Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder

Çetin Turan,Güliz Şenormancı,Salim Neşelioğlu,Yasemin Budak,Özcan Erel,Ömer Şenormancı 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.3

Objective: This study aimed to investigate the blood serum levels of biomarkers specifying oxidative stress status and systemic inflammation between people using methamphetamine (METH) and the control group (CG). Serum thiol/disulfide balance and ischemia-modified albumin levels were studied to determine oxidative stress, and serum interleukin-6 (IL-6) levels and complete blood count (CBC) were to assess inflammation. Methods: Fifty patients with METH use disorder (MUD) and 36 CG participants were included in the study. Two tubes of venous blood samples were taken to measure oxidative stress, serum thiol/disulfide balance, ischemia-modified albumin, and IL-6 levels between groups. The correlation of parameters measuring oxidative stress and inflammation between groups with sociodemographic data was investigated. Results: In this study, serum total thiol, free thiol levels, disulfide/native thiol percentage ratios, and serum ischemia-modified albumin levels of the patients were statistically significantly higher than the healthy controls. No difference was observed between the groups in serum disulfide levels and serum IL-6 levels. Considering the regression analysis, only the duration of substance use was a statistically significant factor in explaining serum IL-6 levels. The parameters showing inflammation in the CBC were significantly higher in the patients than in the CG. Conclusion: CBC can be used to evaluate systemic inflammation in patients with MUD. Parameters measuring thiol/disulfide homeostasis and ischemia-modified albumin can be, also, used to assess oxidative stress.

Antimicrobial Activities of Essential Oil and Hexane Extract of Florence Fennel [Foeniculum vulgare var. azoricum (Mill.) Thell.] Against Foodborne Microorganisms

Bülent Çetin,Hakan Özer,Ahmet Cakir,Tas¸kin Polat,Atilla Dursun,Ebru Mete,Erdog˘an O¨ ztu¨rk,Melek Ekinci 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1

The objective of this study was to determine the chemical compositions of the essential oil and hexane extract isolated from the inflorescence, leaf stems, and aerial parts of Florence fennel and the antimicrobial activities of the essential oil, hexane extract, and their major component, anethole, against a large variety of foodborne microorganisms. Gas chromatography and gas chromatography-mass spectrometry analysis showed that the essential oils obtained from inflorescence, leaf stems, and whole aerial parts contained (E)-anethole (59.28–71.69%), limonene (8.30–10.73%), apiole (trace to 9.23%), β-fenchyl acetate (3.02–4.80%), and perillene (2.16–3.29%) as the main components. Likewise, the hexane extract of the plant sample exhibited a similar chemical composition, and it contained (E)-anethole (53.00%), limonene (27.16%), γ-terpinene (4.09%), and perillene (3.78%). However, the hexane extract also contained less volatile components such as n-hexadecanoic acid (1.62%), methyl palmitate (1.17%), and linoleic acid (1.15%). The in vitro antimicrobial assays showed that the essential oil, anethole, and hexane extract were effective against most of the foodborne pathogenic, saprophytic, probiotic, and mycotoxigenic microorganisms tested. The results of the present study revealed that (E)-anethole, the main component of Florence fennel essential oil, is responsible for the antimicrobial activity and that the essential oils as well as the hexane extract can be used as a food preservative. This study is the first report showing the antimicrobial activities of essential oil and hexane extract of Florence fennel against probiotic bacteria.

Free vibration of an axially functionally graded pile with pinned ends embedded in Winkler-Pasternak elastic medium

Dogan Çetin,Mesut Simsek 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.4

In the present study, free vibration of an axially functionally graded (AFG) pile embedded in Winkler-Pasternak elastic foundation is analyzed within the framework of the Euler-Bernoulli beam theory. The material properties of the pile vary continuously in the axial direction according to the power-law form. The frequency equation is obtained by using Lagrange’s equations. The unknown functions denoting the transverse deflections of the AFG pile is expressed in modal form. In this study, the effects of material variations, the parameters of the elastic foundation on the fundamental frequencies are examined. It is believed that the tabulated results will be a reference with which other researchers can compare their results.

Determination of optimum operation cases in electric arc welding machine using neural network

Tahir Çetin Akinci,Hidir Selçuk Noğay,Gökhan Gökmen 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.4

With arc welding machines, welding is only performed at optimum operating points. Determination of optimum operating points is important so as for welding machines which will be produced in future to be developed in a manner to operate in such parts. In this study,an Artificial Neutral Networks method was used in order to determine the optimum operating points of Electric Arc welding machine. For this purpose, a measurement system used to get the current measurements during the welding operation. A welding process includes some stages like initial case; transient case and operation case respectively. So as to use ANN model, a data set was established via time series. ANN is trained with 90% of data set and tested with 10% thereof. At the end of the test, a prediction of 97.49% was made according to the regression value. And according to the MSE value, it was understood that a successful prediction was made with an error of 0.00353075 values.

The Independent Relationship of Systemic Inflammation With Fragmented QRS Complexes in Patients With Acute Coronary Syndromes

Mustafa Çetin,Sinan Altan Kocaman,Turan Erdog˘ an,Aytun Çanga,Murtaza Emre Durakog˘ lugil,Ömer S¸atırog˘ lu,Özgür Akgül, MD,Tuncay Kırıs,Yüksel Çiçek,Barıs¸ Yaylak,Sıtkı Dog˘ an,smail S¸ahin,Mehmet Bo 대한심장학회 2012 Korean Circulation Journal Vol.42 No.7

Background and Objectives: QRS complex fragmentations are frequently seen on routine electrocardiograms with narrow or wide QRS complex. Fragmented QRS complex (fQRS) is associated with increased morbidity and mortality, sudden cardiac death and recurrent car-diovascular events. In this study, we aimed to interrogate the relationship of systemic inflammation with the presence of fQRS in patients with acute coronary syndromes (ACS). Subjects and Methods: Two-hundred and twenty eligible patients with ACS that underwent coronary angiography were enrolled con-secutively in this study. Patients with significant organic valve disease and those with any QRS morphology that had a QRS duration ≥120 ms as well as patients with permanent pacemakers were excluded from this study. Results: Patients with fQRS were of a higher age (p=0.02), had increased C-reactive protein (CRP) levels (p<0.001), prolonged QRS time (p<0.001), extent of coronary artery disease (CAD) (p<0.001), creatine kinase-MB (CK-MB) levels (p=0.006) and Q wave on admission elec-trocardiography (p<0.001) in comparison to patients with non-fragmented QRS. When we performed multiple logistic regression analysis,fQRS was found to be related to increased CRP levels {odds ratio (OR): 1.2, 95% confidence interval (CI): 1.045-1.316, p=0.007}, QRS du-ration (OR: 1.1, 95% CI: 1.033-1.098, p<0.001), extent of CAD (OR: 1.5, 95% CI: 1.023-2.144, p=0.037), Q wave (OR: 2.2, 95% CI: 1.084-4.598, p=0.03) and CK-MB levels (OR: 1.0, 95% CI: 1.001-1.037, p=0.04) independently. Conclusion: In our study, we found that fQRS was independently related to increased CRP. Fragmented QRS that may result as an end effect of inflammation at cellular level can represent increased cardiac risk by different causative mechanisms in patients with ACS. Background and Objectives: QRS complex fragmentations are frequently seen on routine electrocardiograms with narrow or wide QRS complex. Fragmented QRS complex (fQRS) is associated with increased morbidity and mortality, sudden cardiac death and recurrent car-diovascular events. In this study, we aimed to interrogate the relationship of systemic inflammation with the presence of fQRS in patients with acute coronary syndromes (ACS). Subjects and Methods: Two-hundred and twenty eligible patients with ACS that underwent coronary angiography were enrolled con-secutively in this study. Patients with significant organic valve disease and those with any QRS morphology that had a QRS duration ≥120 ms as well as patients with permanent pacemakers were excluded from this study. Results: Patients with fQRS were of a higher age (p=0.02), had increased C-reactive protein (CRP) levels (p<0.001), prolonged QRS time (p<0.001), extent of coronary artery disease (CAD) (p<0.001), creatine kinase-MB (CK-MB) levels (p=0.006) and Q wave on admission elec-trocardiography (p<0.001) in comparison to patients with non-fragmented QRS. When we performed multiple logistic regression analysis,fQRS was found to be related to increased CRP levels {odds ratio (OR): 1.2, 95% confidence interval (CI): 1.045-1.316, p=0.007}, QRS du-ration (OR: 1.1, 95% CI: 1.033-1.098, p<0.001), extent of CAD (OR: 1.5, 95% CI: 1.023-2.144, p=0.037), Q wave (OR: 2.2, 95% CI: 1.084-4.598, p=0.03) and CK-MB levels (OR: 1.0, 95% CI: 1.001-1.037, p=0.04) independently. Conclusion: In our study, we found that fQRS was independently related to increased CRP. Fragmented QRS that may result as an end effect of inflammation at cellular level can represent increased cardiac risk by different causative mechanisms in patients with ACS.

Experimental and theoretical analyses of a double-cylindrical trough solar concentrator

Cuma Çetiner 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.11

Parabolic trough, Fresnel, heliostat mirror, or dish-type collectors are used to obtain high temperature in solar thermal applications. The operation of this system is similar to that of a Fresnel collector, except for its reflective mirror, which is cylindrical and not flat. The experiments were carried out in the solar energy system manufactured for producing hot water, superheated water, and steam in the cylindrical trough solar concentrator. According to the test results, the thermal power of the system and the average thermal efficiency of the collector were a maximum of 15 kW and approximately 35 %, respectively.

Turkish prospective teachers’ professional goals, beliefs about the attainability of these goals, identities, and possible selves

Güler Çetin,Altay Eren 서울대학교 교육연구소 2019 Asia Pacific Education Review Vol.20 No.3

This study examined the relationships among prospective teachers’ (PTs) professional goals, their beliefs about the attainability of these goals, teacher identities, and teacher possible selves, with a particular focus on the mediating roles of teacher identities and teacher possible selves. A total of 2303 PTs from three large universities located in different regions of Turkey voluntarily participated in the study. Using an explanatory correlational research design, PTs were asked to complete various quantitative measures. Correlation, hierarchical regression, and structural equation modelling analyses were conducted to analyse the data in a comprehensive manner. The results showed that PTs’ professional goals, their beliefs about the attainability of these goals, teacher identities, and expected teacher possible selves (ETPS) were significantly and selectively related to each other. The results also showed that PTs’ teacher identities and expectations of learning to teach played significant mediating roles in the relationships between their professional goals and beliefs about the attainability of these goals. Overall, the results of the study suggest that, by considering the roles of teacher identity and ETPS, teacher educators and policy makers may better understand the factors potentially bridging the gap between professional goals and beliefs about the attainability of these goals.

An Analysis of Myocardial Efficiency in Patients with Severe Asymptomatic Mitral Regurgitation

Rengin Çetin Güvenç,Emre Aruğaslan,Tolga Sinan Güvenç,Fatma Özpamuk Karadeniz,Hülya Kaşıkçıoğlu,Neşe Çam 한국심초음파학회 2020 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.28 No.4

BACKGROUND: It is difficult to determine left ventricular systolic performance in patients with severe mitral regurgitation (MR) since left ventricular ejection fraction (EF) could be preserved until the end stages of the disease. Myocardial efficiency (MEf) describes the amount of external work (EW) done by the left ventricle per unit of oxygen consumed (mVO2). In the present study, we aimed to investigate MEf in patients with asymptomatic severe MR using a novel echocardiographic method. METHODS: A total of 27 patients with severe asymptomatic MR and 26 healthy volunteers were included in this cross-sectional study. EW was measured using stroke volume and blood pressure, while mVO2 was estimated using double product and left ventricular mass. RESULTS: There were no differences between the groups with regards to EF (66% ± 5% vs. 69% ± 7%), while MEf was significantly reduced in patients with severe MR (25% ± 11% vs. 44% ± 12%, p < 0.001). This difference was maintained even after adjustment for age, gender and body surface area (adjusted ̅ : 0.44, 95% CI: 0.39–0.49 for controls and adjusted ̅ : 0.24, 95% CI: 0.19–0.29 for patients with severe MR). Further analysis showed that this reduction was due to an increase in total mVO2 in the severe MR group. MEf of thepatients who were both on β-blockers and angiotensin converting enzyme inhibitors/angiotensin receptor blockers were higher than those who were not on any drugs, but this difference was not statistically significant (32% ± 15% vs. 23% ± 9%, p = 0.41). CONCLUSIONS: MEf was significantly lower in patients with asymptomatic severe MR and preserved EF.

A new type warped product metric in contact geometry

Ahmet Mollaoğulları,Çetin Camcı 호남수학회 2022 호남수학학술지 Vol.44 No.1

This study presents an $\alpha$-Sasakian structure on the product manifold $M_{1}\times\beta(I)$, where $M_{1}$ is a K\"{a}hler manifold with an exact 1-form, and $\beta(I)$ is an open curve. It then defines a new type warped product metric to study the warped product of almost Hermitian manifolds with almost contact metric manifolds, contact metric manifolds, and $K$-contact manifolds.

Effect of vitamin C on pregnancy rate and 8-OHdG levels during heat stress in post-partum dairy cattle

Kirdeci Armağan,Çetin Hayrettin,Raza Sanan 사단법인 한국동물생명공학회 2021 한국동물생명공학회지 Vol.36 No.4

In this study the effect of vitamin C administration on pregnancy rates during summer heat stress in dairy cows was examined. A total of 80 Holstein-Friesian cows were divided into control and treatment groups (n = 40 each). Control group animals were given 10 mL isotonic normal saline, and treatment group, Vitamin C (4 mg/kg) on artificial insemination day (day 0) and 4th, 8th and 12th day post insemination. Pregnancy diagnosis was performed on 30th day post insemination by ultrasonography. Blood samples were randomly taken from 11 animals from each group. Serum P4, GSH, MDA and plasma 8-OHdG levels were determined by using ELISA method. Results showed that 8-OHdG levels were lower in treatment group on day 4, 8 and 12 (p < 0.05) compared with the control group. Similarly, pregnancy rate was higher in treatment group (32.5%) than control (22.5%), respectively. However, MDA, P4 and GSH levels were similar in both groups at 4th, 8th and 12th day. A gradual increase in P4, and MDA levels, and a strong positive correlation between 0, 4th (r = 0.54), 4, 8th (r = 0.59) and 8, 12th (r = 0.51) day was found. Similarly, GSH levels also showed positive correlation at days 0, 4th (r = 0.47) and 4, 8th (r = 0.56). However, a strong negative correlation (r = -0.56) between MDA day 0, and GSH day 8 was found. In conclusion, vitamin C application during insemination period in postpartum cows increases pregnancy rate, and reduces oxidative stress metabolite 8-OHdG levels.