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The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma
김승환,조선욱,민혜숙,김강민,염계정,김은영,이규언,윤여규,박도준,박영주 대한내분비학회 2013 Endocrinology and metabolism Vol.28 No.3
Background: Tumor-associated macrophages (TAMs) play a tumorigenic role related to advanced staging and poor prognosis in many human cancers including thyroid cancers. Yet, a functional role of TAMs in papillary thyroid carcinoma (PTC) has not been established. The aim of this study was to investigate TAM expression in human PTC with lymph node (LN) metastasis. Methods: Thirty-six patients who underwent surgery after being diagnosed with PTC with LN metastasis were included. Primary tumor tissues were immunohistochemically stained with an anti-CD68 antibody and clinical characteristics according to TAM density were evaluated. Results: The TAM densities (CD68+ cells) varied from 5% to 70%, in all tumor areas, while few cells were stained in adjacent normal tissues. TAMs were identified as CD68+ cells with thin, elongated cytoplasmic extensions that formed a canopy structure over tumor cells. Comparing clinicopathologic characteristics between tumors with low (<25%) and high (25% to 70%) TAM densities, primary tumors were larger in the high density group than in the low density group (2.0±0.1 vs. 1.5±0.1; P=0.009). Conclusion: TAMs were identified in primary PTC tumors with LN metastasis and higher TAM densities were related to larger tumor sizes, suggesting a tumorigenic role of TAMs in human PTCs.
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건물 화재 시 LPG소형저장탱크 보호용 화재 저항 재료 성능 실증
김승환,김경식,허승건,이재훈 한국가스학회 2020 한국가스학회지 Vol.24 No.4
The purpose of this study is to validate thermal hinderance effects, i.e., feasibilities,of fire-proof structure for LPG tank exposed to fire from adjacent burning building. Thepanel materials suggested for the fire-proof structure are (1) 10 mm-thick wood, (2) wood withfireproof coating, (3) 75 mm-thick Expanded Polystyrene, (4) 75 mm-thick glass wool filledsandwich panel, and (5) 75 mm-thick autoclaved lightweight concrete. The square planar firesource of 1 m2, a matrix of nozzles releasing 120-140 g/s of LPG, is used to heat up the walland the tank beyond, mimicking heat transfer from burning exterior wall finishes. The feasibilityis tested by inspecting structural integrity after test, and then by examining temperaturesat both sides of panels and tank’s front surface as well as heat fluxes. As a result, it can beconcluded that, among the suggested sample materials, fire-proof wall with ALC panel onlyshowed the feasibility for explosion prevention with the proven evidences of structural integrityand least increase in temperature of tank. 본 연구의 목적은 화재사고가 발생한 건물에 인접한 LPG 탱크용 방화벽의 적용성을 검증하는 것이다. 제안된방화벽 재료는 (1) 두께 10 mm 목재합판, (2) 내화도료를 도포한 목재합판, (3) 두께 75 mm Expanded Polystyrene,(4) 두께 75 mm 유리섬유 충진 샌드위치 판넬, (5) 두께 75 mm Autoclave Lightweight Concrete이다. 화원은 1 m 정사각형으로 120-140 g/s의 LPG를 균일하게 분사하여 방화벽과 후단의 탱크를 가열한다. 적용성은 시험 후 방화벽의구조적 건전성 확인, 방화벽 양면 및 탱크표면 온도, 탱크 인근 복사열을 분석하여 판단한다. 그 결과, ALC 방화벽이유일하게 구조 건전성을 유지하였고 저장탱크 온도를 가작 적게 상승시켜 폭발 방지 적용성을 확인하였다. 본 실험결과를 활용하여 방화벽의 성능평가 기준 마련에 필요한 핵심인자를 도출하였다.
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감각신경성 청각장애를 동반한 18번 염색체 단완 결손 증후군 1례
김승환,홍지연,임신영 대한재활의학회 2008 Annals of Rehabilitation Medicine Vol.32 No.5
Chromosome 18p deletion syndrome is one of the most frequent autosomal abnormalities with more than 150 reported cases in the world and 7 reported cases in South Korea. Frequent clinical features of 18p deletion syndrome include intellectual disability, growth retardation, and dysmorphic features including ptosis. To the best of our knowledge, sensorineural hearing loss has not been reported in the 18p deletion syndrome until now. A case with sensorineural hearing impairment associated with hypoplasia of bilateral cochlear nerves is presented in this paper. The sensorineural hearing impairment seen in this case could be related with deleted gene(s) located in the short arm of chromosome 18 or be an independent feature unrelated with 18p deletion. Further case reports are required in order to better define the relation between sensorineural hearing loss and the 18p deletion syndrome.
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