DSM-Ⅲ 진단기준에 의한 여성 주요우울증 환자군 16명을 동통증상의 다소를 기준으로 소동통우울증군 8명과 다동통우울증군 8명으로 나누어 이들을 대상군으로 하고 정상여성 10명을 대조군으로 하여 submaximum effort tourniquet 방법(SETT)과 electrical cutaneous stimulation(ECS) 방법으로 동통역치와 동통내성치를 측정하고 이들의 혈장 β-endorphin 면역활성치를 radioimmunoassay방법으로 측정한 결과를 다음과 같이 요약한다. 첫째, 소동통우울증군과 다동퉁우울증군 간에 HRSD와 SCL-90-R로 측정한 우울증상과 Spielberger's State Anxiety Inventory 와 SCL-90-R로 측정한 불안증상에 차이가 없었다. 둘째, SETT로 측정한 전체우울증군의 통각예민도는 대조군보다 둔감하였다. 우울증군 중에서도 소동통우울증군이 가장 둔감했고, 다동통우울증군은 대조군과 차이 없었으며 소동통우울증군과 다동통우울증군 간에는 유의한 차이가 없었다. 세째, 혈장 β-endorphin 면역반응치는 전체우울증군, 소동통우울증군 및 다동통우울증군이 모두 대조군보다 높았으나 동통증상의 다소로 분류한 우울증 아집단 간에는 차이가 없었다. 네째, 혈장 β-endorphin 면역반응치와 각종 통각예민도 사이의 상관관계는 다동통우울증군에서만 혈장 β-endorphin치와 SETT로 측정한 통각예민도 사이에서 역상관관계를 보였다. 이상의 결과에서 임상적으로 소동통우울증군과 다동통우울증군 사이에는 endorphin 활성도에 모종의 차이가 있지 않을까 생각한다. The pain sensitivity and plasma β-endorphin immunoreactivity were measured in 16 female patients with major depression diagnosed by DSM-Ⅲ criteria and a control group of 10 normal healthy females. The depression group was divided into two subgroups of 8 depressives with low pain symptoms(DLP) and with high pain symptoms(DHP). The results are summarized as follows: 1)No difference was observed between DLP and DHP in the symptoms of depression as measured by HRSD and SCL-90-R and in the symptoms of anxiety as measured by STAI-I and SCL-90-R. 2)The pain threshold and tolerance of the depression group as measured by submaximum effort tourniquet technique(SETT)was higher compared with the control. The DLP subgroup was more insensitive as compared to the control group, but no difference in all modes of pain stimulation was observed between DHP and the control. Thhere was no significant difference in the pain sensitivities between DLP and DHP. 3)Plasma β-endorphin immuunoreactivities of both DLP and DHP were higher than that of the control. However, no difference was proved between DLP and DHP. 4)The correlations between plama β-endorphin immunoreactivity and the pain sensitivities in each mode of pain stimulation were mostly insignificant, with a striking exception, in the subgroup of DHP, of a significant negative correlation between plasma β-endorphin immunoreactivity and the pain sensitivities as measured by SETT. On the basis of the above stated results, the author suggests that there may be certain qualitative difference of endorphin activity between DLP and DHP.
김명정,홍창희,김성곤 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.3
In order to evaluate perception of others' emotion in the schizophrenic patients, videotapes showing actors' emotional expressions of various kinds and intensities were shown to 41 male schizophrenic patients, 33 male alcoholics and 30 normal controls and their perception of the actors' emotion was measured and compared. The results are as follows : 1) The schizophrenic patients perceived the actor's unpleasant emotion as less unpleasant than the alcoholic patients and the normal controls. 2) The schizophrenic patients perceived the actor's neutral emotion as more pleasant than the alcoholic patients. 3) The schizophrenic patients perceived the actor's unpleasant emotion in short playing videotapes as less unpleasant than the alcoholic patients and the normal controls. 4) Above results were not related with duration of illness, duration of hospital stay and BPRS score of schizophrenic patients.
김명정,김상욱,김홍근 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.1
The effect of caffeine on the negative symptoms of schizophrenia was studied. Twenty three schizophrenics of the negative type were treated with caffeine and placebo in a double blind cross-over design. For a period of 5 weeks, the symptoms were evaluated using Positive and Negative Syndrome Scale, Scale for the Assessment of Negative Symptoms and Negative Symptom Rating Scale. The results were as follows: 1) The negative symptoms improved significantly after one day of caffeine administration in all three scales of the measurement and this effect continued up to 7days of caffeine administration in two scales out of three. This effect however disappeared after 2 weeks of caffeine treatment in all three scales. 2) No significant effect was observed in positive scores and general psychopathology scores of Positive and Negative Syndrome. The above results suggest that caffeine has only transient therapeutic effect on negative symptoms of schizophrenia.
김명정 大韓神經精神醫學會 1973 신경정신의학 Vol.12 No.2
The author reported 2 cases of schizophrenia anteceded mainly by clinical pictures of hysterical neurosis bofore more apparent pictures of full blown schizophrenia emerged, by describing their symptomatology, course of illness, life histories, psychological test results and other laboratory data. Focussing upon points of differentiation between simple hysteria and unnsual hysteria developing eventually into schizophrenia, the followings were observed in the reported cases; a. Pan-neurotic or mixed syndrome like pictures of predominantly hysterical symptoms together with overtly manifested anxiety, obsessive-compulsive tendencies and depression. b. Aggravation of intensity and diffusion of distribution of the somatic symptoms, finally becoming generalized and unbearable. c. Somehow bizarre ways of complaining their somatic symptoms. d. Obscure and vague precipitating events and factors. e. Schizophrenogenic possiblities of the personalities of the parents during patient's infanthood and/or childhood. f. Co-existence of schizoid and compulsive personalities prior to the emergence of hysterical tendency and continuous failure of all the defenses that the patients resorted to. g. Several differential points in the psychological test results. The author does not deem any one of the above findings as providing any evidence, but when all or many of them are observed, he does expect the hysterical symptoms to develope into schizophrenia.
金明正,金光日 大韓神經精神醫學會 1973 신경정신의학 Vol.12 No.4
Psychiatric practice in many developing countries is hampered by financial difficulty and discrepancy of disease concept and attitude toward mental illness between traditional culture and modern psychiatry. Since the modern psychiatry has been introduced to Korea circa 1920, the development of psychiatric facility has been relatively limited because of poorly socialized medical system and poor financial support inspite of recent economical improvement and rapid modernization. The purpose of this study was to evaluate some sociocultural backgrounds which lead to failure of successful psychiatric treatment in a small intensive therapeutic unit in Seoul. Materials were obtained from the discharged cases against medical advice from the psychiatric ward of Kyung Hee University Hospital during the period of 18 months from January 1972 to June 1973. The discharged cases by medical advice during the same period were used as the control. All the cases of the both groups were supported financially by their families for hospital treatment. Among the total number of 220 cases discharged during the above period, 14 cases (5 cases transferred to other departments or hospitals, 4 insurance cases, one foreigner, 2 expired cases and 2 legal cases) were excluded. One hundred and fifteen cases (55.82%) were discharged against medical advice among total 206 cases studied. No significant difference between two groups was proved in educational level and occupational status of the patients. And no difference was also obtained from the diagnotic distribution between the two groups except all of 9 cases of alcoholism was discharged against advice. History of previous psychiatric admission was significantly higher in the group discharged by advice. Mean days of hospital staying were 21.95±19.91 in the groups discharged against advice, and 43.84±37.27 in the group discharged by advice; the difference was statistically proved. Rates of successful follow-up were 31.81 per cent in the group discharged against advice, and 76.14 per cent in the group discharged by advice; the difference was also significant. Among the total discharged cases, 97 per cent was discharged by family member's decision, only 3 per cent by patients themselves. No difference was proved in educational level and socioeconomic status of the persons responsible for discharge between the two groups. No difference was also noted in religious and occupational status except shamanism which was prevalent in the group discharged against advice and educator prevalent in the group discharged by advice. The reason of discharge against advice were economical difficulty by 20.84 per cent, disagreement in disease concept and way of treatment by 40.28 per cent, personal or intrafamilial neurotic conflict by 29.18 per cent, really incurable state of the parients by 2.77 per cent, patient's intolerable urge to discharge by 4.17 per cent and other inevitable external situation by 2.77 per cent. The above results indicate a substantial difficulty in psychiatric practitioning in Korea due not only to financial difficulty but also to marked discrepancy of disease concept and attitude toward mental illness between the public and the psychiatrists Additional discussion was carried out on the overt influence of family in psychiatric practice. Treatment and management of psychiatric patients are crucially affected by family member's concept of illness and their attitude toward the patient. The reasons of family's incessant and penetrating influence to the treatment are poseibly their tight family tie and mutual interdependent way of life in the traditional extended family. Psychiatrist's practice in Korea is really intervened and disturbed by the family member's meddlesome behavior, but the greater tolerance and emotional support of the extended family and the protective milieu of the family which places relatively few occupational and social demands on the psychiatric patient are able to contribute to the successful reintegration of the patient into community life during the rehabilitation period.
김명정(Kim, Myung-Jung),전훈(Jeon, Hun) 한국사회과교육연구학회 2015 사회과교육 Vol.54 No.2
교과서의 내용 오류에 대한 사회적 관심이 높아지고 있다. 본 연구는 2009 개정 교육과정에 따른 중학교 사회 교과서에 대한 검정심사를 근거로 오류의 유형과 빈도를 분석하였다. 심사본의 내용 오류에 대한 분석 결과 표기·표현 오류가 전체 오류의 68%를 차지하였고, 내용 오류는 32% 수준이었다. 내용 오류 중에는 기술 내용의 정치적·문화적 공정성과 관련한 오류, 사실이나 개념, 이론의 정확성과 관련한 오류 그리고 독도 표시, 동해 표기 등 지도와 관련한 오류가 다수를 차지하였다. 사회 교과서의 내용 오류를 줄이기 위한 대안으로 기초조사의 영향력 강화, 연구위원의 증대, 기간본의 질 관리 강화를 제안하였다. 이를 위해서는 기초조사의 운영 방식 변화와 인력 확대에 따른 예산 증액과 같은 행·재정적 변화가 필요하다. 그러나 무엇보다 중요한 것은 오류의 가능성을 수용하고 그것을 바로잡는 과정을 통해 교과서를 지속적으로 개선해 나갈 수 있다는 인식을 공유하는 것이다. Textbook of content error is increasing in the social interest. This research was conducted by 2009 revised curriculum of middle school textbook on social studies to content error. The results showed that each notation and representation errors and content error was 68% and 32% in submitted for authorization textbook. Content error were related to the political and cultural fairness and errors of description Some error, the correctness of the theory. Especially, an error occurred East sea and Dokdo mark. The primary strategies for reducing content errors of social studies should be enhancing in the first review and increasing research committee members, the quality management of publication textbook. in addition, for changing the first review and manpower enlargement, we need support to administration and expend the budget. Above all things, we should be share the recognition of accommodates the possibility of error and revision process textbooks.
김명정,정영인 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.2
DSM-Ⅲ의 새로운 진단 범주인 범불안장애와 공황장애의 임상적 양상을 정리해 보고 양군 사이에 몇가지 임상 특성의 차이 유무를 검토하기 위하여 범불안장애 환자 33명과 공황장애 환자 20명을 대상으로 조사하여 다음과 같은 결과를 얻었다. 범불안장애는 공황장애에 비해 1) 비교적 낮은 교육 수준의 여성에서 많았고 사회계급도 낮은 경향이었다. 2) 발병 연령이 낮고 대체로 서서히 발병하여 만성적인 경과를 취하며 이환 기간이 길었다. 3) 이차성 우울증이 더 빈번했으며 불안과 연관된 위험 주제에 있어서도 신체적 위해보다는 심리적 위해가 더 많이 의식되었다. 4) SLC-90R을 시행한 결과, 대인예민성 척도와 적대감 척도에서 유의하게 높은 점수를 보였고, STAI에서는 특성불안 점수가 유의하게 높았다. In order to delineate the newly classified diagnostic entities of the generalized anxiety disorder and the panic disorder in DSM-Ⅲ, several clinical parameters were compared between the two groups. The subjects studied were 33 patients with the generalized anxiety disorder and 20 of the panic disorder diagnosed using DSM-Ⅲ criteria. The results were as follows; In comparison with the patients with the panic disorder, those with the generalized anxiety disorder 1) were more frequent in female with lower educational background and probably in the lower social classes, 2) took more insidious onset in younger ages and had longer duratin of illness, 3) revealed more frequently the secondary depression and ideational contents of psychological than physical disasters, 4) and showed higher scores of interpersonal sensitivity and hostility of the Symptom Checklist-90R and of trait anxiety of the spielberger's State-Trait Anxiety Inventary.
알코올 의존 환자에서 갈근이 혈중 알코올 농도와 음주 효과에 미치는 영향
김명정,정영인,박제민,김성곤,최영길 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6
갈근의 장기 투여가 혈중 알코올 농도와 음주 효과에 미치는 영향을 알아 보기 위하여 알코올 의존으로 입원하여 급성 알코올 중독과 금단 증상에서 회복된 남자 환자를 대상으로 갈근 투여군과 대조약 투여군으로 나누어 갈근과 대조약을 4주간 투여하였다. 갈근 혹은 대조약 투여 전후에 우울과 불안을 측정하고, 알코올 함량이 25%인 소주를 체중 kg당 ml를 음주하게 한 후 음주 전, 음주 후 10, 30, 60, 90, 120분에 각각 혈중 알코올 농도와 음주 효과를 측정하고 4주 동안의 일일 음식 섭취량을 측정하여 다음과 같은 결과를 얻었다. 1) 갈근 투여 전후 사이 그리고 실험군과 대조군 사이에 음주 후 혈중 알코올 농도에 유의한 차이가 없었다. 2) 갈근 투여 전에 비하여 투여 후에 음주 후 수축기 혈압은 음주 후 10, 30, 60, 90분에 그리고 이완기 혈압은 음주 후 10, 30, 60, 90, 120분에서 유의하게 낮았다. 갈근 투여 전의 수축기 혈압은 음주 후 10분에서 그리고 이완기 혈압은 음주 후 10, 30, 60분에서 음주 전에 비해 유의하게 상승하였으나 갈근 투여 후에는 알코올에 의한 위의 혈압 상승 효과가 차단되었다. 3) 갈근 투여 전에 비하여 투여 후에 운동량은 음주 60, 90분에서 유의하게 낮았고 목소리는 음주 후 10, 30, 60, 90분에서 유의하게 작았다. 갈근 투여 전의 운동량은 음주 후 10분부터 음주 전에 비하여 유의하게 상승하였으나 갈근 투여 후의 운동량은 음주 후 60분부터 유의하게 상승하여 알코올에 의한 상승 효과가 지연되었다. 4) 우울과 불안은 갈근 투여 전과 위약 투여 전 그리고 갈근 투여 후와 대조약 투여 후 간에는 유의한 차이가 없었다. 5) 음식 섭취량은 갈근 투여군과 대조약 투여군 모두에서 실험 기간 동안 유의한 변화가 없었다. Effect of radix puerariae on blood alcohol concentration and on alcohol effect in alcoholic patients was studied. The subjects were 57 hospitalized male alcoholics recovered from acute intoxication and withdrawal symptoms. They were divided into two groups of 29 subjects of experimental group and 28 control group. The experimental group was adminitrered with 10g/day of powder of radix puerarize and the control group with mixture of 4g/day of radix glycyrrhizae and 6g/day of flour for 4 weeks, respectively. Before and after treatment of the drugs, blood alcohol concentration, vital signs, and mania rating scale were measured at -5, 10, 30, 60, 90 and 120 minutes after administration of 25% alcohol at a dose of 6ml/kg b.w.p.o. The results were as follows: 1) Blood alcohol concentration was not changed by four weeks of radix puerariae treatment and no difference in the blood alcohol concentration was noted between the radix puerariae and the control groups. 2) Radix puerariae significantly lowered systolic blood pressures at 10, 30, 60 and 90 minutes after alcohol intake and diastolic blood pressures at 10, 30, 60, 90 and 120 minutes after alcohol intake as compared to the corresponding pre-treatment levels. Moreover, before radix puerariae treatment, alcohol-induced elevation of systolic blood pressure was significant at 10 minutes after alcohol intake and that of diastolic blood pressure was significant at 10, 30 and 60 minutes after alcohol intake. But after radix puerariae treatment, such elevation was abolished. 3) Radix puerariae reduced significantly levels of motor activity at 60 and 90 minutes after alcochol intake and levels of voice at 10, 30, 60 and 90 minutes after alcohol intake as compared to the respective pre-treatment levels. Alcohol-induced enhancement of motor activity was significantly increased from 10 minutes after alcohol intake before radix puerariae treatment. But after the drug treatment, it was significantly increased from 60 minutes after alcohol intake. Thus radix puerariae delayed the development of alcohol-induced enhancement of motor activity. 4) No significant differences were noted in the levels of anxiety and depression between the index group and the control, either before or after respective drug treatment. 5) Food intake was not changed during the experimental period in both groups.
교사-유아 간 상호작용적 과학저널활동의 교육적 의미탐색
김명정 한국영유아교원교육학회 2011 유아교육학논집 Vol.15 No.5
This purpose of this study was to investigate the educational effects of interactive science journal writing between teacher and children. Participatory observation came into effect in a 5years old class for about 5 months from March to July in 2010. The research method was to collect data from participatory observation, Interview with teacher, teacher’s and children’s science journal, and voice and movie recording. The major findings of this study are as follows. At first, children had ‘anxiety about forecast and simple drawing.’ They had concrete drawing through ‘reflection of sensitive observation and active survey,’ were get used to write journal. Finally children joined science activities. Furthermore, they did ‘start science activities in their life and to be a cognitive-scientist.’ Second, teachers could give simple feedback as reacting to their children’s emotion.’ Teachers took a deep interest in science teaching when children zoom in science. Finally, teachers could enjoy science. 본 연구는 교사-유아 간 상호작용적 과학저널활동의 교육적 의미를 유아의 변화와 교사의 변화, 두 가지 측면으로 나누어 이해하고자 한 연구이다. 2010년 3월부터 7월까지 서울시에 위치한 A유치원 만 5세반(20명)에서 이루어진 활동으로 주 2회의(총 36회)참여관찰, 교사면담, 교사의 과학저널 및 일화기록, 유아들의 과학저널 결과물 수집 등의 방법으로 자료를 수집하였다. 연구결과, 유아들의 경우 ‘잘못된 기록을 두려워하며 단순하게 표상’함으로 시작된 활동이 과학저널활동을 통해 ‘과학적 탐구동기가 반영된 민감한 관찰과 적극적 조사활동을 하게 되어 구체적으로 표상’하게 되었고 나아가 ‘일상생활 속 과학 활동을 시작함으로 능동적인 과학자’가 되어갔다. 교사의 경우 ‘유아들의 기록한 감정을 반영하는 단순한 피드백을’하는 것으로 시작된 저널활동이 ‘과학교수에 대한 반성적 사고가 반영되어 과학저널활동지원을 위한 적극적인 준비’를 하게 되면서 나아가 ‘일상생활 속에서 스스로 과학을 즐기는 교사’가 되어가는 양상이 두드러지는 것을 알 수 있었다.