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Clinical and Genomic Characteristics of Adult Diffuse Midline Glioma
박창희,김태민,배정모,윤홍석,김진욱,최승홍,이순태,이주호,박성혜,박철기 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2
Purpose The treatment outcomes and genomic profiles of diffuse midline glioma (DMG) in adult patients are rarely characterized. We performed a retrospective study to evaluate the clinicogenomic profiles of adult patients with brain DMG. Materials and Methods Patients aged ≥ 18 years diagnosed with brain DMG at Seoul National University Hospital were included. The clinicopathological parameters, treatment outcomes, survival, and genomic profiles using 82-gene targeted next-generation sequencing (NGS) were analyzed. The 6-month progression-free survival (PFS6) after radiotherapy and overall survival (OS) were evaluated. Results Thirty-three patients with H3-mutant brain DMG were identified. The median OS from diagnosis was 21.8 months (95% confidence interval [CI], 13.2 to not available [NA]) and involvement of the ponto-medullary area tended to have poor OS (median OS, 20.4 months [95% CI, 9.3 to NA] vs. 43.6 months [95% CI, 18.2 to NA]; p=0.07). Twenty-four patients (72.7%) received radiotherapy with or without temozolomide. The PFS6 rate was 83.3% (n=20). Patients without progression at 6 months showed significantly prolonged OS compared with those with progression at 6 months (median OS, 24.9 months [95% CI, 20.4 to NA] vs. 10.8 months [95% CI, 4.0 to NA]; p=0.02, respectively). Targeted NGS was performed in 13 patients with DMG, among whom nine (69.2%) harbored concurrent TP53 mutation. Two patients (DMG14 and DMG23) with PIK3CAR38S+E545K and KRASG12A mutations received matched therapies. Patient DMG14 received sirolimus with a PFS of 8.4 months. Conclusion PFS6 after radiotherapy was associated with prolonged survival in adult patients with DMG. Genome-based matched therapy may be an encouraging approach for progressive adult patients with DMG.
박창희,김기덕,박창서 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.1
Purpose : To propose a standard value for the maxillary sinus volume of a normal Korean adult by measuring the width and height of the sinus and analyzing their correlation and the difference of the sinus size respectively between sexes, and on the right and left sides. Materials and Methods : Fifty-two (95 maxillary sinuses) out of 20 years or over aged patients who had taken CT in the Department of Dental Radiology, Yonsei University, Dental Hospital, between February 1997 and July 1999 who were no specific symptom, prominent bony septa, pathosis, clinical asymmetry and history of surgery in the maxillary sinus were retrospectively analyzed. Results : The mean transverse width, antero-posterior width, height and volume of the normal Korean adult's maxillary sinuses were 28.33 mm, 39.69 mm, 46.60 mm and 21.90㎤, respectively. There was a significant sex difference in the sinus volume (P< 0.05). In the mean antero-posterior width, height and volume of the sinus, no significant difference was observed between both sides. All four measurements showed a significant correlation between both sides (P< 0.0001). The widths and height of the sinus all showed a significant correlation with the Sinus volume(P< 0.0001). Conclusion : In the Korean normal adult's maxillary sinus, males tended to be larger than females. Except for the transverse width, all of the measurements showed no significant difference between the right and left side, but significant correlations in the four measurements between both sides were observed. Thus, the overgrowth or undergrowth in the unilateral maxillary sinus may suggest a certain pathosis or developmental abnormalities in the maxillary sinus (Korean J Oral Maxillofac Radiol 2000; 30: 63-70)
박창희,김미소,곽윤진,문경철,김세현,김범석,김유정,김태민,김동완 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4
Purpose Angiosarcoma is a highly aggressive mesenchymal tumor. Although systemic chemotherapy is often considered for the inoperable or metastatic angiosarcoma, the outcome of such treatment is unsatisfactory and poorly delineated. Materials and Methods We reviewed electronic medical records of 75 patients with angiosarcoma who were treated with systemic chemotherapy for inoperable or metastatic disease. Patients were classified as having liver involvement if they had either primary or metastatic hepatic lesions. Results Among the patients evaluated, 51 patients (68%) were male and 24 patients (32%) had primary cutaneous angiosarcoma. Liver involvement was present in 28 patients (37.3%). A total of 59 patients received first-line weekly paclitaxel (wPac) and showed an objective response rate (ORR) of 23.7% (n=14), a median progression-free survival (mPFS) of 4.0 months (95% confidence interval [CI], 3.0 to 6.1), and a median overall survival (mOS) of 10.2 months (95% CI, 7.0 to 14.6). Among patients without liver involvement, patients receiving wPac (n=35) had significantly prolonged mPFS (5.8 months vs. 3.2 months, respectively; p=0.014) with a tendency for prolonged mOS (13.8 months vs. 11.6 months, respectively; p=0.13) than those receiving other regimens (n=12). A total of 24 patients received second- or later-line pazopanib monotherapy and showed an ORR of 16.7% (n=4), a mPFS of 2.4 months (95% CI, 1.8 to 4.3) and a mOS of 5.4 months (95% CI, 3.5 to not available). Conclusion Treatment with first-line wPac and later-line pazopanib seems to provide survival benefit, especially for patients with advanced angiosarcoma without liver involvement.
박창희,강진석,성미영,박종승,김장형,Park, Chang-Hee,Kang, Jin-Suk,Sung, Mee-Young,Park, Jong-Song,Kim, Jang-Hyung 한국정보통신학회 2006 한국정보통신학회논문지 Vol.10 No.11
본 논문은 모바일 상에서 GPS와 전자지도를 이 용하여 차량 영상의 번호판 및 이동물체의 위치를 실시간 및 시뮬레이션 동작 모드로 전자지도상에 보여주는 시스템을 구현하였다. 또한, 모바일 단말기 일종의 하나인 PDA에 부착되어 있는 카메라를 통하여 입력되는 차량의 전, 후면의 번호판을 자동으로 인식, 검증하는 모바일 영상처리 기술을 이용하여 차량 번호를 검출하고 무선 통신망을 통해 원격 서버에 차량 번호와 모바일 단말기의 위치 정보를 함께 전송함으로써 GPS에 의하여 지형 및 위치 정보를 측정하고 PDA와 무선 통신을 이용하여 실시간으로 전송함으로써 차량의 정보를 효과적으로 획득할 수 있다. 이는 위치 정보의 획득과 차량의 번호판을 영상 처리하여 실시간으로 중앙관제소에 텍스트 형태로 전송하고 이를 도면화 한다. GPS에 의한 위치 정보획득과 PDA에 의한 영상처리를 활용하여 정확한 차량의 위치 및 위치 정보를 측정하고 중앙관제소로 전송하여 관제소에서 차량의 유형, 이상여부 및 위치 정보를 실시간으로 획득하여 각종 정보에 이용하며, 이러한 특성 정보를 통해 적합한 위치를 추적이 가능한 임베디드형 시스템을 구현한다. In this thesis, GPS and the electronic mapping were used to realize such a system by recognizing license plate numbers and identifying the location of objects that move at synchronous times with simulated movement in the electronic map. As well, throughout the study, a camera attached to a PDA, one of the mobile devices, automatically recognized and confirmed acquired license plate numbers from the front and back of each cu. Using this mobile technique in a wireless network searches for specific plate numbers and information about the location of the car is transmitted to a remote sewer. The use of such a GPS-based system allows for the measurement of topography and the effective acquisition of a car's location. The information is then transmitted to a central controlling center and stored as text to be reproduced later in the form of diagrams. Getting positional information through GPS and using image-processing with a PDA makes it possible to estimate the correct information of a car's location and to transmit the specific information of the car to a control center simultaneously, so that the center will get information such as type of the cu, possibility of the defects that a car might have, and possibly to offer help with those functions. Such information can establish a mobile system that can recognize and accurately trace the location of cars.
朴昌熙 단국대학교 1995 論文集 Vol.29 No.-
This thesis is for comparing, by eras, the reunification policies proceeded by the South Korea and the North Korea for an half century since national division after liberation from Japan on Aug. 15, 1945, and finding out the possible measures of reunification of Korean peninsula. It consists of 5 chapters. Chapter 1 raise the question which is Korean people as an unitary nation had been living under same culture but they are getting more and more different as the time goes after division, therefore, the national reunification must be accomplished, and that the country after reunification should be in the state to promote the national freedom, democracy, peace, prosperity and welfare. Chapter 2 compares the reunification policies of the South and the North in 1940s and 1950s. The policy of the South Korea in 1940s was to reunify the country by selecting 100 representatives through election under observation of the United Nations in the North Korea only then having them join in the National Assembbly of the South, otherwise, to use the armed force for reunification if the North government rejects this proposal, The North also intended to reunify by armed force for the same period. In Chapter 3, the reunification policies of the South and the North in 1960s and 1970s are compared. In 1960, the South Korean government of the 2nd Republic led by the Democratic Party suggested a peaceful measure to accomplish reunification through general election of the South and the North under observation of the United Nations. However, the 3rd Repubblic governed by military power and elites which was established thereafter also presented the peaceful policy through direct dialogs on the basis of the policy "construction first, reunification later". In the meantime, the North proposed a federal system for reunification as an interim action in August, 1960. And they concentrated to the peace tactics. The policy of the South in 1970s was still to accomplish reunification through direct dialogs with the keynote of "construction first, reunification later". The policy of the North for the federal system remained at that time. Chapter 4 compares the reunification policies of the South and the North in 1980s and 1990s. In 1980s, the policy of the South is divided into two streams. The policy of the 5th Republic led by Chun Doo Hwan was 「national harmonization, democratic reunification」 and the one of the 6th Republic led by Roh Tae Woo was 「one Korea」. On Oct. 10, 1980, the North presented the revised plan of 「Establishment of Republic of Korea Democratic Federation」. Entering into 1990s, the current government of the South led by Kim Young Sam presents Phase Ⅲ policy to make 「one nation, one country」 after the federal system through reconciliation and cooperation while following the policy of the 6th Republic. The North repeats their claim on 「Establishment of Republic of Korea Democratic Federation」. Finally, Chapter 5 describes the opinions of the researcher as conclusion. I don't think that reunification has not been accomplished because of policy. There are two measures to enable practical reunification. One is frontal attack of both sides, i,e. war using the armed force, which is no acceptable because of critical risk. The other one is to wait for either system to be destroyed. Thus, the North failed in the system competition, the innovative changes in the eastern Europe and destroy of Soviet Union were the product of the 20th century proving that the socialism could not exist till the 21st century. Therefore, the socialist system is expected not to exist continually in the 21st century. Reunification theory to unify the Korean peninsula by obtaining the destroyed system of the North is the summary of this thesis.