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      • KCI등재후보

        고혈압을 동반한 제 2 형 당뇨병 환자의 섬유소 용해능 및 혈중 Lipoprotein(a) 농도

        박용수,김성연,이홍규,고창순,민헌기,박선양,박경수 대한내과학회 1994 대한내과학회지 Vol.47 No.2

        Background: Hypertensive patients have an increased risk profile for cardiovascular disease even in the absence of diabetes mellitus. Much evidence exist to show that insulin resistance plays a key role in eliciting several metabolic. and fibrinolytic abnormalities in patients with hypertension. In patients with type 2 diabetes, the onset of hypertension is associated with obesity, advancing age, and the coexistence of essential hypertension. Much less is known about specific vascular abnormalities. leading to thrombosis and the relationship between the hyperinsulinemia and thrombosis in diabetics. Therefore, we want to compare the fibrinolytic and metabolic profile between the type 2 diabetic patients with and without hypertension to investigate whether coexisting hypertension and diabetes act as additive risk factors to accelerate vascular complication. We also want to assess the relationship between levels of the regulators of fibrinolysis, serum lipid profiles including lipoprotein(a) (Lp(a)) and plasma insulin levels. Methods: In thirty-four type 2 diabetic patients with hypertension and 32 type 2 diabetic patients without hypertension, we measured the levels of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1), the regulators of the fibrinolysis, lipoprotein profile including serum Lp(a) level and the serum c-peptide concentration, as the degree of insulin resistance. Results: Type 2 diabetic patients with hypertension have increased levels of t-PA (p$lt;0.05), PAI-1 (p$lt;0.05), total cholesterol (p$lt;0.05), and plasma Lp(a) (p$lt;0.05) as compared with those without hypertension. A significant correlation between PAI-1 levels and body mass index (BMI) (r=0.3, p$lt;0,05), fasting C-peptide levels (r =0.54, p$lt;0.01) and serum triglyceride levels (r=0.28, p$lt;0.05) was observed in the diabetic patients. But we could not find a significant association between either t-PA or PAI-1 levels and Lp(a) levels in them. Stepwise forward regression analyses using BMI, fasting C-peptide level, age, systolic blood pressure, HbAlc, triglyceride, t-PA and PAI-1 level as independent variables showed that only the fasting C-peptide levels correlated with PAI-1 levels (F=5,61; p$lt;0.05), Conclusion: These results suggest that the type 2 diabetic patients with hypertension seem to have lower fibrinolysis or higher Lp(a) levels than the normotensive diabetics. It might be possible that coexisting hypertension and diabetes act as additive risk factors to accelerate vascular complication by way of aggravating the level of insulin resistance, when we consider the strong association between the level of hypofibrinolysis and dyslipidemia and the hyperinsulinemia, a measure of insulin resistance in the diabetic patients.

      • KCI등재

        C-Mn-Si 계 변태유기소성강의 성형상에 미치는 베이나이트 변태 온도 및 응력상태의 영향

        박찬경,전현조,오진후,홍승갑 대한금속재료학회(대한금속학회) 2000 대한금속·재료학회지 Vol.38 No.9

        The effects of TRansformation Induced Plasticity(TRIP) phenomena on the plastic deformation of 0.2C-1.5Si-1.5Mn multiphase steel have been investigated at various heat treatment and stress conditions. In order to estimate a deformation behavior under multi-axial stress rotate, the hole expansion(HE) tests were carried out. It is shown that the formability evaluation from the uni-axial tensile tests was quite different from the formability measured from multi-axial HE-tests because of different stress state. The formability in the multi-axial stress state decreased due to the extinction of the transformable retained austenite at relatively earlier deformation stage and the production of irregular α' martensite. The voids of TRIP steel were initiated exactly at the interface between transformed martensite and ferrite matrix regardless of stress state. In addition, new form of experimental formula is proposed in order to predict the multi-axial formability of the TRIP steel from the results of uniaxial tensile test.

      • KCI등재

        Spline 보간식을 이용한 물체재질인식센서의 성능개선

        박종건,임영철,조경영,김이곤,장영학 한국센서학회 1992 센서학회지 Vol.1 No.1

        This paper describes a noble robot sensor designed to recognize an unknown material by measuring its thermal conductivity on various ambient temperature. The excellent agreement has been obtained between the measured sensor temperature and the calculated sensor temperature by cubic spline interpolation. The active sensor to measure the thermal conductivity of a gripped object was designed and the software program using C language to discriminate objects made of different materials was developed. The temperature response characteristics of different materials on the same ambient temperature was investigated. The temperatures on three comparing points varied linearly and had parallel relation with one another in accordance with various ambient temperature.

      • SCOPUSKCI등재

        간농양 치유 후 추적 영상진단상 이상 소견을 나타내는 간농양의 조직병리학적소견

        김원호,최흥재,이동기,한광협,박찬일 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1

        Medical therapy is standard for intrahepatic abscess and generally effective, but frequently radiologically abnormal lesion persist for long time followed by ultrasonography(US) or abnormal C-T, even after successful medical treatment including aspiration and complete clinical recovery. To access the histologic features of medically healed abscess but not disappeared completely in follow-up US or ahdominal C-T we performed liver biopsies in 5 cases of healed liver abscesses. The biopsy specimens were obtained at the margin of the lesions by cutting needle with ultrasono-graphic guiding. The biopsies were performed one time in one patient at variable period after treatment, 4 weeks in 2 cases, 6, 12 weeks & 17 months in each one case. The lobular architecture of the liver was relatively well preserved except the 2 specimens obtained at 4 weeks after treatment. And the specimens within 2 months showed hemorrhagic features rather than inflammatory, such as central hemorrhagic necrosis with extravasation of RBC. The sinusaidal system was dilated slightly. Some fibrosis involving portal tract and parenchyme of the liver was noted in the specimen of 6 weeks and 12 weeks. The specimen obtained at 17 months after treatment showed nearly normal liver architecture except minimal infiltration of lymphocyte in portal tract and parenchyme. Therefore, we concluded that in completely healed liver abscess, enen if abnormal reaiologic lesion persist for long time, the histologic feature of the lesion showed some hemorrhagic necrosis and infiltration of chronic inflammatory cells.

      • KCI등재

        BLT (Bi3.25La0.75Ti3O12) 박막의 결정립 배향성이 잔류 분극과 누설 전류에 미치는 영향

        서주형,오상호,박찬향 대한금속재료학회(대한금속학회) 2001 대한금속·재료학회지 Vol.39 No.11

        Effect of grain orientation on the electrical polarization and leakage current characteristics of Bi_(3.25)La_(0.75)Ti₃O_(12) (BLT) thin films was investigated in terms of c-axis off alignment. The c-axis epitaxial and various c-axis off aligned BLT films have been successfully grown by using different electrode materials (Pt and SrRuO₃) and heat-treatments. In order to evaluate the crystallinity and the film texture of various c-axis off-aligned BLT thin films, X-ray diffraction (XRD) and transmission electron microscopy (TEM) were carried out. BLT thin film grown on the SrRuO₃/SrTiO₃ (100) substrate revealed that its c-axis aligned completely parallel to the substrate normal, by developing cube-on-cube epitaxial relathionship with underlying SrRuO₃ film. The corresponding P-E curve showed nearly paraelectric property. The polycrystalline (117) and (014) oriented BLT films grown in this study were shown that their c-axis off alignment about growth direction increased by amount more than 50°. As the degree of c-axis off-alignment was increased, remanent polarization was increased due to the anisotropic polarization characteristic of BLT film, however, the surface roughness of BLT films was increased and it resulted in degraded leakage current characteristic. Therefore, grain orientation of BLT thin films is a crucial factor controlling the polarization properties and leakage current characteristics.

      • SCOPUSKCI등재

        제 2 형 당뇨병에서 미세혈관 합병증과 대혈관 합병증의 대비

        강문호,이기영,정연실,김홍규,서찬종,송광식,박혜영,이원기 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.2

        Background: Type 2 diabetes is a heterogeneous disease. As to its complications, microangiopathy predominantly develop in some patients while macroangiopathy is more predominant in others. Therefore, this study was performed to identify the factors associated with such dissociation. Methods: Type 2 diabetic patients were classified into the macro and microangiopathy groups by carotid intima-medial thickness (IMT) and the presence of severe diabetic retinopathy. Patients with IMT ≤ 0.83 mm and severe NPDR or PDR were assigned to microangiopathy group; those with IMT 0.84 mm and no diabetic retinopathy were assigned to macroangiopathy group. Of 95 patients studied, 14 were classified as microangiopathy group and 20 as macroangiopathy group. Results: When the microangiopathy and macroangiopathy groups were compared, the microangiopathy group were significantly younger at the time of examination and at the onset of diabetes, and had longer duration of diabetes. Percentage of patients receiving insulin treatment was significantly higher and plasma C-peptide significantly lower in the microangiopathy group. However, HDL-cholesterol levels were significantly lower in the macroangiopathy group. Furthermore, the multiple logistic regression analyses revealed that younger onset of type 2 diabetes was an independent factor that was associated with the acceleration of microangiopathy. Conclusion: This study suggests that the age at onset of diabetes is an important independent risk factor that is associated with predominant development of microangiopathy in type 2 diabetic patients.

      • KCI등재

        신발제조업체에서 사용되는 접착제에 관한 연구

        이채언,문덕환,박대희 한국산업위생학회 1991 한국산업보건학회지 Vol.1 No.2

        In order to acquire the fundamental data for the organic solvents in bond and to contribute the health improvement of workers in department of organic solvents in shoes manufacturing industries. The authors surveyed the contents of organic solvent in adhesive and determined the amount of volatilization of organic solvent by time and temperature with gaschromatography from March to September 1990. The results were as follows ; 1) The kinds for organic solvents in bond were 9 that was Toluene, C-Hexane, N-Hexane, C-Hexanon, Aceton, Methyl Ethyl Keton, Dimethyl Formamide, Etyly Acetate. 2) Toluene and Methyl Ethyl Keton among the organic solvents in adhesive were over 80.18%. 3) The amount of volatilization of Methyl Cyclohexanone and Aceton by time and temperature were the most level than other compounds.

      • SCOPUSKCI등재

        독성미만성 갑상선종 환자에서 방사성옥소(131I) 투여후 발생하는 영구적 갑상선기능저하증

        이정상,이문호,고창순,이홍규,박선양 대한핵의학회 1977 핵의학 분자영상 Vol.11 No.1

        저자들은 방사성옥소투여후에 발생하는 갑상선기능저하증의 발생상황을 알아보기 위하여 1960년부터 1977년까지 서울대학교 의과대학 부속병원 내과 방사성동위원소진료실에서 131I 치료를 받은 독성미만성 갑상선종환자 794명을 대상으로 단회투여군과 다회투여군, 소량투여군과 다량투여군, 그리고 연령군별 및 안구돌출유무에 따른 갑상선기능저하증의 발생빈도를 조사하여 다음과 같은 결과를 얻었다. 1) 631명의 방사성옥소 단회투여군에서는 갑상선기능저하증의 발생빈도가 치료후 1년에 7.4%, 2년에 11.8%, 3년에 16.2%, 4년에 22.1% 그리고 5년에는 25.5%였으며, 163명의 다회투여군에서는 1년에 8.6%, 2년에 10.4%, 3년에 13.3%, 4년에 29.1% 및 5년에는 54.1%로 양군에서 모두 시간이 경과함에 따라 증가하였으며 4년 이후에는 다량투여군에서 그 발생빈도가 급격히 증가하였다. 2) 5mCi 이하의 131I를 1회만 투여받아 평균 4.3±0.6mCi의 131I 치료를 받은 550명의 소량투여군에서의 갑상선기능저하증의 발생빈도는 치료후 1년에 6.8%, 2년에 11.4%, 3년에 15.4%인 반면, 5.5mCi 이상의 131I 투여를 받아 평균 6.3±0.5mCi의 131I 치료를 받은 다량투여군환자 81명에서는 1년에 12.0%, 2년에 15.4% 그리고 3년에 20.4%로 다량투여군에서 발생빈도가 높은 것을 알 수 있었다. 그러나 방사성옥소 치료후 정상 갑상선기능상태로 되는 기간은 소량투여군과 다량투여군에서 각각 평균 5.1±3.6개월 및 4.8±2.8개월로 양군간에 통계학적으로 유의한 차이가 없었다(p$gt;0.1). 3) 방사성옥소 단회소량투여군환자 550명을 대상으로 조사한 연령군별 갑상선기능저하증의 발생빈도는 30세미만의 환자에서는 1년에 4.3%, 2년에 7.7%, 30세에서 49세까지의 환자들에서는 1년에 5.8%, 2년에 11.1% 그리고 50세 이상의 환자들에서는 1년에 11.0%, 2년에 14.4%로 연령이 많을수록 증가하는 경향을 보였다. 4) 역시 방사성옥소 단회소량 투여군환자 300명을 대상으로 조사한 안구돌출유뮤에 따른 갑상선기능저하증의 발생빈도는 치료후 1년과 2년에 각각 안구돌출이 있는 환자들에서는 7.1% 및 12.1%, 그리고 없는 환자에서는 7.3% 및 12.2%로 양군간에 차이가 없었다. 이상에서 저자들은 독성미만성 갑상선종환자에서 방사성옥소 치료후 발생하는 갑상선기능저하증은 과거 국내에서 보고된 것보다 그 발생빈도가 높으며 시간이 경과함에 따라 증가하고, 특히 다회투여군에서는 치료후 4년 이후에 연증가율이 급격에 증가하며, 초회치료로 호전되는 환자에서는 방사성옥소투여량을 줄임으로써 그 발생빈도를 감소시킬 수 있음을 관찰하였다. Radioactive ioine(RAI), principally 131I, effectively controls hyperthyroidism in the majority of patients. The subsequent development of hypothyroidism, however, has been of increasing concern since it was first pointed out by Chapman and Maloof in 1955. And the steady increase of late hypothyroidism during the passage of time was known with its relation with dosage of RAI. The authors have investigated the development of hypothyroidism in 935 patients with diffuse toxic goiter(DTG) who were treated with RAI(131I) at the Seoul National University Hospital from 1960 to 1977 to reveal its relation with the number of RAI treatments, dosage of RAI, age of patients and exophthalmos with the following results. 1)The incidence of hypothyroidism by year after RAI therapy among 631 patients with DTG who were treated with single RAI regimen was 7.4%(1 year), 11.8%(2 year), 16.2%(3 year), 22.1%(4 year) and 25.5%(5 year), and that anong 163 patients given multipie RAI treatments was 8.6%(1 year), 10.4%(2 year), 13.3%(3 year), 29.1%(4 year), and 54.1%(5 year) respectively showing much higher yearly increments from 4 years after RAI treatmenet in comparison with the former. 2) Among 550 patients in the lower dose group treated with single RAI regimen less than 5.0mCi(Mean±S.D.: 4.3±0.6mCi), the incidence of hypothyroidism by year after RAI treatment was 6.8%(1 year), 11.4%(2 year), 15.4%(3 year), while among 81 patients in the higher dose group given single RAI treatment not less than 5.5mCi (Mean±S.D.: 6.3±0.5mCi) it was 12.0%(1 year), 15.4%(2 year) and 20.4%(3 year) respectively. However, the duration till euthyroid state after RAI therapy in the two groups was 5.1±3.6 months and 4.8±2.8 months respectively showing no statistically signficant difference (p$gt;0.1). 3) The incidence of hypothyroidism after RAI treatment in patients younger than 30 years of age was 4.3%(1 year) and 7.7%(2 year); in patients from 30 years to 49 years of age, 5.8%(1 year) and 11.1%(2 year); and in those older than 50 years, 11.0%(1year) and 2 year). The data revealed rising incidence of hypothyroidism with increase of patients' age. 4) Among 116 patients with exophthames the incidence of hypothyroidism by year after RAI treatment was 7.1%(1 year) and 12.15(2 year) while that among 184 patients without exophthalmes was 7.3%(1 year) and 12.2%(2 year) respectively. With the above data the authors could conclude that the hypothyroidism in patients with DTG who were treated by RAI developed more frequently than reported by others in Korea till now, and increased with the passage of time, the yearly increments from 4 years after RAI treatment increasing markedly in the multiple dose group, and the incidence could be reduced by decreasing the administered RAI dose not increasing the duration till euthyroid state after RAI therapy.

      • 한국산 홍점무당벌레 아과(亞科)(딱정벌레목(目) : 무당벌레과)의 분류학적 연구

        윤일병,박해철 고려대학교 한국곤충연구소 1993 昆蟲硏究誌 Vol.19 No.1

        韓國産 홍점무당벌레亞科(딱정벌레目 : 무당벌레科)의 分類學的 硏究. 朴海喆, 尹一炳(高麗大學校 生物學科)昆蟲硏究. 19 : 35-44, 1993. 韓國産 홍점무당벌레亞科는 3族 4屬 7種으로 분류되었다; 그 중에서 Exochomus georgi Furach는 E.(Anexochomus) mongol Barovsky의 同種異名이고 Chilocorus esakii H. Kamiya는 C. kuwanae Silvestri의 誤同定이었으며, Telsimia nigra Weise는 國內 分布가 의심스러운 종이었다. 또한 이들 種의 捿息處 및 宿主에 대한 生物學的 情報를 追加 整理하였다. The paper is a taxonomic review of the subfamily Chilocorinae, as a part of taxonomie study on the family Coccinellidae in Korea. 7 species of 4 genera among 3 tribes are recognized. Out of 7 species, Exochomus georgi Fu¨rsch is a synonym of E. (Anexochomus) mongol Barovsky, Chilocorus esakii H. Kamiya is the misidentification of C. kuwanae Silvestri and Telsimia nigra Weise is a doubted species for its distribution in Korea. Their biological information including habitats and hosts are discussed in Korean fauna.

      • 고분자 압전센서 신호를 이용한 Gr/Ep 복합재 적층판의 손상유발 충격하중의 복원

        박찬익,김인걸,이영신 한국복합재료학회 2002 Composites research Vol.15 No.5

        압전필름센서는 복합재 구조물의 저속충격응답을 관측하기에 우수한 특성을 지니고 있다. 본 연구에서는 Gr/Ep 복합재 적충판이 손상이 발생할 수 있을 정도의 충격에너지를 받았을 때 압전필름센서 신호를 이용하여 충격거동을 모니터링할 수 있는 가능성에 대하여 고찰하였다. 손상이 발생하지 않는 저에너지 충격조건부터 국부적인 손상을 유발할 수 있는 충격조건까지 압전 필름센서가 부착된 Gr/Ep복합재 적층판에 대하여 16가지의 저속충격시험을 수행하였다. 세 가지 조건의 충격시험에서 기지균열 및 층간분리 등의 국부적인 손상이 발생하였으나. 충격력과, 변위, 변형률, 압전센서신호와의 관계를 이용한 선형해석 모델을 사용하여 충격하중에 의한 복합재 적층판의 응답을 예측하는 정방향 문제와 압전센서 신호로부터 충격력을 복원하는 역방향 문제에서 시험과 해석 결과는 비교적 잘 일치하는 경향을 보였다. 복원된 충격력으로부터 국부적인 손상이 발생할 정도의 충격에너지까지는 압전필름센서 신호를 이용하여 충격력을 정확히 복원할 수 있음을 확인하였다. The piezoelectric thin film sensor has good characteristics to observe the impact responses of composite structures. The capabilities for monitoring impact behavior of Gr/Ep laminates subjected to damage-induced impact using the PVDF(polyvinylidence fluoride) film sensor were examined. For a series of low-velocity impact tests from low energy to damage-induced energy(matrix cracking and delamination) were found at three impact tests, but the measured signals agreed well with the simulated sensor signals based on the linear relationship between the impact forces and the PVDF film sensor signal. And the inverse technique was applied to reconstruct the impact forces using the PVDF film sensor signals. Most of reconstructed impact forces had good agreement with the measured forces. The comparison results showed that the local damage due to low-velocity impact didn't disturb the global impact responses of composite laminates and the reconstruction of impact forces from PVDF sensor signals wasn't affected by the local damage.

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