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윤철주(Chul-Joo Yoon),장성민(Sung-Min Jang),박순동(Soon-Dong Park),원유헌(Yoo-Hun Won) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.2Ⅲ
오늘날 초고속 통신망의 발달로 인해서 비디오와 오디오와 같은 멀티미디어 스트림의 요청이 많아지고 있다. 하지만 기존에 사용되고 있는 웹 캐슁 기법들은 아직까지 멀티미디어 스트림과 같이 크기가 큰 파일을 적절하게 처리하지 못하고 있다. 본 논문에서는 멀티미디어 스트림을 효율적으로 처리하여 캐쉬의 적중률을 높이고 사용자의 지연 시간을 줄이는 캐슁 기법을 제안한다.
Enhanced cell growth inhibition by thiacremonone in paclitaxel-treated lung cancer cells
반정옥,황철주,박미희,황인국,정헌상,이희범,현병국,김지영,윤해석,함영완,윤도영,한상배,송민종,홍진태 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.7
Activation of nuclear factor kappa-B (NF-jB) is implicated in drug resistant of lung cancer cells. Our previous data showed that thiacremonone inhibited activation of NF-jB. In the present study, we investigated whether thiacremonone enhanced susceptibility oflungcancercellstoa common anti-cancer drug paclitaxel by further inhibition of NF-jB. Thus, we used the threefold lower doses of IC50 values (50 lg/ml thiacremonone and 2.5 nM paclitaxel). We found that combination treatment with thiacremonone and paclitaxel was more susceptible (combination index; 0.40inNCI-H460cellsand0.46inA549cells)incellgrowth inhibition of two types of lung cancer cell lines compared to a single agent treatment. Consistent with the combination effect on cancer cell growth inhibition, the combination treatment further induced apoptotic cell death and arrested the cancer cells in G2/M phase accompanied with a much lowerexpressionofcdc2andcyclinB1,andinhibitedcolony formation. Much more inactivation of NF-jB and greater expression of NF-jB target apoptosis regulated genes such as caspase-8 and PARPs were found by the combination treatment. Molecular model and pull down assay as well as MALDI-TOF analysis demonstrated that thiacremonone directly binds to p50. These data indicated that thiacremonone leads to increased apoptotic cell death in lung cancer cell lines through greater inhibition of NF-jB by the combination treatment with paclitaxel.
김평화,신현주,윤희망,최영훈,남궁정만,김대연,고경남,이미정,윤혜성,류철주,한정우,한승민,조영아 대한암학회 2022 Cancer Research and Treatment Vol.54 No.1
Purpose In 2017, the Children’s Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system was introduced. We aimed to evaluate the accuracy of CHIC-HS System for the prediction of event-free survival (EFS) in Korean pediatric patients with hepatoblastoma. Materials and Methods This two-center retrospective study included consecutive Korean pediatric patients with histopathologically confirmed hepatoblastoma from March 1988 through September 2019. We compared EFS among four risk groups according to the CHIC-HS system. Discriminatory ability of CHIC-HS system was also evaluated using optimism-corrected C-statistics. Factors associated with EFS were explored using multivariable Cox regression analysis. Results We included 129 patients (mean age, 2.6±3.3 years; female:male, 63:66). The 5-year EFS rates in the very low, low, intermediate, and high-risk groups, according to the CHIC-HS system were 90.0%, 82.8%, 73.5%, and 51.3%, respectively. The CHIC-HS system aligned significantly well with EFS outcomes (p=0.004). The optimism-corrected C index of CHIC-HS was 0.644 (95% confidence interval [CI], 0.561 to 0.727). Age ≥ 8 (vs. age ≤ 2; hazard ratio [HR], 2.781; 95% CI, 1.187 to 6.512; p=0.018), PRE-Treatment EXTent of tumor (PRETEXT) stage IV (vs. PRETEXT I or II; HR, 2.774; 95% CI, 1.228 to 5.974; p=0.009), and presence of metastasis (HR, 2.886; 95% CI, 1.457 to 5.719; p=0.002), which are incorporated as the first three nodes in the CHIC-HS system, were independently associated with EFS. Conclusion The CHIC-HS system aligned significantly well with EFS outcomes in Korean pediatric patients with hepatoblastoma. Age group, PRETEXT stage, and presence of metastasis were independently associated with EFS. Purpose In 2017, the Children’s Hepatic Tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system was introduced. We aimed to evaluate the accuracy of CHIC-HS System for the prediction of event-free survival (EFS) in Korean pediatric patients with hepatoblastoma.Materials and Methods This two-center retrospective study included consecutive Korean pediatric patients with histopathologically confirmed hepatoblastoma from March 1988 through September 2019. We compared EFS among four risk groups according to the CHIC-HS system. Discriminatory ability of CHIC-HS system was also evaluated using optimism-corrected C-statistics. Factors associated with EFS were explored using multivariable Cox regression analysis.Results We included 129 patients (mean age, 2.6±3.3 years; female:male, 63:66). The 5-year EFS rates in the very low, low, intermediate, and high-risk groups, according to the CHIC-HS system were 90.0%, 82.8%, 73.5%, and 51.3%, respectively. The CHIC-HS system aligned significantly well with EFS outcomes (p=0.004). The optimism-corrected C index of CHIC-HS was 0.644 (95% confidence interval [CI], 0.561 to 0.727). Age ≥ 8 (vs. age ≤ 2; hazard ratio [HR], 2.781; 95% CI, 1.187 to 6.512; p=0.018), PRE-Treatment EXTent of tumor (PRETEXT) stage IV (vs. PRETEXT I or II; HR, 2.774; 95% CI, 1.228 to 5.974; p=0.009), and presence of metastasis (HR, 2.886; 95% CI, 1.457 to 5.719; p=0.002), which are incorporated as the first three nodes in the CHIC-HS system, were independently associated with EFS.Conclusion The CHIC-HS system aligned significantly well with EFS outcomes in Korean pediatric patients with hepatoblastoma. Age group, PRETEXT stage, and presence of metastasis were independently associated with EFS.
멀티미디어 스트림 처리를 위한 효율적인 프록시 캐슁 기법
元裕憲,朴淳東,尹鐵柱 弘益大學校 科學技術硏究所 2000 科學技術硏究論文集 Vol.11 No.-
The growth of the internet in the past few years has led to network congestion and server overloading. Use of proxy cache solve this problem. Despite success of proxy cache in the internet, proxy cache is not efficient for multimedia stream such as video and audio. In this paper, we propose a new proxy cache policy and a efficient cache replacement algorithm for multimedia stream. We expect that a new proxy cache policy is efficient for multimedia stream.