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강석균,박기진,SunLu,Limei Peng 한국시뮬레이션학회 2017 한국시뮬레이션학회 학술대회집 Vol.2017 No.-
'스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.
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이유희,강석균,안병준 충남대학교 약학대학 의약품개발연구소 1986 藥學論文集 Vol.2 No.-
A strongly cytotoxic fraction (Fc-2, ED_50=0.0003㎍/㎖) against L1210 cell was obtained from the root, seed and fruit of Trichosanthes kirilowii, Administration of Fc-2 prolonged the life span of the BDF1 mice bearing L1210 and the ICR mice bearing S-180 by 135% and 130%, respectively. The Fc-2 affected L1210 cells were enlarged in their diameters two or three times in comparison with the untreated ones. When 20㎎/㎏ of Fc-2 was administered, intraperitoneally, all the mice were killed.
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괄루성 엑기스가 백서에서의 Alloxan 유발 당뇨에 미치는 영향
백병걸,강석균,안병준 대한약학회 1985 약학회지 Vol.29 No.3
In order to investigate the antidiabetogenic activity of T. kirilowii on the alloxan-treated mice, the effects of the oral administration of the methanol extract on the blood glucose, the survival rate and the histological changes of the Langerhans' islet were observed. The blood glucose was reached at the highest levels of $265.03\pm15.07$ and $186.41\pm0.16mg/dl at 30 min after alloxan injection, and at the lowest levels of $43.35\pm5.28$ at 4 hour and $20.40\pm3.264mg/dl at 10. hour in experimental and control group, respectively. 57.15% of the experimental group and 4.2%, of the control group were survived more than 24 hours. The life spans of the mice, which were dead within 24 hours, were $631.45\pm60.17$ for the experimental group and $414.60\pm36.24$ min for the control group. The mice from the control group, which were dead within 10 hours, showed totally necrotized $\alpha$- and $\betha$-cells. However, 3 of the 10 mice from the experimental group, which were survived until 24 hours, showed a normal histological feature of the Langerhans' islet.
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