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프로트롬빈시간과 활성부분트롬보플라스틴시간이 연장된 소아에서 루프스항응고인자의 의의
조정현,손동우,전인상 대한소아혈액종양학회 2016 Clinical Pediatric Hematology-Oncology Vol.23 No.1
Background: The prolongation of prothrombin time (PT)/activated partial thromboplastin time (aPTT) in vitro occurs from various causes and lupus anticoagulant (LA) is one of them. This study was performed to investigate the association between prolonged PT/aPTT and LA in children. Methods: This study included 66 subjects, who showed prolonged PT/aPTT on routine examination and screening test prior to an invasive procedure. LA was investigated in subjects with only PT prolongation, only aPTT prolongation, and PT/aPTT prolongation. The aPTT prolongation subjects were subdivided into more prolonged (≥60 sec) and less prolonged (39.6≤aPTT<60 sec). In addition, the sensitivity and specificity of LA in PT or aPTT prolongation was evaluated by ROC (receiver operating characteristics) curve. Results: The frequency of LA positivity was 60.6% in PT or aPTT prolongation subjects. The frequency and titer of LA were higher in the order of prolonged PT group, prolonged aPTT group, and prolonged PT/aPTT (P<0.01). The frequency and titer of LA were higher in more prolonged aPTT group than less prolonged group (P<0.01). The accuracy of sensitivity and specificity of LA in cases with PT prolongation was low (area under the ROC curve was 0.68), however, was high (0.89) in cases with aPTT prolongation. The sensitivity and specificity of LA in predicting aPTT prolongation time of more than 42.9 sec were 0.83 and 1.00, respectively. Conclusion: PT was less affected than aPTT by LA and aPTT prolongation could more accurately predict LA existence. A large portion of PT or aPTT prolongation found in children without obvious past or family history of bleeding, especially accompanying infectious disease, might be associated with LA.
The Potential of Renal Progenitor Cells in Kidney Diseases: Preclinical Findings
조정현,김기훈,김태민 사단법인 한국동물생명공학회 2019 한국동물생명공학회지 Vol.34 No.2
The kidney is a highly complex organ, and acute or chronic renal diseases can occur with various complications such as diabetes and hypertension. So far, no target specific treatment is available in acute or chronic renal failure, necessitating the development of alternative therapeutic strategy. Recent experimental findings suggest that the renal function and structure can be restored after being treated with various sources of stem/progenitor cells. In this review, we discuss up-to-date findings of the potential of renal progenitor/stem cells in alleviating renal injuries with a focus on preclinical studies. We also review cellular mechanisms underlying the therapeutic function of these cells.
조정현,Cho Jeong-Hyun Korean Institute of Information Scientists and Eng 2004 정보과학회논문지 : 기술교육 Vol.1 No.1
본 논문은 클립아트 이미지로부터 색상정보와 모양정보를 추출한 후에 다른 클립아트 이미지로부터 추출된 색상정보와 모양정렬 사이의 유사성을 측정하는 방법에 대해 제안한다. 클립아트 이미지의 모양정보를 표현하기 위해서, 제안된 방법은 사각형의 비율을 이용해서 외각선을 오목면과 볼록면의 비율로 표현한다. 모양의 외각선은 사각형으로 표현되고 체인 코드로 변환한다. 반면에, 색상은 HSV 색상 좌표계로 양자화된 간 색상 영역사이의 위치 정보 그리고 색상 영역사이의 크기로 표현된다. 이 색상정보는 자연 이미지보다 적은 칼라수를 가지는 클림아트를 표현하는 데 있어 보다 나은 정확성을 갖는다. 실험 결과는 모양과 색상을 표현하는 데 있어 이전에 연구되었던 방법보다 제안된 방법이 우위에 있음을 보여준다.