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박호성,장규윤,김경열,이학용,Tarnawski Andrzej S.,Majumdar Adhip P. N.,강명재,이동근,문우성 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.6
Background : It has been well demonstrated that the overexpression of epidermal growth factor receptor (EGFR) is associated with numerous gastrointestinal malignancies, including gallbladder carcinoma. However, the cellular events that regulate EGFR in cancer cells have not been fully elucidated. A novel negative regulator of EGFR that is referred to as EGFR related protein (ERRP) has recently been identified. The aim of this study was to investigate the expression and localization of ERRP in gallbladder carcinoma and to examine a possible role for ERRP. Methods : We examined the immunohistochemical expressions of ERRP, p53 and proliferating cell nuclear antigen labeling index (PCNA-LI) in formalin-fixed, paraffinembedded specimens of 43 cases of gallbladder carcinoma, 7 cases of adenoma and 3 cases of dysplasia. Results : In the normal mucosa, ERRP immunoreactivity was positive in over 64% of specimens. In contrast, the ERRP staining was positive in only 46% of the cancer specimens. The expression of ERRP in cancer cells was inversely correlated with tumor cell proliferation. The loss of ERRP expression correlated with the p53 overexpression. Conclusions : Our data indicate that the down-regulation or loss of ERRP could play an important role in the progression of gallbladder carcinoma. The inverse relationship between the ERRP expression and PCNA-LI suggests that ERRP may play a role in the inhibition of tumor cell proliferation in gallbladder cancer.
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박호성,공태식,장규윤,정명자,문우성,이동근,강명재 대한병리학회 2004 Journal of Pathology and Translational Medicine Vol.38 No.3
Histologic alterations of lymph nodes following fine-needle aspiration have not been well described. Only two cases of lymph node infarction following fine-needle aspiration have currently been reported. We report here on a case of near total infarction of a lymph node that was detected 16 days after fine-needle aspiration in a 74-year old man. A fine-needle aspiration smear of the right inguinal lymph node showed scattered and clustered cells including lymphocytes, plasma cells, neutrophils that were seen as a reactive nodal hyperplasia in the clean background. There were no malignant cells, granulomas or necrotic debris. In the incisional biopsy of the same lymph node, the sections revealed a thin rim of viable lymphocytes, granular tissue was noted peripherally and extensive necrosis associated with vascular thrombi was noted centrally. There was no evidence of malignancy or granulomatous inflammation.
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대두박(大豆粕)의 Formaldehyde 처리와 단백질 아미노산의 이용율 그리고 단백질 이용률 평가
박호성,맹원재,장문백,송병춘 한국영양사료학회 1988 韓國營養飼料學會誌 Vol.12 No.6
大豆粕을 0, 0.3, 0.6, 그리고 0.9% formaldehyde로 處理한 後 各種 溶液에 의한 溶解度를 비교하였고 nylon bag과 pepsin-trypsin處理에 의한 蛋白質 및 아미노酸의 利用率을 平價하였다. 그리고 nylon bag과 pepsin-trypsin에 의한 蛋白質의 利用率 平價와 protease에 의한 蛋白質 利用率 平價方法을 비교하였다. ADF 溶液에 의한 大豆粕 窒素의 溶解度는 formaldehyde 處理에 큰 영향을 받지 않았으나 NDF溶液, 10% Burroughs' buffer 溶液 그리고 酵素에 의한 溶解度는 無處理 大豆拍에 比해 formaldehyde處理 大豆粕은 현저히 減少되었다. Nylon bag에 의한 反芻胃內에서 消化된 蛋白質의 量은 處理水準이 0, 0.3, 0.6, 그리고 0.9%로 증가함에 따라 各各 85.45%, 33.72%, 15.85% 그리고 13.62%로 현저히 감소되어진 반면에 pepsin-trapsin에 의해서 消化된 量은 各各 13.22%, 60.02% 그리고 73.55%로 증가되었다. 總아미노酸의 nylon bag에 의한 反芻胃內에서 消化된 量은 無處理 大豆粕이 83.75%인데 비해 0.6% formaldehyde 處理 大豆粕은 10.63%였으며 pepsin-typsin에 의해 消化된 量은 各各 14.50%와 77.00%로서 formaldehyde 處理에 의한 反芻胃內 分解率이 월등히 감소되었고 小腸內 消化된 量이 크게 증가되었다. 大豆蛋白質의 protease에 의한 實驗室的 平價는 nylon bag과 pepsin-tripsin에 의한 平價方法과 유사한 결과를 얻을 수 있었다. Soybean meal was treated with 0, 0.3, 0.6, and 0.9 % formaldehyde air dry basis and measured solubilities and the protein and amino acid availability by nylon bag inserted in the rumen of fistulated steer and pepsin-trypsin treatment. Soybean protein fractions were evaluated with nylon bag and pepsin-trypsin and protease in laboratory method. Nitrogen solubilities with ADF solution were not much different from untreated and formaldehyde treated soybean meal, but NDF, Burroughs buffer solution and enzymes were decreased greatly the solubilities of soybean meal nitrogen after formaldehyde treatment. The ruminal disappearance of soybean meal nitrogen estimated by nylon bag technique were decreased by increasing formaldehyde treatment levels and were 85.45%, 33.72 %, 15.85% and 13.62%, respectively with 0.3, 0.6, and 0.9% formaldehyde treatment levels. On the other hand nitrogen disappearance of soybean meal estimated by pepsin-trypsin were 13.22%, 60.02 %, 73.55% and 73.55 % respectively with given formaldehyde levels. The total amino acid disappearance in the rumen and pepsin-trypsin were 83.75 % and 10.63% with untreated soybean meal and 14.50 % and 7.00 % with 0.6 % fomlaldehyde treated soybean meal. Evaluation of available protein fraction of soybean meal with nylon bag and pepsin-trypsin and protease were comparable method.
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박호성,장규윤,정명자,이동근,강명재 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.3
Most cases of primary squamous cell carcinoma of the ovary are associated with mature teratoma or Brenner tumor, and a few cases are related to endometriosis of the ovary. But a few cases of ovarian primary squamous cell carcinoma have occurred without clear associated etiology. Although some of them are concurred with cervical carcinoma in situ, they have not shown clear associations with the ovarian primary squamous cell carcinoma. We report a case of primary squamous cell carcinoma of the ovary appearing in pure form. A left ovarian mass was detected in a 43-year-old woman. A total hysterectomy and bilateral adnexectomy with regional lymph node dissection were performed. Histologically, the tumor was predominantly composed of polygonal tumor cells with keratinization and intercellular bridge, dyskeratotic cells, necrotic cell debris, and inflammatory cells. Also, metastasis to paraaortic lymph node was detected.
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박호성,장규윤,이상용,김정렬,Park, Ho-Sung,Jang, Kyu-Yun,Lee, Sang-Yong,Kim, Jung-Ryul 대한근골격종양학회 2004 대한골관절종양학회지 Vol.10 No.1
골 섬 (bone island)은 해면골 내에 성숙된 치밀골 병소가 존재하는 것이다. 골 섬은 특징적인 임상적 및 방사선학적 소견으로 진단될 수 있다. 병변은 무증상인 경우가 많으며 골반, 대퇴골, 그리고 다른 장골에서 호발한다. 방사선 검사상 병변은 해면골 내에 난원형, 원형, 또는 길게 늘어진 모양의 균질하고 진한 경화성 병변으로 관찰되며 "가시 방사" 또는 "위족"으로 알려진 방사상 뼈 줄무늬가 특징적인 소견이다. 대부분의 골 섬은 직경이 0.1 cm 부터 2.0 cm 로 크기가 작다. 직경이 2 cm 이상으로 정의된 거대 골 섬은 보고가 극히 드물다. 저자들은 31세 남자에서 발생한 10${\times}$1.7${\times}$1 cm 크기의 거대 골 섬 1예를 보고하고자 한다. A bone island represents a focus of mature compact bone within the cancellous bone. It can be diagnosed based on characteristic clinical and radiologic features. The lesion is typically asymptomatic with a preference for the pelvis, femur, and other long bones. On the radiologic study, the lesion appears as an ovoid, round, or oblong homogeneously dense and sclerotic focus in the cancellous bone. Characteristic feature of this lesion is radiating bony streaks, known as "thorny radiations" or "pseudopodia". Most bone islands are small, and majority of the lesions measure from 0.1 to 2.0 cm. Giant bone island, defined as a diameter greater than 2 cm, has been rarely reported in the literature. We report a case of giant bone island measured by 10${\times}$1.7${\times}$1 cm in the diaphysis of right tibia in 31-year-old man.
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박호성,장규윤,정명자,문우성,이동근,강명재 대한병리학회 2004 Journal of Pathology and Translational Medicine Vol.38 No.3
Heterotopic bone formation in the eyeball is a rare finding. Some etiologic factors, such as trauma, chronic inflammation, and long-standing retinal detachment have been associated with the onset of intraocular ossification. We report here on a case of a 21-year-old woman with a history of blunt trauma fifteen years ago, who complained of right eye blindness. When the right eyeball eviceration was done, a hard, grayish mass was found. On histopathologic examination, the mass showed lamellar bone with fatty marrow and hyalinized tissue with dystrophic calcification. We diagnosed her case as intraocular ossification. Intraocular Ossification
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