적혈구 무형성증과 특발성 혈소판강소성 자반증을 동반한 Human parvovirus B19 감염 1예

조희순,배성익,문진영,김경동 대한임상병리학회 1998 대한임상병리학회지 Vol.18 No.3

내가 얻은 감

조희순 새가정사 1977 새가정 Vol.- No.-

ICHPP에 依한 學生들이 健康問題 分類에 關한 硏究

曺喜順 한국학교보건학회 1989 韓國學校保健學會誌 Vol.2 No.1

A Case of Constitutional Trisomy 8 Mosaicism

조희순,이채훈,김경동,이은실 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Constitutional trisomy 8 is a relatively rare aneuploidy; most identified cases are mosaic with a normal cell line. The phenotype is highly variable from apparently normal to severe disability. The proportion of abnormal cells is dramatically different between tissues and the severity of the phenotype is not directly related to the level of mosaicism. Therefore, it is very difficult to provide a definitive prognosis. We report here a case of constitutional trisomy 8 mosaicism with agenesis of the corpus callosum, congenital heart disease and micrognathia. The trisomy 8 cell line was not detected by prenatal cytogenetic study. This is the fourth reported case of constitutional trisomy 8 mosaicism in Korea

만성신부전 환자에서 혈청 가용성 트란스페린 수용체와 혈청 페리틴,트란스페린 포화도의 비교

조희순,이채훈,김경동 대한진단검사의학회 2004 Annals of Laboratory Medicine Vol.24 No.5

Background : In chronic renal failure (CRF) patients, iron deficiency is a common problem and a primary cause of resistance to recombinant human erythropoietin (rHuEPO) therapy. Serum ferritin and transferrin saturation (TS) are most commonly used parameters of iron status in CRF patients but may be influenced by the presence of inflammation and malnutrition. Recently soluble transferrin receptor (sTfR) has been advocated as a useful parameter of iron deficiency. We evaluated sTfR as an iron deficient marker in CRF patients. Methods : Included in this study were 73 CRF patients, 30 uncomplicated iron deficiency anemia (IDA) patients, and 55 normal control. Serum sTfR, serum ferritin, TS, and complete blood count were measured. The CRF patients were classified as absolute iron deficient, functional iron deficient, non-iron deficient, and iron overload groups according to National Kidney Foundation Kidney Disease and Dialysis Outcome Quality Initiative (NKF-K/DOQI) guideline. Results : The sTfR concentrations were significantly higher in uncomplicated IDA patients (3.9± 1.5 mg/L) and significantly lower in CRF patients (1.1±0.4 mg/L) than in normal controls (1.4±0.4 mg/L). In uncomplicated IDA patients, sTfR was inversely correlated with MCV, MCH, and MCHC. In CRF patients, sTfR had a weak inverse correlation with TS and MCHC, but not significantly different between the four groups. The sTfR was not significantly different between the CRF patients with the normal CRP and those with an increased CRP. Conclusions : The sTfR is useful for diagnosis of uncomplicated IDA, but not for the detection of iron deficiency in CRF patients. Further studies are needed for the evaluation of sTfR as an erythropoietic marker with rHuEPO therapy. (Korean J Lab Med 2004; 24: 267-72) 배경 : 만성신부전 환자에서 철결핍이 동반되는 경우가 많고recomvinant human EPO ( rHuEPO) 치료불응의 주원인이다.혈청 페리틴과 트란스페린 포화도가 체내 철 상태 분석에 가장많이 사용되는 지표이지만 이는 염증 및 영양상태의 영향을 받는다. 최근 가용성 트란스페린 수용체가 철결핍의 유용한 지표로 알려졌다. 저자 등은 만성신부전 환자에서 가용성 트란스페린 수용체가 철결핍 지표로 유용한지 알아보고자 본 연구를 시행하였다.방법 : 정상대조군(5명), 단순 철결핍성빈혈 환자(30명)와 만성신부전 환자(73명)를 대상으로 가용성 트란스페린 수용체, 혈청 페리틴, 트란스페린 포화도 및 일반 혈액검사를 시행하였다. 만성신부전 환자는 National Kidney Foundation kidney Diseaseand Dialysis Outcome Quality Intiative (NKF-K/DOQI) 기준에 따라 절대적 철결핍, 기능적 철결핍, 비철결핍, 철분과잉 등네 개의 군으로 분류하였다.결과 : 정상대조군에서 가용성 트란스페린 수용체 농도는 1.4±0.4 mg/L였다. 단순 철결핍성빈혈 환자의 가용성 트란스페린 수용체 농도는 3.9± 1.5 mg/L로 정상대조군에 비해 유의하게 높았고 만성신부전 환자는 1.1± 0.4 mg/L로 유의하게 감소되어 있었다. 단순 철결핍성 빈혈환자에서 가용성 트란스페린 수용체 농도는 Mean corpuscular volume (MCV), Mean corpuscular hemo -globin (MCH), Mean corpuscular hemoglobin concentration(MCHC)와 유의한 역상관관계를 보였다. 만성신부전 환자에서가용성 트란스페린 수용체 농도는 트란스페린 포화도, MCHC와약한 역상관관계가 있었으나 네 개의 군 간에는 유의한 차이가 없었고 C-reactive protein (CRP)가 정상인 환자와 CRP가 증가된환자 간에도 유의한 차이가 없었다. 결론 : 가용성 트란스페린 수용체는 단순 철결핍성빈혈의 진단에는 유용하나 만성신부전 환자에서 철결핍의 진단에는 유용하지 못할 것으로 생각되었고 rHuEPO 투여 후 적혈구생성 지표로서의 유용성 여부에 대하여 앞으로 더 많은 연구가 필요하다고 사료되었다.

A Novel Translocation t(1;5)(p32;q31) that Was Not Associated with the TAL1 Rearrangement in a Case of T Lymphoblastic Leukemia/Lymphoma

조희순,김민경,배영경 대한진단검사의학회 2009 Annals of Laboratory Medicine Vol.29 No.3

Chromosome 1 band p32 (1p32) aberrations are common in T lymphoblastic leukemia/lymphoma (T-ALL/LBL). Two types of 1p32 aberrations include translocations with different partners and submicroscopic interstitial deletion. Both aberrations are known to result in TAL1 gene deregulation. The t(1;5)(p32;q31) is a rare translocation of 1p32 in T-ALL. We now present the second case of t(1;5)(p32; q31) in T-ALL, which was present as a primary cytogenetic abnormality, with a review of the relevant literature. Interestingly, neither the translocation of the TAL1 gene nor aberrant expression of TAL1 protein was detected by fluorescent in situ hybridization (FISH) and by immunohistochemical staining in this case. Chromosome 1 band p32 (1p32) aberrations are common in T lymphoblastic leukemia/lymphoma (T-ALL/LBL). Two types of 1p32 aberrations include translocations with different partners and submicroscopic interstitial deletion. Both aberrations are known to result in TAL1 gene deregulation. The t(1;5)(p32;q31) is a rare translocation of 1p32 in T-ALL. We now present the second case of t(1;5)(p32; q31) in T-ALL, which was present as a primary cytogenetic abnormality, with a review of the relevant literature. Interestingly, neither the translocation of the TAL1 gene nor aberrant expression of TAL1 protein was detected by fluorescent in situ hybridization (FISH) and by immunohistochemical staining in this case.

동맥혈 가스분석에서 검사전 오차의 요인 분석

조희순,김경동 대한임상병리학회 1998 대한임상병리학회지 Vol.18 No.2

새로운 심층면담 기법으로써 모래이야기면담(Sandplay Narrative Interview)의 이해

조희순,조재성 한국질적탐구학회 2018 한국질적탐구학회 학술대회 자료집 Vol.2018 No.1

조선 후기 정재(呈才)에 나타난 효(孝)

조희순 한국예술융합학회 2023 예술융합연구 Vol.6 No.-

본고는 조선 후기 왕실의 효 정책을 살펴보고 궁중정재(宮中呈才) 창사(唱詞) 사설에 나타난 효를 고찰하였다. 조선건국 이래 문화의 황금기라 칭하는 영·정조와 순조 시대를 선택하여 이 시기 정재에 나타난 효를 살펴본 결과는 다음과 같다. 첫째, 영·정조대의 탕평책은 연이어 실행함으로써 왕권확립을 위한 노력이었으며, 왕실에 서 효를 정치안정의 실행방법으로 적극 활용하였다. 둘째, 조선 후기 영조의 효를 함축하면 ‘사친추승(私親追崇)’이고, 정조의 효는 ‘화성성역 (華城城役)’이며, 순조대의 효를 함축하면 ‘연향정재(宴享呈才)’라 할 수 있다. 셋째, 조선 후기 정재 창사 사설의 내용은 왕권의 정통성(正統性)과 왕의 만수무강과 효(孝) 에 관계된 사설들이다. 따라서 가을과 겨울보다 봄 경치를 예찬하였고, 군왕의 건강과 장수 이외에 다산(多産)을 암시하는 사설이 많았다. 정재는 춤과 함께 노래를 통해서 효(孝)와 관련한 내용을 설파하고 있는데, 이는 영·정조 시대의 문화예술 사조가 다음 세대인 순조대(純祖代) 효명세자에게 꽃피울 수 있는 배경을 만들어 주었다. 효명세자는 효로써 천하를 다스리려는 꿈을 정재로 표현하였다. This paper examines the royal family's Filial duty policy in the late Joseon Dynasty and examines the Filial duty shown in the royal court's Changsa editorial. The results of examining the cinematic duty that appeared in Jeongjae during this period by selecting the Yeongjo and Sunjo periods, which are called the golden ages of culture since the founding of the Joseon Dynasty, are as follows. First, the Tangpyeong policy of the Yeongjo and Jeongjo periods was an effort to establish royal authority by implementing it one after another, and the royal family actively used Filial duty as a method of implementing political stability. Second, Yeongjo‘s Filial duty in the late Joseon Dynasty is ‘Sachinchuseung(私親追崇)’, Jeongjo‘s Filial duty is ‘Hwaseongseongyeok(華城城役)’, Soonjo's Filial duty is implied, it can be called 'YeonhyangJeongjae(宴享呈才)'. Third, the contents of the Jeongjae Changsa Editorial in the late Joseon Dynasty are editorials related to the legitimacy of the royal authority and the king's Mansumugang and Filial duty. Therefore, the spring scenery was praised more than autumn and winter, and there were many editorials suggesting Dasan in addition to the health and longevity of the king. Jeongjae preaches the contents related to cinematic duty through songs along with dance, which created the background for the culture and art trend of the Yeongjo and Jeongjo periods to bloom to the next generation, Prince Hyo Myung of the Sunjo period. Prince Hyo Myung expressed his dream of governing the world with Filial duty as Jeongjae.

Individual Variation in Growth Factor Concentrations in Platelet-rich Plasma and Its Influence on Human Mesenchymal Stem Cells

조희순,송인환,박소영,성민철,안면환,송경은 대한진단검사의학회 2011 Annals of Laboratory Medicine Vol.31 No.3

Background: The objective of this study was to explore whether individual variations in the concentration of growth factors (GFs) influence the biologic effects of platelet-rich plasma (PRP) on human mesenchymal stem cells (HMSCs). Methods: The concentrations of 7 representative GFs in activated PRP (aPRP) were measured using ELISA. The effects of PRP on the proliferation and alkaline phosphatase (ALP) activity of HMSCs were examined using several concentrations of aPRP from 3 donors; the relationships between the GF levels and these biologic effects were then evaluated using 10% aPRP from 5 subgroups derived from 39 total donors. HMSCs were cultured in DMEM with the addition of aPRP for 4 or 12 days; then, DNA content and ALP activity were measured. Results: The quantity of DNA increased significantly at a 10% concentration of aPRP, but the ALP activity was suppressed at this concentration of aPRP. The GF concentrations varied among donors, and 5 subgroups of characteristic GF release patterns were identified via cluster analysis. DNA levels differed significantly between groups and tended to be higher in groups with higher concentrations of transforming growth factor-beta1 (TGF-β1) and platelet-derived growth factors (PDGFs). DNA quantity was positively correlated with TGF-β1 concentration, and was negatively correlated with donor age. ALP activity was negatively correlated with PDGF-BB concentration. Conclusions: The varying GF concentrations may result in different biologic effects; thus, individual differences in GF levels should be considered for reliable interpretation of the biologic functions and standardized application of PRP. Background: The objective of this study was to explore whether individual variations in the concentration of growth factors (GFs) influence the biologic effects of platelet-rich plasma (PRP) on human mesenchymal stem cells (HMSCs). Methods: The concentrations of 7 representative GFs in activated PRP (aPRP) were measured using ELISA. The effects of PRP on the proliferation and alkaline phosphatase (ALP) activity of HMSCs were examined using several concentrations of aPRP from 3 donors; the relationships between the GF levels and these biologic effects were then evaluated using 10% aPRP from 5 subgroups derived from 39 total donors. HMSCs were cultured in DMEM with the addition of aPRP for 4 or 12 days; then, DNA content and ALP activity were measured. Results: The quantity of DNA increased significantly at a 10% concentration of aPRP, but the ALP activity was suppressed at this concentration of aPRP. The GF concentrations varied among donors, and 5 subgroups of characteristic GF release patterns were identified via cluster analysis. DNA levels differed significantly between groups and tended to be higher in groups with higher concentrations of transforming growth factor-beta1 (TGF-β1) and platelet-derived growth factors (PDGFs). DNA quantity was positively correlated with TGF-β1 concentration, and was negatively correlated with donor age. ALP activity was negatively correlated with PDGF-BB concentration. Conclusions: The varying GF concentrations may result in different biologic effects; thus, individual differences in GF levels should be considered for reliable interpretation of the biologic functions and standardized application of PRP.