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박찬일,조보연,이홍규,고창순,민헌기,문형로,박용수,김성연,조병규,양세원,이병두,서창인 대한내분비학회 1988 Endocrinology and metabolism Vol.3 No.2
To elucidate the clinical characteristics of the intracranial germ cell tumor, to find out the appropriate diagnostic measures and to evaluate the different effect of various therapeutic modalities on survival, 60 patients with intracranial germ cell tumor were examined retrospectively. Intracranial germ cell tumors displayed specificity in site of origin. Ninety-five percent arose along the midline from the suprasellar cistern to the pineal gland. The age distribution of the afflicted patients was unimodal, centering with an abrupt surge in frequency in the early pubertal years. Pineal germ cell tumors demonstrated an earlier onset of age than suprasellar germ cell tumors. While pineal tumors presented as the posterior third ventricular masses with hydrocephalus and midbrain compression, suprasellar tumors commonly presented with diabetes insipidus, visual field defect and hypothalamic-pituitary failure. With a subpopulation of 55 conventionally treated patients, two factors were of prognostic significance: 1) follow-up CT after 2000 rad irradiation 2) relapse after treatment response. At present, it might be assumed that it is an optimalapproach to observe the response after 2000 rad irradiation consigering the high operative risk especially in case of pineal tumor.
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