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        • KCI등재후보

          혈구포식 림프조직구증을 동반한 Kikuchi병 1례

          오준혁,박주현,황상연,이선희,김성일,김지연,이창훈,정주섭,이은엽,조군제 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

          Kikuchi병은 경부 림프절 종대와 발열을 특징으로 하는 양성질환으로, 대부분 수주에서 6개월 이내에 증상의 호전을 보이고, 아직 정립된 효과적인 치료는 없다. 드물게 재발 또는 전신성 홍반성 루푸스와 같은 다른 질환들이 동반되는 경우가 있어 추적 관찰이 필요하다. 특히 혈구포식 림프조직구증(hemophagocytic lymphohistiocytosis)이 Kikuchi병에 동반되어 발생하는 경우에는 매우 드물게 보고되고 있다. 저자들은 발진 및 고열, 경부 종괴를 주소로 내원한 35세 여자환자에서 경부 림프절 조직 검사를 시행하였고, 조직검사에서 괴사성 림프절염 소견이 관찰되어 Kikuchi병을 진단하였다. 스테로이드 강압요법 및 대중적 치료하였으나 환자의 증상이 악화되었고, 일반 혈액 검사에서 범혈구 감소 및 혈청 ferritin이 증가하여 시행한 골수 및 간 조직검사에서 적혈구와 혈소판, 림프구 등을 탐식한 조직구들의 증식이 관찰되었다. Kikuchi병에 동반된 혈구포식 림프조직구증을 진단한 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Kikuchi's disease usually occurs in young women and is characterized by localized lymphadenitis (mostly cervical) usually associated with fever. It is considered a self-limited disease and most patients recover spontaneously within a few weeks to 6 months without any serious sequelae. However, patients with Kikuchi's disease require a systemic survey and regular follow-up for several years because it may be associated with other diseases such as systemic lupus erythematosus. To our knowledge, there are very few reports of Kikuchi's disease accompanied by hemophagocytic lymphohistiocytosis. Biopsy of a right cervical lymph node in a 35-year-old female who presented with fever and masses in the right cervical region showed necrotizing lymphadenitis and a diagnosis of Kikuchi's disease was reached. She was started on methylprednisolone pulse therapy (500 ㎎ for 3 days) but developed generalized rash and fever. Laboratory data showed pancytopenia, elevation of serum transaminase and ferritin levels. Bone marrow and liver biopsy showed proliferation of histiocytes and Kupffer's cells engulfing lymphocytes, platelets and red blood cells, respectively. We report a case of Kikuchi's disease accompanied by hemophagocytic lymphohistiocytosis

        • KCI등재

          Hemodynamic Significance of Coronary Cameral Fistula Assessed by Fractional Flow Reserve

          오준혁,이혜원,차광수 대한심장학회 2012 Korean Circulation Journal Vol.42 No.12

          Coronary cameral fistula (CCF) is a rare anomaly, where a communication exists between an epicardial coronary artery and a cardiac cham -ber. Assessing the hemodynamic significance of the fistula is crucial to make a decision concerning the management process. We present two cases of CCF, draining into the left ventricle, in which the hemodynamic significance was assessed by a fractional flow reserve.

        • KCI등재

          Normal Reference Plots for the Bioelectrical Impedance Vector in Healthy Korean Adults

          오준혁,송승환,이하린,이선학,김두엽,최정천,안진희,박진섭,신명준,전윤경,이혜원,최정현,이한철,차광수 대한의학회 2019 Journal of Korean medical science Vol.34 No.30

          Background: Accurate volume measurement is important in the management of patients with congestive heart failure or renal insufficiency. A bioimpedance analyser can estimate total body water in litres and has been widely used in clinical practice due to its non- invasiveness and ease of results interpretation. To change impedance data to volumetric data, bioimpedance analysers use equations derived from data from healthy subjects, which may not apply to patients with other conditions. Bioelectrical impedance vector analysis (BIVA) was developed to overcome the dependence on those equations by constructing vector plots using raw impedance data. BIVA requires normal reference plots for the proper interpretation of individual vectors. The aim of this study was to construct normal reference vector plots of bioelectrical impedance for Koreans. Methods: Bioelectrical impedance measurements were collected from apparently healthy subjects screened according to a comprehensive physical examination and medical history performed by trained physicians. Reference vector contours were plotted on the RXc graph using the probability density function of the bivariate normal distribution. We further compared them with those of other ethnic groups. Results: A total of 242 healthy subjects aged 22 to 83 were recruited (137 men and 105 women) between December 2015 and November 2016. The centers of the tolerance ellipses were 306.3 Ω/m and 34.9 Ω/m for men and 425.6 Ω/m and 39.7 Ω/m for women. The ellipses were wider for women than for men. The confidence ellipses for Koreans were located between those for Americans and Spaniards without overlap for both genders. Conclusion: This study presented gender-specific normal reference BIVA plots and corresponding tolerance and confidence ellipses on the RXc graph, which is important for the interpretation of BIA-reported volume status in patients with congestive heart failure or renal insufficiency. There were noticeable differences in reference ellipses with regard to gender and ethnic groups

        • KCI등재

          The Relationship between Microcirculatory Resistance and Fractional Flow Reserve in Patients with Acute Myocardial Infarction

          오준혁,차광수,안지희,김진희,양미진,이혜원,최정현,이한철,홍택종,김창훈 대한심장학회 2013 Korean Circulation Journal Vol.43 No.8

          Background and Objectives: It was demonstrated that the fractional flow reserve (FFR) with partial balloon obstruction may have impli-cations for assessing viable myocardium. In a different way, the index of microcirculatory resistance (IMR) was introduced as a useful in-dicator for assessing microvascular function. We evaluated the relationship between the FFR 0.8 and the IMR. Subjects and Methods: We studied 48 consecutive patients who had undergone coronary intervention for acute myocardial infarction (AMI). After revascularization using stent(s), an undersized short balloon was positioned inside the stent and inflated to create a specific normalized pressure drop of FFR (distal coronary/aortic pressure=0.80) at rest. The FFR 0.8 was obtained during hyperemia with the fixed state balloon-induced partial obstruction. IMR was measured by three injections of saline. The association between the FFR 0.8 and the IMR was investigated. Results: The mean age of the patients was 60±12 years and 36 (75%) overall presented with ST-segment elevation myocardial infarc-tion. The mean FFR 0.8 was 0.68±0.06. A statistically significant correlation between the FFR 0.8 and the log-transformed IMR true (LnIMR true )was found through a multivariable linear regression analysis (β=0.056, p<0.001). Both the FFR 0.8 and the LnIMR true had a positive correla-tion with the log-transformed peak troponin I (TnI) with statistical significance (r 2 =0.119, p=0.017; r 2 =0.225, p=0.006, respectively). Conclusion: There was a positive correlation between the LnIMR true and the FFR 0.8 . Both of the values were associated with peak TnI. Those values may be used as appropriate surrogate measures of microvascular function after AMI.

        • KCI등재

          大田地域 朝鮮時代 竪穴住居址에 대한 一硏究

          吳焌赫 중앙문화재연구원 2008 중앙고고연구 Vol.0 No.4

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          촌락은 전통적 생활공동체의 최소단위로 국가의 지배체계가 미치는 말단의 행정단위이다. 촌락 내에는 양반·상민·천민 등 다양한 구성원이 함께 거주하며, 家垈의 크기와 집의 間數, 장식 등을 나라에서 계급별로 한정하는 강한 家舍規制의 체계 내에 있었다. 고고학적으로 조사·보고된 조선시대 수혈주거지는 家舍規制에서 제외된 주거형태로 동시기의 기와집이나 초가집과 같은 일반적인 거주지와 큰 차이를 보이고 있다. 수혈주거는 家舍規制에서 다루어지지 않을 정도로 역사에서 배재되어 있었으나 전국적으로 분포하고 있어 실생활에서 유용하게 활용되었음을 짐작할 수 있게 한다. 하지만 조선시대 수혈주거지는 평면형태나 구조에서 규칙성이나 규격성은 확인되지 않는다. 또한 이전시기에 비해 복잡해진 사회상을 고려한다면 주거지의 내부공간이 너무 협소하다. 상부구조를 이루는 주혈은 확인되지 않거나 정형성을 띠고 있지 않으며, 공통적으로 확인되는 아궁이는 난방과 취사에 부적합한 형태를 하고 있다. 이러한 수혈주거지로서의 구조적 취약성은 상면에서 온돌이 확인된 타지역의 주거지 사례를 통해 독립적으로 사용된 것이 아니라 상면의 온돌과 함께 사용되었을 것으로 추정할 수 있다. 평지에서 확인된 수혈주거지와 대전지역과 같이 구릉지에서 확인되는 수혈주거지의 아궁이 형태는 차이를 보이고 있다. 이것은 상면으로 열전달을 효과적으로 하기 위한 구조로 판단되며, 지형적인 요인으로 인해 평지에 입지한 수혈주거지 상면의 온돌구조가 양호하게 잔존한 것으로 알 수 있다. 이와 같이 구릉지의 사면에서 확인된 대전지역 조선시대 수혈주거지 중 아궁이 시설만 확인되는 경우 문헌에서 보이는 온돌구조의 일부로 이해할 수 있으며, 잔존상태는 상부 고래부가 유실된 것으로 이해될 수도 있을 것이다. A village is a minimal unit of traditional residential community, and it is also a terminal administrative unit controlledby central government. During the Joseon Period, noblemen, commoners, and the humble resided altogether within the village, but there was rigid regulation to limit size of residence to the social class. Unlike other contemporary houses such as thatched cottages and tile-roofed houses under regulation of house size, semi-subterranean houses of the Joseon Period, archaeologically investigated and reported, seem to be out of the size regulation. Even though semi-subterranean houses were not a matter of concern and even out of the house regulation during the Joseon Period, they seem to have been useful enough in actual life to be distributed in the whole peninsular during the period. They do not display any regularity or standard in structure and shape of plan and considering social complexity of that period, inner space of the houses seems to be too small. Also, postholes to support upper structure are not identified or donot display regularity, and fireplaces, commonly identified, have inappropriate structure for heating and cooking. Considering houses equipped with the ondol (Korean underfloor heating system) above the fireplace reported from other regions, the fireplace of the houses in Daejeon region seems to have been used with the ondol facility rather than independently. Semi- subterraneanhouses constructed in the flat and hillside display some differences in the structure and formof fireplace, and these differences may be related to effective delivery of heat. Topographically, the ondolfacility of the house constructed in the flat seems to be preserved well. The fireplaces identified from the house in the hillside without the ondol may be understood as a part of the ondol facility of which the upper structure was already missing.

        • KCI등재후보

          혈구포식 림프조직구증을 동반한 Kikuchi병 1례

          오준혁,이창훈,정주섭,이은엽,조군제,박주현,황상연,이선희,김성일,김지연 대한감염학회 2004 Infection and Chemotherapy Vol.36 No.3

          Kikuchi병은 경부 림프절 종대와 발열을 특징으로 하는 양성질환으로, 대부분 수주에서 6개월 이내에 증상의 호전을 보이고, 아직 정립된 효과적인 치료는 없다. 드물게 재발 또는 전신성 홍반성 루푸스와 같은 다른 질환들이 동반되는 경우가 있어 추적 관찰이 필요하다. 특히 혈구포식 림프조직구증(hemophagocytic lymphohistiocytosis)이 Kikuchi병에 동반되어 발생하는 경우는 매우 드물게 보고되고 있다. 저자들은 발진 및 고열, 경부 종괴를 주소로 내원한 35세 여자환자에서 경부 림프절 조직 검사를 시행 하였고, 조직검사에서 괴사성 림프절염 소견이 관찰 되어 Kikuchi병을 진단하였다. 스테로이드 강압요법 및 대중적 치료하였으나 환자의 증상이 악화되었고, 일반혈액 검사에서 범혈구 감소 및 혈청 ferritin이 증가하여 시행한 골수 및 간 조직검사에서 적혈구와 혈소판, 림프구 등을 탐식한 조직구들의 증식이 관찰되었다. Kikuchi병에 동반된 혈구포식 림프조직구증을 진단한 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Kikuchi's disease usually occurs in young women and is characterized by localized lymphadenitis (mostly cervical) usually associated with fever. It is considered a self-limited disease and most patients recover spontaneously within a few weeks to 6 months without any serious sequelae. However, patients with Kikuchi's disease require a systemic survey and regular follow-up for several years because it may be associated with other diseases such as systemic lupus erythematosus. To our knowledge, there are very few reports of Kikuchi's disease accompanied by hemophagocytic lymphohistiocytosis. Biopsy of a right cervical lymph node in a 35-year-old female who presented with fever and masses in the right cervical region showed necrotizing lymphadenitis and a diagnosis of Kikuchi's disease was reached. She was started on methylprednisolone pulse therapy (500 mg for 3 days) but developed generalized rash and fever. Laboratory data showed pancytopenia, elevation of serum transaminase and ferritin levels. Bone marrow and liver biopsy showed proliferation of histiocytes and Kupffer's cells engulfing lymphocytes, platelets and red blood cells, respectively. We report a case of Kikuchi's disease accompanied by hemophagocytic lymphohistiocytosis

        • 웹 애플리케이션에서 하드웨어 엑세스를 위한 웹서버 기반의 중계시스템 개발

          오준혁 ( Junhyeok Oh ),안재용 ( Jaeyong An ),김동연 ( Dong-yeon Kim ),임태윤 ( Tae Yoon Lim ),원진섭 ( Won Jinsub ),황준호 ( Jun Ho Hwang ),김유식 ( You Sik Kim ),우덕하 ( Deok Ha Woo ),이석 ( Seok Lee ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2

          본 논문에서는 웹 애플리케이션에서 하드웨어를 엑세스 하기 위한 중계시스템을 개발하는데 목적이 있다. 웹 애플리케이션의 일종인 Scratch에서 스마트 블록과 같은 하드웨어를 엑세스 하기위해 웹 서버기반의 중계시스템을 개발하였다. 중계시스템 개발을 통해 Scratch와 스마트 블록을 활용하여 피지컬 컴퓨팅 교육을 통해 학습자의 컴퓨팅적 사고 함양에 기여 한다.

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