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최규성,고정환,심형석,노웅래,박정주,조광래 한국항공우주학회 2013 한국항공우주학회 학술발표회 논문집 Vol.2013 No.4
나로호(KSLV-I)의 3차 비행시험이 2013년 1월 30일 나로우주센터에서 수행되었다. 레이다를 비롯한 추적시스템으로부터의 비행데이터 및 발사체 내부 데이터를 이용한 비행상황 감시는 정상적으로 이루어졌으며, 실시간으로 동작하는 비행안전 알고리듬 계산도 정상적으로 수행되었다. 본 논문은 비행안전시스템 및 비행안전영역 설정을 설명하고 비행중 실시간으로 처리된 데이터 및 수행된 알고리듬의 분석결과를 제시하였다. The third flight test of KSLV-I was performed on January 30th, 2013 at Naro space center. Utilizing flight data obtained by tracking system such as radar and onboard telemetry data, monitoring of flight status is normally performed and the algorithms for flight safety calculations including the one for instantaneous impact point computations are also executed normally. This paper describes flight safety hazard areas and flight safety information system and presents algorithm"s analysis results and data processed in real-time during KSLV-I 3rd flight test.
Cd(Ⅱ)이온과 N_1S_3및 N_2S_4포단드와의 착물형성에 관한 연구
최규성,이상천,김용성,강동현 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.1
황을 포함하는 포단드 리간드인 tri(2-phenylthio-ethyl)amine (Podand N_1S_3)과 tetra(phenylthio-2-ethyl)ethylenediamine (Podand N_2S_4)의 합성을 확인하고, 이들의 양성자 첨가반응에 의한 평형상수(protonation constant)와 중금속 이온인 Cd(Ⅱ) 이온과의 착물형성에 따르는 안정도상수(stability constant)를 양성자들 첨가한 95% MeOH 용액에서 전위차 적정법을 사용하여 측정하였다. 리간드에 대한 양성자 첨가반응의 평형상수는 Podand N_1S_3 보다는 Podand N_2S_4 리간드가 큰 값을 보였다. 또한 Cd(Ⅱ) 이온과의 착물형성에 따르는 안정도상수의 크기도 Podand N_2S_4가 Podand N_1S_3 리간드보다 큰 값을 보이고 있다. 양성자 첨가반응에 대한 평형상수와 안정도상수를 여러 온도에서 측정하여 엔탈피 및 엔트로피의 열역학적 파라미터를 구한 결과 착물형성에 대한 -ΔH는 Podand N_2S_4가 Podand N_1S_3보다 크게 나타났으며, TΔS는 Podand N_1S_3보다는 Podand N_2S_4가 큰 값을 보였다. The protonation and stability constant of complexation of Cd(Ⅱ) ion with sulfur-containing podand ligands such as tri(phenylthio-2-ethyl)amine (Podand-N_1S_3) and tetra(phenylthio-2-ethyl)ethylenediamine (Podand N_2S_4)have been determined by using potentiometric titration in 95% MeOH at various temperature. We observed that Podand N_2S_4 ligand showed the largest protonation constant. The values of not only protonation constant but also stability constant of Cd(Ⅱ) ion were increased Podand N_1S_3 rather than Podand N_2S_4. In addition, thermodynamic parameters ΔH and changes of Pb(Ⅱ) ion complexes is Podand N_1S_3 < Podand N_2S_4.
Matlab/Simulink를 이용한 FTS 수신기 디코더부의 FPGA 설계
최규성,고정환,심형석,노웅래,황수설,노성민 한국항공우주학회 2012 한국항공우주학회 학술발표회 논문집 Vol.2012 No.11
아날로그 신호를 사용하는 IRIG 톤 방식은 우주발사체용 비행종단시스템에서 오랜 기간동안 사용되고 있으나 보안성 문제와 외부 잡음 신호에 취약한 특성을 가지고 있어 안정적인 운영을 위해서 디지털 명령 전송 방식으로의 변경이 검토되고 있다. 이의 일환으로, FTS 수신기 decoder부의 디지털 신호 처리를 FPGA(Field Programmable Gate Array)로 구현하였다. 본 논문에서는 Matlab/Simulink와 System Generator를 이용하여 FPGA 알고리즘 설계 및 검증을 수행하였다. IRIG standard tone method based on an analogue signal has been used in the flight termination system of space launch vehicle for decades. However, due to the vulnerabilities to signal security and external noise signal of the current flight termination system, modification of digital command transmitting method is reviewed for the purpose of stable operation. As a part of this, digital signal processing of FTS receiver decoder is implemented in a Field Programmable Gate Array(FPGA). In this paper, design and verification of FPGA algorithm are performed utilizing Matlab/Simulink and System Generator.
최규성,김지대,김효철,민상일,민승기,제환준,정진욱 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.4
To evaluate the technical feasibility and clinical outcome of percutaneous aspiration embolectomy for embolic occlusion of the superior mesenteric artery (SMA). Between January 2010 and December 2013, 9 patients with embolic occlusion of the SMA were treated by percutaneous aspiration embolectomy in 2 academic teaching hospitals. The aspiration embolectomy procedure was performed with the 6-Fr and 7-Fr guiding catheter. Thrombolysis was performed with urokinase using a multiple-sidehole infusion catheter. The clinical outcome was investigated retrospectively. Superior mesenteric artery occlusion was initially diagnosed by computed tomography (CT) in all patients, and all patients had no obvious evidence of bowel infarction on CT scan. Percutaneous aspiration embolectomy was primarily performed in 6 patients, and thrombolysis was initially performed in 3 patients. In 3 patients who received primary thrombolysis, percutaneous aspiration was undertaken because the emboli were resistant to urokinase. Complete angiographic success was achieved in 6 patients and partial angiographic success was accomplished in 3 patients. One patient underwent bowel resection. One patient died of whole bowel necrosis and sepsis, and 8 patients survived without complications. Percutaneous aspiration embolectomy is a useful tool in recanalization of embolic occlusion of the SMA in select patients.
Clinical Immune Tolerance in Liver Transplantation: Present and Future
최규성 한양대학교 의과대학 2014 Hanyang Medical Reviews Vol.34 No.4
Liver transplantation is the most effective treatment for end-stage liver diseases (ESLD) with satisfactory clinical results and so is considered as the treatment of choice for ESLD and early hepatocellular carcinoma with cirrhotic liver. Unfortunately, adverse effects of life-long immunosuppression prevent the development of alternative strategies to achieve better long-term outcome. Achieving clinical operational tolerance is one of the ultimate goals in the clinical transplantation field. Around 15% of liver transplantation recipients develop spontaneous operational tolerance after immunosuppression withdrawal, and the percentage may be even higher in pediatric living donor liver transplantation recipients. One of the possible explainable mechanisms is a T cell fatigue from large amount of antigen loaded. Despite continuing progress, clinical operational tolerance is still rare in liver transplantation. Reprogramming the recipient immune system by creating chimerism and utilizing regulatory cell therapies are among the newer promising means to achieve clinical liver transplantation tolerance in the future. In animal studies, administration of donor specific regulatory T cells allows a prolonged survival without immunosuppressive agents. In this review, proposed mechanisms for clinical tolerance will be offered and current experimental trial will be introduced.