http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Martin Herrera Trejo,Eddy Alfaro Lopez,Jose Jorge Ruiz Mondragon,Manuel de Jesus Castro Roman,Hugo Solis Tovar 대한금속·재료학회 2010 METALS AND MATERIALS International Vol.16 No.5
The solidification path and contraction generated during the solidification of three carbon steels were studied. Two of the carbon steels were of hypo-peritectic chemical composition, with 0.11 % C and 0.15 % C, while one of the carbon steels were hyper-peritectic with 0.16 % C. The steels with 0.11 % C and 0.16 % C solidified as expected due to their chemical composition. In contrast, the chemically hypo-peritectic steel with 0.15 % C solidified as hyper-peritectic steel, which was associated with the microsegregation of Mn. For the steel exhibiting a hypo-peritectic solidification path, peritectic transformation occurred at solid fraction values higher than 0.9, where it was assumed that the contraction generated in the mushy shell cannot be fed by the liquid. However, for steels exhibiting a hyper-peritectic solidification path, peritectic transformation began at solid fraction values lower than 0.9, where the contraction generated by the peritectic transformation was partly fed by the liquid. Hence, the highest cracking susceptibility was associated with the hypo-peritectic solidification mode.
Structural Performance of RC Beams containing Tension-Only Nodes
Manuel Alejandro Fernandez-Rui,Luisa Marı´a Gil-Martin,Enrique Hernandez-Montes 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.1
Strut and Tie (S&T) models are used for the design of what are known as ‘‘discontinuity regions’’ in reinforced concrete (RC) structures. Building codes such as ACI-318 and Eurocode 2 do not give information on the nodes that only connect ties in S&T models (called TTT or tension-only nodes). However, their use is not explicitly prohibited in the design of RC structures. In this work, a comparison between solutions which have been designed both considering and not considering TTT nodes is evaluated. Four RC beams (designed with and without TTT nodes) were subjected to three-point bending. Experimental results show that TTT nodes are a good design solution for special cases of discontinuity regions in RC structures. However, the experimental campaign has proven that this type of node is more vulnerable to errors during construction than solutions designed without TTT nodes.
Usefulness of Pharmacogenetic Analysis in Psychiatric Clinical Practice: A Case Report
Manuel A. Franco-Martin,Francisco Sans,Belen García-Berrocal,Cristina Blanco,Carlos Llanes-Alvarez,María Isidoro-García 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3
There are many factors involved in the effectiveness and efficiency of psychiatric drug treatment. One of them is psychotropic drug metabolism, which takes place mostly in the liver through the P450 enzyme system. However, there are genotypic variants of this system’s enzymes that can directly affect both the efficacy and the onset of side effects of a given therapeutic regimen. These genotypic changes could partly explain the lack of efficacy of treatment in certain patients. We report the case of a patient diagnosed with bipolar type I disorder that presented multiple and frequent manic episodes in which the efficacy and tolerability of several pharmacological regimens with mood stabilizers and antipsychotics was scarce. The choice of medical treatment should be based on its efficacy and side effect profile. This decision can be made more accurately using the information provided by pharmacogenetic analysis. This case illustrates the importance of pharmacogenetic studies in clinical practice. The results of pharmacogenetic analysis helped to decide on a better treatment plan to achieve clinical improvement and reduce drug-induced adverse effects.
Automatic Tools of Match Analysis: Inspecting Soccer Team`s Dispersion
( Filipe Manuel Clemente ),( Micael Santos Couceiro ),( Fernando Manuel Lourenco Martins ),( Ajit Korgaokar ) 한국스포츠정책과학원(구 한국스포츠개발원) 2012 International Journal of Applied Sports Sciences Vol.24 No.2
The contracting-expanding soccer teams` relationship is one of the most important dynamic behaviors of the game. Therefore, a soccer game was analyzed using the centroid and stretch index method, while recording the team`s ball possession status (with or without ball possession). The correlation test suggest an inverse relationship between opposing teams (r (1508)=- 0.054) during all game. When considering ball possession by the teams, the results of the stretch index confirm that there are statistical differences with a small effect between the moments with and without possession of the ball for team B (F(1; 1506)=22.777; p-value≤0.001; =0.015; Power=0.998). Therefore, it was possible to confirm that the contracting -expanding relationship is an intrinsic behaviour of a soccer game in relation to ball possession.
Rufino Mondejar,Jose Manuel Garcia-Moreno,Rocio Rubio,Francisca Solano,Mercedes Delgado,Begona Garcia-Bravo,Juan Jose Rios-Martin,Amalia Martinez-Mir,Miguel Lucas 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.1
Background Lipoid proteinosis (LP) is a rare autosomal recessive disorder characterized bya hoarse voice, variable scarring, and infiltration of the skin and mucosa. This disease is associated with mutations of the gene encoding extracellular matrix protein 1 (ECM1). Case Report This was a clinical and molecular study of a new case of LP with a severe phenotype. A 35-year-old female born to nonconsanguineous parents developed dermatologicaland extracutaneous symptoms in her 9th month of life. The neurological abnormalities of thedisease began to appear at the age of 19 years. Computed tomography revealed cranial calcifications. Conclusions The diagnosis of LP was confirmed by histopathological findings and direct sequencing of ECM1. A new homozygous nonsense mutation was identified in exon 7 of ECM1, c.1076G>A (p.Trp359*). This mutation was not detected in 106 chromosomes of healthy individuals with a similar demographic origin. Microsatellite markers around ECM1 were used to construct the haplotype in both the parents and the patient. Reports on genotype-phenotype correlations in LP point to a milder phenotype in carriers of missense mutations in the Ecm1a isoform, whereas mutations in the Ecm1b isoform are thought to be associated with more severe phenotypes. The present findings in a Spanish patient carrying a truncating mutation in exon 7 revealed complete dermatological and neurological manifestations.
Diagnostic methods for assessing maxillary skeletal and dental transverse deficiencies
Dena Sawchuk,Kris Currie,Manuel Lagravere Vich,Juan Martin Palomo,Carlos Flores-Mir 대한치과교정학회 2016 대한치과교정학회지 Vol.46 No.5
Objective: To evaluate the accuracy and reliability of the diagnostic tools available for assessing maxillary transverse deficiencies. Methods: An electronic search of three databases was performed from their date of establishment to April 2015, with manual searching of reference lists of relevant articles. Articles were considered for inclusion if they reported the accuracy or reliability of a diagnostic method or evaluation technique for maxillary transverse dimensions in mixed or permanent dentitions. Risk of bias was assessed in the included articles, using the Quality Assessment of Diagnostic Accuracy Studies tool-2. Results: Nine articles were selected. The studies were heterogeneous, with moderate to low methodological quality, and all had a high risk of bias. Four suggested that the use of arch width prediction indices with dental cast measurements is unreliable for use in diagnosis. Frontal cephalograms derived from cone-beam computed tomography (CBCT) images were reportedly more reliable for assessing intermaxillary transverse discrepancies than posteroanterior cephalograms. Two studies proposed new three-dimensional transverse analyses with CBCT images that were reportedly reliable, but have not been validated for clinical sensitivity or specificity. No studies reported sensitivity, specificity, positive or negative predictive values or likelihood ratios, or ROC curves of the methods for the diagnosis of transverse deficiencies. Conclusions: Current evidence does not enable solid conclusions to be drawn, owing to a lack of reliable high quality diagnostic studies evaluating maxillary transverse deficiencies. CBCT images are reportedly more reliable for diagnosis, but further validation is required to confirm CBCT’s accuracy and diagnostic superiority.
Immobilization of commercial acid phosphatases from wheat germ and potato onto ion exchangers
Lima Frederico Alves,Martins Pedro Alves,Wilson Galvão de Morais Júnior,Ribeiro Eloízio Júlio,Guisán José Manuel,de Resende Miriam Maria 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.9
A very simple and fast immobilization technique based on ion exchange was investigated to improve the thermal stability of acid phosphatase from wheat germ and potato. Immobilization was not efficient for the DEAE-sepharose, and MANAE-agarose supports. On the other hand, Toyopearl DEAE-650s proved to be a promising support, with immobilization yield above 95% and recovery of activity above 85% for both enzymes. A second step was introduced in the immobilization protocol to improve the thermal stability of these biocatalysts. For this, oxidation and reduction of glycosidic chains of acid phosphatase were carried out, allowing the formation of aldehyde groups and subsequent interaction with the amine groups to further stabilize the different forms (free and immobilized). Both biocatalysts showed residual activity after 1 hour of inactivation at the temperature of 60 °C, a fact not observed for the free enzyme. The wheat germ acid phosphatase derivative was the most stable, with residual activity of 66.7% for the only immobilized derivative and 76.2% for the oxidized/reduced derivative. Also, the derivatives prepared by ion exchange adsorption on Toyopearl (TOYO), followed by oxidation/reduction and intramolecular crosslinking, were approximately 15 and 41 times more stable than the free enzyme from wheat germ.
Martín Avellanal,Mónica Martin-Corvillo,Laura Barrigon,Manuel Vazquez Espi,Clara M. Esteban Escolar 대한척추신경외과학회 2019 Neurospine Vol.16 No.2
Objective: To evaluate the direct costs of various spinal surgical procedures within 1 year of follow-up and to compare the profiles of neurosurgeons and orthopedic surgeons. Methods: All spinal procedures performed within a 10-month period in patients covered by a private insurance company were included. Costs related to the spinal interventions were systematically registered in the company database. Associated costs during the 1-year follow-up were recorded. Results: In total, 1,862 patients were included, with a total cost of €11,050,970, of whom 34.8% underwent noninstrumented lumbar decompression (€3,473), 27.1% dorsolumbar instrumented fusion (€6,619), 14.6% nucleoplasty (€1,323), 13.5% cervical surgery (€4,463), 3.4% kyphoplasty (€4,200), 2.9% scoliosis (€15,414), 1.2% oncologic surgery (€5,590), 0.5% traumatic compression (€7,844), and 4.7% (€1,343) other minor interventions (mainly rhizotomies). Approximately 42% of patients required reinterventions within the first year, with a global extra cost of €7,280,073; 11% were referred to the pain clinic, with a €114,663 cost; 55.5% were men; and the most common age range of patients who received an intervention was 65–75 years. Neurosurgeons performed 60% of all interventions. Noninstrumented lumbar operations were performed by neurosurgeons twice as often as instrumented operations, and they performed 76% of cervical operations. Orthopedic surgeons performed 2.5 times more instrumented than noninstrumented lumbar operations, and almost all scoliosis and rhizotomy procedures. Conclusion: The direct costs of spinal surgery in Spain were generally lower than those reported in other European Union countries and the United States. Neurosurgeons and orthopedic surgeons had different spine surgical profiles and costs.